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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 3 | Cooperative task assignment of multi-UAV system显示文摘With the rapid development of Unmanned Aerial Vehicle(UAV)technology,one of the emerging fields is to utilize multi-UAV as a team under autonomous control in a complex environment.Among the challenges in fully achieving autonomous control,Cooperative task assignment stands out as the key function.In this paper,we analyze the importance and difficulties of multiUAV cooperative task assignment in characterizing scenarios and obtaining high-quality solutions.Furthermore,we present three promising directions for future research:Cooperative task assignment in a dynamic complex environment,in an unmanned-manned aircraft system and in a UAV swarm.Our goal is to provide a brief review of multi-UAV cooperative task assignment for readers to further explore. | Jun ZHANG Jiahao XING | 2020 | Chinese Journal of Aeronautics2020，33，11： | 17 |
| 4 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 5 | Sequence Thickness and its Response to Episodic Tectonic Evolution in Paleogene Qikou Sag, Bohaiwan Basin显示文摘The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed. | CHEN Si WANG Hua ZHOU Lihong HUANG Chuanyan WANG Jiahao REN Peigang XIANG Xuemei | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 11 |
| 6 | A novel stability prediction approach for thin-walled component milling considering material removing process显示文摘The milling stability of thin-walled components is an important issue in the aviation manufacturing industry, which greatly limits the removal rate of a workpiece. However, for a thin-walled workpiece, the dynamic characteristics vary at different positions. In addition, the removed part also has influence on determining the modal parameters of the workpiece. Thus,the milling stability is also time-variant. In this work, in order to investigate the time variation of a workpiece's dynamic characteristics, a new computational model is firstly derived by dividing the workpiece into a removed part and a remaining part with the Ritz method. Then, an updated frequency response function is obtained by Lagrange's equation and the corresponding modal parameters are extracted. Finally, multi-mode stability lobes are plotted by the different quadrature method and its accuracy is verified by experiments. The proposed method improves the computational efficiency to predict the time-varying characteristics of a thin-walled workpiece. | Jiahao SHI Qinghua SONG Zhanqiang LIU Xing AI | 2017 | Chinese Journal of Aeronautics2017，30，5： | 9 |
| 7 | Paleozoic Intrusive Rocks in the Nalati Mountain Range(NMR), Southwest Tianshan: Geodynamic Evolution Based on Petrology and Geochemical Studies显示文摘A synthesis involving the data for the Nalati mountain region(NMR) in west Tianshan with a dataset including zircon U-Pb ages, Hf isotopic composition, major and trace elements of Paleozoic intrusions are presented to improve the understanding of regional geodynamic evolution. Paleozoic intrusive rocks in the NMR could be classified into four categories based on chronological and geochemical data: 480?5 Ma, 445–410 Ma, 345–320 Ma, and 295 Ma, which correspond to(1) closure of the Terskey Ocean and the opening of the south Tianshan back-arc basin, which was followed with the opening of the south Tianshan Ocean,(2) initial subduction of the south Tianshan oceanic crust,(3) major subduction stage, and(4) collision to post-collisional stage, respectively. Following the closure of the Terskey Ocean, the south Tianshan Ocean opened at Early Silurian and subducted under Yili-central Tianshan by the end of Early Carboniferous Period. The following breakoff of the subducted slab triggered partial melting of continental crust and formed voluminous granitic rocks in the NMR. | Huichao Zhang Yongfeng Zhu Wanyi Feng Yuwen Tan Fang An Jiahao Zheng | 2017 | Journal of Earth Science2017，28，2： | 9 |
