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| 1 | Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with double-phase contrast material-enhanced computed tomography显示文摘评估双阶段的功效的目的在 preliminarily 在 bronchogenic 癌估计没有外科的治疗反应对比提高材料的计算断层摄影术(CT ) 。有在没有外科的治疗以后的 bronchogenic 癌的 52 个病人经历了双阶段的方法对比提高材料的计算断层摄影术。在非离子的对比材料经由赌注被管理以后,二螺线 CT 扫描分别地在 25 和 90 秒点被获得以由使用一个汽车注射者的 4 mL/s 的率的肘的静脉。每扫描上的 Precontrast 和柱子对比变细被记录,山峰高度是计算的。改进模式在在对比媒介的注射以后在 25 和 90 秒点获得的图象上被评估。结果 Precontrast 变细,在 25 和 90 秒点的柱子对比变细是 42.20 ± 7.43 胡, 57.35 ± 10.09 胡和 71.85 ± 12.45 胡分别地。在 precontrast 变细的统计上重要的差别都没在我们在治疗前在情况中被获得的旧学习(吝啬的 precontrast 变细 40.70 胡) 在学习和结果在我们的结果之间被发现(t = 1.455, P = 0.152 >
0.05 ) 。在没有外科的治疗以后的 bronchogenic 癌的山峰高度(29.46 ± 10.85 胡) 是比在在我们的旧学习获得的治疗前的 bronchogenic 癌的显著地低的(吝啬的山峰高度 35.79 胡;t = 4.206, P = 0.001 <
0.05 ) 。52 个盒子中的 32 个在 90 秒点显示出同类的改进。32 个盒子,与不同类的改进有 21, 7 与不同类的改进, 2 与中央改进并且 2 与在 25 秒点的外部改进。在没有外科的处理以后的结论 Bronchogenic 癌在对比材料的管理以后显示出渐渐的增加到山峰高度。山峰高度能反映 bronchogenic 癌的血供应并且可能是为在 bronchogenic 癌的没有外科的治疗反应的评估的索引。 | Shenjiang Li Yong Zhao Yan Zhu Feng Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 9 |
| 2 | Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery显示文摘Numerous systems have been designed during the past three decades to improve bioavailability of ophthalmic drug delivery,including:ocular prodrugs and nanotechnology-based drug delivery system.The former can improve the efficacy of ocular drug via enhancing corneal penetration of ocular drugs,prolonging their duration of action and/or reducing the systemic side-effects,unfortunately,some characteristics of the pro-drugs,such as poorly aqueous stability,poorly aqueous solubility and severe eye irritation probably,limit their clinical practice and cannot be ignored.As we all know,nanotech-nology for ocular drug delivery can carry poorly soluble drugs,protect the encapsulated molecules from hydrolysis,control the rate of drug delivery and prolong the precorneal retention of drugs.All of these merits may solve the problems in the utilization of ocular prodrugs and increase the bioavailability of ocular drug delivery.By reviewing recent ad-vances of prodrugs and nanostructures in ocular drug delivery,this paper focus specifically on the promising prospects of nanocarriers overcoming the drawbacks of prodrugs for ophthalmic drug delivery by precorneal routes. | Tiantian Ye Kun Yuan Wenji Zhang Shuangshuang Song Fen Chen Xinggang Yang Shujun Wang Jianwei Bi Weisan Pan | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 3 |
| 3 | 显示恶性孤立肺结节分叶征的理想CT层厚(英文)显示文摘Objective: The aim of this study was to determine an optimal slice thickness that was efficient in revealing lobulation of malignant solitary pulmonary nodules (SPNs) on multi-slice spiral computed tomography (MSCT) images preliminarily. Methods: Fifty patients with malignant SPNs (diameter ≤ 3 cm) underwent multidetector-row computed tomography of the chest in a single-breath-hold technique. The raw data were acquired with a collimation of 0.625 mm. Three sets of contiguous images were reconstructed with 1-, 2-, and 5-mm slice thickness, respectively. The lobulation sign of SPNs on the computed tomography (CT) images presented in 1-, 2-, and 5-mm slice thickness was compared. Using the 1-mm sections as the gold standard, an optimal slice thickness in revealing lobulation sign of SPNs was determined. Results: The 1-mm-thick images CT revealed 98 lobulations (25 with chord distance < 1 mm; 30 with chord distance 1-2 mm; 43 with chord distance > 2 mm) of 45 malignant SPNs. 18 lobulations with chord distance < 1 mm presented in 2-mm-thick sections were as same as those in 1-mm-thick sections. Statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.023 < 0.05). 16 lobulations with chord distance < 1 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.004 < 0.05). The 24 lobulations with chord distance 1-2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number were found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.261 > 0.05). 