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| 1 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 2 | Terahertz spoof surface-plasmon-polariton subwavelength waveguide显示文摘Surface plasmon polaritons(SPPs) with the features of subwavelength confinement and strong enhancements have sparked enormous interest. However, in the terahertz regime, due to the perfect conductivities of most metals, it is hard to realize the strong confinement of SPPs, even though the propagation loss could be sufficiently low. One main approach to circumvent this problem is to exploit spoof SPPs, which are expected to exhibit useful subwavelength confinement and relative low propagation loss at terahertz frequencies. Here we report the design,fabrication, and characterization of terahertz spoof SPP waveguides based on corrugated metal surfaces. The various waveguide components, including a straight waveguide, an S-bend waveguide, a Y-splitter, and a directional coupler, were experimentally demonstrated using scanning near-field terahertz microscopy. The proposed waveguide indeed enables propagation, bending, splitting, and coupling of terahertz SPPs and thus paves a new way for the development of flexible and compact plasmonic circuits operating at terahertz frequencies. | YING ZHANG YUEHONG XU CHUNXIU TIAN QUAN XU XUEQIAN ZHANG YANFENG LI XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 9 |
| 3 | Optical generation,detection and non-destructive testing applications of terahertz waves显示文摘Optoelectronic terahertz generation and detection play a key role in the applications of non-destructive testing,which involves different areas such as physics,biological,material science,imaging,explosions detection,astronomy applications,semiconductor technology and superconductiong electronics. In this article,we present a reviewof the principle and performance of typical terahertz sources,detectors and non-destructive testing applications. On this basis,the newdevelopment and trends of terahertz radiation detectors are also discussed. | ZHANG Weili LIANG Dachuan TIAN Zhen HAN Jiaguang GU Jianqiang HE Mingxia OUYANG Chunmei | 2016 | Instrumentation2016，3，1： | 8 |
| 4 | Terahertz surface plasmonic waves: a review显示文摘Terahertz science and technology promise many cutting-edge applications.Terahertz surface plasmonic waves that propagate at metal–dielectric interfaces deliver a potentially effective way to realize integrated terahertz devices and systems.Previous concerns regarding terahertz surface plasmonic waves have been based on their highly delocalized feature.However,recent advances in plasmonics indicate that the confinement of terahertz surface plasmonic waves,as well as their propagating behaviors,can be engineered by designing the surface environments,shapes,structures,materials,etc.,enabling a unique and fascinating regime of plasmonic waves.Together with the essential spectral property of terahertz radiation,as well as the increasingly developed materials,microfabrication,and time-domain spectroscopy technologies,devices and systems based on terahertz surface plasmonic waves may pave the way toward highly integrated platforms for multifunctional operation,implementation,and processing of terahertz waves in both fundamental science and practical applications.We present a review on terahertz surface plasmonic waves on various types of supports in a sequence of properties,excitation and detection,and applications.The current research trend and outlook of possible research directions for terahertz surface plasmonic waves are also outlined. | Xueqian Zhang Quan Xu Lingbo Xia Yanfeng Li Jianqiang Gu Zhen Tian Chunmei Ouyang Jiaguang Han Weili Zhang | 2020 | Advanced Photonics2020，2，1： | 7 |
| 5 | Plasmon-induced transparency in terahertz metamaterials显示文摘The quantum phenomena of electromagnetically induced transparency(EIT)or plasmonic analogue of electromagnetically induced transparency(PIT)can be mimicked in the classical resonators,leading to a unique way to explore the coherent coupling mechanism in metamaterial systems.Various metamaterial structures have been proposed to excite and manipulate the PIT efect with flexibility and performance with geometry-controllable,polarization-independent,broadband-transparency and active-modulated characteristics.These in turn promise the fascinating functionalities and applications of the PIT efects,such as slow-light components,nonlinear devices and high-sensitivity sensors.Here,we present a review on the progress in developing the PIT efect in terahertz metamaterials over the past few years. | JING HuiHui ZHU ZhiHua ZHANG XueQian GU JianQiang TIAN Zhen OUYANG ChunMei HAN JiaGuang ZHANG WeiLi | 2013 | Science China(Information Sciences)2013，56，12： | 5 |
