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| 1 | Organellar genome assembly methods and comparative analysis of horticultural plants显示文摘Although organellar genomes(including chloroplast and mitochondrial genomes)are smaller than nuclear genomes in size and gene number,organellar genomes are very important for the investigation of plant evolution and molecular ecology mechanisms.Few studies have focused on the organellar genomes of horticultural plants.Approximately 1193 chloroplast genomes and 199 mitochondrial genomes of land plants are available in the National Center for Biotechnology Information(NCBI),of which only 39 are from horticultural plants.In this paper,we report an innovative and efficient method for high-quality horticultural organellar genome assembly from next-generation sequencing(NGS)data.Sequencing reads were first assembled by Newbler,Amos,and Minimus software with default parameters.The remaining gaps were then filled through BLASTN search and PCR.The complete DNA sequence was corrected based on Illumina sequencing data using BWA(Burrows–Wheeler Alignment tool)software.The advantage of this approach is that there is no need to isolate organellar DNA from total DNA during sample preparation.Using this procedure,the complete mitochondrial and chloroplast genomes of an ornamental plant,Salix suchowensis,and a fruit tree,Ziziphus jujuba,were identified.This study shows that horticultural plants have similar mitochondrial and chloroplast sequence organization to other seed plants.Most horticultural plants demonstrate a slight bias toward A+T rich features in the mitochondrial genome.In addition,a phylogenetic analysis of 39 horticultural plants based on 15 protein-coding genes showed that some mitochondrial genes are horizontally transferred from chloroplast DNA.Our study will provide an important reference for organellar genome assembly in other horticultural plants.Furthermore,phylogenetic analysis of the organellar genomes of horticultural plants could accurately clarify the unanticipated relationships among these plants. | Xuelin Wang Feng Cheng Dekai Rohlsen Changwei Bi Chunyan Wang Yiqing Xu Suyun Wei Qiaolin Ye Tongming Yin Ning Ye | 2018 | Horticulture Research2018，5，1： | 4 |
| 2 | PulseNet China,a model for future laboratory-based bacterial infectious disease surveillance in China显示文摘Surveillance is critical for the prevention and control of infectious disease.China’s real-time web-based infectious disease reporting system is a distinguished achievement.However,many aspects of the current China Infectious Disease Surveillance System do not yet meet the demand for timely outbreak detection and identification of emerging infectious disease.PulseNet,the national molecular typing network for foodborne disease surveillance was first established by the Centers for Disease Control and Prevention of the United States in 1995 and has proven valuable in the early detection of outbreaks and tracing the pathogen source.Since 2001,the China CDC laboratory for bacterial pathogen analysis has been a member of the PulseNet International family;and has been adapting the idea and methodology of PulseNet to develop a model for a future national laboratory-based surveillance system for all bacterial infectious disease.We summarized the development progress for the PulseNet China system and discussed it as a model for the future of China’s national laboratory-based surveillance system. | Wei Li Shan Lu Zhigang Cui Jinghua Cui Haijian Zhou Yiqing Wang Zhujun Shao Changyun Ye Biao Kan Jianguo Xu | 2012 | Frontiers of Medicine2012，6，4： | 4 |
| 3 | Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects显示文摘Both opioids and nonsteroidal anti-inflammatory drugs(NSAIDS)produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain.Peripheral neuroinflammation(PN)is critical for initiation and development of inflammatory pain.A better understanding of molecular mechanisms underlying PN would facilitate the discovery of new analgesic targets and the development of new therapeutics.Emerging evidence suggests that peripheral sensory neurons are not only responders to painful stimuli,but are also actively engaged in inflammation and immunity,whereas the intrinsic regulatory mechanism is poorly understood.Here we report the expression of proton-selective ion channel Hv1 in peripheral sensory neurons in rodents and humans,which was previously shown as selectively expressed in microglia in mammalian central nervous system.Neuronal Hv1 was up-regulated by PN or depolarizing stimulation,which in turn aggravates inflammation and nociception.Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain,mitigated the imbalance in downstream SHP-1-pAKT signaling,and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.Thus,our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects. | Qiansen Zhang Yimin Ren Yiqing Mo Peipei Guo Ping Liao Yuncheng Luo Jie Mu Zhuo Chen Yang Zhang Ya Li Linghui Yang Daqing Liao Jie Fu Juwen Shen Wei Huang Xuewen Xu Yanyan Guo Lianghe Mei Yunxia Zuo Jin Liu Huaiyu Yang Ruotian Jiang | 2022 | Cell Research2022，32，5： | 3 |
