|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Review of pantograph and catenary interaction显示文摘 | Weihua ZHANG Dong ZOU Mengying TAN Ning ZHOU Ruiping LI Guiming MEI | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 6 |
| 2 | RESEARCH AND DEVELOPMENT OF VIRTUAL PROTOTYPE OF RUNNING GEARS FOR RAILWAY VEHICLE显示文摘Virtual prototype is an important idea to resolve design problems of railway vehicle. A different development method,which is based on national product and autonomous development,and would like to reflect the specialty of railway vehicle development in China,is presented. According to the developing process of railway vehicle,the research contents and developing method are pointed out. The integration between CAD and performance analysis software on dynamics and strength is mainly considered. In CAD environment,the properties for dynamics computing are extracted directly from the model and exported with model. This method can avoid data losing caused by model rebuilding in CAE software,and increase the direct dependence of product CAD. Then the vehicle model with properties will be used for real-time dynamics and kinematics analysis and simulation. Therefore,the strength of the parts can be analyzed. The results of dynamics and strength analysis will be fed back to optimize the design model. All operations are dispatched by a control platform,and all data are managed according to the principle of PDM. Testing results show this method is correct. | ZOU Yisheng DING Guofu ZHANG Weihua XU Mingheng HE Yong | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 6 |
| 3 | InGaN metal-insulator-semiconductor photodetector using Al_2O_3 as the insulator显示文摘In this paper,an InGaN metal-insulator-semiconductor(MIS) photodetector with an ultra-thin Al2O3 insulation layer deposited by atomic layer deposition(ALD) was studied.A high photoelectric responsivity of 0.25 A/W and a spectral responsivity rejection ratio of about three orders of magnitude at 1 V reverse bias were achieved for this MIS photodetector.The dominant carrier transport mechanism in the InGaN MIS photodetectors is submitted to the space charge limited current(SCLC) mechanism at high field and exhibits an Ohmic-like conduction at low electric field.The results indicate that the ultra-thin Al2O3 film deposited by the ALD technique can act as an excellent insulation dielectric for the InGaN photodetectors. | ZHANG KaiXiao MA AiBin JIANG JingHua XU Yan TAI Fei GONG JiangFeng ZOU Hua ZHU WeiHua | 2013 | Chinese Science Bulletin2013，58，7： | 4 |
| 4 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 5 | The lifestyle transition of Arthrobotrys oligospora is mediated by microRNA-like RNAs显示文摘The lifestyle transition of fungi,defined as switching from taking organic material as nutrients to pathogens,is a fundamental phenomenon in nature.However,the mechanisms of such transition remain largely unknown.Here we show microRNA-like RNAs(milRNAs)play a key role in fungal lifestyle transition for the first time.We identified milRNAs by small RNA sequencing in Arthrobotrys oligospora,a known nematode-trapping fungus.Among them,7 highly expressed milRNAs were confirmed by northern-blot analysis.Knocking out two milRNAs significantly decreased A.oligospora’s ability to switch lifestyles.We further identified that two of these milRNAs were associated with argonaute protein QDE-2 by RNA-immunoprecipitation(RIP)analysis.Three of the predicted target genes of milRNAs were found in immunoprecipitation(IP)products of QDE-2.Disruption of argonaute gene qde-2 also led to serious defects in lifestyle transition.Interestingly,knocking out individual milRNAs or qde-2 lead to diverse responses under different conditions,and qde-2 itself may be targeted by the milRNAs.Collectively,it indicates the lifestyle transition of fungi is mediated by milRNAs through RNA interference(RNAi)machinery,revealing the wide existence of miRNAs in fungi kingdom and providing new insights into understanding the adaptation of fungi from scavengers to predators and the mechanisms underlying fungal infections. | Xinglai Ji Heng Li Weihua Zhang Jiai Wang Lianming Liang Chenggang Zou Zefen Yu Shuqun Liu Ke-Qin Zhang | 2020 | Science China(Life Sciences)2020，63，4： | 4 |
