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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Design Schemes and Comparison Research of the End-effector of Large Space Manipulator显示文摘The end-effector of the large space manipulator is employed to assist the manipulator in handling and manipulating large payloads on orbit.Currently,there are few researches about the end-effector,and the existing end-effectors have some disadvantages,such as poor misalignment tolerance capability and complex mechanical components.According to the end positioning errors and the residual vibration characters of the large space manipulators,two basic performance requirements of the end-effector which include the capabilities of misalignment tolerance and soft capture are proposed.And the end-effector should accommodate the following misalignments of the mechanical interface.The translation misalignments in axial and radial directions and the angular misalignments in roll,pitch and yaw are ±100 mm,100 mm,±10°,±15°,±15°,respectively.Seven end-effector schemes are presented and the capabilities of misalignment tolerance and soft capture are analyzed elementarily.The three fingers-three petals end-effector and the steel cable-snared end-effector are the most feasible schemes among the seven schemes,and they are designed in detail.The capabilities of misalignment tolerance and soft capture are validated and evaluated,through the experiment on the micro-gravity simulating device and the dynamic analysis in ADAMS software.The results show that the misalignment tolerance capabilities of these two schemes could satisfy the requirement.And the translation misalignment tolerances in axial and radial directions and the angular misalignment tolerances in roll,pitch and yaw of the steel cable-snared end-effector are 30mm,15mm,6°,3° and 3° larger than those of the three fingers-three petals end-effector,respectively.And the contact force of the steel cable-snared end-effector is smaller and smoother than that of the three fingers-three petals end-effector.The end-effector schemes and research methods are beneficial to the developments of the large space manipulator end-effctor and the space docking mechanism. | FENG Fei LIU Yiwei LIU Hong CAI Hegao | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 13 |
| 3 | Synergistic effect between Sn and K promoters on supported platinum catalyst for isobutane dehydrogenation显示文摘Catalytic dehydrogenation of isobutane has recently received considerable attention because of the increasing demand for isobutene.In this study,the synergistic effect between Sn and K on PtSnK/γ-Al2O3 catalysts has been investigated by changing the content of Sn.It was found that with the presence of potassium,suitable addition of Sn could not only increase the metal dispersion,but also reduce the catalyst acidity.In these cases,the synergistic effect could also strengthen the interactions between the metal and support,which resulted in an increase in both catalytic activity and stability.In our experiments,Pt-0.6SnK/Al catalyst exhibited the lowest deactivation rate (12.4%) and showed a selectivity to isobutene higher than 94% at the isobutane conversion of about 45.3% after running the reaction for 6 h.However,with the excessive loading of Sn,surface property of active sites and the interactions between metal and support were changed.As a result,the initial optimal ratio between the metallic function and acid function would be destroyed,which was disadvantageous to the reaction. | Yiwei Zhang Yuming Zhou Lihui Wan Mengwei Xue Yongzheng Duan Xuan Liu | 2011 | Journal of Natural Gas Chemistry2011，20，6： | 12 |
| 4 | In vitro inhibitory and pro-apoptotic effect of Stellera Chamaejasme LExtract on human lung cancer cell line NCI-H157显示文摘OBJECTIVE:To investigate the inhibitory and pro-apoptotic effect of Stellera Chamaejasme L extract(ESC) in vitro.METHODS:ESC was first extracted with ethanol,and then washed using a polyamide column with 60% ethanol.ESC was then decompressively recycled and vacuum dried at room temperature to obtain active fractions.Subsequently,the cytotoxic and apoptotic effects of ESC on NCI-H157 human lung cancer cells were determined.RESULTS:The results showed that ESC was rich in isomers of Chamaejasminor,neochamaejasmine and Sikokianin.ESC had significant cytotoxicity against NCI-H157 cells,with an IC 50 of approximately 18.50 μg.mL-1.ESC caused significant increase in total apoptotic rate,the activity of caspase 3 and 8,and Fas protein expression(P<0.05).CONCLUSION:The inhibitory effect of ESC on NCI-H157 tumor cells might partly be attributed to its apoptotic induction through activation of the Fas death receptor pathway. | Xiaoni Liu Yujie Li Qing Yang Ying Chen Xiaogang Weng Yiwei Wang Ning Li Xiaoxin Zhu | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 8 |
