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| 1 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 2 | Unsaturated creep tests and empirical models for sliding zone soils of Qianjiangping landslide in the Three Gorges显示文摘Creep of sliding zone soils may cause significant displacement in large-scale landslides in the Three Gorges reservoir area.To investigate the effects of water on the soil creep behavior of the Qianjiangping landslide,a series of unsaturated triaxial creep tests on the sliding zone soils were performed.Based on the analyses of testing results,a new stress intensity incorporating matric suction was defined and an unsaturated Singh-Mitchell creep model was developed.Predicted results are in good agreement with the experimental results,which indicates that the established unsaturated model can reasonably simulate the effects of water on the soil creep behavior of the landslide.Finally,relationships between matric suction and the parameters of the model were analyzed.This study provides a calculation model and parameters for the evaluation of long-term stability of landslides under the influence of water. | Xiaoling Lai Shimei Wang Hongbin Qin Xianfeng Liu | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，2： | 4 |
| 3 | Combined Electric and Heat System Testbeds for Power Flow Analysis and Economic Dispatch显示文摘In combined electric and heat systems,selecting a suitable testbed for power flow analysis or economic dispatch is not easy:a large number of existing testbeds are not opensource,while others are difficult to be reused by other researchers due to the particularity of system scale,topology,and data.In this paper,we present three open-source testbeds with different scales based on practical combined electric and heat systems.To satisfy researchers'specific demands on the system topology and data,we also discuss how to modify testbeds based on existing topologies and data.Researchers can use the testbeds presented in this paper to test their innovative methods for power flow analysis and economic dispatch,and can also design their own testbeds based on the methodology in this paper,using published topologies and data. | Xin Qin Xinwei Shen Ye Guo Zhaoguang Pan Qinglai Guo Hongbin Sun | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 3 |
| 4 | Recent progress in advanced core-shell metal-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide reduction(CO_(2)RR)plays an important role in solving the problem of high concentration of CO_(2)in the atmosphere and realizing carbon cycle.Core-shell structure has many unique features including tandem catalysis,lattice strain effect,defect engineering,which exhibit great potential in electrocatalysis.In this review,we focus on the advanced core-shell metal-based catalysts(CMCs)for electrochemical CO_(2)RR.The recent progress of CMCs in electrocatalytic CO_(2)RR is described as the follow-ing aspects:(1)The mechanism of electrochemical CO_(2)RR and evaluation parameters of electrocatalyst performance,(2)preparation methods of core-shell metal catalysts and core-shell structural advantages and(3)advanced CMCs towards electrochemical CO_(2)RR.Finally,we make a brief conclusion and propose the opportunities and challenges in the field of electrochemical CO_(2)RR. | Fengqi Wang Wenlong Zhang Hongbin Wan Chenxi Li Wankai An Xia Sheng Xiaoyu Liang Xiaopeng Wang Yunlai Ren Xin Zheng Dongcan Lv Yuchen Qin | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 5 | Steam Oxidation Resistance of Silicon Carbide Castables at Elevated Temperatures显示文摘Silicon carbide castables of different SiC contents(86%and 71%,by mass)were prepared using white fused corundum,silicon carbide particles and fines,activated alumina powder,silica fume and pure calcium aluminate cement as main starting materials,heat treating at 1000℃ for 3 h,and oxidizing in steam atmosphere at 1000℃ for different durations(100,200,300,400 and 500 h).The mass and volume before and after oxidation,the bulk density,the apparent porosity and the cold compressive strength were tested.The phase composition and the microstructure before and after oxidation were analyzed by XRD and SEM.The results indicate that:(1)within 300 h of oxidation duration,silicon carbide shows an increasing oxidation rate;however,the oxidation rate is low during 300-500 h of oxidation duration;2)the oxidation rate of the specimen with 71%SiC is slightly higher than the one with 86%SiC;3)with the increasing oxidation degree of silicon carbide,the apparent porosity of the specimens tends to increase,followed by the declining bulk density and cold compressive strength. | SHI Huiying WANG Jiaping WU Jiguang HUANG Zhigang QIN Hongbin | 2021 | China's Refractories2021，30，3： | 2 |
