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| 1 | TBM penetration rate prediction based on the long short-term memory neural network显示文摘Tunnel boring machines(TBMs)are widely used in tunnel engineering because of their safety and efficiency.The TBM penetration rate(PR)is crucial,as its real-time prediction can reflect the adaptation of a TBM under current geological conditions and assist the adjustment of operating parameters.In this study,deep learning technology is applied to TBM performance prediction,and a PR prediction model based on a long short-term memory(LSTM)neuron network is proposed.To verify the performance of the proposed model,the machine parameters,rock mass parameters,and geological survey data from the water conveyance tunnel of the Hangzhou Second Water Source project were collected to form a dataset.Furthermore,2313 excavation cycles were randomly composed of training datasets to train the LSTM-based model,and 257 excavation cycles were used as a testing dataset to test the performance.The root mean square error and the mean absolute error of the proposed model are 4.733 and 3.204,respectively.Compared with Recurrent neuron network(RNN)based model and traditional time-series prediction model autoregressive integrated moving average with explanation variables(ARIMAX),the overall performance on proposed model is better.Moreover,in the rapidly increasing period of the PR,the error of the LSTM-based model prediction curve is significantly smaller than those of the other two models.The prediction results indicate that the LSTM-based model proposed herein is relatively accurate,thereby providing guidance for the excavation process of TBMs and offering practical application value. | Boyang Gao RuiRui Wang Chunjin Lin Xu Guo Bin Liu Wengang Zhang | 2021 | Underground Space2021，6，6： | 4 |
| 2 | Design and optimization on rootstock cutting mechanism of grafting robot for cucurbit显示文摘Cutting mechanisms in existing grafting machines are unable to completely cut through the rootstock growth point and can easily damage seedlings.During the mechanical operation of splice grafting,the cutting angle of the rootstock is an essential factor for ensuring the quality and survival rate of grafting seedlings and a stable process for grafting robots.Therefore,in this study,commonly used grafting rootstocks,e.g.,cucurbita moschata,and calabash gourd were used as research objects for studying and analyzing the cutting angle of a splice grafting method.The morphological and structural parameters of the rootstock and scion were measured,and a structural model of the internal cavity of the rootstock was constructed using an image analysis method.The critical cutting angles for the cucurbita moschata and calabash gourd seedlings were obtained.According to the analysis,the grafting cutting angles for cucumber seedlings matching with cucurbita moschata seedlings were 20°and 25°,respectively,and the fitting rate of the cutting surface of the rootstock and scion was 99.04%.A cutting mechanism for the rootstock growth point and geometric model of the cutting operation were established,and the structural parameters of the mechanism and cutting angle adjustment were optimized.A cutting performance test showed that the success rate of the pressing the cotyledons of cucurbita moschata seedlings was 96.67%,and the success rate of cutting was 98%.The cutting accuracy was 96.8%,and the cutting surface fitting rate of the rootstock and scion was 98.61%.The latter differed by 0.43%from the theoretical rate but met the requirements for the splice grafting method.Thus,this study can provide a reference for the design of a cutting mechanism for a grafting robot. | Kai Jiang Qian Zhang Liping Chen Wenzhong Guo Wengang Zheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
| 3 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 4 | Transjugular Intrahepatic Portosystemic Shunt for Portal Cavernoma with Symptomatic Portal Hypertension in Non-cirrhotic Patients显示文摘 | Xingshun Qi Guohong Han Zhanxin Yin Chuangye He Jianhong Wang Wengang Guo Jing Niu Wei Zhang Ming Bai Daiming Fan | 2012 | Digestive Diseases and Sciences2012，，4： | 1 |
| 5 | Transarterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: Prognostic Factors in a Single-Center Study of 188 Patients显示文摘 | Lei Liu Cheng Zhang Yan Zhao Xingshun Qi Hui Chen Wei Bai Chuangye He Wengang Guo Zhanxin Yin Daiming Fan Guohong Han Qing He | 2014 | BioMed Research International2014，，： | 1 |
