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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 3 | Multiple-target tracking with adaptive sampling intervals for phased-array radar显示文摘A novel adaptive sampling interval algorithm for multitarget tracking is presented.This algorithm which is based on interacting multiple models incorporates the grey relational grade(GRG) into the particle swarm optimization(PSO).Firstly,the desired tracking accuracy is set for each target.Secondly,sampling intervals are selected as particles,and then the advantage of the GRG is taken as the measurement function for resource management.Meanwhile,the fitness value of the PSO is used to measure the difference between desired tracking accuracy and estimated tracking accuracy.Finally,it is suggested that the radar should track the target whose prediction value of the next sampling interval is the smallest.Simulations show that the proposed method improves both the tracking accuracy and tracking efficiency of the phased-array radar. | Zhenkai Zhang Jianjiang Zhou Fei Wang Weiqiang Liu Hongbing Yang | 2011 | Journal of Systems Engineering and Electronics2011，22，5： | 9 |
| 4 | Growth, photosynthesis and podophyllotoxin accumulation of Dysosma versipellis in response to a light gradient and conservation implications显示文摘Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation. | ZHAO YunPeng GONG HuaDong LU WeiQiang JIANG WeiMei ZHOU XiaoLong FU ChengXin | 2011 | Chinese Science Bulletin2011，56，24： | 6 |
| 5 | Evaluation index system of shared energy storage market towards renewable energy accommodation scenario:A China’s Qinghai province context显示文摘With the ever-increased installed capacity of renewable energy generation units in a power system,the so-called shared energy storage(SES),a novel business model under the umbrella of the shared economy principle,has the potential to play an essential role in the accommodation of renewable energy generation.However,unified evaluation standards and methods,which can help decision-makers analyze the performance of the SES market,are still not available.In this paper,an evaluation index system of the SES market is designed based on the trading rules of China’s Qinghai province and the structure-conduct-performance(SCP)analytical model.Moreover,the definition and characteristics of the indices,which can show the performance of the SES market from different perspectives,are given.Furthermore,the ideal cases are presented as the evaluation benchmark based on the development expectation of the SES market,and the analytic hierarchy process(AHP)and the technique for order preference by similarity to an ideal solution(TOPSIS)are applied to evaluate the SES market comprehensively.Finally,a case study based on actual data of the SES trading pilot project in Qinghai shows that the evaluation index system can reflect the operation status,existing problems and influencing factors of the SES market. | Baomin Fang Weiqiang Qiu Maochun Wang Wei Zhou Zhenzhi Lin Fushuan Wen | 2022 | Global Energy Interconnection2022，5，1： | 5 |
| 6 | Facile preparation of antibacterial MOF‐fabric systems for functional protective wearables显示文摘Metal‐organic frameworks(MOFs)have shown numerous potentials as promising materials to address real‐world problems.However,their practical utilization in commercial products was largely limited by the lack of downstream processing methodologies to transform MOF powders into functional products.In this study,a commercially viable solution for the general synthesis of MOF‐fabric composites was introduced.On account of coordination bonding between poly(acrylic acid)and MOF substrates,MOF powders securely adhered onto the surface of fabric materials via a drip cast method to give MOF‐fabric composites easily.This strategy can be applied to different MOF types,as well as a wide variety of fabric materials.The prepared materials showed excellent bacterial killing efficacy attributed to the embedded HKUST‐1 MOF.In light of the recent coronavirus disease 2019 pandemic,this methodology could enable the large‐scale fabrication of essential MOF‐based personal protective wearables(e.g.,clothing and masks)for use by healthcare professionals. | Wei Liang Teo Jiawei Liu Weiqiang Zhou Yanli Zhao | 2021 | SmartMat2021，2，4： | 4 |
| 7 | Selenium-functionalized metal-organic frameworks as enzyme mimics显示文摘 | Weiqiang Zhou Hongfeng Li Bin Xia Wenlan Ji Shaobo Ji Weina Zhang Wei Huang Fengwei Huo Huaping Xu | 2018 | Nano Research2018，11，10： | 3 |
