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| 1 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 2 | The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant显示文摘The anthocyanin content in apple skin determines its red coloration,as seen in a Fuji apple mutant.Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant.A novel R2R3-MYB transcription factor,MdMYB90-like,was uncovered as the key regulatory gene for enhanced coloration in the mutant.The expression of MdMYB90-like was 21.3 times higher in the mutant.MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis.MdMYB90-like bound to the promoters of both structural genes(MdCHS and MdUFGT)and other transcription factor genes(MdMYB1 and MdbHLH3)in the yeast one-hybrid system,electrophoretic mobility shift assay,and dual-luciferase assay.Transgenic analysis showed that MdMYB90-like was localized in the nucleus,and its overexpression induced the expression of other anthocyanin-related genes,including MdCHS,MdCHI,MdANS,MdUFGT,MdbHLH3,and MdMYB1.The mutant had reduced levels of DNA methylation in two regions(−1183 to−988 and−2018 to−1778)of the MdMYB90-like gene promoter,which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin. | Chao Sun Chunming Wang Wang Zhang Shuai Liu Weiyao Wang Xinyi Yu Tao Song Maxwell Yu Weichang Yu Shenchun Qu | 2021 | Horticulture Research2021，8，1： | 6 |
| 3 | Flavone Content and Bioactivity of Aqueous-Ethanolic Extracts of Phellinus Fruit Bodies显示文摘The flavone content of aqueous ethanolic extracts of Phellinus fruit bodies obtained from seven different locations was determined.Anti-tumor and antioxidant activities associated with the extracts were investigated in vitro using the Alamar Blue assay and a chemiluminecence-based method,respectively.Extracts of the seven Phellinus samples generated very similar HPLC profiles in qualitative terms although the areas of several peaks varied according to the sample type indicating quantitative differences in the case of some components.All the extracts,especially those of artificially cultivated Phellinus baumii fruit bodies,inhibited L1210 tumor cell proliferation and exhibited superoxide radical scavenging activity although there was no obvious correlation with flavone content. | HAO Ruixia ZHOU Shuai YANG Yan XI Junzhe LI Weiyao TANG Qingjiu WANG Chenguang | 2008 | 食用菌学报2008，15，2： | 6 |
| 4 | Magnetic plasmon resonances in nanostructured topological insulators for strongly enhanced light-MoS_(2) interactions显示文摘Magnetic resonances not only play crucial roles in artificial magnetic materials but also offer a promising way for light control and interaction with matter.Recently,magnetic resonance effects have attracted special attention in plasmonic systems for overcoming magnetic response saturation at high frequencies and realizing high-performance optical functionalities.As novel states of matter,topological insulators(TIs)present topologically protected conducting surfaces and insulating bulks in a broad optical range,providing new building blocks for plasmonics.However,until now,high-frequency(e.g.visible range)magnetic resonances and related applications have not been demonstrated in TI systems.Herein,we report for the first time,to our knowledge,a kind of visible range magnetic plasmon resonances(MPRs)in TI structures composed of nanofabricated Sb_(2)Te_(3) nanogrooves.The experimental results show that the MPR response can be tailored by adjusting the nanogroove height,width,and pitch,which agrees well with the simulations and theoretical calculations.Moreover,we innovatively integrated monolayer MoS_(2) onto a TI nanostructure and observed strongly reinforced light-MoS_(2) interactions induced by a significant MPR-induced electric field enhancement,remarkable compared with TI-based electric plasmon resonances(EPRs).The MoS_(2) photoluminescence can be flexibly tuned by controlling the incident light polarization.These results enrich TI optical physics and applications in highly efficient optical functionalities as well as artificial magnetic materials at high frequencies. | Hua Lu Zengji Yue Yangwu Li Yinan Zhang Mingwen Zhang Wei Zeng Xuetao Gan Dong Mao Fajun Xiao Ting Mei Weiyao Zhao Xiaolin Wang Min Gu Jianlin Zhao | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Rigid-Flexible Coupling Dynamic Analysis of Sub-Launched Vehicle During the Vertical Tube-Exit Stage显示文摘During the launching stage,hydrodynamic pressure and adapters' reaction loads can influence the vehicle's rigid motion as well as cause its structural vibration,which is a typical rigid-flexible coupling dynamic problem. This paper presents a 2-D rigid-flexible coupling model to calculate the vehicle's dynamic responses in that period.The vehicle was equivalent to a flexure beam with axial deformation. Hybrid