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| 1 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 2 | 腹腔内温热化学灌注在局灶性晚期腹部恶性肿瘤治疗中的应用显示文摘 | Wim P Ceelen 陈立宇 | 2002 | 中国实用外科杂志2002，22，12： | 9 |
| 3 | Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves显示文摘干旱容忍的草 Brachypodium distachyon 是为适度的草和谷物庄稼的新兴的模型种。为了为干旱探索这种的实用性,学习,一在 vivo 可再现干旱试金被开发。弄干的自发的土壤在叶尺寸导致了 45% 减小,并且这主要由于在细胞扩大的减少,而细胞分割由干旱仍然保持大部分未受影响。调查观察的叶生长减小的分子的基础,第三片 Brachypodium 叶在三个地区被把,也就是增长,扩大,和成熟地区,并且使分析遭到了到 transcriptome,基于一个整个染色体的并列数组。这条途径允许我们加亮不同的发展的叶地区的侧面不同地回答到干旱的那 transcriptome。涉及干旱忍耐的几基因和功能的过程被识别。transcriptome 数据在增长地区建议增加的精力可获得性,与甾醇合成的一条起来规定一起,那可以影响膜流动性。这个信息可以被用来改进适度的谷物的忍耐到干旱,它无疑是今天并且在不久的将来的农业面对的主要环境挑战之一。 | Wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé | 2013 | Molecular Plant2013，6，2： | 6 |
| 4 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 5 | Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review显示文摘BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography(ICGA) is an easy assessment tool for gastric tube(GT) perfusion, and it might predict anastomotic leakage(AL).AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL.METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy.Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction.RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group(P <0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger(AL well-perfused group 6.3% vs control group 20.5%, P <0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group(6.3%) and significantly less than the poorly perfused group(47.8%)(P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome.CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome. | Elke Van Daele Yves Van Nieuwenhove Wim Ceelen Christian Vanhove Bart P Braeckman Anne Hoorens Jurgen Van Limmen Oswald Varin Dirk Van de Putte Wouter Willaert Piet Pattyn | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 3 |
| 6 | Synthetic peptide viccines : unexpected fullfillment of discarded Hope 显示文摘 | Rob H M Langeveld P M Wim M M | 2001 | Biologicals2001，29，34： | 1 |
| 7 | The prognostic value of histology in the assessment of patients with Budd–Chiari syndrome显示文摘 | Thjon J Tang Kenneth P Batts Piet C de Groen Bart van Hoek Elizabeth B Haagsma Wim C.J Hop Harry L.A Janssen | 2001 | Journal of Hepatology2001，，3： | 1 |
| 8 | Peritoneal minimal residual disease in colorectal cancer: mechanisms, prevention, and treatment显示文摘 | Wim P Ceelen Marc E Bracke | 2009 | Lancet Oncology2009，，1： | 1 |
| 9 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 10 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 11 | Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques显示文摘 | Gotthard Martin Bleeker-Rovers Chantal P Boerman Otto C Oyen Wim JG | 2010 | The Journal of Nuclear Medicine2010，，： | 1 |
| 12 | Subjective and Objective Knowledge as Determinants of Organic Vegetables Consumption 显示文摘 | Zuzanna P Joris A Wim V | 2010 | Food Quality and Preference2010，21，6： | 1 |
| 13 | Elucidation of multiplayer growth of amphiphiles on liquid surfaces显示文摘 | Kristian Kjaer Wim Bouwman | 1996 | J Phys Chem1996，100，： | 1 |
| 14 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 15 | Synthetic peptide viccines : unexpected fullfillment of discarded hope 显示文摘 | Rob H M Langeveld P M Wim M M | 2001 | Biologicals2001，29，34： | 1 |
| 16 | Kinetic study of COS with tertiary Alkanolamine Solution显示文摘 | Rob J L Geet F V Wim P M | 1992 | Ind Eng Chem Res1992，31，5： | 1 |
| 17 | A new bidirectional search algorithm with shortened postprocessing显示文摘 | Wim P Henk P | 2009 | European journal of operational research2009，198，2： | 1 |
| 18 | Sample geometry as critical factor for stability research 显示文摘 | de Klerk Wim P C Boers Marco N | 2003 | Thermochimica Acta2003，401，： | 1 |
| 19 | A novel interconnected fluidized bed for the combined flash pyrolysis of biomass and combustion of char显示文摘 | Arthur M C Janse P Maarten Biesheuvel Wolter Prins Wim P M van Swaaij | 2000 | Chemical Engineering Journal2000，，76： | 1 |
| 20 | First world-wide interlaboratory study on polybrominated diphenyl ethers(PBDE) 显示文摘 | Jacob D B Wim P | 2002 | Chemosphere2002，46，： | 1 |
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