|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnostic value of whole-body MRI with diffusion-weighted sequence for detection of peritoneal metastases in colorectal malignancy显示文摘Objective:To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence(WB-DWI)to determine the peritoneal cancer index(PCI)in correlation with surgical and histopathological findings.Methods:Twenty-seven patients underwent preoperative WB-MRI,followed by cytoreductive surgery for primary tumors of the appendix(n=15),colorectum(n=12),and associated peritoneal disease.A total of 351 regions were retrospectively reviewed.The sensitivity,specificity,and accuracy were calculated at 13 anatomical sites.The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.Results:No statistical difference was found between the WB-DWI PCI and surgical PCI(P=0.574).WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy(88.9%),including 10 of 10 patients with small-volume tumor,12 of 14 with moderate-volume tumor,and 2 of 3 with large-volume tumor.WB-DWI correctly depicted tumors in 163 of 203 regions,with 40false-negative and 23 false-positive regions.The overall sensitivity,specificity,and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%,84.5%,and 82.1%,respectively.For lesions<0.5 cm in diameter,WB-DWI demonstrated good sensitivity(69.4%).Conclusions:WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery. | Huan Zhang Weixing Dai Caixia Fu Xu Yan Alto Stemmer Tong Tong Guoxiang Cai | 2018 | Cancer Biology & Medicine2018，15，2： | 3 |
| 2 | Exogenous nitric oxide improves seed germination in wheat against mitochondrial oxidative damage induced by high salinity显示文摘 | Chunfang Zheng Dong Jiang Fulai Liu Tingbo Dai Weicheng Liu Qi Jing Weixing Cao | 2009 | Environmental and Experimental Botany2009，，1： | 2 |
| 3 | Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method显示文摘 | Peng Jiang Weixing Dai Shikai Yan Zhongliang Chen Ruilin Xu Jianmi Ding Li Xiang Shuping Wang Runhui Liu Weidong Zhang | 2011 | Journal of Ethnopharmacology2011，，2： | 2 |
| 4 | Characterizing physiological N-use efficiency as influenced by nitrogen management in three rice cultivars显示文摘 | Ligeng Jiang Tingbo Dai Dong Jiang Weixing Cao Xiuqin Gan Shanqing Wei | 2004 | Field Crops Research2004，，2： | 2 |
| 5 | Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its majorbioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS显示文摘 | Ye Ji Zhang Xi Dai Weixing | 2009 | J Pharm Biomed Anal2009，49，3： | 1 |
| 6 | Modeling plant nitrogen uptake and grain nitrogen accumulation in wheat显示文摘 | Jie Pan Yan Zhu Dong Jiang Tingbo Dai Yingxue Li Weixing Cao | 2006 | Field Crops Research2006，，2： | 1 |
| 7 | Relationships of endogenous plant hormones to accumulation of grain protein and starch in winter wheat under different post-anthesis soil water statusses显示文摘 | Zhujie Xie Dong Jiang Weixing Cao Tingbo Dai Qi Jing | 2003 | Plant Growth Regulation2003，，2： | 1 |
| 8 | GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies显示文摘Cancer cells are usually characterized by hyperactive glucose metabolism,which can often lead to glucose scarcity;thus,alternative pathways to rewire cancer metabolism are required.Here,we demonstrated that GLUT3 was highly expressed in colorectal cancer(CRC)and negatively linked to CRC patient outcomes,whereas GLUT1 was not associated with CRC prognosis.Under glucoselimiting conditions,GLUT3 expedited CRC cell growth by accelerating glucose input and fuelling nucleotide synthesis.Notably,GLUT3 had a greater impact on cell growth than GLUT1 under glucose-limiting stress.Mechanistically,low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 pathway.Furthermore,high GLUT3 expression remarkably increased the sensitivity of CRC cells to treatment with vitamin C and vitamin C-containing regimens.Together,the results of this study highlight the importance of the AMPK/CREB1/GLUT3 pathway for CRC cells to withstand glucose-limiting stress and underscore the therapeutic potential of vitamin C in CRC with high GLUT3 expression. | Weixing Dai Ye Xu Shaobo Mo Qingguo Li Jun Yu Renjie Wang Yanlei Ma Yan Ni Wenqiang Xiang Lingyu Han Long Zhang Sanjun Cai Jun Qin Wen-Lian Chen Wei Jia Guoxiang Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 9 | Effects of exogenous hormones on floret development and grain set in wheat显示文摘 | Wang Zhaolong Cao Weixing Dai Tingbo Zhou qin | 2001 | Plant Growth Regulat ion2001，35，： | 1 |
| 10 | Biomarkers in the early period of acute myocardial infarction in rat serumand protective effects of Shexiang Baoxin Pill using a metabolomic method 显示文摘 | Jiang Peng Dai Weixing Yah Shikai | 2011 | J Ethnopharmacol2011，138，2： | 1 |
| 11 | Multiple heat priming enhances thermo-tolerance to a later high temperature stress via improving subcellular antioxidant activities in wheat seedlings显示文摘 | Xiao Wang Jian Cai Fulai Liu Tingbo Dai Weixing Cao Bernd Wollenweber Dong Jiang | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 12 | Characterizing physiological N-use efficiency as influenced by nitrogen management in three rice cultivars显示文摘 | Ligeng Jiang Tingbo Dai Dong Jiang Weixing Cao Xiuqin Gan Shanqing Wei | 2004 | Field Crops Research2004，，2： | 1 |
| 13 | Biomarkers in the early period of acute myocardial infarction in rat serum and effects of Shexiang Baoxin Pill usin a metabolomic method protective 显示文摘 | Peng Jiang Weixing Dai Shikai Yan | 2011 | J Ethnopharmacol2011，，38： | 1 |