| 5 | Effects of RapidEye Imagery's Red-edge Band and Vegetation Indices on Land Cover Classification in an Arid Region显示文摘Land cover classification(LCC) in arid regions is of great significance to the assessment, prediction, and management of land desertification. Some studies have shown that the red-edge band of RapidE ye images was effective for vegetation identification and could improve LCC accuracy. However, there has been no investigation of the effects of RapidE ye images' red-edge band and vegetation indices on LCC in arid regions where there are spectrally similar land covers mixed with very high or low vegetation coverage information and bare land. This study focused on a typical inland arid desert region located in Dunhuang Basin of northwestern China. First, five feature sets including or excluding the red-edge band and vegetation indices were constructed. Then, a land cover classification system involving plant communities was developed. Finally, random forest algorithm-based models with different feature sets were utilized for LCC. The conclusions drawn were as follows: 1) the red-edge band showed slight contribution to LCC accuracy; 2) vegetation indices had a significant positive effect on LCC; 3) simultaneous addition of the red-edge band and vegetation indices achieved a significant overall accuracy improvement(3.46% from 86.67%). In general, vegetation indices had larger effect than the red-edge band, and simultaneous addition of them significantly increased the accuracy of LCC in arid regions. | LI Xianju CHEN Gang LIU Jingyi CHEN Weitao CHENG Xinwen LIAO Yiwei | 2017 | Chinese Geographical Science2017，27，5： | 8 |
| 6 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 7 | Effect of Ga Addition on Catalytic Performance of PtSnNa/ZSM-5 Catalyst for Propane Dehydrogenation显示文摘PtSnNaGa/ZSM-5 catalysts with different contents of Ga were prepared and characterized by X-ray diffraction (XRD), nitrogen adsorption, hydrogen chemisorption, ammonia temperature-programmed desorption (NH3-TPD), hydrogen temperature-programmed reduction (H2-TPR), and temperature-programmed oxidation (TPO) techniques. The performances of these catalysts for propane dehydrogenation were investigated. The test results indicated that the addition of Ga not only could improve the catalytic stability and propene selectivity, but also could effectively prevent the catalysts from coking. It was found that the PtSnNaGa(0.5 m%)/ZSM-5 catalyst exhibited the best performance in terms of propene selectivity and propane conversion. The high catalytic performance was most probably attributed to the presence of Ga that could strength- en the interaction between metals and the support to stabilize the catalytic active sites. | Liu Xuan Zhou Yuming Zhang Yiwei Duan Yongzheng Xue Mengwei Wan Lihui (School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189) | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，4： | 7 |
| 8 | Effect of cerium addition on catalytic performance of PtSnNa/ZSM-5 catalyst for propane dehydrogenation显示文摘The effect of cerium addition on the catalytic performance of propane dehydrogenation over PtSnNa/ZSM-5 catalyst has been investigated by reaction tests and some physicochemical characterization such as XRD,BET,TEM,XPS,NH 3-TPD,H 2 chemisorption,TPR and TPO techniques.It has been found that with suitable amount of cerium addition,the platinum dispersion increased,while the carbon deposition tended to be eliminated easily.In these cases,the presence of cerium could not only realize the better distribution of metallic particles on the support,but also strengthen the interactions between Sn species and the support.Additionally,XPS spectra confirmed that more amounts of tin could exist in oxidized form,which was advantageous to the reaction.In our experiments,PtSnNaCe(1.1 wt%)/ZSM-5 catalyst exhibited the best catalytic performance.After running the reaction for 750 h,propane conversion was maintained higher than 30% with the corresponding selectivity to propylene of about 97%. | Mengwei Xue Yuming Zhou Yiwei Zhang Xuan Liu Yongzheng Duan Xiaoli Sheng | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 6 |
