|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization显示文摘AIM: To determine the role of interleukin (IL)-17 in gastric ulcerogenesis. METHODS: Thirty-six gastric ulcer (GU) patients and 29 non-ulcer (NU) patients were enrolled in this study. Mucosal biopsy samples were obtained from the gastric antrum and GU site during endoscopy. Samples were used in in situ stimulation for 48 h in the presence of 10 μg/mL phytohemagglutinin-P (PHA), histological examination, and Helicobacter pylori(H pylori) culture. IL-17 and IL-8 protein levels in culture supernatants were assayed by ELISA. IL-17 mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). H pylori cagA and vacA status was assessed by reverse hybridization using a line probe assay (LiPA). IL-8 levels in culture supernatants were assayed after AGS cells were co-cultured with H pylori strain 26 695 or recombinant human (rh) IL-17. RESULTS: All 36 GU patients and 15 of 29 NU patients were found to be H pylori-positive, while 14 NU patients were H pylori-negative. All 51 H pylori strains from both GU and NU patients were cagA- and vacAs1/m1-positive. Antral mucosal tissues from H pylori-positive patients contained significantly (H pylori-positive NU patients: median 467 pg/mg/protein, range 53-2 499; H pylori-negative NU patients: median 104 pg/mg/protein, range 16-312, P<0.0005) higher levels of IL-17 than those from uninfected patients. IL-17 levels at the ulcer site were significantly (ulcer site: median 1356 pg/mg/protein, range 121-1 3730; antrum: median 761 pg/mg/protein, range 24-7 620, P<0.005) higher than those at distant sites in the antrum. Biopsies from H pylori-positive GU and NU patients showed IL-17 mRNA expression in all samples whereas those from the antrum of the H pylori-negative controls showed no detectable expression. A significant correlation was seen between IL-17 and IL-8 levels at each biopsy site (ulcer: r= 0.62, P<0.0001; antrum: r = 0.61, P<0.0001) in GU patients. RhIL-17 and H pylori strain 26 695 each stimulated IL-8 production from AGS cells. CONCLUSION: IL-17 may play an important role in the inflammatory response to H pylori colonization, and may ultimately influence the outcome of H pylori-associated diseases that arise within the context of gastritis. | Tomokazu Mizuno Takafumi Ando Kazuo Nobata Tomoyuki Tsuzuki Osamu Maeda Osamu Watanabe Masaaki Minami Kenji Ina Kazuo Kusugami Richard M. Peek Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，40： | 18 |
| 2 | ICRF Heated Long-Pulse Plasma Discharges in LHD显示文摘A long-pulse plasma discharge for more than 30 min.was achieved on the LargeHelical Device(LHD).A plasma of n_e=0.8×10^(19)m^(-3)and T_(iO)=2.0 keV was sustained withP_(ICH)=0.52 MW,P_(ECH)=0.1 MW and averaged P_(NBI)=0.067 MW.Total injected heatingenergy was 1.3 GJ,which was a quarter of the prepared RF heating energy.One of the keys to thesuccess of the experiment was a dispersion of the local plasma heat load to