| 6 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 7 | Time-domain terahertz optoacoustics: manipulable water sensing and dampening显示文摘Radiation at terahertz frequencies can be used to analyze the structural dynamics of water and biomolecules,but applying the technique to aqueous solutions and tissues remains challenging since terahertz radiation is strongly absorbed by water.While this absorption enables certain analyses,such as the structure of water and its interactions with biological solutes,it limits the thickness of samples that can be analyzed,and it drowns out weaker signals from biomolecules of interest.We present a method for analyzing water-rich samples via time-domain terahertz optoacoustics over a 104-fold thickness ranging from microns to centimeters.We demonstrate that adjusting the temperature to alter the terahertz optoacoustic(THz-OA)signal of water improves the sensitivity with which it can be analyzed and,conversely,can reduce or even“silence”its signal.Temperature-manipulated THz-OA signals of aqueous solutions allow detection of solutes such as ions with an order of magnitude greater sensitivity than terahertz time-domain spectroscopy,and potentially provide more characteristic parameters related to both terahertz absorption and ultrasonic propagation.Terahertz optoacoustics may be a powerful tool for spectroscopy and potential imaging of aqueous solutions and tissues to explore molecular interactions and biochemical processes. | Jiao Li Yixin Yao Liwen Jiang Shuai Li Zhihao Yi Xieyu Chen Zhen Tian Weili Zhang | 2021 | Advanced Photonics2021，3，2： | 4 |
| 8 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 9 | D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy显示文摘Near-infrared(NIR)small molecular organic dyes as photothermal agents for cancer photothermal therapy(PTT)have attracted considerable research attention.Herein,two donor-acceptor-donor(D-A-D)structured NIR dyes,BBTT and SeBTT,are rationally designed,where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium(Se).More importantly,SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency(PTCE≈65.3%).In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging(PAI)agent,and succeed in tumor suppression without noticeable damage to main organs under NIR photoirradiation.This study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT. | Zijin Cheng Tian Zhang Weili Wang Qing Shen Ying Hong Jinjun Shao Xiaoji Xie Zhenghao Fei Xiaochen Dong | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 10 | Impact of clinical research on public health policy of neonatal screening for congenital heart disease in China显示文摘Congenital heart disease(CHD)is one of the most common congenital malformations,with a prevalence of approximately 1%in live births.[1,2]Among them,1/4 to 1/3 are major CHD,including critical CHD(CCHD)and serious CHD,which require surgical or catheter intervention before 1 year of age.[3]Major CHD,if left untreated,may cause serious outcomes,such as heart failure,cardiogenic shock,acidosis,and hypoxic-ischemic brain damage,and is one of the leading causes of infant death and childhood disability.[4]The missed diagnosis rate of CCHD in four nurseries ranges from 13%to 48%in developed countries,[4,5]but in China,is>71%before serious symptoms occur after birth.[6]Therefore,screening for CHD is useful for early detection,diagnosis,and treatment and helps to improve prognosis and reduces the medical,economic,and mental burden to both the family and the society.[5,7] | Miao Yang Youping Tian Pin Jia Xiaojing Ma Xiaoling Ge Xiaojing Hu Quming Zhao Fang Liu Bing Jia Weili Yan Qing Gu Guoying Huang | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 11 | GIS-based emission inventories of urban scale: A case study of Hangzhou, China显示文摘 | Qingyu Zhang Yumei Wei Weili Tian Kemin Yang | 2008 | Atmospheric Environment2008，，20： | 2 |
| 12 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 13 | Broadband terahertz rotator with an all-dielectric metasurface显示文摘Polarization manipulation is essential in developing cutting-edge photonic devices ranging from optical communication displays to solar energy harvesting. Most previous works for efficient polarization control cannot avoid utilizing metallic components that inevitably suffer from large ohmic loss and thus low operational efficiency.Replacing metallic components with Mie resonance-based dielectric resonators will largely suppress the ohmic loss toward high-efficiency metamaterial devices. Here, we propose an efficient approach for broadband, highquality polarization rotation operating in transmission mode with all-dielectric metamaterials in the terahertz regime. By separating the orthogonal polarization components in space, we obtain rotated output waves with a conversion efficiency of 67.5%. The proposed polarization manipulation strategy shows impressive robustness and flexibility in designing metadevices of both linear-and circular-polarization incidences. | QUANLONG YANG XIEYU CHEN QUAN XU CHUNXIU TIAN YUEHONG XU LONGQING CONG XUEQIAN ZHANG YANFENG LI CAIHONG ZHANG XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，，11： | 2 |
| 14 | Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy显示文摘The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics. | Hanming Dai Zijin Cheng Tian Zhang Weili Wang Jinjun Shao Wenjun Wang Yongxiang Zhao Xiaochen Dong Liping Zhong | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 15 | Meta-optics inspired surface plasmon devices显示文摘Surface plasmons(SPs)are electromagnetic surface waves that propagate at the interface between a conductor and a dielectric.Due to their unique ability to concentrate light on two-dimensional platforms and produce very high local-field intensity,SPs have rapidly fueled a variety of fundamental advances and practical applications.In parallel,the development of metamaterials and metasurfaces has rapidly revolutionized the design concepts of traditional optical devices,fostering the exciting field of meta-optics.This review focuses on recent progress of meta-optics inspired SP devices,which are implemented by the careful design of subwavelength structures and the arrangement of their spatial distributions.Devices of general interest,including coupling devices,on-chip tailoring devices,and decoupling devices,as well as nascent SP applications empowered by sophisticated usage of meta-optics,are introduced and discussed. | Quan Xu Yuanhao Lang Xiaohan Jiang Xinyao Yuan Yuehong Xu Jianqiang Gu Zhen Tian Chunmei Ouyang Xueqian Zhang Jiaguang Han Weili Zhang | 2023 | Photonics Insights2023，2，1： | 1 |