| 8 | Photonic tractor beams:a review显示文摘Usually,an unfocused light beam,such as a paraxial Gaussian beam,can exert a force on an object along the direction of light propagation,which is known as light pressure.Recently,however,it was found that an unfocused light beam can also exert an optical pulling force(OPF)on an object toward the source direction;the beam is accordingly named an optical tractor beam.In recent years,this intriguing force has attracted much attention and a huge amount of progress has been made both in theory and experiment.We briefly review recent progress achieved on this topic.We classify the mechanisms to achieve an OPF into four different kinds according to the dominant factors.The first one is tailoring the incident beam.The second one is engineering the object’s optical parameters.The third one is designing the structured material background,in which the light–matter interaction occurs,and the fourth one is utilizing the indirect photophoretic force,which is related to the thermal effect of light absorption.For all the methods,we analyze the basic principles and review the recent achievements.Finally,we also give a brief conclusion and an outlook on the future development of this field. | Weiqiang Ding Tongtong Zhu Lei-Ming Zhou Cheng-Wei Qiu | 2019 | Advanced Photonics2019，1，2： | 2 |
| 9 | First spaceborne demonstration of BeiDou-3 signals for GNSS reflectometry from CYGNSS constellation显示文摘The full constellation of Chinese Global Navigation Satellite System(GNSS)Bei Dou-3 has been deployed completely and started fully operational service.In addition to providing global Positioning,Navigation and Timing(PNT)services,the Bei Dou-3 satellites transmissions can also be used as the sources of illumination for Earth Observation(EO)with a bistatic radar configuration.This innovative EO concept,known as GNSS reflectometry(GNSS-R),allows to measure the Earth surface characteristics at high resolution via the reflected L-band radar signals collected by a constellation of small,low cost and low Earth orbiting satellites.For the first time in orbit,earth reflected Bei Dou-3 signal has been detected from the limited sets of raw data collected by the NASA’s Cyclone GNSS(CYGNSS)constellation.The feasibility of spaceborne Bei Dou-3 reflections on two typical applications,including sea surface wind and flooding inundation detection,has been demonstrated.The methodology and results give new strength to the prospect of new spaceborne GNSS-R instruments and missions,which can make multi-GNSS reflectometry observations available to better capture rapidly changing weather systems at better spatio-temporal scales. | Weiqiang LI Estel CARDELLACH Serni RIBO Antonio RIUS Bo ZHOU | 2021 | Chinese Journal of Aeronautics2021，34，9： | 2 |
| 10 | Molecular biological analysis of remains from Jiangjungou Cemetery in Inner Mongolia显示文摘在亢奋的可变区域的 364-bp 核苷酸顺序(HVRI ) 我成功地从在始于的内部蒙古在 Jiangjungou 公墓埋葬的一张古老的人口的 11 个个人从 9 mitochondrial DNA 被放大在中国的打仗的状态时期。有不同变化的九碎片被获得。种系发生的树并且多维的可伸缩(MDS ) 阴谋的 A 从古老的人口和几张现代亚洲人口用 mtDNA 序列被构造。结果证明那张古老的人口与东方亚洲人口分享一种更近基因的关系那与诺思和中央亚洲人口一起。基因、历史的证据提起人口可能是来自 Zhongyuan 区域的移民的可能性,由赵状态的伍灵国王送了从匈奴对攻击看守国家。 | WANG Haijing LIU Weiqiang FU Yuqin ZHANG Xiaolei ZHOU Hui ZHU Hong | 2006 | Progress in Natural Science:Materials International2006，16，7： | 2 |
| 11 | Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression显示文摘 | Weiqiang Wang Jingjing Zhao Hongbin Wang Yonggang Sun Zhihong Peng Gang Zhou Lilin Fan Xingwei Wang Shiming Yang Rongquan Wang Dianchun Fang | 2010 | Experimental Cell Research2010，，15： | 2 |
| 12 | Characteristics of HPV prevalence among women in Liaoning province, China 显示文摘 | Sun Zhengrong Ji Yaohua Zhou Weiqiang | 2010 | IntJGynaeeolObstet2010，109，2： | 1 |
| 13 | Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells显示文摘 | Weiqiang Zhou Guangdi Wang Shanchun Guo | 2013 | BBA - Reviews on Cancer2013，，2： | 1 |
| 14 | Research on automatic for identification technology by meteorological satellite remotesensing显示文摘 | Zhou Hongmei Ge Weiqiang Bai Hua | 2009 | Journal of Tropical Meteorology2009，4，1： | 1 |
