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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | MECHANICAL-ELECTRIC COUPLING DYNAMICAL CHARACTERISTICS OF AN ULTRA-HIGH SPEED GRINDING MOTORIZED SPINDLE SYSTEM显示文摘On the basis of the traditional mechanical model of a grinding wheel rotor and the mechanical-electric coupling model with ideal sinusoidal supply,taking high-frequency converting current of inverter power switches into further consideration,a modified mechanical-electric coupling model is created.The created model consists of an inverter,a motorized spindle,a grinding wheel and grinding loads.Some typical non-stationary processes of the grinding system with two different supplies,including the starting,the speed rising and the break in grinding loads,are compared by making use of the created model.One supply is an ideal sinusoida]voltage source,the other is an inverter.The theoretical analysis of the high-order harmonic is also compared with the experimental result.The material strategy of suppressing high-order harmonic mechanical-electric coupling vibration by optimizing inverter operating parameters is proposed. | LUE Lang XIONG Wanli GAO Hang | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 23 |
| 3 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 4 | A Volumetric Model for Evaluating Tight Sandstone Gas Reserves in the Permian Sulige Gas Field,Ordos Basin,Central China显示文摘To accurately measure and evaluate reserves is critical for ensuring successful production of unconventional oil and gas. This work proposes a volumetric model to evaluate the tight sandstone gas reserves of the Permian Sulige gas field in the Ordos Basin. The reserves can be determined by four major parameters of reservoir cutoffs, net pay, gas-bearing area and compression factor Z, which are controlled by reservoir characteristics and sedimentation. Well logging, seismic analysis, core analysis and gas testing, as well as thin section identification and SEM analysis were used to analyze the pore evolution and pore-throat structure. The porosity and permeability cutoffs are determined by distribution function curve,empirical statistics and intersection plot. Net pay and gas-bearing area are determined based on the cutoffs, gas testing and sand body distribution, and the compression factor Z is obtained by gas component. The results demonstrate that the reservoir in the Sulige gas field is characterized by ultralow porosity and permeability, and the cutoffs of porosity and permeability are 5% and 0.15×10^(–3) μm^2, respectively. The net pay and gas-bearing area are mainly affected by the sedimentary facies, sand body types and distribution. The gas component is dominated by methane which accounts for more than 90%, and the compression factor Z of H_8(P_2h_8) and S_1(P_1s_1) are 0.98 and 0.985, respectively. The distributary channels stacked and overlapped, forming a wide and thick sand body with good developed intergranular pores and intercrystalline pores. The upper part of channel sand with good porosity and permeability can be sweet spot for gas exploration. The complete set of calculation systems proposed for tight gas reserve calculation has proved to be effective based on application and feedback. This model provides a new concept and consideration for reserve prediction and calculation in other areas. | CUI Mingming FAN Aiping WANG Zongxiu GAO Wanli LI Jinbu LI Yijun | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 4 |
| 5 | Late Cretaceous Transpressional Fault System: A Case Study of the Yishu Fault Belt, Shandong Province, Eastern China显示文摘On the basis of field observations of the structures of three profiles from the Linshu region, deformation characteristics and the tectonic background of the Yishu fault belt in the Late Cretaceous–Early Cenozoic have been discussed in detail.Three structural profiles, whose deformations consist mainly of earlier transpressional faults and later normal faults, were developed for the Mengtuan Formation of the Lower Cretaceous Dasheng Group.Typical positive flower structures, duplex structures, and break-through faults were found in these profiles.On the basis of analyses of the structural deformation and previous geochronological studies, it was concluded that the earlier transpressional faults of the profiles were triggered by the sinistral transpression of the Yishu fault belt in the Late Cretaceous–Early Paleogene, and that the later normal faults, formed during the Late Paleogene–Neogene extension, truncated the earlier transpressional faults.With consideration of the tectonic evolution of the Tan-Lu fault belt and the different drift directions of the Pacific plate since the Cretaceous, we suggest that the major tectonic events of the Late Cretaceous–Neogene in eastern China were mainly controlled by the subduction of the Pacific plate. | LI Chunlin WANG Zongxiu WU Qingzi LIU Yongqing GAO Wanli TAN Yuanlong KUANG Hongwei LI Huijun | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 3 |
