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| 1 | A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding显示文摘一个高密度的单个核苷酸多型性(SNP ) 数组为遗传学者和分子的 breeders.With 是极其重要的 genomic 的巨大的数量的累积重新定序为精确 SNP 察觉的数据和可得到的技术,设计高密度、高质量的米饭 SNP 数组是可能的。这里,我们报导一个高密度的 riceSNP 数组和它的实用程序的开发。SNP 探针被屏蔽超过 10 设计从变化和一个数组说出 RiceSNP50 的 801 米饭的 re-sequencingdata 提取的 000 000 SNP loci 在 Illumina Infinium 站台上被生产。数组 contained51 478 个均匀地分布式的标记,其 68% 个在遗传因子的区域以内。有 parent/F1 relationshipswere 的几百米饭植物过去常为精确 SNP 打电话产生一个高质量的簇文件。应用程序测试证明这穿有的 highgenotyping 精确性,并且能被用于不同目的。例如,有好分辨率的精英米饭变化 wasclustered 的一个核心集合。染色体宽的协会研究(GWAS ) 分析正确地识别了描绘的 QTL.Further,这个数组成功地为变化确认和特点基因渗入被使用。作为一个精确 high-throughputgenotyping 工具, RiceSNP50 将在两功能的 genomics 学习和分子的 breeding.Key 词起一个重要作用: | Haodong Chen Weibo Xie Hang He Huihui Yu Wei Chen Jing Li Renbo Yu Yue Yao Wenhui Zhang Yuqing He Xiaoyan Tang Fasong Zhou Xing Wang Deng Qifa Zhang | 2014 | Molecular Plant2014，7，3： | 38 |
| 2 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 3 | A new interpretation of the tectonic setting and age of meta-basic volcanics in the Ondor Sum Group, Inner Mongolia显示文摘The Ondor Sum Group in the central Inner Mongolia is mainly composed of meta-basic volcanics intercalated with ferruginous quartzite and quartz schist,and has been interpreted as slices of oceanic crust or an ophiolite suite of the Early Paleozoic or much older ages.This paper presents new LA-ICP-MS zircon U-Pb dating and geochemical data for the meta-basic volcanics.The results show that zircons in the meta-basic volcanics were derived from complicated sources,most of which may be captured by basic magma from the country rocks or other sources.They yield a large age range from the Late Archean to Early Mesozoic with the youngest age group between 246 and 261 Ma,constraining the protolith of the meta-basic volcanics formed in the Late Permian to Early Triassic.The meta-basic volcanics have an affinity to E-MORB in geochemistry,and also a similarity toward OIB,representing a tectonic setting of limited intra-continental ocean basin.This limited basin might have been related to the continuous extension of the area since the Early Permian and finally closed in the Early Mesozoic. | CHU Hang ZHANG JinRui WEI ChunJing WANG HuiChu REN YunWei | 2013 | Chinese Science Bulletin2013，58，28： | 25 |
| 4 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 5 | Serum cystatin C concentration as an independent marker for hypertensive left ventricular hypertrophy显示文摘Background Serum cystatin C levels can be used to predict morbidity and mortality in patients with cardiovascular disease. However, the clinical relevance of serum cystatin C levels in patients with hypertensive left ventricular hypertrophy (LVH) has rarely been investigated. We designed the present study to investigate whether serum cystatin C levels are associated with cardiac structural and functional alterations in hypertensive patients. Methods We enrolled 823 hypertensive patients and classified them into two groups:those with LVH (n=287) and those without LVH (n=536). All patients underwent echocardiography and serum cystatin C testing. We analyzed the relationship be-tween serum cystatin C levels and LVH. Results Serum cystatin C levels were higher in hypertensive patients with LVH than in those without LVH (P<0.05). Using linear correlation analysis, we found a positive correlation between serum cystatin C levels and interven-tricular septal thickness (r=0.247, P<0.01), posterior wall thickness (r=0.216, P<0.01), and left ventricular weight index (r=0.347, P<0.01). When analyzed by multiple linear regression, the positive correlations remained between serum cystatin C and interventricular septal thickness (β=0.167, P<0.05), posterior wall thickness (β=0.187, P<0.05), and left ventricular weight index (β=0.245, P<0.01). Con-clusion Serum cystatin C concentration is an independent marker for hypertensive LVH. | Xin Li Hang Zhu Peng Li Qian Xin Jie Liu Wei Zhang You-Hong Xing Hao Xue | 2013 | Journal of Geriatric Cardiology2013，10，3： | 21 |