coordinate and modal superposition methods were used to describe its large rigid displacement and small deformation. By the second Lagrange equation,the vehicle centroid's displacements,rotational angle and modal coordinates were chosen as generalized coordinates and then the vehicle 's rigid-flexible coupling dynamic equations were obtained. By numerical simulation,the results of vehicle's motion parameters and transverse internal loads were acquired.The calculation results showed that differences of the vehicle's motion parameters between the rigid-flexible coupling model and the rigid body assumption are noticeable and the peak magnitude of the vehicle's transverse internal loads in the rigid-flexible coupling model is higher remarkably than that in the rigid body assumption. | Weiyao Zhang Jingbo Gao Cong Wang | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，2： | 3 |
| 6 | Composite nonlinear feedback control for output regulation problem of linear discrete-time systems with input saturation显示文摘Transient performance for output regulation problems of linear discrete-time systems with input saturation is addressed by using the composite nonlinear feedback(CNF) control technique. The regulator is designed to be an additive combination of a linear regulator part and a nonlinear feedback part. The linear regulator part solves the regulation problem independently which produces a quick output response but large oscillations. The nonlinear feedback part with well-tuned parameters is introduced to improve the transient performance by smoothing the oscillatory convergence. It is shown that the introduction of the nonlinear feedback part does not change the solvability conditions of the linear discrete-time output regulation problem. The effectiveness of transient improvement is illustrated by a numeric example. | Chongwen Wang Xing Chu Weiyao Lan | 2014 | Journal of Systems Engineering and Electronics2014，25，6： | 2 |
| 7 | Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius显示文摘To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction. | TANG Ligen ZHU Weiyao ZHU Huayin SUN Chunhui YANG Fenglai WANG Yan Li Xiaorui Li Haiming CHU Guangzhen WANG Jieming KONG Debin YUE Ming LIU Yuwei HUANG Kun | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 8 | Neural network based robust adaptive control for a class of nonlinear systems represented by input-output models显示文摘 | Dan Wang Jialiang Huang Weiyao Lan | 2009 | Mathematics and Computers in Simulation2009，79，5： | 1 |
| 9 | Adaptive neural control for a class of uncertain nonlinear systems with unknow time delay显示文摘 | Dan Wang Weiyao Lan | 2009 | Int J of Robust and Nonlinear Control2009，19，7： | 1 |
| 10 | Genetic variation and an estimation of effective population size in the pearl oyster Pinctada martensii显示文摘 | Liu Qingyun Chen Weiyao Liu Jialiang Ronglian Huang Qingheng Wang Yu Jiao Du Xiaodong Deng Yuewen Li Junhui | 2014 | Biochemical Systematics and Ecology2014，，： | 1 |
| 11 | Neural network-based robust adaptive control of nonlinear systems with unmodeled dynamics显示文摘 | WANG Dan HUANG Jialiang LAN Weiyao | 2009 | Mathematics and Computers in Simulation2009，79，5： | 1 |
| 12 | Emerging weak antilocalization effect in Ta_(0.7)Nb_(0.3)Sb_(2)semimetal single crystals显示文摘Weak antilocalization(WAL)effect is commonly observed in low-dimensional systems,three-dimensional(3D)topological insulators and semimetals.Here,we report the growth of high-quality Ta_(0.7)Nb_(0.3)Sb_(2)single crystals via the chemical vapor transport(CVT).Clear sign of the WAL effect is observed below 50 K,probably due to the strong spin–orbital coupling in 3D bulk.In addition,it is worth noting that a relatively large MR of 120%appears under 1 T magnetic field at T=2 K.Hall measurements and two-band model fitting results reveal high carrier mobility(>1000 cm^(2)·V^(–1)·s^(–1)in 2–300 K region),and off-compensation electron/hole ratio of~8:1.Due to the angular dependence of the WAL effect and the fermiology of the Ta_(0.7)Nb_(0.3)Sb_(2)crystals,interesting magnetic-field-induced changes of the symmetry of the anisotropic magnetoresistance(MR)from two-fold(≤0.6 T)to four-fold(0.8–1.5 T)and finally to two-fold(≥2 T)are observed.This phenomenon is attributed to the mechanism shift from the low-field WAL dominated MR to WAL and fermiology co-dominated MR and finally to high-field fermiology dominated MR.All these signs indicate that Ta_(0.7)Nb_(0.3)Sb_(2)may be a topological semimetal candidate,and these magnetotransport properties may attract more theoretical and experimental exploration of the(Ta,Nb)Sb_(2)family. | Meng Xu Lei Guo Lei Chen Ying Zhang Shuang-Shuang Li Weiyao Zhao Xiaolin Wang Shuai Dong Ren-Kui Zheng | 2023 | Frontiers of physics2023，18，1： | 0 |
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