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| 1 | Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight显示文摘The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness. | Linjie Wang Zhili Li Cheng Tan Shujuan Liu Jianfeng Zhang Siyang He Peng Zou Weibo Liu Yinghui Li | 2019 | Frontiers of Medicine2019，13，2： | 9 |
| 2 | Our recent progress in epigenetic research using the model ciliate, Tetrahymena thermophila显示文摘Epigenetic research focuses on heritable changes beyond the DNA sequence, which has led to a revolution in biologicalstudies and benefits in many other fields. The well-known model ciliate, Tetrahymena thermophila offers a unique system forepigenetic studies due to its nuclear dimorphism and special mode of sexual reproduction (conjugation), as well as abundantgenomic resources and genetic tools. In this paper, we summarize recent progress made by our research team and collaboratorsin understanding epigenetic mechanisms using Tetrahymena. This includes: (1) providing the first genome-wide basepair-resolution map of DNA N6-methyladenine (6mA) and revealed it as an integral part of the chromatin landscape;(2)dissecting the relative contribution of cis・ and trans- elements to nucleosome distribution by exploring the unique nucleardimorphism of Tetrahymena, (3) demonstrating the epigenetic controls of RNAi-dependent Polycomb repression pathwayson transposable elements, and (4) identifying a new histone monomethyltransferase, TXR1 (Tetrahymena Trithorax 1), thatfacilitates replication elongation through 让s substrate histone H3 lysine 27 monomethylation (H3K27mel). | Ting Cheng Yuanyuan Wang Jie Huang Xiao Chen Xiaolu Zhao Shan Gao Weibo Song | 2019 | Marine Life Science & Technology2019，1，1： | 4 |
| 3 | Effects of reactive oxygen species on cellular wall disassembly of banana fruit during ripening显示文摘 | Guiping Cheng Xuewu Duan John Shi Wangjin Lu Yunbo Luo Weibo Jiang Yueming Jiang | 2008 | Food Chemistry2008，，2： | 1 |
| 4 | Desorption behaviors of BDE 28 and BDE-47 from natural soils with dif- ferent organic carbon contents显示文摘 | LIU Wenxin CHENG Fangang LI Weibo | 2012 | Environmental Pollution2012，163，4： | 1 |
| 5 | Modelling the impact of wind stress and river discharge on Danshui River plume 显示文摘 | LIU Wencheng CHEN Weibo CHENG T Ralph | 2008 | Applied Mathematical Modelling2008，32，： | 1 |
| 6 | Diode-pumpedcw Nd∶YAG three-level laser at 869 nm显示文摘 | Yanfei Lü Jing Xia Weibo Cheng | 2010 | Optics Let-ters2010，35，21： | 1 |
| 7 | The β6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer显示文摘 | Song Liu Jian Wang Weibo Niu Enyu Liu Jiayong Wang Cheng Peng Pengfei Lin Ben Wang Abdul Qadir Khan Huijie Gao Benjia Liang Muhammad Shahbaz Jun Niu | 2013 | Cancer Letters2013，，2： | 1 |
| 8 | Desorption behaviors of BDE-28 and BDE-47 from natural soils with dif- ferent organic carbon contents显示文摘 | LIU Wenxin CHENG Fangfang LI Weibo | 2012 | Environmental Pollution2012，163，4： | 1 |
| 9 | Aquafeed fermentation improves dietary nutritional quality and benefits feeding behavior,meat flavor,and intestinal microbiota of Chinese mitten crab(Eriocheir sinensis)显示文摘Normally,proper fermentation can be an efficient and widely used method to improve feed quality in animal rearing;however,the studies on crustaceans,especially Eriocheir sinensis,remain limited.This study aimed to investigate whether feed fermentation could meliorate dietary nutritional value and benefit E.sinensis rearing.First,non-fermented feed(NFD)and fermented feed(FD)were produced and assessed,respectively.Then,the“Y”maze feed choice behavior test(180 times;30 times,6 rounds)was conducted to assess the attractiveness of these 2 feeds for crabs.Finally,a total of 80 crabs(44.10±0.80 g)were randomly assigned into 2 groups with 4 replicates,and fed the experimental diets for 8 weeks to evaluate the effects of each feed on growth,antioxidant capacity,meat flavor,and intestinal microbiota.In this study,FD showed higher levels of crude protein(P<0.01),soluble protein(P<0.01),amino acids(P<0.05),lactic acid(P<0.001),and lower levels of crude fiber(P<0.05)and antinutritional factors(agglutinin,trypsin inhibitor,glycinin,andβ-conglycinin)(P<0.001)than NFD.Additionally,FD was more attractive to crabs than NFD(P<0.01)and it stimulated the appetite of crabs more than NFD(P<0.05).The growth performance,feed efficiency,and digestive enzyme activity of FDfed crabs were significantly higher than those of NFD-fed crabs(P<0.05).The electronic sensory measurements and free amino acid profiles revealed that the FD diet had positive impacts on the meat flavor of crabs,particularly in“sweet”and“umami”tastes.Moreover,the antioxidant capacity of FD-fed crabs was significantly higher than that of NFD-fed crabs(P<0.05).Fermented feed also affected the diversity and composition of intestinal microflora.The functional prediction of microbial communities showed that crabs fed FD had a better microecological environment in the intestine.In conclusion,the fermentation of aquafeed could be an effective approach to enhance feed quality and therefore benefit E.sinensis rearing. | Weibo Jiang Xiaoyan Jia Ningjun Xie Chuang Wen Shuo Ma Guangzhen Jiang Xiangfei Li Cheng Chi Dingdong Zhang Wenbin Liu | 2023 | Animal Nutrition2023，，3： | 0 |
| 10 | Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury显示文摘Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials. | Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai | 2023 | Bioactive Materials2023，，1： | 0 |
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