| 16 | Exter- nal costs from electricity generation of China up to 2030 in energy and abatement scenarios 显示文摘 | Zhang Qingyu Tian Weili Wei Yumei | 2007 | Energy Policy2007，35，8： | 1 |
| 17 | Population Structure Analysis and Genome-Wide Association Study of Tea(Camellia sinensis(L.)Kuntze)Germplasm in Qiannan,China,Based on SLAF-Seq Technology显示文摘Duyun Maojian tea is a famous tea in China.In this study,the specific-locus amplified fragment(SLAF)sequencing method was used to analyze the population structure and conduct a genome-wide association study(GWAS)of 2 leaf traits of 123 tea plants in Qiannan,China.A total of 462,019 SLAF tags and 11,362,041 single-nucleotide polymorphism(SNP)loci were obtained.The results of phylogenetic tree analysis,cluster analysis,and principal component analysis showed that 123 tea germplasms were clustered into three groups,and the heterozygosity rates for Groups I,II,and II were 0.206,0.224,and 0.34,respectively.Generally,tea germplasms in a production area are clustered in a group,indicating that tea germplasms in different production areas have certain genetic diversity.The traditional Duyun Maojian tea core production areas,TS and DC-SJ,are clustered into Group I and Group II respectively,while the ZY production area is relatively independent in Group III.Furthermore,based on GWAS analysis,11 candidate genes related to leaf apex and 7 candidate genes related to leaf shape were obtained.This study clarified the genetic relationship among eight Duyun Maojian tea production areas and obtained candidate genes related to leaf apex and leaf shape development.The results showed that population structure and candidate genes are an effective basis for the breeding of Duyun Maojian tea germplasm. | Fen Zhang Weili Tian Lu Cen Litang Lv Xiaofang Zeng Yulu Chen Yichen Zhao Yan Li | 2022 | Phyton-International Journal of Experimental Botany2022，91，4： | 1 |
| 18 | Modelling of urban ambient N, N-dimethylformamide concentrations in a small-scale synthetic leather industrial zone 显示文摘 | WEI Yumei TIAN Weili ZHENG Yingyue | 2011 | Journal of Zhejiang University- Science A ( Applied Physics dr Engineering )2011，12，5： | 1 |
| 19 | An overview of the thermography-based experimental studies on roadway excavation in stratified rock masses at CUMTB显示文摘This paper presents an overview of experimental investigations conducted at China University of Mining and Technology Beijing(CUMTB) on roadway excavation using large-scale geomechanical model tests.The simulated sedimentary rocks are composed by alternating layers of sandstone, mudstone and coal seam inclined at varied angles with respect to the horizontal including 0°, 45°, 60°, and 90°. During the excavation, infrared thermography was employed to detect the thermal response of the surrounding rocks under excavation. The obtained raw thermograms were processed using denoising algorithm, data reduction procedure and Fourier analysis. The infrared temperature(IRT) characterizes the overall rock response; the processed thermal images represent the structural behavior, and the Fourier spectrum describes damage development in the frequency domain. Deeper understanding was achieved by the comparative analyses of excavation in differently inclined rock masses using the image features of IRTs, thermal images and Fourier spectra. | Gong Weili Peng Yanyan He Manchao Xie Tian Zhao Shijiao | 2015 | International Journal of Mining Science and Technology2015，25，3： | 1 |
| 20 | Active-Thermal-Tunable Terahertz Absorber with Temperature-Sensitive Material Thin Film显示文摘It is shown that active-tunable terahertz absorbers can be realized in a sandwich-structured system comprising an ultrathin dielectric film(polyimide) on a temperature-sensitive substrate(InSb) with a metal film on the back by utilizing the intrinsic carrier density(N) variation in InSb. When increasing the temperature from 250 to 320 K, N in InSb varied from ~5.50×1015 to ~2.98×1016 cm–3. Fixing the thickness of dielectric film with the value of 1.37 μm, the absorption peak shifted from 1.41 to 3.29 THz while keeping absorption higher than 99%. This active tunability can respond to even a slight temperature perturbation, and shows polarization insensitivity as well as high tolerance of incidence-angle(absorption peak can still exceed 90% even the incidence angle reaches 60°). Besides, the refractive index of polyimide(PI) has thermal stability at the terahertz range and the merit of good workability. These characteristics guarantee the stability of activetunable performance. The peculiarities and innovations of this proposal promise a wide range of high efficiency terahertz devices, such as thermal sensors, spatial light modulators(SLMs) and so on. | Zhao Zhang Zhen Tian Chao Chang Xueguang Wang Xueqian Zhang Chunmei Ouyang Jianqiang Gu Jiaguang Han Weili Zhang | 2018 | Nanotechnology and Precision Engineering2018，1，2： | 1 |
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