13 lobulations with chord distance 1-2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.003 < 0.05). 40 lobulations with chord distance ﹥2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.631 > 0.05). 36 lobulations with chord distance ﹥2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was no statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.264 > 0.05). Conclusion: It is suggested that the use of 1-mm slice thickness is suitable in revealing lobulations with chord distance < 1 mm. A 2-mm slice thickness is suggested to be used in revealing lobulations with chord distance 1-2 mm and 5-mm slice thickness to be used in revealing lobulations with chord distance > 2 mm. | Shenjiang Li Changcheng Li Xin Wang Debin Liu Wenjie Liang Feng Zhu Yan Zhu Xuefeng Cui Wenjie Bi | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 2 |
| 4 | ANALYSIS OF FREEMIUM BUSINESS MODEL CONSIDERING NETWORK EXTERNALITIES AND CONSUMER UNCERTAINTY显示文摘公司逐渐地在联机软件市场使用的一个新兴的企业模型将两个都为为顾客的一种服务或一个产品提供一个免费基本版本和一个付的高级版本。如此的一个背景经常被称为 freemium 模型。免费版本的存在能关于商业软件的评估减少顾客无常并且使用网络效果改进公司利润。然而, freemium 模型可以也让 cannibalization 完成哪个罐头伤害了利润。因此,公司需要为免费版本和最佳的价格决定最佳的内容让高级版本最大化它的利润。在这份报纸,首先,我们获得 freemium 模型和他们的性质的最佳的决定。第二,我们把 freemium 模型与产品满意的所有需要以利润,顾客福利,和社会福利被收的传统的 charge-for-everything 模型作比较。结果证明当顾客显著地低估软件的值,软件的真值足够高时, freemium 模型能产生更高的利润,更高级的顾客福利,和更高社会的福利。否则, freemium 模型不能交付需要的结果。 | Wuhua Chen Zhongsheng Hua Zhe George Zhang Wenjie Bi | 2018 | Journal of Systems Science and Systems Engineering2018，27，1： | 2 |
| 5 | Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China显示文摘The ongoing pandemic of coronavirus disease 2019(COVID-19)caused by a novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2,also named as 2019-nCoV or HCoV-19)poses an unprecedented threat to public health(Zhu et al.,2020;Wang et al.,2020;Jiang et al.,2020).The novel HCoV-19 virus has rapidly spread into multiple countries across the world since it was first reported in December 2019.The World Health Organization(WHO)declared COVID-19 as a pandemic on 11th March 2020.As of 4th July,over 10 million confirmed COVID-19 cases have been reported in over 200 countries/regions with more than 0.5 million deaths,including 85,287 documented cases and 4,648 deaths in China(WHO,2020a). | Jing Yang Peihua Niu Lijuan Chen Liang Wang Li Zhao Baoying Huang Juncai Ma Songnian Hu Linhuan Wu Guizhen Wu Chun Huang Yuhai Bi Wenjie Tan | 2021 | Protein & Cell2021，12，1： | 2 |
| 6 | A Novel Two-stage Phase Noise Estimation Algorithm for Coherent Optical OFDM Systems 显示文摘 | YUAN Jianguo BI Wenjuan BI Wenjie | 2013 | OPTIK2013，124，24： | 1 |
| 7 | Design and research of magnetic field sensor based on grapefruit optical fiber filled with magnetic fluid显示文摘A novel magnetic field sensor was proposed based on the grapefruit optical fiber with the magnetic fluid injected into the six air holes.The sensor utilizes the Mach-Zehnder interference(MZI).The light is transmitted through the single-mode fiber to the fusion splice point and is divided into two parts.When the light passes through the cladding air hole with magnetic fluid,it interferes with the core light,and the change of the interference light is related with the change of the magnetic field.The sensor cavity length is 6 cm.It can be obtained from the experimental results that the magnetic field sensitivity reaches up to 2.243 nm/Oe with the range from 0 to 2.28 Oe.The sensor has the advantages of easy fabrication,easy installation and low cost.The findings provide new ideas for the study of ocean wind electromagnetic fields. | WANG Mengye JIN Wa LIU Xuejing SUN Wenjie ZHANG Chenhui BI Weihong | 2022 | Optoelectronics Letters2022，18，5： | 1 |