| 6 | The DTH8-Hd1 Module Mediates Day-Length-Dependent Regulation of Rice Flowering显示文摘Photoperiodic flowering 是最重要的小径之一在米饭(Oryza sativa ) 管理 flowering,在哪个标题日期 1 (Hd1 ) , Arabidopsis CONSTANS 基因的 ortholog,编码一个枢轴的管理者。Hd1 在短天的条件(SD ) 下面支持 flowering,但是镇压在由调整领导日期 3a (Hd3a ) 的表示的长天的条件(LD ) 下面的 flowering,在米饭的 FLOWERING 地点 T (英尺) ortholog。然而, Hd1 怎么响应天长度改变它的规章的活动的分子的机制仍然保持大部分未知。在这研究,我们证明在由 Hd1 的 LD 的 flowering 的压抑依赖于到领导 8 的抄写因素天(DTH8 ) 。DTH8 功能的损失由 Hd1 导致 Hd3a 的激活,导致早 flowering。我们发现 Hd1 直接与 DTH8 交往并且 DTH8-Hd1 建筑群的形成为由在 LD 的 Hd1 的 Hd3a 的 transcriptional 压抑是必要的,含有 Hd1 功能的开关被 DTH8 在 LD 而非在 SD 调停。而且,我们表明 DTH8 与 Hd3a 倡导者联系在 Hd3a 地点调制 H3K27 trimethylation (H3K27me3 ) 的水平。面对 DTH8-Hd1 建筑群, H3K27me3 水平在 Hd3a 被增加,而 DTH8 功能的损失在 Hd3a 导致了减少的 H3K27me3 水平。一起拿,我们的调查结果显示响应天长度, DTH8 在调停起一个关键作用 ? 由通过到在 photoperiodic flowering 的形状 epigenetic 修正的 DTH8-Hd1 模块的 Hd1 的 Hd3a 的 transcriptional 规定。 | Anping Dul Wei Tian Menghao Wei Wei Yan Hang He Da Zhou Xi Huang Shigui Li Xinhao Ouyang | 2017 | Molecular Plant2017，10，7： | 21 |
| 7 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 8 | Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage显示文摘Ferroptosis is a form of iron-dependent regulated cell death.Evidence of its existence and the effects of its inhibitors on subarachnoid hemorrhage(SAH)is still lacking.In the present study,we found that liproxstatin-1 protected HT22 cells against hemin-induced injury by protecting mitochondrial functions and ameliorating lipid peroxidation.In in vivo experiments,we demonstrated the presence of characteristic shrunken mitochondria in ipsilateral cortical neurons after SAH.Moreover,liproxstatin-1 attenuated the neurological deficits and brain edema,reduced neuronal cell death,and restored the redox equilibrium after SAH.The inhibition of ferroptosis by liproxstatin-1 was associated with the preservation of glutathione peroxidase 4 and the downregulation of acylCoA synthetase long-chain family member 4 as well as cyclooxygenase 2.In addition,liproxstatin-1 decreased the activation of microglia and the release of IL-6,IL-1 b,and TNF-a.These data enhance our understanding of cell death after SAH and shed light on future preclinical studies. | Yang Cao Yin Li Chao He Feng Yan Jian-Ru Li Hang-Zhe Xu Jian-Feng Zhuang Hang Zhou Yu-Cong Peng Xiong-Jie Fu Xiao-Yang Lu Yuan Yao Yu-Yu Wei Yun Tong Yi-Fu Zhou Lin Wang | 2021 | Neuroscience Bulletin2021，37，4： | 16 |
| 9 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 10 | Review on the progress of ultra-precision machining technologies显示文摘 | Julong YUAN Binghai LYU Wei HANG Qianfa DENG | 2017 | Frontiers of Mechanical Engineering2017，12，2： | 15 |
