|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hybrid interference alignment and power allocation for multi-user interference MIMO channels显示文摘This paper proposes a hybrid interference alignment scheme which combines maximizing signal-toleakage-noise ratio(Max-SLNR) at transmitter and maximizing signal-to-interference-noise ratio(Max-SINR) at receiver.The proposed scheme gives the same sum rate as the existing method using Max-SINR at both transmitter and receiver by avoiding the operation of reversing channel,thus it provides a simpler solution.Furthermore,two power allocation procedures are devised based on game theory and water filling.The gain of these schemes over equal power allocation increases to 2 bit/s/Hz in correlated fading channels as large-scale fading becomes significant.Additionally,user fairness is solved by introducing weighting factors. | SHU Feng YOU XiaoHu WANG Mao HAN YuBing LI Yang SHENG WeiXing | 2013 | Science China(Information Sciences)2013，56，4： | 5 |
| 2 | An empirical study of the effect of venture capital participation on the accounting information quality of IPO firms显示文摘Using a sample of IPO companies on the Shenzhen Small and Median Enterprise Board and the ChiNext Stock Market between 2005 and 2009, this paper analyzes the effect of venture capital participation on accounting information quality. We find that venture capitalists have a significant effect on earnings management, with reduced discretionary accruals before the expiration of the equity lock-up period and enhanced discretionary accruals after the expiration of the equity lock-up period. Our findings support the moral hazard hypothesis of venture capital, but not the certification/monitoring role of venture capital in IPOs. In addition, we find that venture capital plays a more important role in the earnings management of non-state-owned IPO companies than of state-owned companies. | Zhiying Hu Weixing Cai Jinjin Han Rula Sa | 2012 | China Journal of Accounting Research2012，，3： | 3 |
| 3 | Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar显示文摘In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere monitoring.The Institute of Geology and Geophysics at the Chinese Academy of Sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large array.In this work,we have summarized the preliminary experimental results based on the SYISR-8.The amplitude and phase among 256 channels were first calibrated through an embedded internal monitoring network.The mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic requirements.The beam directivity was confirmed by crossing screen of the International Space Station.The SYISR-8 was further used to detect the tropospheric wind profile and meteors.The derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS measurements.The SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail echo.These results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent. | XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng Ding BiQiang Zhao Lin Jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 3 |
| 4 | Germanium nanopyramid arrays showing near-100% absorption in the visible regime显示文摘Solar energy is regarded as one of the most plentiful sources of renewable energy. An extraordinary light-harvesting property of a germanium periodic nanopyramid array is reported in this Letter. Both our theoretical and experimental results demonstrate that the nanopyramid array can achieve perfect broadband absorption from 500- to 800-nm wavelength. Especially in the visible regime, the experimentally measured absorption can even reach 100%. Further analyses reveal that the intrinsic antireflection effect and slow-light waveguide mode play an important role in the ultra-high absorption, which is helpful for the research and development of photovoltaic devices. | Qi Han Yongqi Fu Lei Jin Jingjing Zhao Zongwei Xu Fengzhou Fang Jingsong Gao Weixing Yu | 2015 | Nano Research2015，8，7： | 2 |
| 5 | Heat shock proteins and p53 play a critical role in K ^+ channel - mediated tumor cell proliferation and apoptosis显示文摘 | Xiaobing Han Fang Wang Weixing Yao | 2007 | Apoptosis2007，12，： | 1 |
| 6 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jiangang Ren Weixing Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，26： | 1 |
