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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Excellent light-capture capability of trilobal SiNW for ultra-high JSC in single-nanowire solar cells显示文摘Single-.nanowire solar cells with a unique light-concentration property are expected to exceed the Shockley-Queisser limit.The architecture of single nanowire is an important factor to regulate its optical performance.We designed a trilobal silicon nanowire(SiNW)with two cquivalent scales that possesses superior light-absorption efficiency in the whole wavelength range and shows good tolerance for incident angle.The electric field distribution in this geometry is concentrated in the blade with small equivalent scale and pivot with large equivalent scale,respectively,in the short wavelength range and long wavelength range.Corresponding good light absorption of trilobal SiNW in the two wavelength ranges leads to stronger total light absorption capacity than that of cylindrical SiNW.Trilobal single nanowire solar cells can obtain a short-circuit current density(JSC)of 647 mA·cm^2,which provides a new choice for designing single nanowire with excellent light-capture capability. | ZHONGLIANG GAO GUILU Lin YUPENG ZHENG NA SANG YINGFENG LI LEI CHEN MEICHENG LI | 2020 | Photonics Research2020，8，6： | 2 |
| 3 | Intraocular Pressure, Central Corneal Thickness, and Glaucoma in Chinese Adults: The Liwan Eye Study显示文摘 | Dandan Wang Wenyong Huang Yuetao Li Yingfeng Zheng Paul J. Foster Nathan Congdon Mingguang He | 2011 | American Journal of Ophthalmology2011，，3： | 2 |
| 4 | Prevalence and Causes of Visual Impairment and Blindness in an Urban Indian Population: The Singapore Indian Eye Study显示文摘 | Yingfeng Zheng Raghavan Lavanya Renyi Wu Wan-Ling Wong Jie Jin Wang Paul Mitchell Ning Cheung Howard Cajucom-Uy Ecosse Lamoureux Tin Aung Seang-Mei Saw Tien Y. Wong | 2011 | Ophthalmology2011，，9： | 1 |
| 5 | Vapor-liquid equilibrium properties for confined binary mixtures involving CO_2,CH_4,and N_2 from Gibbs ensemble Monte Carlo simulations显示文摘The effects of solid-fluid interactions on the vapor-liquid phase diagram,coexistence density,relative volatility and vaporization enthalpy have been investigated for confined binary systems of CO 2-CH 4,CO 2-N 2 and CH 4-N 2.The Gibbs ensemble Monte Carlo(GEMC) simulation results indicate that the confinement and the solid-fluid interaction have significant influences on the vapor-liquid equilibrium properties.The confinement and the strength of the solid-fluid interaction make the p-x i phase diagram move to higher pressure regions.They also make the two-phase region become narrower for each binary mixture.The strength of the solid-fluid interactions can cause increases in the coexistence liquid and vapor densities,and cause the decrease of the relative volatility and the vaporization enthalpy for the systems studied.As the pore width is decreased,the two-phase region of the binary mixture becomes narrower. | LI YingFeng YU YangXin ZHENG YuanXiang LI JiDing | 2012 | Science China Chemistry2012，55，9： | 1 |
| 6 | The worldwide epidemic of diabetic retinopathy显示文摘 | Yingfeng Zheng Mingguang He Nathan Congdon | 2012 | Indian J Ophthalmo12012，60，5： | 1 |
| 7 | The worldwide epidemic of diabetic retinopathy显示文摘 | Yingfeng Zheng Mingguang He Nathan Congdon | | 0，，05： | 1 |
| 8 | Refractive Error and Visual Impairment in School Children in Rural Southern China显示文摘 | Mingguang He Wenyong Huang Yingfeng Zheng Li Huang Leon B. Ellwein | 2007 | Ophthalmology2007，，2： | 1 |
| 9 | Refractive Error and Visual Impairment in School Children in Rural Southern China显示文摘 | Mingguang He Wenyong Huang Yingfeng Zheng Li Huang Leon B. Ellwein | 2007 | Ophthalmology2007，，2： | 1 |
| 10 | EyeHealer:A large-scale anterior eye segment dataset with eye structure and lesion annotations显示文摘Anterior segment eye diseases account for a significant proportion of presentations to eye clinics worldwide,including diseases associated with corneal pathologies,anterior chamber abnormalities(e.g.blood or inflammation),and lens diseases.The construction of an automatic tool for segmentation of anterior segment eye lesions would greatly improve the efficiency of clinical care.With research on artificial intelligence progressing in recent years,deep learning models have shown their superiority in image classification and segmentation.The training and evaluation of deep learning models should be based on a large amount of data annotated with expertise;however,such data are relatively scarce in the domain of medicine.Herein,the authors developed a new medical image annotation system,called EyeHealer.It is a large-scale anterior eye segment dataset with both eye structures and lesions annotated at the pixel level.Comprehensive experiments were conducted to verify its performance in disease classification and eye lesion segmentation.The results showed that semantic segmentation models outperformed medical segmentation models.This paper describes the establishment of the system for automated classification and segmentation tasks.The dataset will be made publicly available to encourage future research in this area. | Wenjia Cai Jie Xu Ke Wang Xiaohong Liu Wenqin Xu Huimin Cai Yuanxu Gao Yuandong Su Meixia Zhang Jie Zhu Charlotte L.Zhang Edward E.Zhang Fangfei Wang Yun Yin Iat Fan Lai Guangyu Wang Kang Zhang Yingfeng Zheng | 2021 | Precision Clinical Medicine2021，4，2： | 0 |