| 6 | Triassic magmatism in the eastern part of the South China Block: Geochronological and petrogenetic constraints from Indosinian granites显示文摘The granitic dykes in the Badu Group,Zhejiang Province,South China provide important insights on tectonic setting and crustal evolution of the South China Block(SCB) and the Indochina Block during Triassic.Here we report LA-ICP-MS U-Pb data of granitic rocks from the Hucun and Kengkou which show early Triassic ages of 242 ± 2 and 232 ± 3 Ma,respectively,representing their timing of emplacement.The dyke rocks are enriched in K,Al,LREE,Rb,Th.U,and Pb.and are depleted in Nb,Ta,Sr,and Ti.The rocks are characterized by highly fractionated REE patterns with(La/Yb)N ratios of 28.46-38.07 with strong negative Eu anomalies(Eu/Eu* = 0.65-0.73).In situ Hf isotopic analyses of zircons from the Hucun granite yielded ε_(Hf)(t) values of-13.9 to-6.4 and two-stage depleted mantle Hf model ages of 1.68-2.15 Ga,which indicate that the magma was formed by partial melting of the Paleoproterozoic metasedimentary protoliths in the Cathaysia Block.The zircons from the Kengkou granite have ε_(Hf)(t) values ranging from 40.7 to 31.5 and yield two-stage depleted mantle Hf model ages of 0.99-2.49 Ga,indicating magma origin from a mixed source.The Hucun and Kengkou dykes,together with the Triassic A-type granites in SE China were probably generated during magmatism associated with crust-mantle decoupling along the convergent plate boundary between SCB and the Indochina Block. | Wanli Gao Zongxiu Wang Chunlin Li | 2017 | Geoscience Frontiers2017，8，3： | 2 |
| 7 | Discovery of the Early Devonian Sinistral Shear in the Jiangshan-Shaoxing Fault Zone and its Tectonic Significance显示文摘The Jiangshan–Shaoxing fault zone(JSFZ)was formed by the amalgamation of the Yangtze and Cathaysia blocks in the Neoproterozoic.Since the Paleozoic,the JSFZ has experienced three episodes of tectonic activities:the Early Paleozoic ductile strike-slip shear,Early Mesozoic thrust, | WANG Zongxiu LI Chunlin WANG Duixing GAO Wanli | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 8 | Fixation for the helical structure of a glassy cholesteric liquid crystal reflective film显示文摘The planar texture of glassy cholesteric siloxane cyclic side-chain liquid crystals was fixed by quenching initially. Then the polymer network formed by the optically active polymerizable monomers imposed additional constraints on the motion of chain seg-ments of the glassy liquid crystal and then further stabilized the molecule arrangement. A cholesteric liquid crystal film with stable optical properties was developed by this method. | Jiumei Xiao Wanli He Jin Gao Huai Yang | 2006 | Journal of University of Science and Technology Beijing2006，13，5： | 1 |
| 9 | Precisely quantifying bulk transition metal valence evolution in conventional battery electrode by inverse partial fluorescence yield显示文摘Precisely quantifying transition metal(TM) redox in bulk is a key to understand the fundamental of optimizing cathode materials in secondary batteries. At present, the commonly used methods to probe TM redox are hard X-ray absorption spectroscopy(hXAS) and soft X-ray absorption spectroscopy(sXAS).However, they are both facing challenges to precisely quantify the valence states of some transition metals such as Mn. In this paper, Mn-L iPFY(inverse partial fluorescence yield) spectra extracted from Mn-L m RIXS(mapping of resonant inelastic X-ray scattering) is adopted to quantify Mn valence states. Mn-L i PFY spectra has been considered as a bulk-sensitive, non-distorted probe of TM valence states.However, the exact precision of this method is still unclear in quantifying practical battery electrodes.Herein, a series of LiMn_(2)O_(4) electrodes with different charge and discharge states are prepared. Based on their electrochemical capacity(generally considered to be very precise), the precision of Mn iPFY in quantifying bulk Mn valence state is confirmed, and the error range is unraveled. Mn-L mRIXS iPFY thus is identified as one of the best methods to quantify the bulk Mn valence state comparing with hXAS and sXAS. | Kehua Dai Weiwei Shao Beibei Zhao Wenjuan Zhang Yan Feng Wenfeng Mao Guo Ai Gao Liu Jing Mao Wanli Yang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 10 | Coupling simulation of fluid structure interaction in the stirred vessel with a pitched blade turbine显示文摘The interaction between fluid and a down-pumping pitched blade turbine fixed with a flexible shaft in the stirred vessel, as a typical fluid structure interaction phenomenon, was simulated by coupling the Computational Fluid Dynamics and Computational Structural Dynamics. Based on the verification of the simulated impeller torque and dimensionless shaft bending moment with experimental result, the dimensionless shaft bending moment and various loads acting on impeller(including lateral force, axial force and bending moment) were discussed in detail. By separating and extracting the fluid and structural components from those loads, the results show that the shaft bending moment mainly results from the lateral force on impeller although the axial force on impeller is much larger. The impeller mass imbalance increases the shaft bending moment and the lateral force on impeller, but has little influence on the axial force and bending moment acting on impeller. The dominant frequencies of impeller forces are macro-frequency, speed frequency and blade passing frequency, and are associated with the impeller mass imbalance. | Yangyang Liang Zhengming Gao Dai'en Shi Wanli Zhao Ziqi Cai | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 0 |