| 11 | Effects of different mixing ratios on emissions from passenger cars fueled with methanol/gasoline blends显示文摘Regulated and unregulated emissions from four passenger cars fueled with methanol/gasoline blends at different mixing ratios (M15,M20,M30,M50,M85 and M100) were tested over the New European Driving Cycle (NEDC).Volatile organic compounds (VOCs) were sampled by Tenax TA and analyzed by thermal desorption-gas chromatograph/mass spectrometer (TD-GC/MS).Carbonyls were trapped on dinitrophenylhydrazine (DNPH) cartridges and analyzed by high performance liquid chromatography (HPLC).The results showed that total emissions of VOCs and BTEX (benzene,toluene,ethylbenzene,p,m,o-xylene) from all vehicles fueled with methanol/gasoline blends were lower than those from vehicles fueled with only gasoline.Compared to the baseline,the use of M85 decreased BTEX emissions by 97.4%,while the use of M15 decreased it by 19.7%.At low-to-middle mixing ratios (M15,M20,M30 and M50),formaldehyde emissions showed a slight increase while those of high mixing ratios (M85 and M100) were three times compared with the baseline gasoline only.When the vehicles were retrofitted with new three-way catalytic converters (TWC),emissions of carbon monoxide (CO),total hydrocarbon (THC),and nitrogen oxides (NOx) were decreased by 24%-50%,10%-35%,and 24%-58% respectively,compared with the cars using the original equipment manufacture (OEM) TWC.Using the new TWC,emissions of formaldehyde and BTEX were decreased,while those of other carbonyl increased.It is necessary that vehicles fueled with methanol/gasoline blends be retrofitted with a new TWC.In addition,the specific reactivity of emissions of vehicles fueled with M15 and retrofitted with the new TWC was reduced from 4.51 to 4.08 compared to the baseline vehicle.This indicates that the use of methanol/gasoline blend at a low mixing ratio may have lower effect on environment than gasoline. | Hong Zhao Yunshan Ge Jianwei Tan Hang Yin Jiadong Guo Wei Zhao Peipei Dai | 2011 | Journal of Environmental Sciences2011，23，11： | 12 |
| 12 | Attitudes toward organ donation in China显示文摘背景机关移植代表重要进展在里面现代医药科学,和它与机关失败有益于许多病人;然而,机关来源的严重缺乏是限制了这研究的这个技术罐头 bring.The 目的是在中国人民向我们设计了的机关 donation.Methods 的了解和态度上显示出调查的结果的好处的一个瓶颈关于机关捐赠由 20 个短问题组成的一张问询表,它对这些问题的 10 groups.Most 分布式是有多项选择的;与人到机关捐赠和机关 donation.The 调查的发展的态度有关的核心问题在北京 Chao-Yang 医院,一个商业区域,和四职业 colleges.Participants 的门诊病人大厅被保持随机关于性被选择,并且回答问题,年龄,教育背景,职业,并且总共学习 major.Results , 2930 有效回答是 received.Male:female 比率是将近 1:1.2 (意味着年龄 38 年) 90.0 个参加者关于机关 transp 知道了的 .Over 超过 95.0 关于他们有的机关捐赠,而是时间知道了 varied.Nearly 知道它 90.0 个参加者同意了死亡机关捐赠; 73.0 显示他们想捐赠他们的机关帖子 mortem.Participants 对机关失败和机关移植知道了更多的人,是更可能的支持机关 donation.College 学生,当他们获得职业知识,关于机关捐赠是很积极的他们的态度可以 change.Altogether , 65.3 个参加者同意了生活机关捐赠,它显然是比为死亡机关捐赠( P 0.05 )的数字低的 .In 所有, 85.7 | WANG Wei TIAN Hui YIN Hang LIU Hang ZHANG Xiao-dong | 2012 | Chinese Medical Journal2012，，1： | 12 |
| 13 | Recent advances in energy storage mechanism of aqueous zinc-ion batteries显示文摘Aqueous rechargeable zinc-ion batteries(ZIBs)have recently attracted increasing research interest due to their unparalleled safety,fantastic cost competitiveness and promising capacity advantages compared with the commercial lithium ion batteries.However,the disputed energy storage mechanism has been a confusing issue restraining the development of ZIBs.Although a lot of efforts have been dedicated to the exploration in battery chemistry,a comprehensive review that focuses on summarizing the energy storage mechanisms of ZIBs is needed.Herein,the energy storage mechanisms of aqueous rechargeable ZIBs are systematically reviewed in detail and summarized as four types,which are traditional Zn^(2+)insertion chemistry,dual ions co-insertion,chemical conversion reaction and coordination reaction of Zn^(2+)with organic cathodes.Furthermore,the promising exploration directions and rational prospects are also proposed in this review. | Duo Chen Mengjie Lu Dong Cai Hang Yang Wei Han | 2021 | Journal of Energy Chemistry2021，30，3： | 12 |