| 8 | Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics显示文摘 | Yonghui Zhang Xiaojing Lin Fengwei Zhang Jia Wu Wenjie Tan Shengli Bi Jianfang Zhou Yuelong Shu Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 9 | Hepatitis C virus envelope glycoproteins complementation patterns and the role of the ecto- and transmembrane domains显示文摘 | Xiaojing Lin Yonghui Zhang Shengli Bi Jian Lu Honglan Zhao Wenjie Tan Dexin Li Yue Wang | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 10 | HCV envelope protein function is dependent on the peptides preceding the glycoproteins显示文摘 | Tao Bian Yongdong Zhou Shengli Bi Wenjie Tan Yue Wang | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 11 | Effect of Tempered Martensite on Magnetomechanical Damping of Ferritic Matrix Dual Phase Alloys显示文摘The influence of the volume fraction of tempered martensite on magnetomechanical damping of theferritic matrix in dual-phase alloys was studied.The experimental results showed that(1)dual-phase damping alloy is of good combination of strength and toughness: (2)good damping ca-pacity(Q-1≥5.0×10-3)can be obtained in dual-phase alloys only when the volume fraction oftempered martensite was controlled properly.The effect of martensite on magnetomechanical damp-ing of the ferritic matrix was analysed.The damping capacity of dual-phase alloys was related to thevolume fraction Vm of tempered martensite by Q<sup>-1=Q<sup>-1 (1-Vm/1+BVm)at small vibration strainamplitudes εA≤5.0×10-6. | Junsheng LU Xiaodong LIU Wenjie ZHENG Baorong WU Hui BI Central Iron and Steel Research Institute,Beijing,100081,ChinaGuijin WANG Dept.of Materials Science and Engineering,University of Pennsylvania,Philadelphia,PA 19104,USA | 1993 | Journal of Materials Science & Technology1993，9，4： | 0 |
| 12 | CT增强在肺癌非手术治疗疗效评价中的作用(英文)显示文摘Objective:The aim of the study was to evaluate the efficacy of contrast material-enhanced computed tomography(CT) in assessing no-surgical treatment response in bronchogenic carcinoma.Methods:The 67 patients with bronchogenic carcinoma after no-surgical treatment underwent two-phase contrast material-enhanced computed tomography.Two spiral CT scans were obtained at 25 and 90 s respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 4 mL/s by using an autoinjector.Precontrast and postcontrast attenuation values on every scan were recorded and peak height was calculated.Enhancement pattern was evaluated on the image obtained at 25 and 90 s after injection of contrast medium.Results:Precontrast attenuation value,postcontrast attenuation values at 25 and 90 s were(41.26 ± 7.77) Hu,(56.45 ± 10.48) Hu,(70.82 ± 11.99) Hu,respectively.No statistically significant difference in precontrast attenuation was found between our results in this study and the results in our old study(mean precontrast attenuation 40.70 Hu) which was obtained in cases without any therapy(t = 0.593,P = 0.555﹥0.05).Peak height of bronchogenic carcinoma after no-surgical treatment [(29.40 ± 10.73) Hu] were significantly lower than that of bronchogenic carcinoma without any therapy obtained in our old study(mean peak height 35.79 Hu)(t =-4.874,P = 0.001 < 0.05).The 39 among 67 cases appeared homogeneous enhancement at 90 s.At 25 s,there were 26 cases with inhomogeneous enhancement,9 cases with homogeneous enhancement,2 cases with central enhancement,and 2 cases with peripheral enhancement among the 39 cases.Conclusion:Peak heights can reflect the blood supply of bronchogenic carcinoma and might be an index for evaluation of no-surgical treatment response in bronchogenic carcinoma. | Shenjiang Li Feng Zhu Yan Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，5： | 0 |