| 6 | Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma显示文摘Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobiletin affects tumor growth and progression in renal cell carcinoma(RCC)are still unclear.Methods:Cell proliferation,cell cycle and apoptosis analyses,colony-formation assays,immunoblotting analysis,and q RT-PCR analysis were performed to investigate how nobiletin affected RCC cell proliferation in vitro.The nude mouse model was used to test the efficacy of nobiletin alone or in combination with palbociclib.Results:Nobiletin inhibited cell proliferation by inducing G1 cell cycle arrest and cell apoptosis in RCC cells.Mechanistically,nobiletin decreased SKP2 protein expression by reducing its transcriptional level.The downregulated SKP2 caused accumulation of its substrates,p27 and p21,which further inhibited the activity of the G1 phase-related protein,CDK2,leading to inhibition of cell proliferation and tumor formation.A higher SKP2 protein level indicated less sensitivity to the CDK4/6 inhibitor,palbociclib.A combination of nobiletin and palbociclib showed a synergistic tumor inhibition in vitro and in an in vivo model.Conclusions:Nobiletin downregulated the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and showed synergistic tumor inhibition effects with the CDK4/6 inhibitor,palbociclib,on RCC,which indicates a potential new therapeutic strategy. | Tingting Chen Liu Liu Yonghong Zou Xiaoyan Hu Wenfeng Zhang Tao Zhou Xi Luo Weihua Fu Jie Xu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 7 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 8 | Calcium-dependent protein kinase CPK32 mediates calcium signaling in regulating Arabidopsis flowering time显示文摘Appropriate flowering time is critical for the reproductive success of plant species.Emerging evidence indicates that calcium may play an important role in the regulation of flowering time.However,the underlying molecular mechanisms remain unclear.In this study,we demonstrate that calcium-dependent protein kinase 32(CPK32) regulates flowering time by affecting the alternative polyadenylation of FLOWERING CONTROL LOCUS A(FCA) and altering the transcription of FLO WERING LOCUS C(FLC),a central repressor of flowering time.The knockdown of CPK32 results in an obvious late flowering phenotype and dramatically enhanced FL C transcription.CPK32 interacts with FCA,and phosphorylates the serine^(592)of FCA in a Ca^(2+)-dependent manner.Moreover,the ratio of abundance of the FCA transcripts(FCA-D and FCA-P) changes significantly in the cpk32 mutant,which subsequently affects FLC expression and consequently regulates floral transition.The present evidence demonstrates that CPK32 modulates flowering time by regulating FCA alternative polyadenylation and consequent FL C expression. | Xidong Li Limei Chen Li Yao Junjie Zou Jie Hao Weihua Wu | 2022 | National Science Review2022，9，1： | 2 |
| 9 | Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells显示文摘 | Yucui Dong Qinglian Han Yan Zou Zhenling Deng Xinliang Lu Xiaohua Wang Weihua Zhang Hua Jin Jun Su Tao Jiang Huan Ren | 2012 | Molecular and Cellular Biochemistry2012，，1： | 2 |