| 15 | Bioprinted constructs that simulate nerve-bone crosstalk to improve microenvironment for bone repair显示文摘Crosstalk between nerves and bone is essential for bone repair,for which Schwann cells(SCs)are crucial in the regulation of the microenvironment.Considering that exosomes are critical paracrine mediators for intercellular communication that exert important effects in tissue repair,the aim of this study is to confirm the function and molecular mechanisms of Schwann cell-derived exosomes(SC-exos)on bone regeneration and to propose engineered constructs that simulate SC-mediated nerve-bone crosstalk.SCs promoted the proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs)through exosomes.Subsequent molecular mechanism studies demonstrated that SC-exos promoted BMSC osteogenesis by regulating the TGF-βsignaling pathway via let-7c-5p.Interestingly,SC-exos promoted the migration and tube formation performance of endothelial progenitor cells.Furthermore,the SC-exos@G/S constructs were developed by bioprinting technology that simulated SC-mediated nerve-bone crosstalk and improved the bone regeneration microenvironment by releasing SC-exos,exerting the regulatory effect of SCs in the microenvironment to promote innervation,vascularization,and osteogenesis and thus effectively improving bone repair in a cranial defect model.This study demonstrates the important role and underlying mechanism of SCs in regulating bone regeneration through SC-exos and provides a new engineered strategy for bone repair. | Tianchang Wang Wentao Li Yuxin Zhang Xiang Xu Lei Qiang Weiqiang Miao Xiaokun Yue Xin Jiao Xianhao Zhou Zhenjiang Ma Shuai Li Muliang Ding Junfeng Zhu Chi Yang Hui Wang Tao Li Xin Sun Jinwu Wang | 2023 | Bioactive Materials2023，，9： | 1 |
| 16 | Attenuation characteristics of impact-induced seismic wave in deep tunnels:An in situ investigation based on pendulum impact test显示文摘The radiated seismic energy is an important index for the intensity assessment of microseismic(MS)events and the early warning of dynamic disasters.However,the energy of MS signals is significantly attenuated due to the heterogeneity and viscous damping of rock media.Therefore,the study on attenuation characteristics of MS signals in underground engineering has practical significance for the accurately estimation of radiated seismic energy.Based on a pendulum impact test facility and MS monitoring system,an in situ investigation was carried out to explore attenuation characteristics at a deep tunnel.The results show that the seismic energy and peak particle velocity(PPV)attenuation are exponentially related to the propagation distance.The attenuation coefficient of energy is larger than that of PPV.With the increase in the input impact-energy,the seismic energy attenuation coefficient decreases as a power function.An empirical relationship between energy attenuation coefficient and wave impedance of rock mass was established in this scenario.Moreover,the time-frequency characteristics and energy distribution laws of impact-induced signals were investigated by the continuous wavelet transform(CWT)and wavelet packet analyses,respectively.The dominant frequency of signals decreases gradually as the propagation distance increases.Based on the energy attenuation characteristics,a new method was proposed to calculate the released source energy of MS events in the field.This study can provide an insight into energy attenuation characteristics of seismic waves and references for attenuation correction in seismic energy calculation. | Jian Wu Quansheng Liu Xiaoping Zhang Chuiyi Zhou Xin Yin Weiqiang Xie Xu Liang Jiaqi Huang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 17 | The measurement of responsivity of infrared photodetectors using a cavity blackbody显示文摘For the measurement of responsivity of an infrared photodetector,the most-used radiation source is a blackbody.In such a measurement system,distance between the blackbody,the photodetector and the aperture diameter are two parameters that contribute most measurement errors.In this work,we describe the configuration of our responsivity measurement system in great detail and present a method to calibrate the distance and aperture diameter.The core of this calibration method is to transfer direct measurements of these two parameters into an extraction procedure by fitting the experiment data to the calculated results.The calibration method is proved experimentally with a commercially extended InGaAs detector at a wide range of blackbody temperature,aperture diameter and distance.Then proof procedures are further extended into a detector fabricated in our laboratory and consistent results were obtained. | Nong Li Dongwei Jiang Guowei Wang Weiqiang Chen Wenguang Zhou Junkai Jiang Faran Chang Hongyue Hao Donghai Wu Yingqiang Xu Guiying Shen Hui Xie Jingming Liu Youwen Zhao Fenghua Wang Zhichuan Niu | 2023 | Journal of Semiconductors2023，44，10： | 0 |
