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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 3 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 4 | Correlation Between Dynamic Compressive Strength and Fracture Behaviors of Bulk Metallic Glasses显示文摘The mechanical behaviors of Zr43.5Cu43.5Ni4Al8Nb1,Zr55.4Cu31.6Ni4Al8Nb1,Ti32.8Zr30.2Ni5.3Cu9Be22.7(at.%)metallic glass at different strain rates were studied.For all the present alloys,the dispersion over 700 MPa was observed on the strength in the repeated dynamic compressions,which was much stronger than that of the quasi-static compressive strength.Such the dispersion of the dynamic compressive strength was well correlated with the corresponding fracture behaviors.The area of fracture surface was calculated and also showed a strong dispersion for all the fractured specimens tested at the strain rate of 500 s^-1 and 1000 s^-1.All the specimens showed a linear relationship between the square of dynamic compressive strength and the area of fracture surface in the dynamic compression tests.This phenomenon was mainly thought to be related to the difference of mean initial free volume concentration of different samples,stress concentration caused by the split Hopkinson pressure bar experimental setup and high sensitivity of defects under dynamic deformation.These findings were beneficial to deeply understand the effect of strain rate on the mechanical properties of the metallic glass. | Wenqing Li Zhengwang Zhu Guojie Li Long Zhang Zhengkun Li Huameng Fu Hongwei Zhang Hong Li Aimin Wang Haifeng Zhang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，10： | 2 |
| 5 | The enhancedphotoactivity of nanosized Bi2WO6catalyst for the degradationof 4-chlorophenol显示文摘 | Hongbo Fu Wenqing Yao Liwu Zhang etal | 2008 | Materials Research Bulletin2008，43，： | 1 |
| 6 | Strigolactone and gibberellin signaling coordinately regulate metabolic adaptations to changes in nitrogen availability in rice显示文摘Modern semi-dwarf rice varieties of the“Green Revolution”require a high supply of nitrogen(N)fertilizer to produce high yields.A better understanding of the interplay between N metabolism and plant developmental processes is required for improved N-use efficiency and agricultural sustainability.Here,we show that strigolactones(SLs)modulate root metabolic and developmental adaptations to low N availability for ensuring efficient uptake and translocation of available N.The key repressor DWARF 53(D53)of the SL signaling pathway interacts with the transcription factor GROWTH-REGULATING FACTOR 4(GRF4)and prevents GRF4 from binding to its target gene promoters.N limitation induces the accumulation of SLs,which in turn promotes SL-mediated degradation of D53,leading to the release of GRF4 and thus promoting the expression of genes associated with N metabolism.N limitation also induces degradation of the DELLA protein SLENDER RICE 1(SLR1)in an D14-and D53-dependent manner,effectively releasing GRF4 from competitive inhibition caused by SLR1.Collectively,our findings reveal a previously unrecognized mechanism underlying SL and gibberellin crosstalk in response to N availability,advancing our understanding of plant growth–metabolic coordination and facilitating the design of the strategies for improving N-use efficiency in high-yield crops. | Huwei Sun Xiaoli Guo Xiuli Zhu Pengyuan Gu Wei Zhang Wenqing Tao Daojian Wang Yunzhe Wu Quanzhi Zhao Guohua Xu Xiangdong Fu Yali Zhang | 2023 | Molecular Plant2023，16，3： | 1 |
| 7 | Visible-Light-Induced Degradation of Rhodamine B by Nanosized Bi2WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | J Phys Chem B2005，109，22： | 1 |
| 8 | Visiblelightinduced degradation of rhodamine B by nanosized Bi2 WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | The Journal of Physical Chemistry B2005，109，22： | 1 |
| 9 | Visible-Light-Induced Degradation of Rhodamine B by Nanosized Bi2WO6 显示文摘 | Fu Hongbo Pan Chengshi Yao Wenqing | 2005 | The Journal of Physical Chemistry B2005，109，22： | 1 |
| 10 | The enhancedphotoactivity of nanosized Bi2 W()6 catalyst for the degrada-tion of 4-chlorophenol 显示文摘 | Fu Hongbo Yao Wenqing Zhang Liwu | 2008 | Mater Res Bull2008，43，10： | 1 |
| 11 | Craniometrical evidence for population admixture between Eastern and Western Eurasians in Bronze Age southwest Xinjiang显示文摘Xinjiang,the most northwest provincial administrative area of China,was the area where the oriental people met the occidental.The populations in Xinjiang exhibit very high genetic diversity.Previous study revealed that the eastern Xinjiang populations of the Bronze Age were mixed by the Eastern and the Western Eurasians.However,few studies have been performed to reveal when the population admixture started and how far to the west it reached.In this paper,we studied 148 craniofacial traits of 18 skulls from the Bronze Age Liushui graveyard in Khotan(Keriya County) in the southwest of Xinjiang.Seventeen craniometrical parameters of the Khotan samples were then compared with those of other ancient samples from around Xinjiang using dendrogram cluster analysis,principal components analysis,and multidimensional scaling.The results indicated that population sample of Liushui graveyard was mixed by the Western and Eastern Eurasians with about 79% contribution from the east.Therefore,we demonstrated that population admixture between east and west Eurasia can be traced back to as early as 1000 BC in southwest Xinjiang. | TAN JingZe LI LiMing ZHANG JianBo FU WenQing , GUAN HaiJuan2, AO Xue2,WANG LingE1, WU XinHua3, HAN KangXin3, JIN Li1'2 & LI Hui1'2. FU WenQing GUAN HaiJuan AO Xue WANG LingE WU XinHua HAN KangXin JIN Li LI Hui | 2013 | Chinese Science Bulletin2013，58，3： | 1 |
