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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 3 | Variations in air temperature during the last 100 years revealed by δ^(18)O in the Malan ice core from the Tibetan Plateau显示文摘By comprehensive analyses, it was found that the variations in d 18O recorded in Malan ice core from theKekexili Region on the Tibetan Plateau could represent thechanges in air temperature during the summer half year (from May to October) over the Kekexili Region and the northern margin of the Tibetan Plateau. The general increase trend in d18O in this ice core during the past century indicated climate warming, and it was estimated that air temperature during the summer half-year rose about 1.2C over there then. However, this ice core record documented that the study area has been cooling while most of the world has been dramatically warming since the late 1970s. A teleconnection was foundbetween the variations in d 18O in the Malan ice core and the North Atlantic Oscillation. Moreover, the variations in d 18O in this ice core were similar to that in the summer half-year air temperature over the southern Tibetan Plateau on thecenturial time scale, but opposite on the multidecadal timescale. | WANG Ninglian, YAO Tandong, PU Jianchen, ZHANG Yongliang, SUN Weizhen & WANG Youqing Key Laboratory of Ice Core and Cold Regions Environment, Cold and Arid Regions Environmental and Engineering Research Institute, ChineseAcademy of Sciences, Lanzhou 730000, China | 2003 | Chinese Science Bulletin2003，48，19： | 19 |
| 4 | Relative humidity reconstruction for northwestern China's Altay Mountains using tree-ring δ^(18)O显示文摘Relative humidity is an important factor in water and water vapor feedback cycles.In this study,we established a 222-year annual tree-ring δ^(18)O chronology for Siberian larch(Larix sibirica Ldb.)from the Altay Mountains in northwestern China.Climate response analyses revealed that the relative humidity was the primary factor limiting tree-ring δ^(18)O fractionation.Based on our analysis,tree-ring δ^(18)O can be used to reconstruct the July–August relative humidity based on both a reasonable mechanism of tree-ring δ^(18)O fractionation and a statistically significant regression model.We used this model to reconstruct variations in the July–August relative humidity,and the model explained 47.4% of the total variation in the measured relative humidity data from 1961 to 2011.The relative humidity in the study area increased from 1900 to the 1990s and decreased thereafter.Two regime-shift dry periods were detected during the study period(one from 1817 to 1830 and the other from 2004 to 2011). | Guobao Xu Xiaohong Liu Dahe Qin Tuo Chen Wenzhi Wang Guoju Wu Weizhen Sun Wenling An Xiaomin Zeng | 2014 | Chinese Science Bulletin2014，59，2： | 14 |
| 5 | Moisture variations over the past millennium characterized by Qaidam Basin tree-ring δ^(18)O显示文摘High-resolution tree-ring δ18O chronologies covering the last millennium,although scarce,are essential in understanding patterns of climatic changes in the northeastern region of the Qinghai-Tibetan Plateau.For this study,a tree-ring δ18O chronology with a temporal resolution of 3-years was developed from the long-lived Qilian juniper(Sabina przewalskii Kom.),extending back in time to AD 991.This long δ18O chronology was significantly correlated with the yearly δ18O in tree rings during the common period from 1800 to 2006,and was an effective proxy for relative humidity during the growing season.A low-frequency moisture pattern signified the occurrence of a slight drought during the Medieval Climate Anomaly,a marked occurrence of a wet period during the Little Ice Age,and a trend in increasing moisture levels,although lower than average,alongside the Twentieth Century warming trend.Comparisons to other hydroclimatic reconstructions indicate that this tree-ring18O chronology serves as a reliable paleo-humidity proxy for the Qaidam Basin as well as documenting details of past humidity levels in the region. | WANG WenZhi LIU XiaoHong XU GuoBao SHAO XueMei QIN DaHe SUN WeiZhen AN WenLing ZENG XiaoMin | 2013 | Chinese Science Bulletin2013，58，32： | 14 |
