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您的检索式：作者名="Wenqing Le"
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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Plasma-inducedε-MnO_(2)based aqueous zinc-ion batteries and their dissolution-deposition mechanism显示文摘MnO_(2)has attracted great interest in working as the cathode of zinc ion batteries.However,the development of high-capacity,high-energy-density,and durable manganese-based cathodes with an easy synthesis strategy and proper energy storage mechanism remains an ongoing challenge.Herein,a facile plasmainduced strategy was demonstrated to introduce oxygen vacancies into theε-MnO_(2),and the obtained oxygen vacancies-richε-MnO_(2)nanosheets(ε-MnO_(2-x))show satisfactory electrochemical performances.Furthermore,an appropriate energy storage mechanism for dissolution/deposition was proposed.Thanks to a synergistic effect of the oxygen vacancies inε-MnO_(2)nanosheets and the exposed free-standing collector for Mn^(2+) dissolution/deposition,theε-MnO_(2-x) nanosheets electrode delivers a remarkable capacity(337 mAh g^(-1)at 0.1 A g^(-1))and exhibits an ultrahigh energy density of 462 Wh kg^(-1)(based on the weights of the cathode active material).Furthermore,impressive durability with 85.9%capacity retention after 1000 cycles was obtained.The superior electrochemical performance makes the plasma-induced strategy promising for designing advanced metal oxide electrode materials for high-performance aqueous zinc ion batteries. | Le Zhang Shuhua Yang Wenqing Fu Yanwei Cui Jieqiang Wang Degang Zhao Chao Yang Xiutong Wang Bingqiang Cao | 2022 | Journal of Materials Science & Technology2022，，32： | 0 |
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