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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Effect of base strength and basicity on catalytic behavior of solid bases for synthesis of dimethyl carbonate from propylene carbonate and methanol显示文摘 | WEI T WANG M H WEI W SUN Y H ZHONG B | 2003 | Fuel Processing Technology2003，83，13： | 1 |
| 4 | Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics 显示文摘 | Zhao W J Wang B J Wei C M | 2008 | J Clin Pharm Ther2008，33，： | 1 |
| 5 | Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappa B survival pathway signaling 显示文摘 | Weston VJ Austen B Wei W | 2004 | Blood2004，104，5： | 1 |
| 6 | Catalytic decomposition of ammonia over nitrided MoNx/α-Al2O3 and NiMoNy/ α-Al2O3 catalysts显示文摘 | Liang C H Li W Z Wei Z B | 2000 | Industrial & Engineering Chemistry Research2000，39，： | 1 |
| 7 | Synthe- sis and electrochemical characterizations of amorphous manganese oxide and single walled carbon nanotube composites as supercapacitor electrode materials 显示文摘 | SUBRAMANIAN V ZHU H W WEI B Q | 2006 | Electrochem Commun2006，8，5： | 1 |
| 8 | Isolation and characterization endophytic bacteria from Sedum alfredii Hance and their potential to promote phytoextraction of zinc polluted soil 显示文摘 | LONG X X CHEN X M CHEN Y G WONG J W WEI Z B WU Q T | 2010 | World Journal Microbiology Biotechnology2010，27，： | 1 |
| 9 | Amino acid mutations in the capsid protein produce novel porcine circovirus type 2 neutralizing epitopes显示文摘 | Liu J B Huang L P Wei Y W | | 0，，： | 1 |
| 10 | Preparation and properties of novel inherent flame-retardant cyclotriphosphazene-containing epoxy resins 显示文摘 | Liu F F Wei H Huang X B Zhang J W Zhou Y B Tang X Z | 2010 | Journal of Macromolecular Science Part B: Physics2010，49，5： | 1 |
| 11 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | General axisymmetricactive earth pressure by method of characteristics-theory and numerical formulation显示文摘 | CHENG Y M HU Y Y WEI W B | 2007 | International Journal of Geomechanics2007，7，1： | 1 |
| 13 | On g-inverse of a bordered matrix: revisited显示文摘 | Wei M S Gao W B | 2002 | Linear Algebra Appl2002，347，： | 1 |
| 14 | Stress-whitening of highimpact poly(propylene):Characterization and analysis显示文摘 | LIU X B GUO M F WEI W J | 2012 | Macromol Syrup2012，，1： | 1 |
| 15 | Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently显示文摘 | Wei H Kang B Wei W | | 0，，1： | 1 |
| 16 | The effects of crystal structure of the precursor MnO2 on electrochemical properties of spinel LiMn2O4显示文摘 | WEI Q L WANG X Y YANG X K SHU H B JU B W HU B N SONG Y F | 2012 | J Solid State Electrochem2012，16，7： | 1 |
| 17 | Preparation and electrochemical behaviors of composite solid polymer electrolytes based on polyethylene oxide with active inor- ganic-organic hybrid polyphosphazene nanotubes as fillers显示文摘 | Zhang J W Huang X B Wei H | 2011 | New Journal of Chemistry2011，35，3： | 1 |
| 18 | Synthesis and electrochemical characterizations of amorphous manganese oxide and single walled carbon nanotube composites as supercapacitor electrode materials 显示文摘 | SUBRAMANIAN V ZHU H W WEI B Q | 2006 | Electrochem Commun2006，8，5： | 1 |
| 19 | On the properties of reflexive g-inverses of a bordered matrix显示文摘 | Gou W B Wei M S | 2003 | Journal of East China Normal University2003，1，： | 1 |
| 20 | Reconfigurable bandpass filter based on net-type stepped-impedance resonator 显示文摘 | LIU B W WEI F WEI X W | 2010 | Electronics Letters2010，46，22： | 1 |
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