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| 1 | New insights into eutrophication management:Importance of temperature and water residence time显示文摘Eutrophication and harmful cyanobacterial blooms threaten water resources all over the world.There is a great controversy about controlling only phosphorus or controlling both nitrogen and phosphorus in the management of lake eutrophication.The primary argument against the dual nutrients control of eutrophication is that nitrogen fixation can compensate the nitrogen deficits.Thus,it is of great necessary to study the factors that can significantly affect the nitrogen fixation.Due to the difference of climate and human influence,the water quality of different lakes(such as water temperature,N:P ratio and water residence time)is also quite different.Numerous studies have reported that the low N:P ratio can intensify the nitrogen fixation capacities.However,the effects of temperature and water residence time on the nitrogen fixation remain unclear.Thus,30 shallows freshwater lakes in the eastern plain of China were selected to measure dissolved N_(2) and Ar concentrations through N_(2):Ar method using a membrane inlet mass spectrometer to quantify the nitrogen fixation capacities and investigate whether the temperature and water residence time have a great impact on nitrogen fixation.The results have shown that the short lake water residence time can severely inhibit the nitrogen fixation capacities through inhibiting the growth of nitrogenfixing cyanobacteria,changing the N:P ratio and resuspending the solids from sediments.Similarly,lakes with low water temperature also have a low nitrogen fixation capacity,suggesting that controlling nitrogen in such lakes is feasible if the growth of cyanobacteria is limited by nitrogen. | Feng Zhao Xu Zhan Hai Xu Guangwei Zhu Wei Zou Mengyuan Zhu Lijuan Kang Yulong Guo Xingchen Zhao Zicong Wang Wei Tang | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 2 | Feature Extraction of Chinese Characters Based on ASM Algorithm显示文摘In Chinese Calligraphy education,the computer-based evaluation on Chinese handwriting is one of the problems in the field of computer intelligent education.In this study,the method of feature comparison is first proposed in the process of computer-based evaluation on Chinese handwriting,focusing on automatically and accurately extracting the features of Chinese characters.Then,the key technologies applied in feature extraction of Chinese character were analyzed.It discussed the representation of features,aligns training samples,and reduces dimensions by principal component analysis,established local grayscale model,and converged the gray-scale information of target feature points through statistical analysis.The experimental results show that the accuracy of the algorithm is 93.84%. | Xingchen Wei Minhua Wu Liming Luo | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 3 | Current Effect of“4+7”Drug Centralized Volume Procurement and Suggestions for Future Improvement显示文摘Objective To explore the impact of the“4+7”city drug centralized procurement policy implemented from April 1st,2019 on China’s pharmaceutical market and the differences between this pilot scheme and the first volume procurement,so as to put forward some suggestions for this policy and improve the drug price formation mechanism.Methods The characteristics of the“4+7”volume procurement policy and its improvements were summarized through literature research,and the distribution of the winning enterprises in volume procurement was shown by the chart.Then the overall situation of pharmaceutical enterprises in China was analyzed.Results and Conclusion According to the main distribution of enterprises in the alliance region,we can see that the first round of bid-winning enterprises with 25 varieties are mainly distributed in the eastern coastal cities of Jiangsu,Zhejiang,Shandong,and Guangdong,which shows a trend of developing to provinces of Sichuan,Hubei,and Hunan.With the increase of volume procurement inland cities will be included in the future.This pilot scheme of volume procurement is a reform of the entire pharmaceutical industry.It has improved the market structure and promoted the transformation and upgrading of regional medicine representatives.The most important thing is to enable the public to better enjoy the benefits brought by the low-priced drugs.However,for some pharmaceutical enterprises and drug retail industry,it is a challenge.Therefore,it is necessary to improve the policy and strengthen market supervision and management. | Piao Huiling Wei Xingchen Wang Nan Wang Xing Zhou Yusheng Dong Li | 2020 | Asian Journal of Social Pharmacy2020，15，4： | 0 |