| 9 | Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures显示文摘Vascular endothelial growth factor A(Vegfa) signaling regulates vascular development during embryogenesis and organ formation.However,the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood.In this study,we utilized transcription activator-like effector nuclease(TALEN) to generate zebrafish vegfaa mutants.vegfaa^(-/-) embryos are embryonic lethal,and display a complete loss of the dorsal aorta(DA) and expansion of the cardinal vein.Activation of Vegfa signaling expands the arterial cell population at the expense of venous cells during vasculogenesis of the axial vessels in the trunk.Vegfa signaling regulates endothelial cell(EC) proliferation after arterial-venous specification.Vegfa deficiency and overexpression inhibit the formation of tip cell filopodia and interfere with the pathfinding of intersegmental vessels(ISVs).In the head vasculature,vegfaa^(-/-) causes loss of a pair of mesencephalic veins(MsVs) and central arteries(CtAs),both of which usually dvelop via sprouting angiogenesis.Our results indicate that Vegfa signaling induces the formation of the DA at the expense of the cardinal vein during the trunk vasculogenesis,and that Vegfa is required for the angiogenic formation of MsVs and CtAs in the brain.These findings suggest that Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures. | Daqing Jin Diqi Zhu Yabo Fang Yiwei Chen Gaihong Yu Weijun Pan Dong Liu Fen Li Tao P.Zhong | 2017 | Journal of Genetics and Genomics2017，44，10： | 6 |
| 10 | Brief Introduction to a Unique Edible Bolete---Phlebopus portentosus in Southern China显示文摘 | Chunxia Zhang Mingxia He Jing Liu Xinjing Xu Yang Cao Feng Gao Yiwei Fang Wenbing Wang Yun Wang | 2017 | Journal of Agricultural Science and Technology(B)2017，7，6： | 6 |
| 11 | Classification and comparison of physical and chemical properties of corn stalk from three regions in China显示文摘Corn stalk samples from Anhui,Jiangxi and Shanghai were used as test materials.Their physical,chemical and thermo-chemical engineering characteristics were analyzed.The similarities and differences in properties of corn stalk from the three regions were determined using SIMCA-P and SPSS software in order to obtain a proper energy utilization method of corn stalk.The results show that the corn stalk from Shanghai has significant differences from the samples of Jiangxi and Anhui.In particular,the following properties of corn stalk from Shanghai such as the contents of cellulose,calcium(Ca),iron(Fe),crude ash,volatile matter,carbon(C),nitrogen(N),and oxygen(O)are significantly different from those of Jiangxi and Anhui samples(P<0.05).While other properties such as the contents of magnesium(Mg),copper(Cu),zinc(Zn),moisture,hydrogen(H),and sulfur(S)have no significant difference among samples of three regions.Compared with the corn stalk in Anhui and Jiangxi,the Shanghai samples are more suitable for the production of ethanol because of their higher ratio of cellulose to hemi-cellulose content.Because of its high content of ash and low calorific value,the Shanghai corn stalk is suitable for the gasification process instead of for direct combustion or bio-oil production.The research can provide a reference for raw material selection for biomass energy production and utilization. | Wang Lu Liu Ronghou Sun Chen Cai Wenfei Tao Yiwei Yin Renzhan Mei Yuanfei | 2014 | International Journal of Agricultural and Biological Engineering2014，7，6： | 5 |
| 12 | Stochastic processes in renewable power systems: From frequency domain to time domain显示文摘With the increasing penetration of renewable energy resources(RESs), the uncertainties of volatile renewable generations significantly affect the power system operation. Such uncertainties are usually modeled as stochastic variables obeying specific distributions by neglecting the temporal correlations. Conventional approaches to hedge the negative effects caused by such uncertainties are thus hard to pursue a trade-off between computation efficiency and optimality. As an alternative, the theory of stochastic process can naturally model temporal correlation in closed forms. Attracted by this feature, our research group has been conducting thorough researches in the past decade to introduce stochastic processes within renewable power systems. This paper summarizes our works from the perspective of both the frequency domain and the time domain, provides the tools for the analysis and control of power systems under a unified framework of stochastic processes, and discusses the underlying reasons that stochastic process-based approaches can perform better than conventional approaches on both computational efficiency and optimality. These work may shed a new light on the research of analysis, control and operation of renewable power systems.Finally, this paper outlooks the theoretic developments of stochastic processes in future’s renewable power systems. | SONG YongHua CHEN XiaoShuang LIN Jin LIU Feng QIU YiWei | 2019 | Science China(Technological Sciences)2019，62，12： | 4 |