| 7 | GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies显示文摘Cancer cells are usually characterized by hyperactive glucose metabolism,which can often lead to glucose scarcity;thus,alternative pathways to rewire cancer metabolism are required.Here,we demonstrated that GLUT3 was highly expressed in colorectal cancer(CRC)and negatively linked to CRC patient outcomes,whereas GLUT1 was not associated with CRC prognosis.Under glucoselimiting conditions,GLUT3 expedited CRC cell growth by accelerating glucose input and fuelling nucleotide synthesis.Notably,GLUT3 had a greater impact on cell growth than GLUT1 under glucose-limiting stress.Mechanistically,low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway.Furthermore,high GLUT3 expression remarkably increased the sensitivity of CRC cells to treatment with vitamin C and vitamin C-containing regimens.Together,the results of this study highlight the importance of the AMPK/CREB1/GLUT3 pathway for CRC cells to withstand glucose-limiting stress and underscore the therapeutic potential of vitamin C in CRC with high GLUT3 expression. | Weixing Dai Ye Xu Shaobo Mo Qingguo Li Jun Yu Renjie Wang Yanlei Ma Yan Ni Wenqiang Xiang Lingyu Han Long Zhang Sanjun Cai Jun Qin Wen-Lian Chen Wei Jia Guoxiang Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 8 | The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Liol and Resveratrol in Ameliorating Colitis in Mice显示文摘Currently approved therapeutical strategies for inflammatory bowel diseases(IBD)suffer from variable efficacy and association with risk of serious side effects.Therefore,efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation.In this study,we show that the probiotic strain Ligilactobacillus salivarius Li01(Li01)and the phytochemical prebiotic resveratrol(RSV)have synergistic effect in ameliorating colitis in mice.Oral coadministration of Li01(109 CFU/d)and RSV(1.5 g/kg/d)promoted restoration of various inflammatory injuries and gut microbiota composition,exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice.The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1βand IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum.Moreover,the combination treatment was found to alter the composition and metabolism of the gut microbiota,especially influencing the production of short chain fatty acids and anti-inflammatory related molecules.The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor(AHR)and tryptophan metabolism pathway.Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites,including dihydroresveratrol(DHR),resveratrol-sulfate,and resveratrol-glucuronide.DHR was found to be the dominant metabolite of RSV in conventional and colitis mice.An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect.DHR is considered as a potential AHR ligand.The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1,SERT,and 5-HT7R leading to amelioration of colitis in mice.Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD;further investigation of this combination in clinical settings is warranted. | Yiqiu Fei Shuobo Zhang Shengyi Han Bo Qiu Yanmeng Lu Weixing Huang Fang Li Deying Chen Bjorn Berglund Hang Xiao Lanjuan Li Mingfei Yao | 2022 | Research2022，，4： | 1 |
| 9 | Shaped-Beam Pattern Synthesis Through the Construction of Weighted Generalized Rayleigh Quotient显示文摘A novel shaped-beam pattern synthesis method of generating an arbitrary footprint pattern under an arbitrary array structure is proposed. The embedded element pattern information is included in the pattern model, and a new cost function composed of three optimization items which are sidelobe levels,mainlobe ripples and mainlobe gains is constructed through the model. During the optimization process,to further enhance the performance of the synthesized pattern, a weight matrix is designed and added to the optimization items, then the generalized Rayleigh quotient approximation method is used to obtain the final array element excitations. To illustrate the good performance of the provided method, several synthesis examples with different arrays and footprints are presented. Compared with other algorithms such as Weighted alternating reverse projection(WARP) method, the proposed method can achieve better results with lower sidelobe levels, smaller mainlobe ripples and less computational load. | YANG Yin WAN Chuan SHENG Weixing HAN Yubing MA Xiaofeng | 2019 | Chinese Journal of Electronics2019，28，1： | 1 |