divertors,accomplishedby shifting the magnetic axis inward and outward. | R. KUMAZAWA T. SEKI T. MUTOH K. SAITO T. WATARI Y. NAKAMURA M. SAKAMOTO T. WATANABE S. KUBO T. SHIMOZUMA Y. YOSHIMURA H. IGAMI Y. TAKEIRI Y. OKA K. TSUMORI M. OSAKABE K. IKEDA K. NAGAOKA O. KANEKO J. MIYAZAWA S. MORITA K. NARIHARA M. SHOJI S. MASUZAKI M. GOTO T. MORISAKI B. J. PETERSON K. SATO T. TOKUZAWA N. ASHIKAWA K. NISHIMURA H. FUNABA H. CHIKARAISHI T. NOTAKE Y. TORII H. OKADA M. ICHIMURA H. HIGAKI Y. TAKASE H. KASAHARA F. SHIMPO G.NOMURA C.TAKAHASHI M.YOKOTA A. KATO 赵燕平 J. S. YOON J. G. KWAK H. YAMADA K. KAWAHATA N. OHYABU K. IDA Y. NAGAYAMA N. NODA A. KOMORI S. SUDO O. MOTOJIMA | 2006 | Plasma Science and Technology2006，8，1： | 4 |
| 3 | Nonpolypoid neoplastic lesions of the colorectal mucosa显示文摘 | Shin ei Kudo René Lambert John I. Allen Hiroaki Fujii Takahiro Fujii Hiroshi Kashida Takahisa Matsuda Masaki Mori Hiroshi Saito Tadakazu Shimoda Shinji Tanaka Hidenobu Watanabe Joseph J. Sung Andrew D. Feld John M. Inadomi Michael J. O’Brien David A. Lieb | 2008 | Gastrointestinal Endoscopy2008，，4： | 3 |
| 4 | Endoscopic Surveillance for Gastric Remnant Cancer after Early Cancer Surgery显示文摘 | O. Hosokawa Y. Kaizaki K. Watanabe M. Hattori K. Douden H. Hayashi S. Maeda | 2002 | Endoscopy2002，，06： | 2 |
| 5 | Phase I/II study of intraperitoneal docetaxel plus S-1 for the gastric cancer patients with peritoneal carcinomatosis显示文摘 | S. Fushida J. Kinoshita M. Kaji Y. Hirono F. Goda Y. Yagi K. Oyama Y. Sudo Y. Watanabe T. Fujimura | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 2 |
| 6 | Stable transformation of Pleurotus ostreatus to hygromycin B resistance using Lentinus edodes GPD expression signals显示文摘 | T. Irie Y. Honda T. Hirano T. Sato H. Enei T. Watanabe M. Kuwahara | 2001 | Applied Microbiology and Biotechnology (-)2001，，5： | 1 |
| 7 | Carboxin resistance transformation of the homobasidiomycete fungus Pleurotus ostreatus显示文摘 | Y. Honda T. Matsuyama T. Irie T. Watanabe M. Kuwahara | 2000 | Current Genetics2000，，3： | 1 |
| 8 | Whole-body positron emission tomography with F-18 fluorodeoxyglucose for the detection of recurrence in uterine sarcomas显示文摘 | M. MURAKAMI H. TSUKADA M. SHIDA M. WATANABE H. MAEDA S. KOIDO T. HIRASAWA T. MURAMATSU T. MIYAMOTO S. NASU S. YASUDA H. KAJIWARA M. YASUDA M. IDE | 2006 | International Journal of Gynecological Cancer2006，，： | 1 |
| 9 | Microcystin composition of an axenic clonal strain of Microcystis viridis and Microcystis viridis-containing waterblooms in Japanese freshwaters显示文摘 | Kunimitsu Kaya Makoto M. Watanabe | 1990 | Journal of Applied Phycology1990，，2： | 1 |
| 10 | Lafutidine can improve the quality of gastric ulcer healing in humans: a randomized, controlled, multicenter trial显示文摘 | K. Higuchi T. Watanabe K. Tominaga M. Shiba K. Nakagawa H. Uno K. Kitada H. Satoh S. Chono N. Oshitani Y. Fujiwara T. Arakawa | 2006 | Inflammopharmacology (-)2006，，5： | 1 |