| 4 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 5 | COPPER:a combinatorial optimization problem solver with processing-in-memory architecture显示文摘The combinatorial optimization problem(COP),which aims to find the optimal solution in discrete space,is fundamental in various fields.Unfortunately,many COPs are NP-complete,and require much more time to solve as the problem scale increases.Troubled by this,researchers may prefer fast methods even if they are not exact,so approximation algorithms,heuristic algorithms,and machine learning have been proposed.Some works proposed chaotic simulated annealing(CSA)based on the Hopfield neural network and did a good job.However,CSA is not something that current general-purpose processors can handle easily,and there is no special hardware for it.To efficiently perform CSA,we propose a software and hardware co-design.In software,we quantize the weight and output using appropriate bit widths,and then modify the calculations that are not suitable for hardware implementation.In hardware,we design a specialized processing-in-memory hardware architecture named COPPER based on the memristor.COPPER is capable of efficiently running the modified quantized CSA algorithm and supporting the pipeline further acceleration.The results show that COPPER can perform CSA remarkably well in both speed and energy. | Qiankun WANG Xingchen LI Bingzhe WU Ke YANG Wei HU Guangyu SUN Yuchao YANG | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，5： | 0 |
| 6 | Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease显示文摘Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases. | Dandan Chu Mengyang Zhao Shisong Rong Wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li | 2024 | Nano-Micro Letters2024，16，6： | 0 |
| 7 | Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation显示文摘With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular matrix (dECM) has been extensively used in the clinical treatment of tissue injury due to its favorable biocompatibility and similarity to the native tissue environment. However, most reported decellularization protocols may cause damage to the native structure of dECM, which undermines its inherent advantages and potential clinical applications. Here, we introduce a mechanically tunable dECM prepared by optimizing the freeze-thaw cycles. We demonstrated that the alteration in micromechanical properties of dECM resulting from the cyclic freeze-thaw process contributes to distinct macrophage-mediated host immune responses to the materials, which are recently recognized to play a pivotal role in determining the outcome of tissue regeneration. Our sequencing data further revealed that the immunomodulatory effect of dECM was induced via the mechnotrasduction pathways in macrophages. Next, we tested the dECM in a rat skin injury model and found an enhanced micromechanical property of dECM achieved with three freeze-thaw cycles significantly promoted the M2 polarization of macrophages, leading to superior wound healing. These findings suggest that the immunomodulatory property of dECM can be efficiently manipulated by tailoring its inherent micromechanical properties during the decellularization process. Therefore, our mechanics-immunomodulation-based strategy provides new insights into the development of advanced biomaterials for wound healing. | Pu Luo Ruoxuan Huang You Wu Xingchen Liu Zhengjie Shan Li Gong Shudan Deng Haiwen Liu Jinghan Fang Shiyu Wu Xiayi Wu Quan Liu Zetao Chen Kelvin W.K.Yeung Wei Qiao Shoucheng Chen Zhuofan Chen | 2023 | Bioactive Materials2023，，10： | 0 |
| 8 | The Status Quo and Countermeasures of“4+7”Quantity Purchase in China显示文摘Objective To understand the effectiveness and problems of centralized drug procurement in China by analyzing the implementation of the“4+7”pilot work for centralized drug procurement in China.Methods The current situation and existing problems of drug procurement in China were analyzed through the literature research method.Results and Conclusion At present,good social benefits have been achieved for China’s drug procurement through pilot projects in several cities,but there are some serious problems.The proposed countermeasures will help to improve the procurement of pharmaceuticals in China. | Zhou Yusheng Wei Xingchen Piao Huiling Wang Nan Wang Xing Dong Li | 2020 | Asian Journal of Social Pharmacy2020，15，2： | 0 |