| 4 | The influence of hyaluronic acid on vascular endothelial cell proliferation and the relationship with ezrin/merlin expression显示文摘它被建立了那玻尿的酸(哈) glycans (nHA ) 和 oligosaccharide (oHA ) 在脉管的 endothelial 房间(EC ) 的生物功能上施加不同效果,导致 angiogenesis 的改变的规定。然而,特定的机制仍然是不清楚的。我们的学习在 EC 在 ezrin 和灰背隼蛋白质上集中了于 nHA 和 oHA 的效果。ezrin 和灰背隼的表示在 EC 生长以及 mRNA 表示上是由 siRNA,和规定的 silenced, ezrin 和灰背隼的激活(phosphorylation ) 由 oHA 刺激了, nHA 被调查。结果表明当与 nHA 对待时,在 ezrin 表示或激活没有重要变化。在与 oHA 被对待以后,而在灰背隼表示没有明显的变化, ezrin 的表示和激活决定性地被增加(包括它的 phosphorylation ) 。与 ezrin 表示 silenced,象它的 phosphorylation 一样的灰背隼的表示在刺激 nHA 的人的脐的静脉 endothelial 房间铺平显著地被提高,当没有重要变化, oHA 导致时。与灰背隼表示 silenced,没有明显的变化在 ezrin 的表示被发现(包括它的 phosphorylation ) 由 nHA 导致了。相反地, ezrin 的表示和它的激活显著地在与 oHA 被对待以后被改进。结果建议为由 oHA 的 EC 增长的提升的机制与 ezrin 的表示和激活有关是可能的,并且由 nHA 的 EC 增长的抑制与灰背隼的表示和激活有关是可能的。 | Wei Mo Cuixia Yang Yiwen Liu Yiqing He Yingzhi Wang Feng Gao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 3 |
| 5 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 6 | All-optical logic devices based on black arsenic-phosphorus with strong nonlinear optical response and high stability显示文摘The Kerr nonlinearity in two-dimensional(2D)nanomaterials is emerging as an appealing and intriguing research area due to their prominent light processing,modulation,and manipulation abilities.In this contribution,2D black arsenic-phosphorus(B-AsP)nanosheets(NSs)were applied in nonlinear photonic devices based on spatial self-phase modula-tion(SSPM)method.By applying the Kerr nonlinearity in 2D B-AsP,an all-optical phase-modulated system is proposed to realize the functions of“on”and“off”in all-optical switching.By using the same all-optical phase-modulated system,another optical logic gate is proposed,and the logical“or”function is obtained based on the 2D B-AsP NSs dispersions.Moreover,by using the SSPM method,a 2D B-AsP/SnS_(2) hybrid structure is fabricated,and the result illustrates that the hybrid structure possesses the ability of the unidirectional nonlinear excitation,which helps in obtaining the function of spatial asymmetric light propagation.This function is considered an important prerequisite for the realization of diode functionalization,which is believed to be a factor in important basis for the design of isolators as well.The initial investig-ations indicate that 2D B-AsP is applicable for designing optical logical devices,which can be considered as an import-ant development in all-optical information processing. | Leiming Wu Taojian Fan Songrui Wei Yijun Xu Ye Zhang Dingtao Ma Yiqing Shu Yuanjiang Xiang Jun Liu Jianqing Li Krassimir Panajotov Yuwen Qin Han Zhang | 2022 | Opto-Electronic Advances2022，5，1： | 3 |
| 7 | Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease显示文摘Huntington's disease(HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene. Mutant Huntingtin protein(m HTT) forms abnormal aggregates and intranuclear inclusions in specific neurons, resulting in cell death. Here,we tested the ability of a natural heat-shock protein 90 inhibitor, Gedunin, to degrade transfected m HTT in Neuro-2 a cells and endogenous m HTT aggregates and intranuclear inclusions in both fibroblasts from HD patients and neurons derived from induced pluripotent stem cells from patients. Our data showed that Gedunin treatment degraded transfected m HTT in Neuro-2 a cells, endogenous m HTT aggregates and intranuclear inclusions in fibroblasts from HD patients, and in neurons derived from induced pluripotent stem cells from patients in a dose-and time-dependent manner, and its activity depended on the proteasomal pathway rather than the autophagy route. These findings also showed that although Gedunin degraded abnormal m HTT aggregates and intranuclear inclusions in cells from HD patient, it did not affect normal cells, thus providing a new perspective for using Gedunin to treat HD. | Weiqi Yang Jingmo Xie Qiang Qiang Li Li Xiang Lin Yiqing Ren Wenlei Ren Qiong Liu Guomin Zhou Wenshi Wei Hexige Saiyin Lixiang Ma | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 8 | Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura显示文摘 | Hongyun Liu Xianfeng Ouyang Yiqing Li Hua Zeng Xiuju Wang Shuangfeng Xie Danian Nie Jie Xiao Jing Wei Yudan Wu Songmei Yin Liping Ma | 2013 | Thrombosis Research2013，，： | 2 |
