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| 1 | Hydrogel Microneedle Arrays for Transdermal Drug Delivery显示文摘Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms.In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology. | Xiaoyun Hong Zaozhan Wu Lizhu Chen Fei Wu Liangming Wei Weien Yuan | 2014 | Nano-Micro Letters2014，6，3： | 5 |
| 2 | 纳米尺度HfO_2薄膜的光谱椭偏模型建立显示文摘为了建立厚度为1 nm左右HfO_2超薄膜的光谱椭偏测量方法,采用掠入射X射线反射技术进行国家/地区实验室间比对认证,其膜厚准确量值作为参比值,建立了HfO_2超薄膜的光谱椭偏结构拟合模型。研究了HfO_2超薄膜的光谱椭偏色散模型和拟合参数,最后确定了拟合色散模型为Tauc-Lorentz 3,拟合光谱范围为3.45~4.35 eV,表面污染层孔隙比例为60:40。 | 张寅辉 任玲玲 高慧芳 贾亚斌 Fu Weien 刘小萍 Kim Changsoo Yasushi Azuma | 2017 | 计量学报2017，38，5： | 2 |
| 3 | A machine learning surrogate modeling benchmark for temperature field reconstruction of heat source systems显示文摘The temperature field reconstruction of heat source systems(TFR-HSS)with limited monitoring sensors in thermal management plays an important role in the real-time health detection systems of electronic equipment in engineering.However,prior methods with common interpolations usually cannot provide accurate reconstruction performance as required.In addition,no public dataset exists for the wide research of reconstruction methods to further boost reconstruction performance and engineering applications.To overcome this problem,this work develops a machine learning surrogate modeling benchmark for the TFRHSS task.First,the TFR-HSS task is mathematically modeled from a real-world engineering problem,and four types of computational modelings are constructed to transform the problem into discrete mapping forms.Then,this work proposes a set of machine learning surrogate modeling methods,including general machine learning methods and deep learning methods,to advance the state-of-the-art methods over temperature field reconstruction.More importantly,this work develops a novel benchmark dataset,namely the temperature field reconstruction dataset(TFRD),to evaluate these machine learning surrogate modeling methods for the TFR-HSS task.Finally,a performance analysis of typical methods is given on the TFRD,which can serve as the baseline results on this benchmark. | Xiaoqian CHEN Zhiqiang GONG Xiaoyu ZHAO Weien ZHOU Wen YAO | 2023 | Science China(Information Sciences)2023，66，5： | 1 |
| 4 | Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion显示文摘 | Yuan Weien Wu Fei Guo Meiyan | 2009 | Eur J pharm Sci2009，36，23： | 1 |
| 5 | Freeze-Drying Formulations Increased the Adenovirus and Poxvirus Vaccine Storage Times and Antigen Stabilities显示文摘Successful vaccines induce specific immune responses and protect against various viral and bacterial infections. Noninactivated vaccines, especially viral vector vaccines such as adenovirus and poxvirus vaccines, dominate the vaccine market because their viral particles are able to replicate and proliferate in vivo and produce lasting immunity in a manner similar to natural infection. One challenge of human and livestock vaccination is vaccine stability related to the antigenicity and infectivity. Freeze-drying is the typical method to maintain virus vaccine stability, while cold chain transportation is required for temperatures about 2 °C–8 °C. The financial and technological resource requirements hinder vaccine distribution in underdeveloped areas. In this study, we developed a freeze-drying formula consisting of bovine serum albumin(BSA), L-glutamic acid(L-Glu), polyethylene glycol(PEG), and dextran(DEX) to improve the thermal stability and activity of viral vaccines, including vaccinia recombinant vaccine(rTTV-OVA) and adenovirus vaccine(Ad5-ENV). We compared a panel of five different formulations(PEG: DEX: BSA: L-GLU = 50:9:0:0(#1), 50:5:4:0(#2), 50:10:9:0(#3),50:0:0:9(#4), and 50:1:0:8(#5), respectively) and optimized the freeze-drying formula for rTTV-OVA and Ad5-ENV. We found that the freeze-drying formulations #2 and #3 could maintain rTTV-OVA infectivity at temperatures of 4 °C and25 °C and that r TTV-OVA immunogenicity was retained during lyophilization. However, formulations #4 and #5 maintained Ad5-ENV infectivity under the same conditions, and Ad5-ENV immunogenicity had maximum retention with freeze-drying formulation #4. In summary, we developed new freeze-drying formulations that increased virus vaccine storage times and retained immunogenicity at an ambient temperature. | Ye Chen Qibin Liao Tianyue Chen Yuchao Zhang Weien Yuan Jianqing Xu Xiaoyan Zhang | 2021 | Virologica Sinica2021，36，3： | 1 |