| 6 | Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits显示文摘 | Ling Qin Pikkwan Fok Hongbin Lu | 2006 | Clin Biomech2006，21，： | 1 |
| 7 | Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits显示文摘 | Ling Qin Pikkwan Fok Hongbin Lu | 2006 | Clin Biomech2006，21，： | 1 |
| 8 | A DHT-Based Identifier-to-Locator Mapping Approach for a Scalable Internet显示文摘 | LUO Hongbin QIN Yajuan ZHANG Hongke | | 0，，12： | 1 |
| 9 | A DHT-based identifier-to-locator mapping approach for a scalable Internet显示文摘 | Luo Hongbin Qin Yajuan Zhang Hongke | | 0，，12： | 1 |
| 10 | A DHT-Based Identifier-to-Locator Mapping App- roach for a Scalable Internet显示文摘 | LUO Hongbin QIN Yajuan ZHANG Hongke | 2009 | IEEE Transac- tions on Parallel and Distributed Systems2009，20，12： | 1 |
| 11 | Efficient Photogeneration of Hydrogen Boosted by Long-Lived Dye-Modified Ir(III)Photosensitizers and Polyoxometalate Catalyst显示文摘Developing efficient catalysts and photosensitizers is crucial for the construction of effective photocatalytic H2-evolving systems.Here,we report the facile preparation of Coumarin-modified Ir(III)complexes(PS-2 and PS-3)and their utilization as chromophores to drive favorable photocatalytic H2 evolution using Ni-substituted polyoxometalate(Ni_(3)PW_(10))catalyst and triethanolamine(TEOA)as an electron donor.Compared with the commercially available unmodified Ir(III)complex(PS-1),both PS-2 and PS-3 displayed intensive absorption in the range of 400–550 nm with ε_(max) of 110,620 and 91,430 M^(−1) cm6(−1),respectively.Varying the substitutes on the bipyridine ligand affected their physicochemical properties and the corresponding photocatalytic activity dramatically.Under photocatalytic conditions,the quantity of H2 molecules generated by PS-2-and PS-3-containing systems were 13.1 and 2.1 times,respectively,that of the PS-1-containing system.When PS-2 was used as a photosensitizer,the highest turnover number(TON)of 19,739 was obtained versus Ni_(3)PW_(10) catalyst.Various spectroscopic and computational studies have revealed that factors such as strong and broad visible-light-absorbing ability,long-lived triplet state,suitable redox potential,opposed by using polyoxometalate(POM)catalyst,and large highest occupied molecular orbital(HOMO)–lowest unoccupied molecular orbital(LUMO)gap of PS-2 attributed to drastically enhanced photocatalytic activity. | Lin Qin Chongyang Zhao Liao-Yuan Yao Hongbin Dou Mo Zhang Jing Xie Tsu-Chien Weng Hongjin Lv Guo-Yu Yang | 2022 | CCS Chemistry2022，4，1： | 1 |
| 12 | Existence and uniqueness of periodic solutions of an equation of Duffing type显示文摘 | CHEN Hongbin WANG Lihe QIN Junlin | | 0，，： | 1 |
| 13 | Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone–tendon insertion—a partial patellectomy model in rabbits显示文摘 | Ling Qin Pikkwan Fok Hongbin Lu Sanqiang Shi Yang Leng Kwoksui Leung | 2005 | Clinical Biomechanics2005，，4： | 1 |
| 14 | Product platform commonization: platform construction and platform elements capture显示文摘 | Hongbin Qin Yifang Zhong Renbin Xiao Weiguo Zhang | 2005 | The International Journal of Advanced Manufacturing Technology (-)2005，，11： | 1 |
| 15 | Chinese registry of rheumatoid arthritis(CREDIT)V:sex impacts rheumatoid arthritis in Chinese patients显示文摘Background: The impact of sex on the clinical manifestations of rheumatoid arthritis (RA) were diversely reported in the literature. The Chinese Registry of rhEumatoiD arthrITis provides a platform for the investigation of this issue in Chinese patients.Methods: Demographic and clinical parameters were collected from all enrolled patients with RA and from patients with early RA (disease duration ≤6 months). The differences in data regarding disease activity, comorbidities, and medications for RA were compared between men and women. The proportions of patients who achieved remission and low disease activity were compared at enrollment and during 3-, 6-, and 12-month follow-up visits.Results: A total of 11,564 patients were enrolled, 83.6% of whom were female. In all the enrolled patients and patients with early RA, C-reactive protein (CRP, 12.0vs. 6.7 mg/L), pain visual analogue scale (4.8vs. 4.5), patient’s and physician’s global assessment (4.9vs. 4.5 and 4.9vs. 4.5), 28-joint disease activity score using DAS28-CRP (4.3vs. 4.0) simplified disease activity index (21.9vs. 19.9), and clinical disease activity index (19.3vs. 18.0) were significantly higher in men than in women. Additionally, the swollen joint count/tender joint count and DAS28 using erythrocyte sedimentation rate were higher in male patients than in female patients with early RA. More female patients with