| 11 | Multiple dural arteriovenous fistulae involving the cavernous and sphenoparietal sinuses显示文摘 | T. Watanabe Y. Matsumaru M. Sonobe T. Asahi K. Onitsuka K. Sugita S. Takahashi T. Nose | 2000 | Neuroradiology2000，，10： | 1 |
| 12 | Numerical simulation of coal gasification in entrained flow coal gasifier显示文摘 | H. Watanabe M. Otaka | 2006 | Fuel2006，，12： | 1 |
| 13 | Appendiceal mucocele: sonographic findings显示文摘 | K. Sasaki H. Ishida T. Komatsuda T. Suzuki K. Konno M. Ohtaka M. Sato J. Ishida T. Sakai S. Watanabe | 2003 | Abdominal Imaging2003，，1： | 1 |
| 14 | Background exposure of urban populations to lead and cadmium: comparison between China and Japan显示文摘 | Zuo-Wen Zhang Chan-Seok Moon Takao Watanabe Shinichro Shimbo Feng-Sheng He Y.-Q. Wu Shun-Fu Zhou De-Ming Su Jiang-Bin Qu M. Ikeda | 1997 | International Archives of Occupational and Environmental Health1997，，4： | 1 |
| 15 | Background exposure of general population to cadmium and lead in Tainan city, Taiwan显示文摘 | M. Ikeda Z.-W. Zhang C.-S. Moon Y. Imai T. Watanabe S. Shimbo W.-C. Ma C.-C. Lee Y.-L. L. Guo | 1996 | Archives of Environmental Contamination and Toxicology1996，，1： | 1 |
| 16 | Squalene Quantification Using Octadecylbenzene as the Internal Standard显示文摘 | Hiroshi Matsuura Makoto M. Watanabe Kunimitsu Kaya | 2012 | Procedia Environmental Sciences2012，，： | 1 |
| 17 | Microcystin composition of an axenic clonal strain of Microcystis viridis and Microcystis viridis-containing waterblooms in Japanese freshwaters显示文摘 | Kunimitsu Kaya Makoto M. Watanabe | 1990 | Journal of Applied Phycology1990，，2： | 1 |
| 18 | Admission blood glucose levels and early change of neurological grade in poor-grade patients with aneurysmal subarachnoid haemorrhage显示文摘 | M. Sato M. Nakano J. Asari K. Watanabe | 2006 | Acta Neurochirurgica2006，，6： | 1 |
| 19 | Contribution of the Large Helical Device Plasmas to Alfvén Eigenmode Physics in Toroidal Plasmas显示文摘在有三种维的配置的大螺旋状的设备(LHD ) , Alfv é n eigenmodes (AE ) 由精力充沛的离子使动摇广泛地用中立横梁被调查有单音的补品和非单调的旋转变换(ι/2π) 的激烈的血浆侧面。在有单音的补品 ι/2π-profile 的血浆,象全球的一样的核心局部性的导致 toroidicity 的 Alfv é n eigenmode (TAE ) 经常被观察。随平均 toroidal 贝它价值的增加,定义为全部的血浆压力的比率到 toroidal 磁性的压力,有低 toroidal 模式数字的核心局部性的 TAE 变得全球。在有单音的补品 ι/2π-profile 的相对高的贝它血浆,有不同 toroidal 模式数字的二 TAE 经常线性地非交往并且通过联合的三个波浪产生另外一个模式。在有强烈相反中立的横梁水流开车产生的非单调的 ι/2π-profile 的血浆,逆行砍 Alfv é n eigenmode (RSAE ) 和精力充沛的离子激动的测地学的声学的模式(鲸鱼群) 在螺旋状的血浆第一次被观察。非线性的联合也在 RSAE 和鲸鱼群之间被观察。 | K. TOI M. ISOBE M. OSAKABE F. WATANABE K. OGAWA T. TOKUZAWA A. SHIMIZU T. IDO K. IDA, T. ITO S. MORITA K. NAGAOKA K. NARIHARA M. NISHIURA S. OHDACHI S. SAKAKIBARA K. TANAKA LHD Experiment Group | 2009 | Plasma Science and Technology2009，11，4： | 1 |
| 20 | Measurement of Tricuspid Annular Diastolic Velocities by Doppler Tissue Imaging to Assess Right Ventricular Function in Patients with Congenital Heart Disease显示文摘 | M. Watanabe S. Ono T. Tomomasa Y. Okada T. Kobayashi T. Suzuki A. Morikawa | 2003 | Pediatric Cardiology2003，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员