| 9 | Making radiation therapy more effective in the era of precision medicine显示文摘Cancer has become a leading cause of death and constitutes an enormous burdenworldwide.Radiation is a principle treatment modality used alone or in combination with other forms of therapy,with 50%–70%of cancer patients receiving radiotherapy at some point during their illness.It has been suggested that traditional radiotherapy(daily fractions of approximately 1.8–2 Gy over several weeks)might select for radioresistant tumor cell sub-populations,which,if not sterilized,give rise to local treatment failure and distant metastases.Thus,the challenge is to develop treatment strategies and schedules to eradicate the resistant subpopulation of tumorigenic cells rather than the predominant sensitive tumor cell population.With continued technological advances including enhanced conformal treatment technology,radiation oncologists can increasinglymaximize the dose to tumors while sparing adjacent normal tissues,to limit toxicity and damage to the latter.Increased dose conformality also facilitates changes in treatment schedules,such as changes in dose per treatment fraction and number of treatment fractions,to enhance the therapeutic ratio.For example,the recently developed large dose per fraction treatment schedules(hypofractionation)have shown clinical advantage over conventional treatment schedules in some tumor types.Experimental studies suggest that following large acute doses of radiation,recurrent tumors,presumably sustained by the most resistant tumor cell populations,may in fact be equally or more radiation sensitive than the primary tumor.In this review,we summarize the related advances in radiotherapy,including the increasing understanding of the molecular mechanisms of radioresistance,and the targeting of thesemechanisms with potent small molecule inhibitors,whichmay selectively sensitize tumor cells to radiation. | Xingchen Peng Zhigong Wei Leo E.Gerweck | 2020 | Precision Clinical Medicine2020，3，4： | 0 |
| 10 | Photometric Redshift Estimates using Bayesian Neural Networks in the CSST Survey显示文摘Galaxy photometric redshift(photoz)is crucial in cosmological studies,such as weak gravitational lensing and galaxy angular clustering measurements.In this work,we try to extract photoz information and construct its probability distribution function(PDF)using the Bayesian neural networks from both galaxy flux and image data expected to be obtained by the China Space Station Telescope(CSST).The mock galaxy images are generated from the Hubble Space Telescope-Advanced Camera for Surveys(HST-ACS)and COSMOS catalogs,in which the CSST instrumental effects are carefully considered.In addition,the galaxy flux data are measured from galaxy images using aperture photometry.We construct a Bayesian multilayer perceptron(B-MLP)and Bayesian convolutional neural network(B-CNN)to predict photoz along with the PDFs from fluxes and images,respectively.We combine the B-MLP and B-CNN together,and construct a hybrid network and employ the transfer learning techniques to investigate the improvement of including both flux and image data.For galaxy samples with signal-to-noise ratio(SNR)>10 in g or i band,we find the accuracy and outlier fraction of photoz can achieve σ_(NMAD)=0.022 and η=2.35% for the B-MLP using flux data only,and σ_(NMAD)=0.022 and η=1.32% for the B-CNN using image data only.The Bayesian hybrid network can achieve σ_(NMAD)=0.021 and η=1.23%,and utilizing transfer learning technique can improve results to σ_(NMAD)=0.019 and η=1.17%,which can provide the most confident predictions with the lowest average uncertainty. | Xingchen Zhou Yan Gong Xian-Min Meng Xuelei Chen Zhu Chen Wei Du Liping Fu Zhijian Luo | 2022 | Research in Astronomy and Astrophysics2022，22，11： | 0 |
| 11 | miR-338-3p acts as a tumor suppressor in lung squamous cell carcinoma by targeting FGFR2/FRS2显示文摘Background:Lung cancer refers to the occurrence of malignant tumors in the lung,and squamous cell carcinoma is one of the most common pathological types of non-small cell lung cancer.Studies have shown that microRNAs(miRNAs)play an important role in the occurrence,development,early diagnosis,and treatment of lung cancer.This study aimed to explore the role and possible mechanism of MicroRNA-338-3p(miR-338-3p)in lung squamous cell carcinoma(LUSC). | Xia Shan Cheng Zhang Chunyu Li Xingchen Fan Guoxin Song Jingfeng Zhu Risheng Cao Xiuwei Zhang Wei Zhu | 2023 | Cancer Pathogenesis and Therapy2023，1，2： | 0 |
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