| 13 | Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize显示文摘Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory infestation.Composed of a complex mixture of very-long-chain fatty acids(VLCFAs)and their derivatives,cuticular wax constitutes the first physical line of defense against herbivores.Here,we report the function of Glossy 8(ZmGL8),which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex,in orchestrating wax production and jasmonic acid(JA)-mediated defenses against herbivores in maize(Zea mays).The mutation of GL8 enhanced chemical defenses by activating the JA-dependent pathway.We observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred lines.In addition,we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical defenses.Comprehensive transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and signaling.These results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses. | Jiong Liu Lu Li Zhilong Xiong Christelle AMRobert Baozhu Li Shan He Wenjie Chen Jiasheng Bi Guanqing Zhai Siyi Guo Hui Zhang Jieping Li Shutang Zhou Xi Zhang Chun‐Peng Song | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 14 | Synthesis of hierarchical shell-core SnO2 microspheres and their gas sensing properties显示文摘Using SnSO4,D-glucose,urea and water,hierarchical shell-core SnO2 microspheres were successfully synthesized via a simple hydrothermal method.The characte rization results showed that the sizes of asprepared SnO2 microspheres were 0,6-1μm,with shell thicknesses of 4060 nm,The shell and large core of the SnO2 microspheres were all comprised of the same basic rice-like nanoparticles with diameters of 16-25 nm and lengths of 16-45 nm.Further investigaton showed that the glucose and urea served as structural guiding agents,and urea facilitated the formation of the hierarchical structure.The as-prepared SnO2 nanomaterials were used to fabricate a gas sensor with an electrode blade used for the gas sensitivity tests,The hierarchical shell-core SnO2 microspheres exhibited high sensitivity and selectivity toward ethanol,with a responsivity of 63.8 for 50 ppm ethanol at 250℃,while the response and recovery time were 7 s and 28 s,respectively.Moreover,the responsivity of the materials showed good linearity at ethanol concentrations from 500 ppb to 10 ppm.The simple synthetic method,environmentally-friendly raw materials,and excellent gas sensitivity demonstrate that the as-prepared SnO2 nanomaterial has great potential applications for the sensing of ethanol gas. | Li Zheng Wenjie Bi Zhao Jin Shantang Liu | 2020 | Chinese Chemical Letters2020，31，8： | 0 |
| 15 | MRI增强三期扫描在肺癌非手术治疗疗效评价中的初步研究(英文)显示文摘Objective:The aim of this study was to evaluate the efficacy of three-phase contrast material-enhanced MRI in assessing no-surgical treatment response in peripheral bronchogenic carcinoma preliminarily.Methods:Twenty-two patients with bronchogenic carcinoma after no-surgical treatment underwent three-phase contrast material-enhanced MRI.Three scans were obtained at 25 s,120 s and 180 s respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 2 mL/s by using an autoinjector.Precontrast and postcontrast signal intensity on every scan was recorded.Peak Height(PH) and Maximum Enhancement(Emax) were calculated.Enhancement pattern was evaluated on the images obtained at 120 s and 180 s after injection of contrast medium.Results:Precontrast signal intensity,postcontrast signal intensity at 120 s and 180 s were 478 ± 108,926 ± 209 and 1050 ± 252.PH(571 ± 225) and Emax(119 ± 49) of bronchogenic carcinoma after no-surgical treatment were significantly lower than those of bronchogenic carcinoma without any therapy(mean PH 655,mean Emax 150)(t = 2.178,P = 0.005 < 0.05,t = 4.196,P = 0.001 < 0.05).Six cases among 22 appeared homogeneous enhancement at 180 s.At 120 s,there were 4 cases with inhomogeneous enhancement,1 case with homogeneous enhancement,1 case with peripheral enhancement among the 6 cases.Conclusion:Bronchogenic carcinoma after no-surgical treatment shows a gradual increase to the PH after administration of contrast material.Three-phase contrast material-enhanced MRI can reflect the blood supply of bronchogenic carcinoma and might be effective approach for evaluation of no-surgical treatment response in bronchogenic carcinoma. | Shenjiang Li Xuefeng Cui Debin Liu Wenjie Liang Yan Zhu Wenjie Bi | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，8： | 0 |
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