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| 1 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 2 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 3 | The association of heart rate variability with parkinsonian motor symptom duration显示文摘 | Harnod D Wen SH Chen SY | 2014 | Yonsei Med J2014，55，： | 1 |
| 4 | Plexin-A4-semaphorin 3a signaling is required for toll-like receptor-and sepsis-induced cytokine storm显示文摘 | Wen H Lei Y Eun SY | | 0，，13： | 1 |
| 5 | Oxidative stress-mediated apoptosis显示文摘 | Wen J You KR Lee SY | 2002 | J Biol Chem2002，277，38： | 1 |
| 6 | Fabrication and optimization of the multiplex PCR-based oligonucleotide microarray for detection of Neisseria gonorrhoeae,Chlamydia trachomatis and Ureaplasma urealyticum显示文摘 | Shi G Wen SY Chen SH | 2005 | J Microbiol Methods2005，62，2： | 1 |
| 7 | Oxidative stress-mediated apoptosis 显示文摘 | Wen J You KR Lee SY | 2002 | J Biol Chem2002，277，38： | 1 |
| 8 | Application site adverse events associated with the buprenorphine transdermal system:a pooled analysis显示文摘 | WEN W LYNCH SY MUNERA C | 2013 | Expert Opin Drug Saf2013，12，3： | 1 |
| 9 | Preparation of mPEG_(2000) - PLA- modified Xingnaojing microemulsion and evaluation in mucosal irri-tation 显示文摘 | Wen R Li HY Du SY | 2014 | J B iomaterials Sci2014，25，9： | 1 |
| 10 | Enhancement of Cardiac Function and Suppression of Heart Failure Progression By Inhibition of Protein Phosphatase 1显示文摘 | Anand Pathak Federica del Monte Wen Zhao Jo-El Schultz John N. Lorenz Ilona Bodi Doug Weiser Harvey Hahn Andrew N. Carr Faisal Syed Nirmala Mavila Leena Jha Jiang Qian Yehia Marreez Guoli Chen Dennis W. McGraw E Kevin Heist J Luis Guerrero Anna A. DePaoli | 2005 | Circulation Research2005，，7： | 1 |
| 11 | Studies on the control of hookworm and other soil-transmitted helminthiases in farmers in Zhejiang Province, China显示文摘 | Xia ZH Yao SY Wen LY | 1991 | Southeast Asian J Trop Med Public Health1991，22，： | 1 |
| 12 | Multiple system atrophy:a review of 203 pathologically proven cases 显示文摘 | Wenning GK Tison F Ben SY | 1997 | Mov Disord1997，12，2： | 1 |
| 13 | Oxidantive stress - mediated apoptosis显示文摘 | Wen J You KR Lee SY | 2002 | J Biol Chem2002，277，38： | 1 |
| 14 | DNA microarrays assay for simultaneous detection and identification of multiple common intestinal pathogens显示文摘 | Jin DZ Liu GC Wen SY | 2008 | Molecular~Cellular Probes2008，89，20： | 1 |
| 15 | A preliminary study towards downregulation of murine bone marrow eosinophilopoiesis mediated by small molecule inhibition of interleukin-5 receptor alpha gene in vitro显示文摘 | Mao H Wen FO Li SY | 2007 | Respiration2007，74，3： | 1 |
| 16 | Angiolymphoid hyperplasia with eosinophilia in the shoulder显示文摘 | Wen SY | 2001 | Inte J Dermatol2001，40，： | 1 |
| 17 | Multiple system atro- phy : a review of 203 pathologically proven cases 显示文摘 | Wenning GK Tison F Ben SY | 1997 | Mov Disord1997，12，2： | 1 |
| 18 | Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizinin licorice decoction显示文摘 | Hou YC Hsiu SL Ching H Lin YT Tsai SY Wen KC | 2005 | Life Sci2005，76，： | 1 |
| 19 | Application site adverse events associated with the buprenorphine transdermal system: a pooled analysis显示文摘 | Wen W Lynch SY Muner AC | 2013 | Expert Opin Drug Saf2013，12，3： | 1 |
| 20 | Treatment selection and outcomes: re- nal calculi 显示文摘 | WEN CC NAKADA SY | 2007 | Urol Clin North Am2007，34，3： | 1 |
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