| 13 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 14 | Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study显示文摘Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of asthma.This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic response.Results:Our study showed that all measured parameters in patients were at higher levels than those of controls.After one week of treatment,most parameter levels decreased significantly except for serum tIgE.Furthermore,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function indices.Receiver operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic response.The area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of 0.800.Conclusions:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. | Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG Sabina JANCIAUSKIENE Aiguo XU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 3 |
| 15 | Confined Ni-In intermetallic alloy nanocatalyst with excellent coking resistance for methane dry reforming显示文摘Carbon dioxide and methane are two main greenhouse gases which are contributed to serious global warming.Fortunately,dry reforming of methane(DRM),a very important reaction developed decades ago,can convert these two major greenhouse gases into value-added syngas or hydrogen.The main problem retarding its industrialization is the seriously coking formation upon the nickel-based catalysts.Herein,a series of confined indium-nickel(In-Ni)intermetallic alloy nanocatalysts(In_(x)Ni@SiO_(2))have been prepared and displayed superior coking resistance for DRM reaction.The sample containing 0.5 wt.%of In loading(In_(0.5)Ni@SiO_(2))shows the best balance of carbon deposition resistance and DRM reactivity even after 430 h long term stability test.The boosted carbon resistance can be ascribed to the confinement of core–shell structure and to the transfer of electrons from Indium to Nickel in In-Ni intermetallic alloys due to the smaller electronegativity of In.Both the silica shell and the increase of electron cloud density on metallic Ni can weaken the ability of Ni to activate C–H bond and decrease the deep cracking process of methane.The reaction over the confined InNi intermetallic alloy nanocatalyst was conformed to the Langmuir-Hinshelwood(L-H)mechanism revealed by in situ diffuse reflectance infrared Fourier transform spectroscopy(in-situ DRIFTS).This work provides a guidance to design high performance coking resistance catalysts for methane dry reforming to efficiently utilize these two main greenhouse gases. | Wenming Liu Le Li Sixue Lin Yiwei Luo Zhenghong Bao Yiru Mao Kongzhai Li Daishe Wu Honggen Peng | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 16 | Calibration procedures for the CHASE/HIS science data显示文摘The Hα line is an important optical line in solar observations containing the information from the photosphere to the chromosphere. To study the mechanisms of solar eruptions and the plasma dynamics in the lower atmosphere, the Chinese Hα Solar Explorer(CHASE) was launched into a Sun-synchronous orbit on October 14, 2021. The scientific payload of the CHASE satellite is the Hα Imaging Spectrograph(HIS). The CHASE/HIS acquires, for the first time, seeing-free Hα spectroscopic observations with high spectral and temporal resolutions. It consists of two observational modes. The raster scanning mode provides full-Sun or region-of-interest spectra at Hα(6559.7-6565.9 ?) and Fe I(6567.8-6570.6 ?) wavebands. The continuum imaging mode obtains full-Sun photospheric images at around 6689 ?. In this paper, we present detailed calibration procedures for the CHASE/HIS science data, including the dark-field and flat-field correction, slit image curvature correction, wavelength and intensity calibration, and coordinate transformation. The higher-level data products can be directly used for scientific research. | Ye Qiu ShiHao Rao Chuan Li Cheng Fang MingDe Ding Zhen Li YiWei Ni WenBo Wang Jie Hong Qi Hao Yu Dai PengFei Chen XiaoSheng Wan Zhi Xu Wei You Yuan Yuan HongJiang Tao XianSheng Li YuKun He Qiang Liu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 3 |