| 6 | Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres显示文摘 | Hu Z Yajun L Weien Y | 2011 | Colloids and Surfaces B: Biointcrfaces2011，86，1： | 1 |
| 7 | Aanlgesia and sedation of mechanically ventilated patients a national survery of clinical practice显示文摘 | Weien H Stubhaug A Bjerk IT | | 0，，1： | 1 |
| 8 | Advances with RNA interference in Alzheimer’s disease research显示文摘 | Weien Yuan Yinghui Chen Xue-mei Ge Shun Chen Zhenguo Liu Nan Lu | 2013 | Drug Design Development and Therapy (default)2013，，： | 1 |
| 9 | Formulating erythropoietin- loaded sustained-release PLGA microspheres without protein aggre- gation 显示文摘 | Yan Geng Weien Yuan Fei Wu | 2008 | Journal of Controlled Release2008，130，3： | 1 |
| 10 | Preparation of polysaccharide glassy microparticles with stabilization of proteins显示文摘 | Weien Yuan Yan Geng Fei Wu Yajun Liu Meiyan Guo Hao Zhao Tuo Jin | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 11 | Preparing polymer-based sustained-release systems without exposing proteins to water–oil or water–air interfaces and cross-linking reagents显示文摘 | Tuo Jin Jiahao Zhu Fei Wu Weien Yuan Lee L. Geng Hua Zhu | 2008 | Journal of Controlled Release2008，，1： | 1 |
| 12 | CONVERGENCE ANALYSIS OF PARAREAL ALGORITHM BASED ON MILSTEIN SCHEME FOR STOCHASTIC DIFFERENTIAL EQUATIONS显示文摘In this paper,we propose a parareal algorithm for stochastic differential equations(SDEs),which proceeds as a two-level temporal parallelizable integrator with the Milstein scheme as the coarse propagator and the exact solution as the fine propagator.The convergence order of the proposed algorithm is analyzed under some regular assumptions.Finally,numerical experiments are dedicated to illustrate the convergence and the convergence order with respect to the iteration number k,which show the efficiency of the proposed method. | Liying Zhang Jing Wang Weien Zhou Landong Liu Li Zhang | 2020 | Journal of Computational Mathematics2020，38，3： | 1 |
| 13 | Micro and Nanotechnology for Intracellular Delivery Therapy Protein显示文摘Proteins therapy is of great importance in the treatment of protein deficiency disease. Most human diseases are related to the malfunctioning of one or more proteins. The most effective and direct approach is protein therapy, which delivers the proteins into the target cell to replace the dysfunction protein and maintain the balance of organism. However, clinical application is frequently hampered by various biological barriers to their successful delivery. This review aims to discuss the recent advances about microparticles and nanoparticles fabricated using micro and nanotechnology for intracellular delivery therapy protein and give some suggestions about the promising delivery system. | Dan Xu Zhenhua Hu Jing Su Fei Wu Weien Yuan | 2012 | Nano-Micro Letters2012，4，2： | 1 |
| 14 | Porous microsphere and its applications显示文摘 | Weien Yuan Zhenguo Liu Xiaoyun Hong Yinghui Chen Yunpeng Cai | 2013 | 2013 (defa)2013，，： | 1 |
| 15 | PARAREAL ALGORITHMS APPLIED TO STOCHASTIC DIFFERENTIAL EQUATIONS WITH CONSERVED QUANTITIES显示文摘In this paper,we couple the parareal algorithm with projection methods of the trajectory on a specifc manifold,defined by the preservation of some conserved quantities of stochastic differential equations.First,projection methods are introduced as the coarse and fine propagators.Second,we apply the projection methods for systems with conserved quantities in the correction step of original parareal algorithm.Finally,three mumerical experiments are performed by different kinds of algorithms to show the property of convergence in iteration,and preservation in conserved quantities of model systems. | Liying Zhang Weien Zhou Lihai Ji | 2019 | Journal of Computational Mathematics2019，37，1： | 1 |