| 12 | MTT法抗肿瘤药物敏感试验过程中的影响因素分析(英文)显示文摘Objective: The aim of the study was to evaluate the impact of the chemosensitivity assay in vitro and establish a standard process of measuring the anti-cancer drug sensitivity with MTT assay. Methods: Some influencing factors of MTT assay in studying the sensitivity of human peripheral blood mononuclear cells (PBMC) to anti-cancer drugs were observed, including red blood cells, platelets, three different kinds of DMSO and different concentrations of MTT. Meanwhile the stability of tumor drug-coated plate was monitored. Results: The red blood cells and platelets may affect the results at a certain range of concentration. Analytical pure DMSO, both imported and domestic reagents showed the same color with MTT, and the A values of the reaction were dependent on MTT dose. The stability of the freeze-drying drug-coated plates was superior to non freeze-drying ones. Conclusion: To make clear and definite all kinds of influencing factors might contribute to a kind of standard MTT assay for drug sensitivity test in vitro. | Mancang Zhao Wenqing Wei Jing Liu Yan Zhang Juan Jiao Yao Fu Ping An | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 1 |
| 13 | Visible-light-induced degradation of rhodamine B by nanosized Bi2WO6显示文摘 | FU Hongbo PAN Chengshi YAO Wenqing | 2005 | J Phys Chem B2005，109，22： | 1 |
| 14 | Photocatalytic properties of nanosized Bi2WO6 catalysts synthesized via a hydrothermal process 显示文摘 | Fu Hongbo Zhang Liwu Yao Wenqing | 2006 | Appl Catal B2006，66，12： | 1 |
| 15 | Photocatalytic properties of nanosized Bi2WO6 catalysts synthesized via a hydrothermal process显示文摘 | FU Hongbo ZHANG Liwu YAO Wenqing | 2006 | Appl Catal B2006，66，： | 1 |
| 16 | Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes显示文摘 | Jacob A. Tennessen Abigail W. Bigham Timothy D. O’Connor Wenqing Fu Eimear E. Kenny Simon Gravel Sean McGee Ron Do Xiaoming Liu Goo Jun Hyun Min Kang Daniel Jordan Suzanne M. Leal Stacey Gabriel Mark J. Rieder Goncalo Abecasis David Altshuler Deborah A. N | 2012 | Science2012，，6090： | 1 |
| 17 | Photoeatalytic properties of nanosized Bi2WO4 catalysts synthesized via a hydrothermal process显示文摘 | FU Hongbo ZHANG Liwu YAO Wenqing | 2006 | Applied Catal- ysis B: Environmental2006，66，12： | 1 |
| 18 | Application of EDTMPS as a novel calcite depressant in scheelite flotation显示文摘In this study, the innovative use of ethylenediamine tetramethylene phosphonic sodium(EDTMPS) as a calcite depressant in scheelite flotation was investigated by flotation experiments, and its selective depression mechanism was revealed by contact angle measurement, FTIR analysis, Zeta potential test and XPS analysis. The flotation experiment results showed that scheelite and calcite could be efficiently separated under the following conditions: pulp p H=9.5, Na OL concentration of 1.5×10^(-4)mol/L, EDTMPS concentration of 3.0×10^(-5)mol/L, a scheelite concentrate with WO3grade of 65.49%, recovery of 83.29%and separation efficiency of 65.29% could be obtained from the artificially mixed minerals. The analysis results of mineral surface properties demonstrated that EDTMPS was strongly adsorbed onto the calcite surface through the reaction between the phosphonate group and the calcium ions, which hindered Na OL adsorption and increased the hydrophilicity of calcite. However, EDTMPS had weak adsorption strength on the scheelite surface, which didn’t affect further adsorption of Na OL, hence, the scheelite remained hydrophobic. Consequently, the selective adsorption of EDTMPS on the two minerals’ surfaces increased a difference in wettability and thus enabling them to be separated by flotation. Finally, the mechanism model of this flotation separation process was established. | Fen Jiao Wei Li Xu Wang Congren Yang Zhengquan Zhang Liwen Fu Wenqing Qin | 2023 | International Journal of Mining Science and Technology2023，33，5： | 1 |
| 19 | The current status of community mental health services in three northern areas of China显示文摘Objective:This study investigated and discussed the current status of community mental health service in three northern areas of China(Beijing,Harbin,and Karamay)in an effort to improve the community mental health services in China.Methods:In this study 176 residents from communities of the three northern areas of China were involved and divided into 18 groups.The study was conducted according to a self-prepared structured interview outline.Results:The analysis was conducted based on the following four perspectives:1.commu-nity residents’understanding of the mental health problems and how they treated psychiatric patients;2.community residents’access to and application of mental health information;3.com-munity residents’attitude to accept mental health services and the factors influencing community residents to seek help from mental health services;and 4.community residents’attitude and will-ingness to participate in the activities of community mental health services.Conclusion:Based on the investigation and analysis regarding the current status of the com-munity mental health services in three northern areas of China,it is concluded that the residents do not have s clear and complete understanding of mental health.The characteristics of mental health services had a regional correlation.Currently,the mental health services do not work effectively,and the residents are somewhat passive in obtaining information about mental health.Community mental health services should be offered according to different individual needs of the residents and the actual situations of each region. | Xiaoyi Yang Fengchi Yang Wenqing Fu Lingling Guo Lihua Xu Hui Zhang | 2014 | Family Medicine and Community Health2014，2，1： | 1 |
| 20 | Visible-Light-Induced degradation of Rhodamine B by nanosized Bi2WO6 显示文摘 | FU Hongbo PAN Chengshi YAO Wenqing | 2005 | The Journal of Physical Chemistry B2005，109，22： | 1 |
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