| 6 | Structure and Electrochemical Hydrogen Storage Properties of as-Milled Mg-Ce-Ni-Al-Based Alloys显示文摘At room temperature,crystalline Mg-based alloys,including Mg2 Ni,MgNi,REMg12 and La2 Mg17,have been proved with weak electrochemical hydrogen storage performances.For improving their electrochemical property,the Mg is partially substituted by Ce in Mg-Ni-based alloys and the surface modification treatment is performed by mechanical coating Ni.Mechanical milling is utilized to synthesize the amorphous and nanocrystalline Mg1-xCexNi0.9Al0.1(x=0,0.02,0.04,0.06,0.08)+50 wt%Ni hydrogen storage alloys.The effects made by Ce substitution and mechanical milling on the electrochemical hydrogen storage property and structure have been analyzed.It shows that the as-milled alloys electrochemically absorb and desorb hydrogen well at room temperature.The as-milled alloys,without any activation,can reach their maximal discharge capacities during first cycling.The maximal value of the 30-h-milled alloy depending on Ce content is 578.4 mAh/g,while that of the x=0.08 alloy always grows when prolonging milling duration.The maximal discharge capacity augments from337.4 to 521.2 mAh/g when milling duration grows from 5 to 30 h.The cycle stability grows with increasing Ce content and milling duration.Concretely,the S100 value augments from 55 to 82%for the alloy milled for 30 h with Ce content rising from 0 to 0.08 and from 66 to 82%when milling the x=0.08 alloy mechanically from 5 to 30 h.The alloys’electrochemical dynamics parameters were measured as well which have maximum values depending on Ce content and keep growing up with milling duration extending. | Yanghuan Zhang Zhenyang Li Wei Zhang Wengang Bu Yan Qi Shihai Guo | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 1 |
| 7 | Structure and electrochemical hydrogen storage behaviors of Mg-Ce-Ni-Al-based alloys prepared by mechanical milling显示文摘The influences of milling time and Ce content on the electrochemical property and micro structure of asmilled Mg1-xCexNi0.9Al0.1(x=0,0.02,0.04,0.06,0.08)+50 wt%Ni alloys were investigated systematically.The as-milled alloys have an outstanding activation property.The cycle stability conspicuously grows up with milling time and Ce proportion increasing.The capacity retention rate at 100 th cycle of x=0.02 alloy augments from 47% to 63% when prolonging milling time from 5 to 30 h and it grows from55% to 82% for the 30 h milled alloy with Ce content growing from 0 to 0.08.The discharge capacity of x=0.02 alloy grows up invariably with milling time prolonging,while that of the 30 h milled alloys has the maximal value of 578.4 mAh/g with Ce content increasing.Moreover,the electrochemical kinetic properties of alloys significantly improve with milling duration extending,while they have the maximal values with Ce proportion varying. | Yanghuan Zhang Pengpeng Wang Wei Zhang Wengang Bu Yan Qi Shihai Guo | 2020 | Journal of Rare Earths2020，38，10： | 1 |
| 8 | CT features of non-malignant portal vein thrombosis: A pictorial review显示文摘 | Xingshun Qi Guohong Han Chuangye He Zhanxin Yin Wengang Guo Jing Niu Daiming Fan | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，6： | 1 |
| 9 | Transjugular Intrahepatic Portosystemic Shunt for Portal Cavernoma with Symptomatic Portal Hypertension in Non-cirrhotic Patients显示文摘 | Xingshun Qi Guohong Han Zhanxin Yin Chuangye He Jianhong Wang Wengang Guo Jing Niu Wei Zhang Ming Bai Daiming Fan | 2012 | Digestive Diseases and Sciences2012，，4： | 1 |
| 10 | Cavernous vessels around a patent portal trunk in the liver hilum显示文摘 | Xingshun Qi Guohong Han Zhanxin Yin Chuangye He Wengang Guo Jing Niu Kaichu Wu Daiming Fan | 2012 | Abdominal Imaging2012，，3： | 1 |