| 16 | Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus,persisters and biofilms显示文摘Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed biofilms.Here,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and persisters.Even after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop resistance.Besides,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and persisters.Furthermore,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA cycle.Then,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein degradation.Furthermore,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory response.In conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters. | Shutao Zhang Xinhua Qu Juyang Jiao Haozheng Tang Minqi Wang You Wang Hongtao Yang Weien Yuan Bing Yue | 2022 | Bioactive Materials2022，7，8： | 0 |
| 17 | Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing显示文摘Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial roles.IL2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of lymphocytes.Animal models carrying mutations in these genes exhibit notable deficiencies in their immune systems. | Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 18 | Behavioural equivalences of a probabilistic pi-calculus显示文摘Although different kinds of probabilistic π-calculus have been introduced and found their place in quantitative verification and evaluation,their behavioural equivalences still lack a deep investigation.We propose a simple probabilistic extension of the π-calculus,π p,which is inspired by Herescu and Palamidessi's probabilistic asynchronous π-calculus.An early semantics of our π p is presented.We generalise several classic behavioural equivalences to probabilistic versions,obtaining the probabilistic(strong) barbed equivalence and probabilistic bisimulation for π p.Then we prove that the coincidence between the barbed equivalence and bisimilarity in the π-calculus is preserved in the probabilistic setting. | CHEN WeiEn CAO YongZhi WANG HanPin | 2012 | Science China(Information Sciences)2012，55，9： | 0 |
| 19 | Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys显示文摘Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment. | Zhuchi Tu Sen Yan Bofeng Han Cajuan Li Weien Liang Yingqi Lin Yongyan Ding Huiyi Wei Lu Wang Hao Xu Jianmeng Ye Bang Li Shihua Li Xiao-Jiang Li | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 20 | A deep neural network surrogate modeling benchmark for temperature field prediction of heat source layout显示文摘The thermal issue is of great importance during the layout design of heat source components in systems engineering,especially for high functional-density products.Thermal analysis requires complex simulation,which leads to an unaffordable computational burden to layout optimization as it iteratively evaluates different schemes.Surrogate modeling is an effective method for alleviating computation complexity.However,the temperature field prediction(TFP)with complex heat source layout(HSL)input is an ultra-high dimensional nonlinear regression problem,which brings great difficulty to traditional regression models.The deep neural network(DNN)regression method is a feasible way for its good approximation performance.However,it faces great challenges in data preparation for sample diversity and uniformity in the layout space with physical constraints and proper DNN model selection and training for good generality,which necessitates the efforts of layout designers and DNN experts.To advance this cross-domain research,this paper proposes a DNN-based HSL-TFP surrogate modeling task benchmark.With consideration for engineering applicability,sample generation,dataset evaluation,DNN model,and surrogate performance metrics are thoroughly investigated.Experiments are conducted with ten representative state-of-the-art DNN models.A detailed discussion on baseline results is provided,and future prospects are analyzed for DNN-based HSL-TFP tasks. | Xianqi Chen Xiaoyu Zhao Zhiqiang Gong Jun Zhang Weien Zhou Xiaoqian Chen Wen Yao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
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