| 17 | Breakthrough Technologies for the Biorefining of Organic Solid and Liquid Wastes显示文摘有机固液废弃物包含大量能量、养分和水分,不应仅视其为废物。数十年来,人们一直对城市固体废物进行回收、堆制和燃烧,并从中提取能量和有价值的物质。污水的首要管理策略是治理和排放。随着技术的进步,通过新方法使利用固体废物和废水成为可能。考虑到废物特殊的化学、物理和生物性质,需要整合多种技术以使废物的能量和价值回收最大化。为此,生物炼制是完全利用废物中的能量和价值的一个合适的方法。研究证明,不可回收废弃物和生物固体可通过不同方法转化为可利用的热能、电能、燃料和化学品,并且液体废物或能帮助农作物和藻类的成长,为能量回收和食物生产提供不同的选择。本文针对有机固液废物提出新型生物炼制方案,这些废物来源于城市废料、食品和生物加工厂以及动物生产设施。四大新型突破性科技——真空辅助高温厌氧消化、扩展鱼菜共生系统、含油废物经甘油裂解制取生物柴油和微波辅助热化学转化,均可运用于生物炼制方案中,从而成功将废物转化,用以生产化学品、化肥、能量(沼气、合成气、生物柴油和生物油)、食物、饲料,得到干净的水并显著减少污染物的排放。 | Paul Chen Erik Anderson Min Addy Renchuan Zhang Yanling Cheng Peng Peng Yiwei Ma Liangliang Fan Yaning Zhang Qian Lu Shiyu Liu Nan Zhou Xiangyuan Deng Wenguang Zhou Muhammad Omar Richard Griffith Faryal Kabir Hanwu Lei Yunpu Wang Yuhuan Liu Roger Ruan | 2018 | Engineering2018，4，4： | 3 |
| 18 | Development of two TaqMan real-time reverse transcription-PCR assays for the detection of severe acute respiratory syndrome coronavirus-2显示文摘The outbreak of coronavirus disease 2019(COVID-19)in Wuhan,China,was caused by a novel coronavirus(CoV),named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The rapid detection of viral nucleic acids is critical for the early identification of infected cases.We have developed two TaqMan real-time reverse transcription-PCR assays to detect SARS-CoV-2.The designed primers target the nucleocapsid(N)and open reading frame(ORF)1b gene regions,where the probes discriminate SARS-CoV-2 from other human and animal CoVs.The sensitivities are one genomic copy per reaction for theN gene assay and ten copies for the ORF 1b gene assay.The overall linear detection ranges are 1–10^(6)and 10–10^(6)copies per reaction for the N gene assay and the ORF 1b gene assay,respectively.Surveillance of 23 suspected COVID-19 patients demonstrated that SARS-CoV-2 could be detected from 100%(23/23)and 62.5%(16/23)of clinical specimens by the N gene assay and the ORF 1b gene assay,respectively.All of the samples not detected by the ORF 1b gene assay were throat swabs,indicating a lower viral load in the upper respiratory tract and the relatively lower sensitivity of the ORF 1b gene assay.The assays developed in the present study offer alternative diagnostic tests for COVID-19. | Yiwei Liu Yingying Wang Xinming Wang Yan Xiao Lan Chen Li Guo Jianguo Li Lili Ren Jianwei Wang | 2020 | Biosafety and Health2020，2，4： | 3 |
| 19 | Low-temperature sintered(Na_(1/2)Bi_(1/2))TiO_(3)-based incipient piezoceramics for co-fired multilayer actuator application显示文摘Low-temperature sintered(Na_(1/2)Bi_(1/2))_(0.935)Ba_(0.065)Ti_(0.975)(Fe_(1/2)Nb_(1/2))_(0.025)O_(3)(NBT-BT-0.025FN)lead-free incipient piezoceramics were investigated using high-purity Li_(2)CO_(3) as sintering aids.With the ≤0.5 wt%Li_(2)CO_(3) addition,the introduced Li^(+) cations precede to enter the A-sites of the perovskite lattice to compensate for the A-site deficiencies.Once the addition exceeds 0.5 wt%,the excess Lit cations will occupy B-sites and give rise to the generation of oxygen vacancies,which accelerate the mass transport and thus lower the sintering temperature effectively from 1100℃ down to 925℃.It was also found that a small amount of Lit addition has little effect on the phase structure and electromechanical properties of the system,but overweight seriously disturbs these characteristics because of the large lattice distortion.The sintered NBT-BT-0.025FN incipient piezoceramics with 1.25 wt%Li_(2)CO_(3) addition at 925℃ provides a large strain of 0.33% and a corresponding large signal piezoelectric coefficient d_(33)^(*) of 550 pm/V at 60 kV/cm,indicating this system is a very promising candidate for lead-free co-fired multilayer actuator application. | Pengyuan Fan Yangyang Zhang Shan-Tao Zhang Bing Xie Yiwei Zhu Mohsin Ali Marwat Weigang Ma Kai Liu Liang Shu Haibo Zhang | 2019 | Journal of Materiomics2019，5，3： | 3 |
| 20 | PNAS:科学家发现新的精子运动调节器显示文摘南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院MartinM.Matzuk课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1,结果发表于《美国科学院院刊》(PNAs)。 | Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi | 2017 | 现代生物医学进展2017，17，27： | 3 |
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