| 10 | Chinese patients with p.Arg756 mutations of ATP1A3: Clinical manifestations, treatment, and follow-up显示文摘Importance:The phenotypes of ATP1A3 gene mutations are diverse.Relapsing encephalopathy with cerebellar ataxia and fever-induced paroxysmal weakness and encephalopathy(FIPWE)are considered non-classical phenotypes caused by p.Arg756 mutations of ATP1A3.Objective:To summarize the clinical manifestations,treatment,and followup of Chinese patients with p.Arg756 mutations of ATP1A3.Methods:We analyzed the clinical features,treatment,and genotypes of eight children with p.Arg756 mutations of ATP1A3 who were treated in Beijing Children’s Hospital from January 2014 to December 2019.Results:Eight patients(six boys and two girls)were included;seven had been misdiagnosed with encephalitis.The age of onset ranged from 0.8 to 4.5 years.All patients had encephalopathy and had at least one episode of FIPWE.Cerebellar ataxia was present in nine episodes.Reversible splenial lesions of the corpus callosum were found in two patients in the acute phase.Three types of heterozygous ATP1A3 mutations were found:c.2267G>T(p.R756L)(patient 3[P3]),c.2266C>T(p.R756C)(P2 and P4),and c.2267G>A(p.R756H)(P1,P5,P6,P7,and P8).Six mutations were de novo;two mutations were inherited.Both patients with p.R756C and one patient(P7)with p.R756H had four episodes of severe ataxia as the main manifestations.However,in the other three episodes,limb weakness was more prominent than ataxia.P5 with p.R756H exhibited overlap with FIPWE and rapid-onset dystonia-parkinsonism.Interpretation:Acute encephalopathy followed by febrile disease was characteristic of the disease in patients with p.Arg756 mutations of ATP1A3.However,the weakness and ataxia were variable.Phenotypic crossover and overlap were observed among these patients. | Weihua Zhang Jiuwei Li Xiuwei Zhuo Ji Zhou Weixing Feng Shuai Gong Xiaotun Ren Changhong Ding Tongli Han Fang Fang | 2022 | Pediatric Investigation2022，6，1： | 1 |
| 11 | Adaptive monopulse beamforming with partial parallel structure显示文摘A new recursive algorithm with the partial parallel structure based on the linearly constrained minimum variance (LCMV) criterion for adaptive monopulse systems is proposed. The weight vector associated with the original whole antenna array is decomposed into several adaptive weight sub-vectors firstly. An adaptive algorithm based on the conventional LCMV principle is then deduced to update the weight sub-vectors for sum and difference beam, respectively. The optimal weight vector can be obtained after convergence. The required computational complexity is evaluated for the proposed technique, which is on the order of O(N) and less than that of the conventional LCMV method. The flow chart scheme with the partial parallel structure of the proposed algorithm is introduced. This scheme is easy to be implemented on a distributed computer/digital signal processor (DSP) system to solve the problems of the heavy computational burden and vast data transmission of the large-scale adaptive monopulse array. Then, the monopulse ratio and convergence rate of the proposed algorithm are evaluated by numerical simulations. Compared with some recent adaptive monopulse estimation methods, a better performance on computational complexity and monopulse ratio can be achieved with the proposed adaptive method. | Liang Chen Weixing Sheng Xiaofeng Ma Fei Huang and Yubing Han | 2012 | Journal of Systems Engineering and Electronics2012，23，6： | 1 |
| 12 | EUV-dependence of Venusian dayside ionopause altitude:VEX and PVO observations显示文摘The Venusian dayside ionosphere, similar to other planetary ionospheres, is produced primarily by ionization of its neutral upper atmosphere due to solar extreme ultraviolet (EUV) radiation. It has become clear that the expansion of the ionosphere may be strongly controlled by the EUV level, as exhibited in data collected by the Pioneer Venus Orbiter (PVO) during one solar cycle (1978 1992). However, the EUV-dependence of the Venusian dayside ionopause altitude, which defines the outer boundary of the ionosphere, remains obscure because the PVO crossed the dayside ionopause only during the solar maximum;its periapsis lifted too high during the solar minimum. Recently, during the period 2006 2014, which included the longest and quietest solar minimum of the past several decades, Venus Express (VEX) provided measurements of the photoelectron boundary (PEB) over the northern high-latitude region. Since the photoelectron boundary is closely related to the ionopause, we have an opportunity to analyze the EUV effect on the dayside ionopause by combining PVO and VEX observations. We have evaluated and then reduced the orbit bias effect in data from both PVO and VEX, and then used the results to derive a relationship between solar EUV level and the dayside ionopause altitude. We find that the dayside ionopause altitude increases as the solar EUV level increases, which is consistent with theoretical expectations. | QianQian Han Markus Fraenz Yong Wei Eduard Dubinin Jun Cui LiHui Chai ZhaoJin Rong WeiXing Wan Yoshifumi Futaana | 2020 | Earth and Planetary Physics2020，4，1： | 1 |