| 14 | Confirmation of pelitic granulite in the Altai orogen and its geological significance显示文摘The existence of pelitic granulite in the Altai orogen was confirmed for the first time by detailed petrographic research and P-T pseudosection modeling. The pelitic granulite has the assemblage of garnet + cordierite + K-feldspar + biotite + sillimanite + plagioclase + quartz with some samples containing the paragenesis of cordierite + spinel. Peak conditions of the pelitic granulite determined from the P-T pseudosection involved P = 0.5―0.6 GPa, T = 780―800℃, belonging to medium-to low-pressure type. SHRIMP U-Pb dating of zircon presented a metamorphic age of 292.8 ± 2.3 Ma. The discovery of pelitic granulite reflects an extensional environment with high heat flow in the southern margin of the Altai orogen during the Early Permian, which provides an important petrological constraint on the evolution of the Altai orogen. | WANG Wei WEI ChunJing WANG Tao LOU YuXing CHU Hang | 2009 | Chinese Science Bulletin2009，54，14： | 11 |
| 15 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 16 | Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in Young Female Population: A Single-center Study显示文摘 | Pei-Na Meng Chen Xu Wei You Zhi-Ming Wu Du-Jiang Xie Hang Zhang Chang Pan Fei Ye | 2017 | Chinese Medical Journal2017，，13： | 10 |
| 17 | A Global Identification and Analysis of Small Nucleolar RNAs and Possible Intermediate-Sized Non-Coding RNAs in Oryza sativa显示文摘积累的证据建议非编码的 RNA (ncRNAs ) 在许多真核细胞的有机体普遍、机能上地重要。在这研究,我们采用了分别和 cDNA 图书馆构造方法列在后面由的一种特殊尺寸 454 系统地介绍米饭的深定序中间尺寸的 ncRNAs。我们的分析总共导致了 1349 ncRNAs 的鉴定,包括一个未知功能的范畴的 754 新奇 ncRNAs。所有识别 ncRNAs 的染色体分发没显示出海滨偏爱,并且显示了类似于与很少染色体相关性在编码蛋白质的基因观察了那的一个模式。非常, ncRNAs 的一半被集中在附近编码区域的 5 和 3 个终点正海滨。新奇 ncRNAs 的多数是米饭特定,当 78% 小核仁的 RNA (snoRNAs ) 被保存时。双人脚踏车复制驾驶了扩大在 snoRNA 基因家庭的一半上。而且, 90% snoRNA 候选人被显示特别地生产在 2030 nt,其 80% 通常与淘金者蛋白质被联系,和 AGO1b 之间的小 RNA。总的来说,我们的调查结果在 monocot 种提供中间尺寸的非编码的 transcriptome 的一个全面看法,它将为 ncRNA 函数的深入的分析用作一个有用平台。 | Ting-Ting Liu Danmeng Zhu Wei Chen Wei Deng Hang He Guangming He Baoyan Bai Yijun Qi Runsheng Chen Xing Wang Deng | 2013 | Molecular Plant2013，6，3： | 10 |
| 18 | Comorbidity Burden of Dementia:A Hospital-Based Retrospective Study from 2003 to 2012 in Seven Cities in China显示文摘Dementia is increasing dramatically and imposes a huge burden on society. To date, there is a lack of data on the health status of patients with dementia in China. In an attempt to investigate the comorbidity burden of dementia patients in China at the national level, we enrolled 2,938 patients with Alzheimer's disease(AD), vascular dementia(Va D), or other types of dementia, who were admitted to tertiary hospitals in seven regions of China from January2003 to December 2012. The Charlson Comorbidity Index(CCI) was used to evaluate the comorbidity burden of the patients with dementia. Among these patients, 53.4% had AD, 26.3% had Va D, and 20.3% had other types of dementia. The CCI was 3.0 ± 1.9 for all patients,3.4 ± 1.8 for those with Va D, and 3.0 ± 2.1 for those with AD. The CCI increased with age in all patients, andthe length of hospital stay and daily expenses rose with age and CCI. Males had a higher CCI and a longer stay than females. Moreover, patients admitted in the last 5 years of the study had a higher CCI than those admitted in the first 5 years. We found that the comorbidity burden of patients with dementia is heavy. These findings provide a better understanding of the overall health status of dementia patients, and help to increase the awareness of clinicians and policy-makers to improve medical care for patients. | Qing-Hua Wang Xin Wang Xian-Le Bu Yan Lian Yang Xiang Hong-Bo Luo Hai-Qiang Zou Jie Pu Zhong-He Zhou Xiao-Ping Cui Qing-Song Wang Xiang-Qun Shi Wei Han Qiang Wu Hui-Sheng Chen Hang Lin Chang-Yue Gao Li-Li Zhang Zhi-Qiang Xu Meng Zhang Hua-Dong Zhou Yan-Jiang Wang | 2017 | Neuroscience Bulletin2017，33，6： | 10 |
