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| 1 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 2 | Flavone Content and Bioactivity of Aqueous-Ethanolic Extracts of Phellinus Fruit Bodies显示文摘The flavone content of aqueous ethanolic extracts of Phellinus fruit bodies obtained from seven different locations was determined.Anti-tumor and antioxidant activities associated with the extracts were investigated in vitro using the Alamar Blue assay and a chemiluminecence-based method,respectively.Extracts of the seven Phellinus samples generated very similar HPLC profiles in qualitative terms although the areas of several peaks varied according to the sample type indicating quantitative differences in the case of some components.All the extracts,especially those of artificially cultivated Phellinus baumii fruit bodies,inhibited L1210 tumor cell proliferation and exhibited superoxide radical scavenging activity although there was no obvious correlation with flavone content. | HAO Ruixia ZHOU Shuai YANG Yan XI Junzhe LI Weiyao TANG Qingjiu WANG Chenguang | 2008 | 食用菌学报2008，15，2： | 6 |
| 3 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 4 | Magnetic plasmon resonances in nanostructured topological insulators for strongly enhanced light-MoS_(2) interactions显示文摘Magnetic resonances not only play crucial roles in artificial magnetic materials but also offer a promising way for light control and interaction with matter.Recently,magnetic resonance effects have attracted special attention in plasmonic systems for overcoming magnetic response saturation at high frequencies and realizing high-performance optical functionalities.As novel states of matter,topological insulators(TIs)present topologically protected conducting surfaces and insulating bulks in a broad optical range,providing new building blocks for plasmonics.However,until now,high-frequency(e.g.visible range)magnetic resonances and related applications have not been demonstrated in TI systems.Herein,we report for the first time,to our knowledge,a kind of visible range magnetic plasmon resonances(MPRs)in TI structures composed of nanofabricated Sb_(2)Te_(3) nanogrooves.The experimental results show that the MPR response can be tailored by adjusting the nanogroove height,width,and pitch,which agrees well with the simulations and theoretical calculations.Moreover,we innovatively integrated monolayer MoS_(2) onto a TI nanostructure and observed strongly reinforced light-MoS_(2) interactions induced by a significant MPR-induced electric field enhancement,remarkable compared with TI-based electric plasmon resonances(EPRs).The MoS_(2) photoluminescence can be flexibly tuned by controlling the incident light polarization.These results enrich TI optical physics and applications in highly efficient optical functionalities as well as artificial magnetic materials at high frequencies. | Hua Lu Zengji Yue Yangwu Li Yinan Zhang Mingwen Zhang Wei Zeng Xuetao Gan Dong Mao Fajun Xiao Ting Mei Weiyao Zhao Xiaolin Wang Min Gu Jianlin Zhao | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Transient Performance Improvement in Tracking Control for a Class of Nonlinear Systems with Input Saturation显示文摘这份报纸探讨合成非线性的反馈(CNF ) 为有输入浸透的单个产量的非线性的系统与好短暂性能指向追踪改变引用的一时间的 singleinput 的一个类的控制。CNF 控制法律由一条追踪的控制法律和一个表演赔偿者组成。追踪的控制法律被设计驱使系统的输出追踪很快改变引用目标的时间,当性能赔偿者被用来减少追踪的控制法律引起的 overshoot 时。靠近环的系统的稳定性被建立。设计过程和靠近环的系统的短暂性能的改进与一个数字例子和控制凡·德尔·波尔振荡器被说明。 | LU Tao LAN Weiyao LI Zhibin | 2018 | Journal of Systems Science & Complexity2018，31，1： | 2 |
| 6 | Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius显示文摘To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction. | TANG Ligen ZHU Weiyao ZHU Huayin SUN Chunhui YANG Fenglai WANG Yan Li Xiaorui Li Haiming CHU Guangzhen WANG Jieming KONG Debin YUE Ming LIU Yuwei HUANG Kun | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 7 | Genetic variation and an estimation of effective population size in the pearl oyster Pinctada martensii显示文摘 | Liu Qingyun Chen Weiyao Liu Jialiang Ronglian Huang Qingheng Wang Yu Jiao Du Xiaodong Deng Yuewen Li Junhui | 2014 | Biochemical Systematics and Ecology2014，，： | 1 |