| 11 | KDM4C与ATF4协同作用转录调控氨基酸代谢显示文摘组蛋白赖氨酸甲基转移酶(KNITs)和去甲基化酶(KDMs)通过控制组蛋白赖氨酸的甲基化状态,在转录调控中起着重要的作用。 | Erhu Zhao Jane Ding Yingfeng Xia Mengling Liu Bingwei Ye Jeong-Hyeon Choi Chunhong Yan Zheng Dong Shuang Huang Yunhong Zha Liqun Yang 崔红娟 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | 转录分析显示高危险的人类神经母细胞瘤和小鼠神经母细胞瘤的球形细胞中有共同的代谢调节显示文摘高危险性的神经母细胞瘤(neuroblastoma)仍然是一种最致命的幼童癌症之一,而识别驱动或维持高危险性的神经母细胞瘤的代谢途径则可能开辟新的治疗方针。 | Mengling Liu Yingfeng Xia Jane Ding Bingwei Ye Erhu Zhao Jeong-Hyeon Choi Ahmet Alptekin Chunhong Yan Zheng Dong Shuang Huang Liqun Yang Hongjuan Cui 查运红 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 13 | A deep learning model for generating fundus autofluorescence images from color fundus photography显示文摘Background:Fundus Autofluorescence(FAF)is a valuable imaging technique used to assess metabolic alterations in the retinal pigment epithelium(RPE)associated with various age-related and disease-related changes.The practical uses of FAF are ever-growing.This study aimed to evaluate the effectiveness of a generative deep learning(DL)model in translating color fundus(CF)images into synthetic FAF images and explore its potential for enhancing screening of age-related macular degeneration(AMD).Methods:A generative adversarial network(GAN)model was trained on pairs of CF and FAF images to generate synthetic FAF images.The quality of synthesized FAF images was assessed objectively by common generation metrics.Additionally,the clinical effectiveness of the generated FAF images in AMD classification was evaluated by measuring the area under the curve(AUC),using the LabelMe dataset.Results:A total of 8410 FAF images from 2586 patients were analyzed.The synthesized FAF images exhibited an impressive objectively assessed quality,achieving a multi-scale structural similarity index(MS-SSIM)of 0.67.When evaluated on the LabelMe dataset,the combination of generated FAF images and CF images resulted in a noteworthy improvement in AMD classification accuracy,with the AUC increasing from 0.931 to 0.968.Conclusions:This study presents the first attempt to use a generative deep learning model to create authentic and high-quality FAF images from CF images.The incorporation of the translated FAF images on top of CF images improved the accuracy of AMD classification.Overall,this study presents a promising approach to enhance largescale AMD screening. | Fan Song Weiyi Zhang Yingfeng Zheng Danli Shi Mingguang He | 2023 | Advances in Ophthalmology Practice and Research2023，3，4： | 0 |
| 14 | Effect of the Proportion of Bamboo Scraps on the Properties of Bamboo Scraps/Magnesium Oxychloride Composites显示文摘This study was designed to solve the problem of large waste volume from bamboo processing residues in recent years.Using magnesium oxychloride(MO)cementitious material as the main material and bamboo residue(BR)as the reinforcing material,a BR/MO composite material was prepared.The effects of BR amount on the molding properties,mechanical strength,and water resistance of BR/MO composites were examined and discussed.Scanning electron microscopy(SEM),X-ray diffractometry(XRD),and thermogravimetric analysis were used to characterize composite microscopic morphology,crystalline structure,and heat resistance.The results showed that,when the BR content was 1.00%(by wt),the flowability of MO paste was beneficial to composite molding.Composite mechanical properties and water resistance were greatly affected by BR addition.When the BR content was 1.00%,composite compressive and bending strengths and softening coefficient all reached maximum values.Meanwhile,increases in water absorption by 24 h and decreases of contact angle were small.These results suggested that,when the BR content was 1.00%,composite mechanical properties and water resistance were the best and the mechanical strength also improved with extended composite storage time.SEM analysis indicated that BR played the role of a reinforcing phase in MO matrices.However,when the BR content exceeded 1.00%,interfacial bonding between BR and MO became less.XRD analysis showed that,with 1.00%BR content,composites showed more 5-phase crystals with high strength.This further explained the reason why this composite’s mechanical properties were the best and the heat resistance not deteriorated due to BR,which was easily decomposed. | Long Zheng Yiqiang Wu Shu Wang Guoan Sheng Baorong Sun Yingfeng Zuo | 2021 | Journal of Renewable Materials2021，9，10： | 0 |
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