| 10 | The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas:report of 9 cases显示文摘Objective:To investigate the clinical features,pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP).Methods:Nine surgically treated cases of SPTP were retrospectively reviewed.Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases,and the general clinical data was collected.Results:Six patients were asymptomatic except for a palpable mass.Two patients complained of vague-epigastric pain.One patient appeared jaundice.The tumor was encapsulated and solid tissues alternately with cystic tissues.Histologically,the histological structure of solid portion was pseudopapillary with a fibrovascular core.Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns.Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases),AAT(9/9 cases),NSE(9/9 cases),ACT(7/9 cases),CK20(2/9 cases),CgA(1/9 cases),S-100(3/9cases),PR(4/9cases),Syn(3/9 cases) and CD56(5/9cases),negative in CEA and ER.Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms.This tumor has various characteristical histological patterns with different immunophenotype. | Shaoqin Chen Shengquan Zou Qibao Dai Peisheng Huang Weihua Cai Hong Li | 2007 | Journal of Nanjing Medical University2007，21，6： | 2 |
| 11 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 12 | Involvement of a cytoplasmic glyceraldehyde-3-phosphate dehydrogenase GapC-2 in low-phosphate-induced anthocyanin accumulation in Arabidopsis显示文摘Phosphorous is one of the essential mineral elements for plant growth and development.Typically, the shoots of plant seedlings usually turn a dark-brown or purple colour under low-Pi stress. Using protein 2-D gel and peptide mass fingerprinting mapping (PMF) methods, a cytoplasmic glyceralde-hyde-3-phosphate dehydrogenase GapC-2 was identified as a low-Pi responsive protein in Arabidopsisplants. Expression of AtGapC-2 protein was significantly decreased after 4 d of low-Pi stress. Two in-dependent T-DNA insertion lines of GapC-2 gene (At1g13440) showed a hypersensitive phenotype inresponse to low-Pi stress compared with wild type plants, while the transgenic complementation linesof the mutants showed a similar phenotype to the wild type. These results indicate that AtGapC-2 mayplay an important role in Arabidopsis responses to low-Pi stress, possibly by regulation of glycoly-sis-associated 'Pi-pool' and accumulation of anthocyanin pigments in plants. | WANG XiYao CHEN YiFang ZOU JunJie WU WeiHua | 2007 | Chinese Science Bulletin2007，52，13： | 2 |
| 13 | Removal of trace and major metals by soil washing with Na2EDTA and oxalate显示文摘 | Rongliang Qiu Zeli Zou Zhihao Zhao Weihua Zhang Tao Zhang Hanying Dong Xiange Wei | 2010 | Journal of Soils and Sediments2010，，1： | 1 |
| 14 | Kinetic study of adsorption of Cu(II) and Pb(II) from aqueous solutions using manganese oxide coated zeolite in batch mode显示文摘 | Weihua Zou Runping Han Zongzhang Chen Zhang Jinghua Jie Shi | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，，1： | 1 |
| 15 | Sugar-rich sweet sorghum is distinctively affected by wall polymer features for biomass digestibility and ethanol fermentation in bagasse显示文摘 | Meng Li Shengqiu Feng Leiming Wu Ying Li Chunfen Fan Rui Zhang Weihua Zou Yuanyuan Tu Hai-Chun Jing Shizhong Li Liangcai Peng | 2014 | Bioresource Technology2014，，： | 1 |
| 16 | Removal of uranium ( Ⅵ ) from aqueous solutions by manganese oxide coated zeolite:Discussion of adsorption isotherms and pH effect 显示文摘 | Han Runping Zou Weihua Wang Yi | 2007 | Journal of Environmental Radioactivity2007，93，3： | 1 |
| 17 | Analysis of five rice 4-coumarate:coenzyme A ligase enzyme activity and stress response for potential roles in lignin and flavonoid biosynthesis in rice显示文摘 | Haiyan Sun Ying Li Shengqiu Feng Weihua Zou Kai Guo Chunfen Fan Shengli Si Liangcai Peng | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 18 | Comparison of Linear and non-Linear analysis in estimating the Thomas model parameters for methylene blue adsorption onto natural zeolite in fixed-bed column显示文摘 | Han Runping Wang Yi Zou Weihua | 2007 | Journal of Hazardous Materials2007，34，4： | 1 |
| 19 | Biosorplion of copper (Ⅱ) and lead (Ⅱ) from aqueous solutions by chaff in a fixed-bed column 显示文摘 | Hart Runping Zhang Jinghua Zou Weihua | 2006 | Journal of Hazardous Materials B2006，133，： | 1 |
| 20 | The study of operating variables in soil washing with EDTA显示文摘 | Zou Zeli Qiu Rongliang Zhang Weihua | 2009 | Environmental Pollution2009，157，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员