| 18 | Fabrication of MoF-based composite for synergistic catalysis显示文摘Heterogeneous catalyst has received extensive attention in the field of chemical industry due to its high activity and selectivity[1-2].In general,the heterogeneous catalysts exhibit certain advantages,such as large surface area,more exposed active sites,and easily recovery[3].For example,noble metal nanoparticles(NPs)were uniformly supported by the porous materials(e.g.,porous carbon,zeolite,and silica)for preparing the heterogeneous catalysts[46]. | Xin Zhou Yanhu Zhang Weiqiang Zhou Chen Zhou Quan Wang | 2023 | Frontiers of Materials Science2023，17，1： | 0 |
| 19 | Profiling Chromatin Accessibility at Single-cell Resolution显示文摘How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity,and enable complex fate decisions are important open questions.One key regulator is the cell’s epigenome state that drives distinct transcriptional programs by regulating chromatin accessibility.Genome-wide chromatin accessibility measurements can impart insights into regulatory sequences(in)accessible to DNA-binding proteins at a single-cell resolution.This review outlines molecular methods and bioinformatic tools for capturing cell-to-cell chromatin variation using single-cell assay for transposase-accessible chromatin using sequencing(scATAC-seq)in a scalable fashion.It also covers joint profiling of chromatin with transcriptome/proteome measurements,computational strategies to integrate multi-omic measurements,and predictive bioinformatic tools to infer chromatin accessibility from single-cell transcriptomic datasets.Methodological refinements that increase power for cell discovery through robust chromatin coverage and integrate measurements from multiple modalities will further expand our understanding of gene regulation during homeostasis and disease. | Sarthak Sinha Ansuman T.Satpathy Weiqiang Zhou Hongkai Ji Jo A.Stratton Arzina Jaffer Nizar Bahlis Sorana Morrissy Jeff A.Biernaskie | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 0 |
| 20 | Slurry flow characteristics control of 3D printed ceramic core layered structure:Experiment and simulation显示文摘Vat photopolymerization 3D printing ceramic technology provides a feasible process for the preparation of complex internal cooling channels for aeroengine single crystal superalloy hollow blades.However,the typical layered structure characteristics of 3D printing ceramic technology led to the anisotropy of ceramic core strength and sintering shrinkage,which greatly affects the performance and accuracy of the complex structure core and requires further research and improvement.Herein,the influence of the thickness of the slurry layer on the flow characteristics of the slurry in the process of the vat photopolymerization 3D printing slurry spreading was systematically studied by the method of simulation and experiment.The simulation results show that the positions of the turbulent zone and maximum velocity zone in the scraper front affect the redistribution of powder particles with different sizes.The layered structure was caused by the redistribution of ceramic particles of different sizes in the slurry layer.By controlling the turbulent flow zone and the maximum velocity zone of the scraper leading edge,the phenomenon of laminar flow can be weakened and the particle redistribution can be improved.With the increase of the thickness of the printing layer,the layered structure appears gradually,and the pores at the interface of the layered structure gradually concentrated into the interfacial pore lines from the uniform distribution,and the crack propagation changes from intergranular micro-crack to interlayer macro-crack.The combination of finite element simulation and experiment,through the slurry flow characteristics to control the layered structure of reductive vat photopolymerization ceramic core 3D printing,the control of crack propagation mode,element distribution and pore evolution of the core was accomplished,which lays a foundation for the performance control of ceramic 3D printing technology. | Qiaolei Li Yuxiang Qiu Weiqiang Hou Jingjing Liang Hui Mei Jinguo Li Yizhou Zhou Xiaofeng Sun | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
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