| 8 | The constraints of strain partitioning and geochronology in Luonan-Luanchuan tectonic belts on Qinling orogenic belt显示文摘The Luonan-Luanchuan tectonic belt lies between the North China Block and Qinling Mountains, in- cluding the Luonan-Luanchuan fault zone and the strong deformation zone to the north of the fault. The ductile shear zone, imbricate brittle fault and duplex structure in the fault zone now are the expression of the same tectonic event in different depth. Such lineation structure exists in the tectonic belts as mineral lineation, elongation lineation, crenulation lineation, sheath folds and so on, indicating NE-directed plate motion. Fold axes and thrusts in the strong deformation zone are inclined to the Luonan-Luanchuan fault zone at small angles. The structures with different natures show a regular pattern, produced during oblique convergence of plates. The convergence factors are as follows:The direction of plate convergence is 22°, 31° and the angle between the plate convergence direction and plate boundary is 73°, 82° respectively in the west and east segment. The Luonan-Luanchuan tectonic belt was deformed strongly in 372 Ma, resulted from Erlangping back-arc ocean basin subduction sin- istrally and obliquely to North China Block during the collision of North China Block and South China Block. | SONG ChuanZhong ZHANG GuoWei WANG YongSheng LI JiaHao CHEN ZeChao CAI ZhiChuan | 2009 | Science China Earth Sciences2009，52，3： | 9 |
| 9 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 10 | Thermodynamic Modeling of Fluid-Bearing Natural Gas Inclusions for Geothermometer and Geobarometer of Overpressured Environments in Qiongdongnan Basin, South China Sea显示文摘It is a very difficult problem to directly determine fluid pressure during hydrocarbon migration and accumulation in sedimentary basins. pVt modeling of coupling hydrocarbon fluid inclusion of its coeval aqueous fluid inclusion provides a powerful tool for establishing the relationship of formation pressure evolution with time. Homogenization temperature of fluid inclusion can routinely be measured under microthermometric microscopy. Crushing technique has been employed to obtain the composition of fluid inclusions, and the commercial software VTFLINC easily and rapidly completes the construction of p t phase diagram. The minimum trapping pressure of hydrocarbon fluid inclusion would be then determined in the p t space. In this paper, three samples of YC21 1 1 and YC21 1 4 wells at YC21 1 structural closure, Qiongdongnan basin, South China Sea, were selected for the pVt modeling practice, and the formation pressure coefficient (equals to fluid pressure/hydrostatic pressure) changing trend with time has primarily been established. The modeling results also indicate that the reservoirs of Lingshui and Yacheng formations in YC21 1 structure are within a very high potential system and would have undergone a discharging of thermal fluids through top seal rupture, which depicts that there is a very high risk for natural gas exploration in this area. | Chen Honghan Yao Shuzhen Wang Jiahao Li Chunquan Institute of Resources, China University of Geosciences, Wuhan 430074 | 2002 | Journal of China University of Geosciences2002，13，3： | 7 |
| 11 | Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility显示文摘Proteomic 技术在最近的年里经历了重要开发,它在蛋白质研究导致了广泛的进展。当前, proteomic 途径被用于许多科学区域,包括基本研究,各种各样的疾病和恶性肿瘤诊断, biomarker 发现和另外的治疗学的应用。另外,检验繁殖生物学和药的驾驶 proteomics 的研究文章正在变得逐渐地普通。为这个领域的关键挑战是从识别蛋白质的表搬到关于蛋白质功能获得生物信息。现在的文章考察与精子发生有关的可得到的科学文学。另外,这研究使用二维的电气泳动团 spectrometry (2DEMS ) ,构造一系列 proteome 的液体层析(LC ) MS 介绍描述精子发生。蛋白质的这大规模鉴定为阐明提供一个富有的资源位于男富饶和不孕下面的机制。 | Xiaoyan Huang Jiahao Sha | 2011 | Asian Journal of Andrology2011，13，1： | 7 |
