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| 1 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 2 | An approach to graphic genetic modelon 显示文摘 | Tan Jianrong Fan Wenhui Wei Xiuting | 1998 | Journal of Computer Science and Technology1998，13，12： | 1 |
| 3 | An Approach to Graphic Genetic Modelon显示文摘 | Tan Jianrong Fan Wenhui Wei Xiuting | 1998 | Journal of Computer Science and Technology1998，，13： | 1 |
| 4 | Research on Cutter's Position and Pose for Chamfering Spiral Bevel Gear Addendum 显示文摘 | Wei Xiuting Liu Jingcheng Du Qiang | 2010 | Applied Mechanics and Materials2010，，2628： | 1 |
| 5 | Effect of Penetration Rates on the Piezocone Penetration Test in the Yellow River Delta Silt显示文摘Partial drainage often occurs during piezocone penetration testing on Yellow River Delta silt because of its intermediate physical and mechanical properties between those of sand and clay.Yet,there is no accurate understanding for the range of penetra-tion rates to trigger the partial drainage of silt soils.In order to fully investigate cone penetration rate effects under partial drainage condi-tions,indoor 1 g penetration model tests and numerical simulations of cavity expansion at variable penetration rates were carried out on the Yellow River Delta silt.The boundary effect of the model tests and the variation of key parameters at the different cavity ex-pansion rates were analyzed.The 1 g penetration model test results and numerical simulations results consistently indicated that the penetration rate to trigger the partially drainage of typical silt varied at least three orders of magnitude.The numerical simulations also provide the reference values for the penetration resistance corresponding to zero dilation and zero viscosity at any given normalized penetration rate for silt in Yellow River Delta.These geotechnical properties can be used for the design of offshore platforms in Yel-low River Delta,and the understanding of cone penetration rate effects under the partially drained conditions would provide some technical support for geohazard evaluation of offshore platforms. | ZHANG Jiarui MENG Qingsheng ZHANG Yan FENG Xiuli WEI Guanli SU Xiuting LIU Tao | 2022 | Journal of Ocean University of China2022，21，2： | 1 |
| 6 | An Approach to Graphic Genetic Modelon显示文摘 | Tan Jianrong Fan Wenhui Wei Xiuting | 1998 | Journal of Computer Science and Technology1998，13，12： | 1 |
| 7 | Preparation and characterization of carboxymethyl starch microgel with different crosslinking densities显示文摘 | Bao Zhang Benxi Wei Xiuting Hu | 2015 | Carbohydrate Polymers2015，124，： | 1 |
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