| 9 | CsPbBr_(3) quantum dots photodetectors boosting carrier transport via molecular engineering strategy显示文摘Perovskite quantum dots (PQDs) require ligands on their surfaces to passivate defects and prevent aggregation. However, the ligands construct the interface relationship between the PQDs, which may seriously hinder the carrier transport. Hence, we propose a molecular engineering strategy of using 3,4-ethylenedioxythiophene (EDOT) to perfectly solve this problem, benefiting from its high conjugation and passivation ability to CsPbBr_(3) PQDs. Furthermore, EDOT on the surface of PQDs can be in-situ polymerized under the photocurrent of the photodetector, thus interconnecting the PQDs which enhanced the performance of the photodetectors up to 178% of its initial performance. We have thoroughly investigated the electropolymerization process of EDOT and its passivation effect on PQDs. The simple lateral photodetector based on EDOT PQDs exhibits a high responsivity of 11.96 A/W, which is 104 times higher than that of oleic acid caped PQDs. Due to the protection of poly(3,4-ethylenedioxythiophene) (PEDOT), the photodetector prepared from EDOT PQDs exhibited very high stability, retaining 94% of its performance after six months in air. This strategy provides a solution for the application of PQDs in high performances and stable optoelectronic devices. | Wei Yan Jianhua Shen Yihua Zhu Yiqing Gong Jingrun Zhu Zheng Wen Chunzhong Li | 2021 | Nano Research2021，14，11： | 1 |
| 10 | A phase correction algorithm of deformed grating images in the depth measurement of weld pool surface in gas tungsten arc welding 显示文摘 | WEI Yiqing LIU Nansheng HU Xian | 2011 | Optieal Engineering(S0091-3286)2011，50，5： | 1 |
| 11 | Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus显示文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. | Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang | 2019 | Journal of Genetics and Genomics2019，46，1： | 1 |
| 12 | Influence of cementite spheroidization on relieving the micro-galvanic effect of ferrite-pearlite steel in acidic chloride environment显示文摘The corrosion behavior of the as-received steel and the spheroidized steel in acidic chloride environment was investigated. The results indicate the corrosion mode and corrosion rate of two steels are diverse due to their difference in microstructure. For as-received steel with ferrite-pearlite microstructure, severe localized corrosion happens on the pearlite regions, and plenty of cathodic cementite remains in the pits, further strengthening the micro-galvanic effect and accelerating the corrosion rate. While for spheroidized steel with tempered martensite microstructure, the nanosized cementite particles evenly distributed on the ferrite substrate are easy to fall off, which can significantly reduce the cementite accumulation on the steel surface, relieving the acceleration effect of micro-galvanic corrosion. | Hu Liu Jie Wei Junhua Dong Yiqing Chen Yumin Wu Yangtao Zhou Subedi Dhruba Babu Wei Ke | 2021 | Journal of Materials Science & Technology2021，，2： | 1 |
| 13 | Relationship between gravity change and Yangbi M_(S)6.4 earthquake显示文摘Based on the relative and absolute gravity measurements in the southern South-North Seismic Belt since 2015,we analyzed the dynamic change of the regional gravity field and its relationship with the Yangbi M_(S)6.4 earthquake that occurred on May 21,2021.The results show that:(1)The regional gravity field changes are closely related to the Weixi-Qiaohou fault,which reflects the surface gravity field changes caused by the fault activity from 2015 to 2021;(2)The gravity field change related to the preparation of Yangbi earthquake has experienced the evolution process of'steady state-regional gravity anomaly-local gravity anomaly-four-quadrant distribution-large area positive anomaly-earthquake occurring in the reverse change process';(3)The cumulative and differential change images of the gravity field show that there were significant gravity changes in the two years preceding the Yangbi earthquake,and the earthquake occurred in the high-gradient belt of gravity variation,the center of the four-quadrant,and close to the zero contour turn;(4)The dynamic evolution image of the gravity field can well reflect the precursory phenomena during the preparation for the Yangbi MS6.4 earthquake.Based on the anomaly change of mobile gravity,a certain degree of medium-term prediction was made before the Yangbi M_(S)6.4 earthquake,especially the determination of strong earthquake location. | Xiong Yang Yiqing Zhu Yunfeng Zhao Shouchun Wei | 2023 | Geodesy and Geodynamics2023，14，4： | 1 |