| 12 | Algebraic Method‑Based Point‑to‑Point Trajectory Planning of an Under‑Constrained Cable‑Suspended Parallel Robot with Variable Angle and Height Cable Mast显示文摘To avoid impacts and vibrations during the processes of acceleration and deceleration while possessing flexible working ways for cable-suspended parallel robots(CSPRs),point-to-point trajectory planning demands an under-constrained cable-suspended parallel robot(UCPR)with variable angle and height cable mast as described in this paper.The end-effector of the UCPR with three cables can achieve three translational degrees of freedom(DOFs).The inverse kinematic and dynamic modeling of the UCPR considering the angle and height of cable mast are completed.The motion trajectory of the end-effector comprising six segments is given.The connection points of the trajectory segments(except for point P3 in the X direction)are devised to have zero instantaneous velocities,which ensure that the acceleration has continuity and the planned acceleration curve achieves smooth transition.The trajectory is respectively planned using three algebraic methods,including fifth degree polynomial,cycloid trajectory,and double-S velocity curve.The results indicate that the trajectory planned by fifth degree polynomial method is much closer to the given trajectory of the end-effector.Numerical simulation and experiments are accomplished for the given trajectory based on fifth degree polynomial planning.At the points where the velocity suddenly changes,the length and tension variation curves of the planned and unplanned three cables are compared and analyzed.The OptiTrack motion capture system is adopted to track the end-effector of the UCPR during the experiment.The effectiveness and feasibility of fifth degree polynomial planning are validated. | Tao Zhao Bin Zi Sen Qian Jiahao Zhao | 2020 | Chinese Journal of Mechanical Engineering2020，33，4： | 7 |
| 13 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 14 | Selective catalytic reduction of NO by C_2H_2 over Ce-Al_2O_3 catalyst with rate-determining step of NO oxidation显示文摘Ce-Al2O3 catalysts prepared by co-precipitation are investigated both in NO oxidation by O2 and in selective catalytic reduction of NO by C2H2(C 2 H 2-SCR).It is found that C2H2-SCR is initiated and controlled by NO oxidation to NO 2 over Al2O3.Ce loading on Al2O3 is almost inactive for NO oxidation below 350 C,since NO2 strongly adsorbs on cerium oxide,leading to the active sites being blocked,which was characterized by temperature-programmed desorption of NO and NO 2 and Fourier transform infrared spectroscopy after NO+O 2 coadsorption over the samples.However,in the case of C2H2-SCR,Ce loading on Al 2 O 3 significantly improves the reaction by accelerating the NO oxidation step in the temperature range of 250-450 C,since the nitrate species produced by NO 2 adsorption is an active intermediate required by C2H 2-SCR. | Suhua Yan Xinping Wang Wenchen Wang Zequn Liu Jiahao Niu | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 6 |
| 15 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 16 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 17 | Nonlinear quantum interferometry with Bose condensed atoms显示文摘在量 interferometry,为高精确的大小的成就控制并且利用非线性的相互作用是重要的。由于他们的长连贯时间和高可控制性,包括 Bose 的 ultracold 原子压缩了原子广泛地为量 interferometry 被使用了。这里,我们与 Bose 在量 interferometry 的理论研究考察最近的进步压缩原子。特别地,我们集中于原子原子相互作用导致的非线性的现象,并且怎么控制并且利用这些非线性的现象。与吝啬地的描述,由于原子原子相互作用,事波浪 solitons 出现在干扰模式,和宏观的量自我套住在 Bose-Josephson 连接存在。与许多身体描述,原子原子相互作用能产生非古典的纠纷,它能被利用在标准量限制以外完成高精确的大小。 | Chaohong Lee (1) Jiahao Huang (1) Haiming Deng (1) Hui Dai (1) Jun Xu (1) | 2012 | Frontiers of physics2012，7，1： | 6 |
| 18 | Enhanced Electromagnetic Interference Shielding in a Duplex-Phase Mg-9Li-3Al-1Zn Alloy Processed by Accumulative Roll Bonding显示文摘High electromagnetic shielding performance was achieved in the Mg-9Li-3Al-1Zn alloy processed by accumulative roll bonding(ARB).The microstructure,electromagnetic interference shielding effectiveness(SE) in the frequency of 30-1500 MHz and mechanical properties of the alloy were investigated.A model based on the shielding of the electromagnetic plane wave was used to theoretically discuss the EMI shielding mechanisms of ARB-processed alloy.Results indicate that the SE of the material increases gradually with the increase in the ARB pass.The enhanced SE can be attributed to the obvious microstructure orientation caused by ARB,and the alternative arrangement of alpha(Mg) phase and beta(Li)phase.In addition,with the increase in ARB pass,the number of interfaces between layers increases and the grain orientation of each layer tends to alignment along c-axis,which is beneficial to the reflection loss and multiple reflection loss of the incident electromagnetic wave. | Jiahao Wang Lin Xu Ruizhi Wu Jing Feng Jinghuai Zhang Legan Hou Milin Zhang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，4： | 6 |