| 11 | Mechanical deformation properties of Continuous Welded Rail on kilometer-span suspension bridge for high-speed railway显示文摘The complex bridge-track interaction between kilometer-span bridges and continuous Welded Rail(CWR)brings great challenges to CWR designing.Taking a suspension bridge with laying CWR as a case,the mechanical properties of CWR on the bridge are analyzed to reveal the sensitive areas of the track,and the design method of CWR and track structures on the beam ends are proposed.The results show that the unidirectional Rail Expansion Joints(REJ)need to be installed on the beam end of the kilometer-span bridge to reduce rail longitudinal force.Due to the bridge characteristics,there is no CWR fixed area on the kilometer-span bridge,and rail longitudinal force on the main span caused by bending loads needs to be concerned.The deformation of track on the beam end is complex,which is the weak area on the kilometer bridge,the large relative displacement between the stock rail of REJ and the main beam can cause poor stability of ballast bed on beam end,small resistance fasteners need to be laid on the sides of stock rail on the main beam to increase the stability of ballast and fasteners on the beam end.To improve the driving safety and comfort of beam end,the Sleeper-Supporting Apparatus(SSA)should be specially designed to ensure the uniform transition of track on beam ends.Temperature and wind loads have a significant impact on track regularity on the kilometer span bridge,the dynamic response of trains and bridges under those loads needs to be attended to. | Xiaopei Cai Wanli Liu Liang Gao Yonghua Su Jingfan Yang | 2023 | High-Speed Railway2023，1，2： | 0 |
| 12 | The late Early-Paleozoic granitic magmatism in Northwestern Fujian, China: constraints on intraplate orogeny in the South China block显示文摘The Early Paleozoic tectono-thermal event was a significant orogenic activity during the Phanerozoic era,which had a profound impact on the early crust of the South China Block(SCB) and established the foundation for later tectonic activity.The Wuyi-Yunkai orogenic belt in Southeastern China was extensively exposed to Early Paleozoic magmatism,the genetic mechanism of which remains controversial.To shed light on this issue,detailed petrological,geochemical,and zircon U-Pb-Hf isotopic studies were carried out on two granitoids,namely the Yuntongshan pluton and the Gaoqiao pluton,identified in the central Wuyishan.Zircon U-Pb chronology of the Yuntongshan and Gaoqiao bodies yielded ages of437±4 Ma(MSWD=2.2) and 404±2 Ma(MSWD=12),respectively,indicating that they were emplaced during the Early Silurian and Early Devonian periods.These granitoids are primarily composed of biotite-granite and biotite-monzonitic-granites,with high concentrations of S_(i)O_(2)(73.59-75.91 wt%),K_(2)O+Na_(2)O(8.31-8.73wt%),and low contents of MgO,CaO,Cr,Ni.They are classified as high-K calc-alkaline and weakly metaluminous-strongly peraluminous S-type granites.These granitoids are enriched in light rare earth elements(LREEs) and large ion lithophile elements(LILEs) and depleted in heavy rare earth elements(HREEs) and high field strength elements(HFSEs) with arc affinity.The εHf(t) values of-3.3 to-15.4 with two-stage Hf model ages ranging from 2829 to 1644 Ma,combined with the presence of Neoproterozoic inherited zircons,suggest that the primary magma of these granitoids was derived from the partial melting of Neoproterozoic crust with a Paleoproterozoic crustal model age.These findings,combined with the spatio-temporal distribution of regional magmatism,reveal that the late Early-Paleozoic granitoids formed in the intraplate orogenic background originating from the subduction of the proto-Tethys Ocean and proto-Pacific Ocean around the margin of the east Gondwana supercontinent. | WanLi Gao ZongXiu Wang | 2024 | Acta Geochimica2024，43，1： | 0 |
| 13 | Expression and Antigen Activity Determination of Human Thyroid Peroxidase in Silkworm and Yeast显示文摘In this study,we report the expression of human thyroid peroxidase(TPO) in silkworm larvae and Pichia pastoris GS115. Recombinant TPO is sequentially purified from the hemolymph of infected silkworm larvae and yeast using a Ni-NTA resin kit. The concentration of yield of recombinant TPO is 4.87 mg per thousand larvae and 40.83 mg per liter yeast culture. However,the recombinant TPO produced in silkworm show similar binding ability with the specific anti-TPO serum to standard human TPO purified from insect cells. The lower antigen activity indicates the TPO expressed in yeast is not suitable to be used as the coating antigen in enzyme linked immunosorbent assay(ELISA). The cost of TPO expressed in B. mori is about 1/4 that of in insect cells,and the cost of TPO purified from silkworm for ELISA is only 1/8 that of TPO produced from Sf9 cells. It indicates the Bm NPV-silkworm expression system is a cost-effectiv e platform for producing TPO with high antigen activity. | GUO Baodang GAO Wanli Lü Huifang ZHANG Xiaoliang YAO Xiaogui YAO Lunguang | 2016 | Wuhan University Journal of Natural Sciences2016，21，6： | 0 |
| 14 | 乳腺浸润性导管癌组织中HMGB1表达的临床意义(英文)显示文摘Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) were also analyzed. Results: Fortysix cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression(76.67%), statistical significance was observed between HMGB1 expression with clinical staging(P < 0.01), lymph node metastasis(P < 0.01), breast cancer ER(P < 0.05) and HER-2(P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression(P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It's promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis. | Baoping Chang Xiao Wang Songsou Gao Bianfeng Zhao Wanli Wang Shaohua Yang Qian Chu Shiying Yu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，5： | 0 |
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