| 6 | Climatic significance of δ^(18)O records from precipitation on the western Tibetan Plateau显示文摘Analysis of daily precipitation samples for stable oxygen isotopes (δ18O) collected at the Shiquanhe and Gêrzê (Gaize, Gertse) stations in the Ngari (Ali) region on the western Tibetan Plateau indicates that air temperature affects the δ18O variations in precipitation at these stations. In summer, Shiquanhe and Gêrzê show strongly similar trends in precipitation δ18O, especially in simultaneous precipitation events. Moreover, both stations experienced low δ18O values in precipitation during the active monsoon period, resulting from the southwest monsoon (the summer phase of the Indian monsoon). However, during the break monsoon period (during the summer rainy season, when the monsoon circulation is disrupted), δ18O values in summer precipitation remain relatively high and local moisture recycling generally controls the moisture sources. Air temperature correlations with δ18O strengthen during the non-monsoon period (January―June, and October―December) due to continental air masses and the westerlies. In addition, evaporation also influences the δ18O variations in precipitation. The observed temporal and spatial variations of δ18O in precipitation on the western Tibetan Plateau and adjacent regions show that the late May and early June-the late August and early September time frame provides an important period for the transportation of moisture from various sources on the Tibetan Plateau, and that the region of the West Kunlun-Tanggula Ranges acts as a significant climatic divide on the Plateau, perhaps for all of western China. | YU WuSheng MA YaoMing SUN WeiZhen WANG Yu | 2009 | Chinese Science Bulletin2009，54，16： | 9 |
| 7 | Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice显示文摘A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate(PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer's disease(AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a single intraperitoneal(i.p.) injection of lipopolysaccharide(LPS). Levels of i NOS and the cytokines TNFα, IL-1β and IL-10 were elevated in plasma, cerebral cortex and hippocampus after LPS injection and the number of microglia and astrocytes in cortex and hippocampus were increased. LPS also upregulated the expression of heme oxygenase-1(HO-1) in the cortex and hippocampus. PHPB reduced the levels of i NOS and cytokines in the plasma and brain, decreased the number of microglia and astrocytes and further enhanced the upregulation of HO-1. In addition, PHPB inhibited the LPS-induced phosphorylation of ERK, P38 and JNK. These results suggest that PHPB is a potential candidate in the treatment of neurodegenerative diseases through inhibiting neuroinflammation. | Chunyang Zhao Weizhen Hou Hui Lei Longjian Huang Shan Wang Dandan Cui Changhong Xing Xiaoliang Wang Ying Peng | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 8 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 9 | Wet-chemistry synthesis of cobalt carbide nanoparticles as highly active and stable electrocatalyst for hydrogen evolution reaction显示文摘转变金属碳化物(TMC ) nanomaterials 正在答应选择到磅,并且广泛地为电气化学的氢进化反应被用作异构的 electrocatalysts (她的) 。在这个工作,综合的导致溴化物的湿化学的策略公司 2 C nanoparticles (NP ) 被开发。如此的 NP 展出了高 electrocatalytic 活动(= 为 j = 的 181 mV 10 | Siwei Li Ce Yang Zhen Yin Hanjun Yang Yifu Chen Lili Lin Mengzhu Li Weizhen Li Gang HU Ding Ma | 2017 | Nano Research2017，10，4： | 7 |
| 10 | Distribution of δ^(18)O in surface snow along a transect from Zhongshan Station to Dome A,East Antarctica显示文摘Surface snow samples were collected during the 14th(1997/1998)and 24th(2007/2008)Chinese National Antarctica Research Expeditions along a transect from Zhongshan Station to Dome A.The stable oxygen isotope ratios of these samples were measured to investigate their relationships with temperature and geographical parameters(latitude,longitude,altitude and distance to the coast).The results reveal a strong positive correlation(R=0.945)betweenδ18O and mean annual temperature,with a gradient of 0.84‰°C-1,which is a little higher than that in Terre Adelie Land.Regression analyses also show that theδ18O of surface snow is strongly correlated with distance to the coast(R=0.942),latitude(R=0.942),and altitude(R=0.941).But no significant correlation was found betweenδ18O and longitude in study area.Altitude should be the most important factor influencing the δ18O distribution because of distinctive topography.Theδ18O-altitude and T-altitude gradients along this transect are determined to be-1.1‰/100 m and 1.31°C/100 m,respectively. | DING MingHu XIAO CunDe JIN Bo REN JiaWen QIN DaHe SUN WeiZhen | 2010 | Chinese Science Bulletin2010，55，24： | 7 |