| 8 | CpG DNA enhances the im-mune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs显示文摘CpG DNA is DNA sequence that has immune stimulatory effects. Several lines of investigation over the past few years indicate that CpG DNA plays an important role in the induction of immune responses to DNA vaccines. In this study, CpG DNA-containing synthetic oligodeoxynucleotide (CpG-ODN) was cloned into the eukaryotic expression plasmid encoding a fusion protein containing b- galactosidase from E. coli and immunogenic epitopes of foot- and-mouth disease virus (FMDV) type O, and the immune responses induced by the plasmid were assayed. The results showed that guinea pigs immunized with the recombinant plasmid containing CpG-ODN generated a higher level of FMDV-neutralizing antibody and a stronger T cell proliferative response and protection against viral challenge than those receiving the plasmid containing no CpG-ODN. Our study demonstrated that it is an effective route to enhance the efficacy of DNA vaccines by inserting exogenous CpG DNA into the plasmids, and the DNA vaccine developed here is a promising candidate to prevent FMDV infection. | LI Guangjin LI Yingjie YAN Weiyao XU Quanxin WU Yongqing XIE Yong YOU Yongjin ZHENG Zhaoxin | 2001 | Chinese Science Bulletin2001，46，16： | 1 |
| 9 | Rapidly and mildly transferring anatase phase of graphene-activated TiO2 to rutile with elevated Schottky barrier:Facilitating interfacial hot electron injection for Vis-NIR driven photocatalysis显示文摘Visible and even infrared(IR)light-initiated hot electrons of graphene(Gr)catalysts are a promising driven power for green,safe,and sustainable H2O2 synthesis and organic synthesis without the limitation of bandgap-dominated narrow light absorption to visible light confronted by conventional photocatalyst.However,the life time of photogenerated hot electrons is too short to be efficiently used for various photocatalytic reactions.Here,we proposed a straightforward method to prolong the lifetime of photogenerated hot electrons from graphene by tuning the Schottky barrier at Gr/rutile interface to facilitate the hot electron injection.The rational design of Gr-coated TiO2 heterojunctions with interface synergy-induced decrease in the formation energy of the rutile phase makes the phase transfer of TiO2 support proceed smoothly and rapidly via ball milling.The optimized Gr/rutile dyad could provide a H2O2 yield of 1.05 mM·g-1·h-1 under visible light irradiation(λ≥400 nm),which is 30 times of the state-of-the-art noble-metal-free titanium oxide-based photocatalyst,and even achieves a H2O2 yield of 0.39 mM·g-1·h-1 on photoexcitation by near-infrared-region light(~800 nm). | Weiyao Hu Qiyuan Li Dong Xu Guangyao Zhai Shinan Zhang Dong Li Xiaoxiao He Jinping Jia Jiesheng Chen Xinhao Li | 2022 | Nano Research2022，15，12： | 0 |
| 10 | Emerging weak antilocalization effect in Ta_(0.7)Nb_(0.3)Sb_(2)semimetal single crystals显示文摘Weak antilocalization(WAL)effect is commonly observed in low-dimensional systems,three-dimensional(3D)topological insulators and semimetals.Here,we report the growth of high-quality Ta_(0.7)Nb_(0.3)Sb_(2)single crystals via the chemical vapor transport(CVT).Clear sign of the WAL effect is observed below 50 K,probably due to the strong spin–orbital coupling in 3D bulk.In addition,it is worth noting that a relatively large MR of 120%appears under 1 T magnetic field at T=2 K.Hall measurements and two-band model fitting results reveal high carrier mobility(>1000 cm^(2)·V^(–1)·s^(–1)in 2–300 K region),and off-compensation electron/hole ratio of~8:1.Due to the angular dependence of the WAL effect and the fermiology of the Ta_(0.7)Nb_(0.3)Sb_(2)crystals,interesting magnetic-field-induced changes of the symmetry of the anisotropic magnetoresistance(MR)from two-fold(≤0.6 T)to four-fold(0.8–1.5 T)and finally to two-fold(≥2 T)are observed.This phenomenon is attributed to the mechanism shift from the low-field WAL dominated MR to WAL and fermiology co-dominated MR and finally to high-field fermiology dominated MR.All these signs indicate that Ta_(0.7)Nb_(0.3)Sb_(2)may be a topological semimetal candidate,and these magnetotransport properties may attract more theoretical and experimental exploration of the(Ta,Nb)Sb_(2)family. | Meng Xu Lei Guo Lei Chen Ying Zhang Shuang-Shuang Li Weiyao Zhao Xiaolin Wang Shuai Dong Ren-Kui Zheng | 2023 | Frontiers of physics2023，18，1： | 0 |
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