| 19 | On design of physical random access channel in high-speed railway LTE systems显示文摘For the uplink in the long-term evolution(LTE)systems,the physical random access channel(PRACH)adopts Zadoff–Chu(ZC) sequences as preamble sequences,and each user can choose a unique cyclic shift for user identification.In high-mobility scenario,the Doppler frequency shift raises up the false alarm probability by inducing the correlation peak offsetting at the receiver side.Traditional detection method utilizes multiple search windows for searching the potential uplink users.When the Doppler frequency shift is larger than the subcarrier spacing,the energy of correlation peak leaks outside the search window and increases the false alarm probability.In this paper,we present a novel design for PRACH preamble sequence for high-speed railway scenario.Through numerical observation,we find out that the offset of the correlation peaks only depends on the initial root sequence number and the length of ZC sequences.Therefore,the root number of ZC sequences should be carefully designed to generate a preamble sequence to fight against the Doppler frequency shift.Consequently,those offsets of the correlation peaks are concentrated within a single search window,resulting in lower complexity of detection and lower probability of false alarm for random access in LTE uplink. | Gang Wu Hang Yuan Wei Guo Su Hu Shaoqian Li | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 20 | Expression Analysis of miRNAs and Highly-expressed Small RNAs in Two Rice Subspecies and their Reciprocal Hybrids显示文摘Heterosis,or hybrid vigor,is the phenomenon whereby progeny of two inbred lines exhibit superior agronomic performance compared with either parent.We analyzed the expression of miRNAs and highly expressed small RNAs (defined according to Solexa sequencing results) in two rice (Oryza sativa) subspecies (japonica cv.Nipponbare and indica cv.93-11) and their reciprocal hybrids using microarrays.We found that of all the 1141 small RNAs tested,140 (12%,140 of 1141) and 157 (13%,157 of 1141) were identified being significantly differentially expressed in two reciprocal hybrids,respectively.All possible modes of action,including additive,high-and low-parent,above high-and below low-parent modes were exhibited.Both F1 hybrids showed non-additive expression patterns,with downregulation predominating.Interestingly,15 miRNAs displayed stark opposite expression trends relative to midparent in reciprocal hybrids.Computational prediction of targets of differentially expressed miRNAs showed that they participated in multifaceted developmental pathways,and were not distinguishable from the targets of non-differentially expressed miRNAs.Together,our findings reveal that small RNAs play roles in heterosis and add a new layer in the understanding and exploitation of molecular mechanisms of heterosis. | Fangfang Chen Guangming He Hang He Wei Chen Xiaopeng Zhu Manzhong Liang Liangbi Chen Xing Wang Deng | 2010 | Journal of Integrative Plant Biology2010，52，11： | 10 |
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