| 14 | Phase correction al- gorithm of deformed grating images in the depth measurement of weld pool sud'ace in gas tungsten arc welding 显示文摘 | Wei Yiqing Liu Nansheng Hu Xian | 2011 | Optical Engi- neering2011，50，05： | 1 |
| 15 | Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation显示文摘 | Yiqing Yan Wei Jiang Thibaud Spinetti Aubry Tardivel Rosa Castillo Carole Bourquin Greta Guarda Zhigang Tian Jurg Tschopp Rongbin Zhou | 2013 | Immunity2013，，6： | 1 |
| 16 | Efficacy and Safety of Dexamethasone Ointment on Recurrent Aphthous Ulceration显示文摘 | Chuanxia Liu Zengtong Zhou Guanjian Liu Qintao Wang Jiangang Chen Ling Wang Yongmei Zhou Guangying Dong Xueyi Xu Yuechun Wang Yiqing Guo Mei Lin Lan Wu Gefei Du Changlei Wei Xin Zeng Xiaoyi Wang Junzheng Wu Bingqi Li Gang Zhou Hongmei Zhou | 2012 | The American Journal of Medicine2012，，3： | 1 |
| 17 | The synergy between cementite spheroidization and Cu alloying on the corrosion resistance of ferrite-pearlite steel in acidic chloride solution显示文摘In this work,the corrosion behavior of medium-carbon steels(45,45 Cu and 45 Cuq steels)in acidic chloride environment was investigated.The results indicated that the micro-galvanic effect between the anodic ferrite matrix phase and the cathodic cementite secondary phase notably affected the corrosion resistance of the three steels.For 45 steel,serious pitting corrosion happened in and around the pearlite regions,and a large number of lamellar cementite was fixed in the corrosion pits.Meanwhile,the continuously increasing superficial area of cathodic cementite enhanced the micro-galvanic corrosion,resulting in a rapidly increase in corrosion rate with time.While for 45 Cu and 45 Cuq steels,macroscopic uniform corrosion occurred,and the cementite accumulation was markedly reduced as compared with 45 steel,thus the micro-galvanic effect was weakened and the corrosion rate was decreased accordingly.Among these,45 Cuq steel showed the most stable and excellent corrosion resistance during long-term corrosion,indicating the occurrence of a synergistic effect between cementite spheroidization and Cu alloying,thereby significantly improving the corrosion resistance of 45 steel. | Hu Liu Jie Wei Junhua Dong Yangtao Zhou Yiqing Chen Yumin Wu Subedi Dhruba Babu Aniefiok Joseph Umoh Wei Ke | 2021 | Journal of Materials Science & Technology2021，，25： | 1 |
| 18 | A Phase Correction Algorithm o Deformed Grating Images in the Depth Measurement of Weld Pool Surface in Gas Tungsten Are Welding显示文摘 | WEI Yiqing LIU Nansheng HU Xian | 2011 | Optical Engineering2011，50，5： | 1 |
| 19 | Increased trefoil factor 3 levels in the serum of patients with threemajor histological subtypes of lung cancer显示文摘 | Yiqing Qu Yie Yang Dedong Ma Wei Xiao | 2012 | Oncology Reports2012，，4： | 1 |
| 20 | Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,has become a global public health crisis.Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital.How such retest-positive(RTP)patients become infected again is not known.In this study,30 RTP patients,20 convalescent patients,and 20 healthy controls were enrolled for the analysis of immunological characteristics of their peripheral blood mononuclear cells.We found that absolute numbers of CD4^(+)T cells,CD8^(+)T cells,and natural killer cells were not substantially decreased in RTP patients,but the expression of activation markers on these cells was significantly reduced.The percentage of granzyme B-producing T cells was also lower in RTP patients than in convalescent patients.Through transcriptome sequencing,we demonstrated that high expression of inhibitor of differentiation 1(ID1)and low expression of interferon-induced transmembrane protein 10(IFITM10)were associated with insufficient activation of immune cells and the occurrence of RTP.These findings provide insight into the impaired immune function associated with COVID-19 and the pathogenesis of RTP,which may contribute to a better understanding of the mechanisms underlying RTP. | Dongyao Wang Dong Wang Min Huang Xiaohu Zheng Yiqing Shen Binqing Fu Hong Zhao Xianxiang Chen Peng Peng Qi Zhu Yonggang Zhou Jinghe Zhang Zhigang Tian Wuxiang Guan Guiqiang Wang Haiming Wei | 2021 | Journal of Molecular Cell Biology2021，13，10： | 0 |
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