| 14 | Starch granules size distribution in superior and inferior grains of wheat is related to enzyme activities and their gene expressions during grain filling显示文摘 | Chuanhui Zhang Dong Jiang Fulai Liu Jian Cai Tingbo Dai Weixing Cao | 2009 | Journal of Cereal Science2009，，2： | 1 |
| 15 | Effects of exogenous hormones on floret development and grain set in wheat显示文摘 | Wang Zhaolong Cao Weixing Dai Tingbo Zhou qin | 2001 | Plant Growth Regulation2001，35，： | 1 |
| 16 | Attraction and Stability for Neutral Stochastic Functional Differential Equations显示文摘The main aim of this paper is to establish several new criteria on the attractor for the solutions of neutral stochastic func- tional differential equations. A kind of ψ-function is introduced to our discussion, and some results on the attractor for the product of the ψ-function and the solutions are obtained. As a byproduct, a number of new criteria on asymptotic stability are also shown. | CEN Liqun, DAI Weixing, HU Shigeng School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China | 2009 | Wuhan University Journal of Natural Sciences2009，14，3： | 1 |
| 17 | Effects of low nitrogen supply on relationships between photosynthesis and nitrogen status at different leaf position in wheat seedlings显示文摘 | Dandan Li Mengyu Tian Jian Cai Dong Jiang Weixing Cao Tingbo Dai | 2013 | Plant Growth Regulation2013，，3： | 1 |
| 18 | Accumulation of High Molecular Weight Glutenin Subunits in Superior and Inferior Grains of Winter Wheat显示文摘 | Hoang Kim Toan Yun BO Qin Zhou Jian Cai Xiao Wang Zhongwei Tian Tingbo Dai Weixing Cao Dong Jiang | 2015 | Journal of Agricultural Science and Technology(B)2015，5，7： | 0 |
| 19 | PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism显示文摘Background:Abnormal expression of protein tyrosine phosphatases(PTPs)has been reported to be a crucial cause of cancer.As a member of PTPs,protein tyrosine phosphatase receptor type O(PTPRO)has been revealed to play tumor suppressive roles in several cancers,while its roles in colorectal cancer(CRC)remains to be elucidated.Hence,we aimed to explore the roles and mechanisms of PTPRO in CRC initiation and progression.Methods:The influences of PTPRO on the growth and liver metastasis of CRC cells and the expression patterns of different lipid metabolism enzymes were evaluated in vitro and in vivo.Molecular and biological experiments were conducted to uncover the underpinning mechanisms of dysregulated de novo lipogenesis and fatty acidβ-oxidation.Results:PTPRO expression was notably downregulated in CRC liver metastasis compared to the primary cancer,and such a downregulation was associated with poor prognosis of patients with CRC.PTPRO silencing significantly promoted cell growth and liver metastasis.Compared with PTPRO wild-type mice,PTPROknockout mice developed more tumors and harbored larger tumor loads under treatment with azoxymethane and dextran sulfate sodium.Gene set enrichment analysis revealed that PTPRO downregulation was significantly associated with the fatty acid metabolism pathways.Blockage of fatty acid synthesis abrogated the effects of PTPRO silencing on cell growth and liver metastasis.Further experiments indicated that PTPRO silencing induced the activation of the AKT serine/threonine kinase(AKT)/mammalian target of rapamycin(mTOR)signaling axis,thus promoting de novo lipogenesis by enhancing the expression of sterol regulatory element-binding protein 1(SREBP1)and its target lipogenic enzyme acetyl-CoA carboxylase alpha(ACC1)by activating the AKT/mTOR signaling pathway.Furthermore,PTPRO attenuation decreased the fatty acid oxidation rate by repressing the expression of peroxisome proliferator-activated receptor alpha(PPARα)and its downstream enzyme peroxisomal acyl-coenzyme A oxidase 1(ACOX1)via activating the p38/extracellular signal-regulated kinase(ERK)mitogen-activated protein kinase(MAPK)signaling pathway.Conclusions:PTPRO could suppress CRC development and metastasis via modulating the AKT/mTOR/SREBP1/ACC1 and MAPK/PPARα/ACOX1 pathways and reprogramming lipid metabolism. | Weixing Dai Wenqiang Xiang Lingyu Han Zixu Yuan Renjie Wang Yanlei Ma Yongzhi Yang Sanjun Cai Ye Xu Shaobo Mo Qingguo Li Guoxiang Cai | 2022 | Cancer Communications2022，42，9： | 0 |
| 20 | Extracorporeal membrane oxygenation as a bridging therapy for patients with thiamine deficiency-induced pulmonary arterial hypertension显示文摘Thiamine deficiency is characterized by a deficiency of thiamine(vitamin B1),lactic acidosis,pulmonary arterial hypertension(PAH),right-sided heart failure,and peripheral nerve damage.Thiamine deficiency is easily misdiagnosed and missed during clinical practice and is associated with death in severe cases.[1,2]Here we reported a patient who was admitted to the hospital with severe metabolic acidosis and pulmonary hypertension and finally diagnosed with thiamine deficiency by detecting plasma vitamin B1 levels.Since clinically obvious thiamine deficiency is rare,and cases of thiamine deficiency requiring extracorporeal membrane oxygenation(ECMO)treatment are rarer,we believe that our case will be helpful for emergency clinicians. | Fangfang Qiu Weixing Dai Tengyue Huang Min Li | 2024 | World Journal of Emergency Medicine2024，15，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员