| 13 | Impact of Robinia pseudoacacia stand conversion on soil properties and bacterial community composition in Mount Tai,China显示文摘Background:Robinia pseudoacacia is a widely planted pioneer tree species in reforestations on barren mountains in northern China.Because of its nitrogen-fixing ability,it can play a positive role in soil and forest restoration.After clearcutting of planted stands,R.pseudoacacia stands become coppice plantations.The impacts of shifting from seedling to coppice stands on soil bacterial community and soil properties have not been wel described.This study aims to quantify how soil properties and bacterial community composition vary between planted seedling versus coppice stands.Methods:Nine 20 m×20 m plots were randomly selected in seedling and coppice stands.The bulk soil and rhizosphere soil were sampled in summer 2017.Bulk soil was sampled at 10 cm from the soil surface using a soil auger.Rhizosphere soil samples were col ected using a brush.The soil samples were transported to the laboratory for chemical analysis,and bacterial community composition and diversity was obtained through DNA extraction,16 S r RNA gene amplification and high-throughput sequencing.Results:The results showed that,compared to seedling plantations,soil quality decreased significantly in coppice stands,but without affecting soil exchangeable Mg^(2+) and K^(+).Total carbon(C)and nitrogen(N)were lower in the rhizosphere than in bulk soil,whereas nutrient availability showed an opposite trend.The conversion from seedling to coppice plantations was also related to significant differences in soil bacterial community structure and to the reduction of soil bacterialα-diversity.Principal component analysis(PCA)showed that bacterial community composition was similar in both bulk and rhizosphere soils in second-generation coppice plantations.Special y,the conversion from seedling to coppice stands increased the relative abundance of Proteobacteria and Rhizobium,but reduced that of Actinobacteria,which may result in a decline of soil nutrient availability.Mantel tests revealed that C,N,soil organic matter(SOM),nitrate nitrogen(NO^(-)+(3)-N)and available phosphorus positively correlated with bacterial community composition,while a variation partition analysis(VPA)showed that NO^(-)+(3)-N explained a relatively greater proportion of bacterial distribution(15.12%),compared with C and SOM.Surprisingly,N showed no relationship with bacterial community composition,which may be related to nitrogen transportation.Conclusions:The conversion from seedling to coppice stands reduced soil quality and led to spatial-temporal homogenization of the soil bacterial community structure in both the rhizosphere and bulk soils.Such imbalance in microbial structure can accelerate the decline of R.pseudoacacia.This may affect the role of R.pseudoacacia coppice stands in soil and forest restoration of barren lands in mountain areas. | Kun Li Xu Han Ruiqiang Ni Ge Shi Sergio de-Miguel Chuanrong Li Weixing Shen Yikun Zhang Xingzhong Zhang | 2021 | Forest Ecosystems2021，8，2： | 1 |
| 14 | Cigarette smoking status and smoking cessation counseling of Chinese physicians in Wu- han, Hubei province 显示文摘 | Han Zao Li Weixing Sun Fangmei Cheng | 2008 | Asia Pac J Public Health2008，20，3： | 1 |
| 15 | An Investigation Report on Production Conditions of Sugarcane in Guangxi in 2016显示文摘To predict and assess production conditions of sugarcane in Guangxi in 2016,by using methods of field survey and data collection,the seedling situation,breed structure,planting area,planting period,plant diseases and insect pests of sugarcane in six major sugarcane producing cities of Guangxi were surveyed. The results show that the overall situation of sugarcane seedlings in Guangxi in 2016 became slightly worse than that in 2015,but there were enough good sugarcane seedlings in 2016. The dead heart rate of sugarcane decreased in most sugarcane regions from 2015 to 2016,that is,the comprehensive control of borers gave initial results; the smut