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| 1 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 2 | Evaluating Common Land Model Energy Fluxes Using FLUXNET Data显示文摘Given the crucial role of land surface processes in global and regional climates, there is a pressing need to test and verify the performance of land surface models via comparisons to observations. In this study, the eddy covariance measurements from 20 FLUXNET sites spanning more than 100 site-years were utilized to evaluate the performance of the Common Land Model(Co LM) over different vegetation types in various climate zones. A decomposition method was employed to separate both the observed and simulated energy fluxes, i.e., the sensible heat flux, latent heat flux, net radiation, and ground heat flux, at three timescales ranging from stepwise(30 min) to monthly. A comparison between the simulations and observations indicated that Co LM produced satisfactory simulations of all four energy fluxes, although the different indexes did not exhibit consistent results among the different fluxes. A strong agreement between the simulations and observations was found for the seasonal cycles at the 20 sites, whereas Co LM underestimated the latent heat flux at the sites with distinct dry and wet seasons, which might be associated with its weakness in simulating soil water during the dry season. Co LM cannot explicitly simulate the midday depression of leaf gas exchange, which may explain why Co LM also has a maximum diurnal bias at noon in the summer. Of the eight selected vegetation types analyzed, Co LM performs best for evergreen broadleaf forests and worst for croplands and wetlands. | Xiangxiang ZHANG Yongjiu DAI Hongzhi CUI Robert E.DICKINSON Siguang ZHU Nan WEI Binyan YAN Hua YUAN Wei SHANGGUAN Lili WANG Wenting FU | 2017 | Advances in Atmospheric Sciences2017，34，9： | 4 |
| 3 | Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4显示文摘Background: Brucella is a zoonotic Gram-negative pathogen that causes abortion and infertility in ruminants and humans. TLR4 is the receptor for LPS which can recognize Brucella and initiate antigen-presenting cell activities that affect both innate and adaptive immunity. Consequently, transgenic sheep over-expressing TLR4 are an suitable model to investigate the effects of TLR4 on preventing Brucellosis. In this study, we generated transgenic sheep overexpressing TLR4 and aimed to evaluate the effects of different seasons(breeding and non-breeding season) on superovulation and the imported exogenous gene on growth.Results: In total of 43 donor ewes and 166 recipient ewes in breeding season, 37 donor ewes and 144 recipient ewes in non-breeding season were selected for super-ovulation and injected embryo transfer to generate transgenic sheep.Our results indicated the no. of embryos recovered of donors and the rate of pronuclear embryos did not show any significant difference between breeding and non-breeding seasons(P > 0.05). The positive rate of exogenous TLR4 tested were 21.21 % and 22.58 % in breeding and non-breeding season by Southern blot. The expression level of TLR4 in the transgenic sheep was 1.5 times higher than in the non-transgenic group(P < 0.05). The lambs overexpressing TLR4 had similar growth performance with non-transgenic lambs, and the blood physiological parameters of transgenic and non-transgenic were both in the normal range and did not show any difference.Conclusions: Here we establish an efficient platform for the production of transgenic sheep by the microinjection of pronuclear embryos during the whole year. The over-expression of TLR4 had no adverse effect on the growth of the sheep. | Yan Li Di Lian Shoulong Deng Xiaosheng Zhang Jinlong Zhang Wenting Li Hai Bai Zhixian Wang Hongping Wu Juncai Fu Hongbing Han Jianzhong Feng Guoshi Liu Ling Lian Zhengxing Lian | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 4 | Genome and Comparative Transcriptomics of African Wild Rice Oryza Iongistaminata Provide Insights into Molecular Mechanism of Rhizomatousness and Self-Incompatibility显示文摘Dear Editor, Oryza Iongistaminata is an African wild rice species with AA genome type possessing special traits that are highly valued for improving cultivated rice,such as strong resistance to biotic and abiotic stresses (Song et al.,1995) for improving resistance of cultivars,rhizomatousness for perennial breeding (Glover et al.,2010),and self-incompatibility (SI) for new ways to produce hybrid seeds (Ghesquiere,1986).Deciphering the genome of O.longistaminata will be the key to uncovering the mechanism of these hallmark traits and improving cultivated rice. | Yesheng Zhang Shilai Zhang Hui Liu Binying Fu Lijuan Li Min Xie Yue Song Xin Li Jing Cai Wenting Wan Ling Kui Hui Huang Jun Lyu Yang Dong Wensheng Wang Liyu Fluang Jing Zhang Qinzhong Yang Qinfi Shan Qiong Li Wangqi Huang Dayun Tao Muhua Wang Mingsheng Chen Yeisoo Yu Rod A. Wing Wen Wang Fengyi Hu | 2015 | Molecular Plant2015，8，11： | 1 |
| 5 | Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population显示文摘 | Hongyan Chen Yuxiang Gu Wenting Wu Dan Chen Peiliang Li Weiwei Fan Daru Lu Fan Zhao Nidan Qiao Huijia Qiu Chaowei Fu Ying Mao Yao Zhao | 2010 | Journal of Clinical Neuroscience2010，，4： | 1 |