| 19 | Newly Discovered Native Gold and Bismuth in the Cihai Iron-Cobalt Deposit, Eastern Tianshan, Northwest China显示文摘The Cihai iron-cobalt deposit is located in the southern part of the eastern Tianshan ironpolymetallic metallogenic belt. Anomalous native gold and bismuth have been newly identified in Cinan mining section of the Cihai deposit. Ore formation in the deposit can be divided into three stages based on geological and petrographical observations:(I) skarn, with the main mineral assemblage being garnet-pyroxene-magnetite;(II) retrograde alteration, forming the main iron ores and including massive magnetite, native gold, native bismuth, and cobalt-bearing minerals, with the main mineral assemblage being ilvaite-magnetite-native gold-native bismuth; and(III) quartz-calcitesulfide assemblage that contains quartz, calcite, pyrrhotite, cobaltite, and safflorite. Native gold mainly coexists with native bismuth, and they are paragenetically related. The temperature of initial skarn formation was higher than 340℃, and then subsequently decreased to ~312℃ and ~266℃. The temperature of the hydrothermal fluid during the iron ore depositional event was higher than the melting point of native bismuth(271℃), and native bismuth melt scavenged gold in the hydrothermal fluid, forming a Bi-Au melt. As the temperature decreased, the Bi-Au melt was decomposed into native gold and native bismuth. The native gold and native bismuth identified during this study can provide a scientific basis for prospecting and exploration for both gold- and bismuth-bearing deposits in the Cihai mining area. The gold mineralization in Cihai is a part of the Early Permian Cu-Ni-Au-Fe polymetallic ore-forming event, and its discovery has implications for the resource potential of other iron skarn deposits in the eastern Tianshan. | ZHENG Jiahao MAO Jingwen YANG Fuquan CHAI Fengmei LIU Feng | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 5 |
| 20 | A comparative study on different regeneration processes of Pt-Sn/γ-Al2O3 catalysts for propane dehydrogenation显示文摘Three different regeneration processes including hydrogen or nitrogen purging and coke-burning treatment were used to restore the Pt-Sn/γ-Al_2O_3 catalysts, through which propane dehydrogenation reaction was performed in a consecutive reaction-regeneration mode. It was found that the catalyst using hydrogen regeneration showed the best stability compared with those regenerated by nitrogen purging and coke-burning treatment, suggesting that hydrogen regeneration is an effective approach for maintaining the performance of Pt-Sn/γ-Al_2O_3 catalysts in propane dehydrogenation reaction. The effect of different regeneration atmospheres on the metal active center and the coke deposition was investigated by XRD,TEM, N_2-physisorption, TPO, TG and Raman technologies, and the results revealed that hydrogen or nitrogen regeneration resulted in little impact on the size and structure of metal active center, retaining the effective Pt Sn phase over the catalyst. Moreover, hydrogen regeneration not only removed the low dense components of the coke, but also altered the property of the residual coke through hydrogenation, leading to a higher mobility of coke, and thus a higher accessibility of the metal active centers. Whereas nitrogen regeneration only removed the low dense components of the coke. Although coke-burning regeneration caused a thorough coke removal, the catalyst subjected to repeated redox exhibited poor stability due to metal agglomeration, phase segregation and the resulting large Pt_3Sn particle and core-shell structure with a Sn-rich surface. | Changyong Sun Junyin Luo Mingjin Cao Ping Zheng Guocheng Li Jiahao Bu Zhou Cao Shihong Chen Xiaowei Xie | 2018 | Journal of Energy Chemistry2018，27，1： | 5 |
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