infection rate of sugarcane rose from 2015 to 2016 and tended to increase. The situation of decrease in the planting area of sugarcane in three consecutive years was controlled,and the planting area of sugarcane increased slightly from 2015 to 2016. Due to the construction of ' double high' bases,the breed variety of sugarcane in Guangxi was improved further in 2016. It is necessary to strengthen field management and conduct chemical weeding,prevention and control of borers and aphids in the later period in time. | Yuchi DENG Weizan WANG RonghuaZHANG Shiyun TANG Shanhai LIN Qiang LIANG Weixing DUAN Xiang LI Guoying LU Shijian HAN Youzong HUANG Yebin YANG Yanni HUANG Lunwang WANG | 2017 | Asian Agricultural Research2017，9，6： | 0 |
| 16 | A low-cost and high-performance self-trigger method for high-voltage transient measurement显示文摘Stable triggering of acquisition devices is critical to accurately measure electromagnetic transients,especially for very fast transient overvoltages(VFTOs).A highly stable and lowcos t self-trigger method for transient measurement is proposed.An integrated low-voltage arm module was developed to synchronously realise the triggering and VFTO measurement.The trigger branch was developed using a high-pass filter.This component obtained the high-frequency component of the VFTO to trigger the oscilloscope.The trigger branch was integrated with the measurement branch through an impedance converter.An attenuator was implemented before the impedance converter to avoid overvoltage damage to the chip.The circuit parameters of the attenuator were optimised to alleviate the disturbance of the measurement branch.The calibration results demonstrated that the±1 dB bandwidth of the measurement branch in this system ranged from 11.8 Hz to 105 MHz.The low cutoff frequency of the trigger branch was 710 Hz.The VFTO waveforms generated by the operation of a disconnector in a real 252 kV gas insulated switchgear were measured using the proposed system.The test results verified that the self-trigger measurement system can provide stable trigger signals and accurately measure the VFTO waveforms. | Hao Liu Guoming Ma Weiqi Qin Wei Wang Houxian Du Lei Wang Shicong Zhai Fuping Zeng Weixing Han | 2023 | High Voltage2023，8，2： | 0 |
| 17 | Anti-Jamming Null Space Projection Beamforming Based on Symbiotic Radio显示文摘With the development of information technology,more and more devices are connected to the Internet through wireless communication to complete data interconnection.Due to the broadcast characteristics ofwireless channels,wireless networks have suffered more and more malicious attacks.Physical layer security has received extensive attention from industry and academia.MIMO is considered to be one of the most important technologies related to physical layer security.Through beamforming technology,messages can be transmitted to legitimate users in an offset direction that is as orthogonal as possible to the interference channel to ensure the reception SINR by legitimate users.Combining the symbiotic radio(SR)technology,this paper considers a symbiotic radio antijamming MIMO system equipped with a multi-antenna system at the main base station.In order to avoid the interference signal and improve the SINR of the signal received by the user.The base station is equipped with a uniform rectangular antenna array,and using Null Space Projection(NSP)Beamforming,Intelligent Reflecting Surface(IRS)can assist in changing the beam’s angle.The simulation results show that NSP Beamforming could make a better use of the null space of interference,which can effectively improve the received SINR of users under directional interference,and improve the utilization efficiency of signal energy. | Baofeng Ji Yifan Liu Tingpeng Li Ling Xing Weixing Wang Shahid Mumtaz Xiaolong Shang Wanying Liu Congzheng Han | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