| 11 | mTOR and the differentiation of mesenchymal stem cells显示文摘rapamycin (mTOR ) 的哺乳动物的目标, evolutionarily 保存的 serinethreonine 蛋白质 kinase,属于 phosphoinositide 3-kinase (PI3K ) 联系了 kinase 家庭,它在他们的 C 终端区域以内包含一个类脂化合物象 kinase 一样领域。当一个批评细胞内部的分子能察觉到细胞外的精力地位并且在许多房间和纸巾调整房间生长和增长,最近的研究揭示了那 mTOR。这评论在房间区别和织物开发上关于 mTOR 的效果总结我们的当前的理解,与间充质的干细胞的系决心上的一个重音。mTOR 能在白 adipocytes,棕色的 adipocytes,和肌肉卫星房间支持 adipogenesis,当 rapamycin 禁止 mTOR 的 adipogenic 功能时。发信号的 mTOR 可以工作然而,影响造骨细胞增长和区别 rapamycin 被报导了禁止或支持成骨。尽管精确机制仍然保持不清楚, mTOR 为 myogenesis 是不可缺少的。取决于房间别打, rapamycin 被报导了禁止,支持,或有 myogenesis 上的效果。 | Xinxin Xiang Jing Zhao Geyang Xu Yin Li Weizhen Zhang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 12 | Low frequency oscillation characteristics of East China Power Grid after commissioning of Huai-Hu ultra-high voltage alternating current project显示文摘The low frequency oscillation characteristics of East China Power Grid after commissioning of the first ultra-high voltage alternating current(UHVAC)project-the Huai-Hu UHVAC project are studied.Several low frequency oscillation cases occurred in East China Power Grid in the past few years are reviewed and summarized.Based on the analysis of the different typical operation modes,the main low frequency oscillation modes in East China Power Grid in the early stages of development of ultra-high voltage(UHV)are summarized,and the impacts of the significant power grid maintenance on low frequency oscillation characteristics are analyzed.Besides,the oscillation mode of UHV generators to East China Power Grid is researched,and the importance of the power system stabilizator(PSS)is emphasized.Furthermore,the comparative analysis between the time domain and the frequency domain is carried out,and the influences of the governing system on low frequency oscillation characteristics are revealed.Finally,both the focus and the direction of low frequency oscillation research are presented. | Chao WANG Yang LV Hongyang HUANG Jing ZHANG Jihong LI Yingyi LI Weizhen SUN Yong CHANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 6 |
| 13 | Comparative analysis of A,B,C and D genomes in the genus Oryza with C_(0)t-1 DNA of C genome显示文摘Fluorescence in situ hybridization (FISH)was applied to somatic chromosomes preparations of Oryza officinalis Wall. (CC), O. sativa L. (AA)×O. offi-cinalis F1 hybrid (AC), backcross progenies BC1 (AAC and ACC), O. latifolia Desv. (CCDD), O. alta Swallen (CCDD) and O. punctata Kotschy (BBCC) with a labelled probe of C0t-1 DNA from O. officinalis. In O. officinalis, the homologous chromosomes showed similar signal bands probed by C0t-1 DNA and karyotype analysis was conducted based on the band patterns. Using no blocking DNA, the probe identified the chromosomes of C genome clearly, but detected few signals on chromosomes of A genome in the F1 hybrid and two backcross progenies of BC1. It is obvious that the highly and moderately repetitive DNA sequences were considerably different between C and A genomes. The chromosomes of C genome were also discriminated from the chromosomes of D- and B-genome in the tetraploid species O. latifolia, O. alta and O. punctata by C0t-1 DNA-FISH. Compari-son of the fluorescence intensity on the chromo-somes of B, C and D genomes in O. latifolia, O. alta, and O. punctata indicated that the differentiations between C and D genomes are less than that be-tween C and B genomes. The relationship between C and D genomes in O. alta is closer than that of C and D genomes in O. latifolia. This would be one of thecauses for the fact that both the genomes are of the same karyotype (CCDD) but belong to different spe-cies. The above results showed that the C0t-1 DNA had a high specificity of genome and species. In this paper, the origin of allotetraploid in genus Oryza is also discussed. | LAN Weizhen QIN Rui LI Gang HE Guangcun | 2006 | Chinese Science Bulletin2006，51，14： | 6 |