early RA reached the treatment target at baseline than male patients (23.4%vs. 18.2%, assessed by CDAI). At 3 months, 6 months, and 12 months, the proportion of remission and treatment target achievement was similar in both sexes. Coronary artery disease (CAD) and stroke were more frequent in men than in women.Conclusions: In Chinese patients with RA, men were found to have more active disease, as well as more cases of CAD and stroke. Therefore, sex should be carefully considered during the personalization of RA treatment. | Nan Jiang Qin Li Hongbin Li Yongfei Fang Lijun Wu Xinwang Duan Jian Xu Cheng Zhao Zhenyu Jiang Yanhong Wang Qian Wang Xiaomei Leng Mengtao Li Xinping Tian Xiaofeng Zeng CREDIT Co-Authors | 2022 | Chinese Medical Journal2022，135，18： | 1 |
| 16 | Product platform commonization: platform construction and platform elements capture显示文摘 | Hongbin Qin Yifang Zhong Renbin Xiao Weiguo Zhang | 2005 | The International Journal of Advanced Manufacturing Technology (-)2005，，11： | 1 |
| 17 | Low intensity pulsed ultrasound increases the matrix hardness of the healing tissues at bone-tendon insertion-a partial patellectomy model in rabbits显示文摘 | Ling Qin Pikkwan Fok Hongbin Lu | 2006 | Clin Biomech2006，21，： | 1 |
| 18 | Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment显示文摘Human lung adenosquamous cell carcinoma(LUAS),containing both adenomatous and squamous pathologies,harbors strong plasticity and is significantly associated with poor prognosis.We established an up-to-date comprehensive genomic and transcriptomic landscape of LUAS in 109 Chinese specimens and demonstrated LUAS development via adeno-to-squamous transdifferentiation.Unsupervised transcriptomic clustering and dynamic network biomarker analysis identified an inflammatory subtype as the critical transition stage during LUAS development.Dynamic dysregulation of the counteracting lineage-specific transcription factors(TFs),containing adenomatous TFs NKX2-1 and FOXA2,and squamous TFs TP63 and SOX2,finely tuned the lineage transition via promoting CXCL3/5-mediated neutrophil infiltration.Genomic clustering identified the most malignant subtype featured with STK11-inactivation,and targeting LSD1 through genetic deletion or pharmacological inhibition almost eradicated STK11-deficient lung tumors.These data collectively uncover the comprehensive molecular landscape,oncogenic driver spectrum and therapeutic vulnerability of Chinese LUAS. | Shijie Tang Yun Xue Zhen Qin Zhaoyuan Fang Yihua Sun Chongzhe Yuan Yunjian Pan Yue Zhao Xinyuan Tong Jian Zhang Hsinyi Huang Yuting Chen Liang Hu Dasong Huang Ruiqi Wang Weiguo Zou Yuan Li Roman KThomas Andrea Ventura Kwok-Kin Wong Haiquan Chen Luonan Chen Hongbin Ji | 2023 | National Science Review2023，10，4： | 0 |
| 19 | LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma显示文摘This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible mechanism.Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological parameters.Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC.Univariate analysis and multivariate analysis were used to investigate the prognostic factors.Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)screening.GO term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential mechanism.LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues.The LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,respectively.Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle.Finally,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment analysis.Collectively,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis. | Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 20 | Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘Small-cell lung cancer(SCLC)is a recalcitrant cancer characterized by high metastasis.However,the exact cell type contributing to metastasis remains elusive.Using a Rb1^(L/L)/Trp53^(L/L) mouse model,we identify the NCAM^(hi)CD44^(lo/–) subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAM^(lo)CD44^(hi) cell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brg1,significantly inhibits such phenotypic transition and metastasis.Mechanistically,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and metastasis.Importantly,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates metastasis.Single-cell RNA-sequencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient prognosis.These data uncover high SCLC plasticity and identify TAZ as the key molecular switch in orchestrating SCLC phenotypic transition and metastasis. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2022 | National Science Review2022，9，7： | 0 |
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