| 11 | Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island,Shanghai显示文摘Background:Antimicrobial resistance(AMR)is one of the greatest threats to animal and public health.Here,we conducted a dynamic surveillance of Escherichia coli on Chongming Island in Shanghai during 2009-2021 to identify the characteristics and trends of Chongming’s AMR pandemic.Methods:Rectal(cloaca)swabs from four poultry and nine swine farms(Chongming Island,2009-2021)were collected for E.coli strains acquisition.The micro-broth dilution method was used to test antimicrobial susceptibility of E.coli isolates against 10 antimicrobial classes including 15 antimicrobials.Utilizing generalized linear mixed models(GLMMs)and co-occurrence analyses,we further explored the multiple-drug-resistance(MDR)combinations and dynamic patterns of E.coli over 10 years in two food animals.Results:Total of 863 MDR isolates were found among 945 collected E.coli isolates,337 from poultry and 608 from swine.Both isolates exhibited high resistant rates(>70%)to tetracyclines,phenicols,sulfonamides,penicillins,and aminoglycosides(only in swine).The resistant rates of swine isolates to penicillins,aminoglycosides,tetracyclines,phenicols,and polymyxins were significantly higher than those of poultry isolates,whereas resistance to fluoroquinolones was reversed.Resistance to polymyxins decreased similarly in swine(42.4%in 2009 to 0.0%in 2021)and poultry isolates(from 16.5%to 0.0%).However,resistance to other seven antimicrobial classes(excluding carbapenems and penicillins)declined dramatically in swine isolates,particularly fluoroquinolones(from 80.5%to 14.4%),and tendencies of resistance to the seven classes showed markedly divergent patterns in poultry isolates.Using Poisson GLMMs,the AMR carriage since 2016 was significantly lower than that of 2009(odds ratio<1),indicating a decline in the risk of MDR emergence.Furthermore,despite the highly diverse MDR profiles,co-occurrence analysis identified two prominent MDR clusters of penicillins-phenicols-fluoroquinolones in poultry and aminoglycosides-tetracyclines-sulfonamides-phenicols in swine.Conclusions:Our study uncovered vastly distinct AMR patterns and dynamic tendencies of poultry and swine E.coli isolates from Chongming.Meanwhile,Chongming’s AMR status has ameliorated,as indicated by the decline in antimicrobials prevalence(particularly in swine),lower likelihood of MDR emergence and low carbapenem-,cephalosporin-,and polymyxin resistance.Importantly,this surveillance results are the vital basis for future policy development in Chongming and Shanghai. | Chao Lv Jun Shang Wengang Zhang Bingqing Sun Min Li Chaoyi Guo Nan Zhou Xiaokui Guo Shixin Huang Yongzhang Zhu | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
| 12 | Highly Enantioselective Reactions of Cyclohexanone and β,γ-Unsaturated α-Keto Ester: The Tuning of Chemoselectivities by Secondary and Primary Amine Catalysts显示文摘A series of of amphiphilic imidazole based secondary and primary amine catalysts were synthesized and shown to be very effective with an acid cocatalyst for the asymmetric reaction of cyclohexanone to β,γ-unsaturated α-keto ester.Interestingly,primary and secondary amine catalysts show different regio-selectivities in this reaction.Under the catalysis of secondary amine 1,excellent enantioselectivities were observed for the products from direct 3+3 reactions of cyclohexanone withβ,γ-unsaturated α-keto esters using water as the solvent.Moreover,the same reactants catalyzed by the primary amines 2 lead to the aldol reactions,affording the corresponding products with high diastereoselectivities and up to 97%ee.Theoretical studies on the transition states by using a model in gas phase revealed that steric effect plays an important role on different chemo-selective induction between the secondary amine 1 and primary amine 2. | Jianwei Wei Wengang Guo Xin Zhou Xin Du Yan Liu Can Li | 2014 | Chinese Journal of Chemistry2014，32，10： | 0 |
| 13 | Design and experiment on scion cutting mechanism of grafting robot for cucurbit显示文摘The scion cutting mechanism of the traditional grafting machine cannot correct the bending degree of the scion seedling stem so that the cutting angle of the scion seedling is not standard and the survival rate of the grafted seedling is affected.In this study,cucumber seedlings and watermelon seedlings were taken as experimental objects.Based on the analysis of the geometric parameters and mechanical characteristics of scion seedlings,a scion cutting mechanism with holding seedling applied to cucumber seedlings and watermelon was designed and developed.The main structure and operating parameters of V-shaped holding seedling block and cutting unit were determined,and holding seedling and cutting performance tests were carried out.The test results showed that compared with the common arc clamp,the V-shaped holding seedling block had a better guiding and centering effect on the scion seedling,could better correct the bending state of the scion seedling stem,and the success rate of holding seedling of