| 14 | Response of monsoon vari-ability in Himalayas to global warming显示文摘Reconstructed annual net accumulation from the Dasuopu ice core recovered in Himalayas, with a good correlation to Indian monsoon, reflects a major precipitation trend in central Himalayas. The Dasuopu accumulation (DSP An) also shows a strong correlation to the Northern Hemispheric temperature. Generally, as the Northern Hemispheric temperature increases by 0.1 K, the accumulation decreases by about 90 mm and vise versa. Under the condition of global warming, especially since 1920, the Northern Hemispheric mean temperature has increased by about 0.5 K, whereas accumulation in Dasuopu ice core has decreased by about 450 mm. According to the relationship between accumulation and temperature, a scenario prediction of monsoon rainfall in central Himalayas is made. | DUAN Keqin YAO Tandong PU Jianchen SUN Weizhen | 2002 | Chinese Science Bulletin2002，47，21： | 6 |
| 15 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 16 | Simultaneous removal of Cu(Ⅱ) and Cr(Ⅵ) by Mg–Al–Cl layered double hydroxide and mechanism insight显示文摘Mg–Al–Cl layered double hydroxide(Cl-LDH) was prepared to simultaneously remove Cu(Ⅱ)and Cr(VI) from aqueous solution. The coexisting Cu(Ⅱ)(20 mg/L) and Cr(VI)(40 mg/L) were completely removed within 30 min by Cl-LDH in a dosage of 2.0 g/L; the removal rate of Cu(Ⅱ) was accelerated in the presence of Cr(VI). Moreover, compared with the adsorption of single Cu(Ⅱ) or Cr(VI), the adsorption capacities of Cl-LDH for Cu(Ⅱ) and Cr(VI) can be improved by 81.05% and 49.56%, respectively, in the case of coexisting Cu(Ⅱ)(200 mg/L) and Cr(VI)(400 mg/L). The affecting factors(such as solution initial p H, adsorbent dosage, and contact time) have been systematically investigated. Besides, the changes of p H values and the concentrations of Mg^(2+) and Al^(2+)in relevant solutions were monitored. To get the underlying mechanism, the Cl-LDH samples before and after adsorption were thoroughly characterized by X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. On the basis of these analyses, a possible mechanism was proposed. The coadsorption process involves anion exchange of Cr(VI) with Cl-in Cl-LDH interlayer, isomorphic substitution of Mg^(2+) with Cu^(2+), formation of Cu_2Cl(OH)_3precipitation, and the adsorption of Cr(VI) by Cu_2Cl(OH)_3. This work provides a new insight into simultaneous removal of heavy metal cations and anions from wastewater by Cl-LDH. | Xianyang Yue Weizhen Liu Zuliang Chen Zhang Lin | 2017 | Journal of Environmental Sciences2017，29，3： | 6 |
| 17 | Gliquidone versus metformin: differential effects on aorta in streptozotocin induced diabetic rats显示文摘 | Tan Zhongju Xu Zherong Gui Qifeng Wu Weizhen Yang Yunmei | 2014 | Chinese Medical Journal2014，，7： | 4 |
| 18 | Recent progress in ZnO-based heterojunction ultraviolet light-emitting devices显示文摘Wide bandgap(3.37 eV)and high excitonbinding energy of ZnO(60 meV)make it a promising candidate for ultraviolet light-emitting diodes(LEDs)and low-threshold lasing diodes(LDs).However,the difficulty in producing stable and reproducible high-quality p-type ZnO has hindered the development of ZnO p–n homojunction LEDs.An alternative strategy for achieving ZnO electroluminescence is to fabricate heterojunction devices by employing other available p-type materials(such as p-GaN)or building new device structures.In this article,we will briefly review the recent progress in ZnO LEDs/LDs based on p–n heterostructures and metal–insulatorsemiconductor heterostructures.Some methods to improve device efficiency are also introduced in detail,including the introduction of Ag localized surface plasmons and single-crystalline nanowires into ZnO LEDs/LDs. | Yichun Liu Haiyang Xu Chunyang Liu Weizhen Liu | 2014 | Chinese Science Bulletin2014，59，12： | 4 |
| 19 | Optically stimulated luminescence dosimeter based on CaS:Eu,Sm显示文摘Alkaline earth sulfides (MgS,CaS and BaS) crystal doped with rare-earth ions is an optically stimulated luminescence dosimeter with very high sensitivity,short time constant of the optically stimulated luminescence (OSL) separated perfectly from the stimulation.In this paper,an OSL dosimeter is described.It has linear dose response from 0.01 to 1000 Gy.The equipment,relatively simple and small in size is promising for applications in space exploration and for high dose irradiation and dangerous irradiation conditions. | LIU Yanping CHEN Zhaoyang BA Weizhen FAN Yanwei GUO Qi YU Xuefeng CHANG Aiming LU Wu DU Yanzhao | 2008 | Nuclear Science and Techniques2008，19，2： | 4 |
| 20 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
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