| 18 | Signal recovery method based on co-prime array显示文摘A signal waveform recovery method based on the coprime array is investigated to extract the waveform of the desired signal from spatial interferences in narrowband scenarios. The direction of arrivals(DOAs) of the desired signal and interference signals are estimated with the compressive sensing approach based on angle grids, and the signal power together with the noise power are estimated. Thereafter, a modified steepest descent(SD) method is derived to recover the waveform of the desired signal and interferences utilizing the estimated power and directions. The recovered waveform of the desired signal is the output of the proposed method. The situation in which the signals are not on the predefined angle grids is also considered. The DOAs estimated via the predefined angle grids are corrected based on the maximum likelihood(ML) angle estimation. Compared to the existing beamforming methods on co-prime array, the proposed method can obtain the waveform of the desired signal. Simulation results demonstrate that the proposed method can achieve good performance in signal waveform recovery and output signal to noise ratio. | Shuang Qiu Weixing Sheng Xiaofeng Ma Yubing Han Renli Zhang | 2017 | Journal of Systems Engineering and Electronics2017，28，2： | 0 |
| 19 | Phase-only pattern synthesis based on gradient-descent optimization显示文摘By applying phase-only technique in array antenna pattern synthesis, antenna arrays can form desired patterns with the use of phase shifters only. A novel phase-only pattern synthesis algorithm is proposed for the passive phased array seeker. This algorithm synthesizes the main beam of the antenna pattern through least-squares approximation, thus minimizing the errors between the actual and the desired main beams. The synthesis problem can be solved by applying gradient-descent optimization. The item for suppressing side lobes is added to the above synthesis problem. To obtain a side lobe level as low as possible, the algorithm assigns different weights to different directions in the side lobe region. The algorithm is run repeatedly and the weights are adjusted adaptively according to the normalized power in the side lobe directions. Detailed examples are presented to demonstrate the accuracy and effectiveness of the proposed approach. | Chengjun Lu Weixing Sheng Yubing Han Xiaofeng Ma | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 0 |
| 20 | PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism显示文摘Background:Abnormal expression of protein tyrosine phosphatases(PTPs)has been reported to be a crucial cause of cancer.As a member of PTPs,protein tyrosine phosphatase receptor type O(PTPRO)has been revealed to play tumor suppressive roles in several cancers,while its roles in colorectal cancer(CRC)remains to be elucidated.Hence,we aimed to explore the roles and mechanisms of PTPRO in CRC initiation and progression.Methods:The influences of PTPRO on the growth and liver metastasis of CRC cells and the expression patterns of different lipid metabolism enzymes were evaluated in vitro and in vivo.Molecular and biological experiments were conducted to uncover the underpinning mechanisms of dysregulated de novo lipogenesis and fatty acidβ-oxidation.Results:PTPRO expression was notably downregulated in CRC liver metastasis compared to the primary cancer,and such a downregulation was associated with poor prognosis of patients with CRC.PTPRO silencing significantly promoted cell growth and liver metastasis.Compared with PTPRO wild-type mice,PTPROknockout mice developed more tumors and harbored larger tumor loads under treatment with azoxymethane and dextran sulfate sodium.Gene set enrichment analysis revealed that PTPRO downregulation was significantly associated with the fatty acid metabolism pathways.Blockage of fatty acid synthesis abrogated the effects of PTPRO silencing on cell growth and liver metastasis.Further experiments indicated that PTPRO silencing induced the activation of the AKT serine/threonine kinase(AKT)/mammalian target of rapamycin(mTOR)signaling axis,thus promoting de novo lipogenesis by enhancing the expression of sterol regulatory element-binding protein 1(SREBP1)and its target lipogenic enzyme acetyl-CoA carboxylase alpha(ACC1)by activating the AKT/mTOR signaling pathway.Furthermore,PTPRO attenuation decreased the fatty acid oxidation rate by repressing the expression of peroxisome proliferator-activated receptor alpha(PPARα)and its downstream enzyme peroxisomal acyl-coenzyme A oxidase 1(ACOX1)via activating the p38/extracellular signal-regulated kinase(ERK)mitogen-activated protein kinase(MAPK)signaling pathway.Conclusions:PTPRO could suppress CRC development and metastasis via modulating the AKT/mTOR/SREBP1/ACC1 and MAPK/PPARα/ACOX1 pathways and reprogramming lipid metabolism. | Weixing Dai Wenqiang Xiang Lingyu Han Zixu Yuan Renjie Wang Yanlei Ma Yongzhi Yang Sanjun Cai Ye Xu Shaobo Mo Qingguo Li Guoxiang Cai | 2022 | Cancer Communications2022，42，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员