| 6 | Research and Development on PFBC-CC in China and Jiawang Pilot Plant Projec显示文摘ResearchandDevelopmentonPFBC-CCinChinaandJiawangPilotPlantProjectNingshengCai;MingyaoZhang;DanLi;WentingFu(ThermalEnergyEngin... | Ningsheng Cai Mingyao Zhang Dan Li Wenting Fu (Thermal Energy Engineering Research Institute, Southeast University, Nanjing 210096, China) | 1994 | Journal of Thermal Science1994，3，3： | 1 |
| 7 | Measuring and characterizing end-to-end internet service performance显示文摘 | Ludmila Cherkasova Yun Fu Wenting TANG | 2003 | ACM Transactions on Internet Technology2003，3，4： | 1 |
| 8 | The construction of high precision geostrophic currents based on new gravity models of GOCE and satellite altimetry data显示文摘The new gravity field models of gravity field and steady-state ocean circulation explorer(GOCE),TIM_R6 and DIR_R6,were released by the European Space Agency(ESA)in June 2019.The sixth generation of gravity models have the highest possible signal and lowest error levels compared with other GOCE-only gravity models,and the accuracy is significantly improved.This is an opportunity to build high precision geostrophic currents.The mean dynamic topography and geostrophic currents have been calculated by the 5th(TIM_R5 and DIR_R5),6th(TIM_R6 and DIR_R6)release of GOCE gravity field models and ITSG-Grace2018 of GRACE gravity field model in this study.By comparison with the drifter results,the optimal filtering lengths of them have been obtained(for DIR_R5,DIR_R6,TIM_R5 and TIM_R6 models are 1°and for ITSG-Grace2018 model is 1.1°).The filtered results show that the geostrophic currents obtained by the GOCE gravity field models can better reflect detailed characteristics of ocean currents.The total geostrophic speed based on the TIM_R6 model is similar to the result of the DIR_R6 model with standard deviation(STD)of 0.320 m/s and 0.321 m/s,respectively.The STD of the total velocities are 0.333 m/s and 0.325 m/s for DIR_R5 and TIM_R5.When compared with ITSG-Grace2018 results,the STD(0.344 m/s)of total geostrophic speeds is larger than GOCE results,and the accuracy of geostrophic currents obtained by ITSG-Grace2018 is lower.And the absolute errors are mainly distributed in the areas with faster speeds,such as the Antarctic circumpolar circulation,equatorial region,Kuroshio and Gulf Stream areas.After the remove-restore technique was applied to TIM_R6 MDT,the STD of total geostrophic speeds dropped to 0.162 m/s. | Wenyan Sui Junru Guo Jun Song Zhiliang Liu Meng Wang Xibin Li Yanzhao Fu Yongquan Li Yu Cai Linhui Wang Lingli Li Xiaofang Guo Wenting Zuo | 2021 | Acta Oceanologica Sinica2021，40，3： | 0 |
| 9 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 10 | Non-contact biomimetic mechanism for selective hydrogenation of nitroaromatics on heterogeneous metal nanocatalysts显示文摘While the enzymatic reduction of unsaturated compounds usually has high specificity,highly selective reduction processes are hardly realized by heterogeneous industrial catalysts,which is critical for the green production of many fine chemicals.Here,we report an unexpected discovery of a biomimetic behavior of dicyandiamide(DICY)-modified Pt nanocatalysts for the green hydrogenation of a wide range of nitroaromatics.We demonstrate that the surface modification by DICY not only prevents the direct contact of nitroaromatic reactants with Pt surface but also induces an effective non-contact hydrogenation mechanism mediated by protons and electrons.In such a process,the DICY layer serves as a“semi-permeable membrane”to allow the permeation of H_(2) molecules for being activated into electrons and protons at the Pt-DICY interface.With the generation of separated protons and electrons,the nitro group with strong electrophilic properties can be hydrogenated through the electron transfer followed by the proton transfer,which is facilitated by the hydrogen bonding network formed by protonated DICY.The unique mechanism makes it highly directional toward the hydrogenation of nitro groups without side reactions.Owing to its capability to largely eliminate the waste generation,the developed Pt-DICY catalysts have been successfully applied for the green industrial production of many important aniline intermediates. | Wenting Zhou Laiyang Li Ruixuan Qin Jiaxin Zhu Shengjie Liu Shiguang Mo Zaifa Shi Huihuang Fang Pengpeng Ruan Jun Cheng Gang Fu Nanfeng Zheng | 2022 | Science China Chemistry2022，65，4： | 0 |
| 11 | Enhancement of CO_(2)photoreduction efficiency by supporting blue TiO_(2)with photonic crystal substrate显示文摘The catalytic performance of TiO_(2)in photoreduction of CO_(2)is limited by its weak absorption in the visible range.In this work,a photonic crystal supported blue TiO_(2)photocatalyst(BTPC)was prepared to demonstrate a 5-6 times higher activity and improved CH_(4)selectivity compared to the BT catalysts deposited on quartz plate.By investigating the influence of the reflection intensity and wavelength of PC support,the superior catalytic performance was found to be originated from the enhanced light absorption of BT and the increased surface electron density brought by the PC support.Based on the study of BT loading on support,multilayer BTPC catalyst was designed to take the most advantage of the transmitted light and achieve a higher conversion of CO_(2)in the unit area of irradiation. | Dengpeng Lan Wenting Sheng Qianqian Fu Jianping Ge | 2023 | Nano Research2023，16，7： | 0 |
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