the V-shaped holding block reached 98.33%,which was increased by 13.33%compared with the arc-shaped clamp,and the seedling injury rate was only 1.67%.The upper and lower two-point positioning of scion stem by clamping hand and holding seedling block can improve the cutting performance effectively.The cutting accuracy rate of the scion was 97.75%,and the cutting success rate was 98.67%.The cutting performance was closely related to the holding seedling effect.The research results can provide a reference for the design of cutting mechanisms of melon grafting robots. | Liping Chen Kai Jiang Qian Zhang Wenzhong Guo Wengang Zheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 0 |
| 14 | Numerical Simulation of Thermal Stress Field of Water-cooled-wall Pulverized-coal Gasifiers显示文摘the stress field in the gasifier operation to research the damage of refractories and slag layer caused by the thermal stress.The results reveal that:(1)the maximum stress of water-cooled-wall gasifier appears at the interface between anchor nails and refractories as well as the interface between refractories and the slag layer,and the maximum stress of slag layer appears on the surface of the slag layer;(2)the increase of slag layer thickness can significantly reduce the thermal stress at the interface between anchor nails and refractories,but increase the thermal stress between slag layer and refractories;(3)when the thermal conductivity is 2-6 W•m^-1•K^-1,the thermal stress increases rapidly with the increase of the thermal conductivity,but when the thermal conductivity is 6-10 W•m^-1•K^-1,the thermal stress is basically stable;(4)the higher the cooling rate,the faster the decreasing speed of the temperature and thermal stress. | WEI Yi YANG Wengang QIN Hongbin GUO Xiaojun LI Hongxia WANG Yanni | 2019 | China's Refractories2019，28，4： | 0 |
| 15 | Modified corn-core powder for enhancing sludge dewaterability:Synthesis,characterization and sludge dewatering performance显示文摘The high water content of sludge has always posed significant challenges for its treatment.Synthetic flocculants,which are widely used in sewage treatment plants,can cause secondary pollution during their production and use.Thus,natural polymer flocculants made of natural materials have received increased research attention recently.Corncore,an agricultural waste,was modified through alkalization with sodium hydroxide(NaOH)and etherification with cetyltrimethylammonium bromide(CTMAB)in this study.The L16(45)orthogonal array was used to study the modification conditions.The moisture content(MC)of treated sludge was reduced by approximately 37%with the addition of modified corncore powder(MCCP),which was synthesized under optimal conditions.In addition,changes in the functional groups of the material before and after modification were determined by FTIR.Thermogravimetric analysis indicated that MCCP was steady at room temperature,moreover,BET analysis showed that MCCP had greater surface area.The microstructures of material before and after modification were examined by scanning electron microscopy,revealing that MCCP had a flakeshaped structure and had an increased area of contact area with sludge particles.MCCP is a dehydrating agent that can enhance sludge dewaterability through charge neutralization and reagglomeration and provide superior economic benefits. | Zhiying Guo Liping Ma I Quxiu Dai Xinbo Yang Ran Ao Jie Yang Jing Yang Wengang Li | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 0 |
| 16 | One-pot remote desymmetrization/Peterson-olefination for the construction of silicon-stereogenic silyl ethers显示文摘Chiral silyl ethers and silanols are important synthetic intermediates and bioactive compounds.In this work,we developed a onepot remote desymmetrization/Peterson-olefination of silacyclopentene oxides with benzoic acids in the presence of Martin’s sulfurane.This new methodology not only realizes the atom-economy of Peterson olefination,but also represents a catalytic method for synthesis of silicon-stereogenic silyl ethers.Using a bulky chiral phosphoric acid 4i as organocatalyst,the reactions proceeded efficiently to afford various olefin-functionalized organosilyl ethers in excellent diastereoelectivities(up to 25/1 d.r.)and high enantioselectivities(up to 94%ee). | Wengang Guo Qian Li Yan Liu Can Li | 2023 | Science China Chemistry2023，66，10： | 0 |
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