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3篇 您的检索式：作者名="Weizhen Niu"

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		题名	作者	年代	出处	被引量
	1	One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘	Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou	2015	Cell Research2015，25，2：	39
	2	Watershed Allied Telemetry Experimental Research显示文摘	Li Xin Li Xiaowen Li Zengyuan Ma Mingguo Wang Jian Xiao Qing Liu Qiang Che Tao Chen Erxue Yan Guangjian Hu Zeyong Zhang Lixin Chu Rongzhong Su Peixi Liu Qinhuo Liu Shaomin Wang Jindi Niu Zheng Chen Yan Jin Rui Wang Weizhen Ran Youhua	2009	Journal of Geophysical Research Atmospheres2009，，22：	1
	3	ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors显示文摘Mechanosensitive ion channels(MSCs)are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2)and transient receptor potential vanilloid subfamily member 1(TRPV1)have been studied extensively and documented to play important roles.In this study,experiments using aortic arch-aortic nerve preparations isolated from rats revealed that both ASIC2 and TRPV1 are functionally necessary,as blocking either abrogated nearly all pressure-dependent neural discharge.However,whether ASIC2 and TRPV1 work in coordination remained unclear.So we carried out cell-attached patch-clamp recordings in HEK293T cells co-expressing ASIC2 and TRPV1 and found that inhibition of ASIC2 completely blocked stretch-activated currents while inhibition of TRPV 1 only partially blocked these currents.Immunofluorescence staining of aortic arch-aortic adventitia from rats showed that ASIC2 and TRPV1 are co-localized in the aortic nerve endings,and co-immunoprecipitation assays confirmed that the two proteins form a compact complex in HEK293T cells and in baroreceptors.Moreover,protein modeling analysis,exogenous co-immunoprecipitation assays,and biotin pull-down assays indicated that ASIC2 and TRPV1 interact directly.In summary,our research suggests that ASIC2 and TRPV1 form a compact complex and function synergisti-cally in the mechano-electrical transduction of arterial baroreceptors.The model of synergism between MSCs may have important biological significance beyond ASIC2 and TRPV 1.	Xiaodong Yan Sitao Zhang Haiyan Zhao Ping Liu Haixia Huang Weizhen Niu Wei Wang Chen Zhang	2021	Neuroscience Bulletin2021，37，10：	0

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