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| 1 | Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity. | Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 2 | Study on Environmental Risk and Economic Benefits of Rotation Systems in Farmland of Erhai Lake Basin显示文摘This study was designed to find out an optimised planting system of reducing non-point (source) pollution by analyzing the reasons and the factors of influence non-point pollution in farmland of Erhai Lake basin. The results showed that incomes, residual nitrogen in soil, and the loss of nitrogen in surface water in rice-garlic system were higher than those in rice-fava bean system. There were positive correlations between the nitrogen loss of farmland, nitrogen inputs, residual nitrogen in soil, and incomes of farmland. Economic benefits and environment benefits are both appropriate, if the area of rice-garlic system would be reduced to 53% and the area of rice-fava bean system increased to 36% of total cropping area in the investigated watershed. Adjustment of planting structure and introduction of reasonable rotation systems is considered an effective measure of controlling agricultural non-point pollution in watersheds of Erhai Lake. | TANG Qiu-xiang REN Tian-zhi Wilko Schweers LIU Hong-bin LEI Bao-kun LIN Tao ZHANGGui-long | 2012 | Journal of Integrative Agriculture2012，11，6： | 3 |
| 3 | Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?显示文摘 | Ulrike Heger Susanne Blank Christiane Wiecha Rupert Langer Wilko Weichert Florian Lordick Thomas Bruckner Martin Dobritz Maria Burian Christoph Springfeld Lars Grenacher J?rg-Rüdiger Siewert Markus Büchler Katja Ott | 2014 | Annals of Surgical Oncology2014，，5： | 2 |
| 4 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 5 | An evidence-based analysis of periodontally accelerated orthodontic and osteogenic techniques:a synthesis of scientific perspective 显示文摘 | Wilcko MT Wilko WM Bissada NF | 2008 | Seminars Orthod2008，14，4： | 1 |
| 6 | A Model of Solar Energy Utilisation in the Anaerobic Digestion of Cattle Manure 显示文摘 | E1-Mashad Hamed M Loon Wilko K P van Zeeman Grietje | 2003 | Biosystems Engineering2003，84，2： | 1 |
| 7 | Percolation Thresholds in 2-Dimensional Prefractal Models of Porous Media*显示文摘 | Michael C. Sukop Gert-Jaap van Dijk Edmund Perfect Wilko K. P. van Loon | 2002 | Transport in Porous Media2002，，2： | 1 |
| 8 | Design of a Solar Thermophilie Anaerobic Re- actor for Small Farms 显示文摘 | E1-Mashad Hamed M Loon Wilko K P van Zeeman Grietje | 2004 | Biosystems Engineering2004，87，3： | 1 |
| 9 | Bilateral cochlear implantation in children: A systematic review and best‐evidence synthesis显示文摘 | Marc J.W. Lammers Geert J.M.G. Heijden Vanessa E.C. Pourier Wilko Grolman | 2014 | The Laryngoscope2014，，7： | 1 |
| 10 | Design of a Solar thermophilic anaerobic reactor for small farms显示文摘 | El-Mashad Hamed M van Loon Wilko K P Grietje Zeeman | 2004 | Biosystems Engineering2004，87，3： | 1 |
| 11 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 1 |
| 12 | Heavily skewed pricing in two-sided markets显示文摘 | Wilko Bolt Alexander F. Tieman | 2007 | International Journal of Industrial Organization2007，，5： | 1 |
| 13 | Analysis and design of reliable computer networks显示文摘 | Wilko R S | 1972 | IEEE Trans on Communication1972，20，3： | 1 |
| 14 | Pesticide Use and Mycotoxin Production in Fusarium and Aspergillus Phytopathogens显示文摘 | J.P. Felix D’Mello Ann M.C. Macdonald David Postel Wilko T.P. Dijksma Aude Dujardin Cristina M. Placinta | 1998 | European Journal of Plant Pathology1998，，8： | 1 |
| 15 | Fiscal Planning, Budgeting and Rebudgeting Using Revenue Semaphores 显示文摘 | Cornia G C Nelson R D Andrea Wilko | 2004 | Public Administration Re- view2004，64，2： | 1 |
| 16 | Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart显示文摘 | Jan Wilko Schrickel Klaus Fink Rainer Meyer Christian Grohé Florian Stoeckigt Klaus Tiemann Alexander Ghanem Lars Lickfett Georg Nickenig Thorsten Lewalter | 2009 | Journal of Interventional Cardiac Electrophysiology2009，，1： | 1 |
| 17 | Molecular dissection of the photoreceptor ribbon synapse:physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex显示文摘 | SUSANNE D WILKO DA MICHAEL M K | 2005 | J Cell Biol2005，168，5： | 1 |
| 18 | A Model of solar energy utilisation in the anaerobic digestion of cattle manure 显示文摘 | HAMED M EL MASHAD WILKO K P VAN LOON GRIETJE ZEEMAN | 2003 | Biosys- terns Engineering2003，84，2： | 1 |
| 19 | Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease显示文摘 | Eva J. J. Verver Vedat Topsakal Henricus P. M. Kunst Patrick L. M. Huygen Paula G. Heller Nuria Pujol-Moix Anna Savoia Marco Benazzo Tiziana Fierro Wilko Grolman Paolo Gresele Alessandro Pecci | 2016 | Ear and Hearing2016，，： | 1 |
| 20 | Tumor lymphatics显示文摘 | Jonathan Sleeman Anja Schmidband Wilko Thiele | 2009 | Seminars in Cancer Biology2009，19，5： | 1 |
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