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| 1 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | A contract net based intelligent agent system for solving the reactive hoist scheduling problem 显示文摘 | DAVID J DAE - WON K | 2006 | Expert Systems with Applications2006，30，2： | 1 |
| 4 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 5 | Giant magnetoresistance in La1-xSrxMnO2 films near room temperature 显示文摘 | JU H L K WON C LI Q GREENE R L VENKATESAN T | 1994 | Appl Phys Lett1994，65，16： | 1 |
| 6 | Micro RNA-199b-Sp is in- volved in the Notch signaling pathway in osteosarcoma显示文摘 | Won K Y Kim Y W Kim H S | 2013 | Hum Pathol2013，44，8： | 1 |
| 7 | Production and properties of a soymilk-clotting enzyme system from a microorganism显示文摘 | Yang won Park Isao K | 1985 | Biol Chem1985，49，11： | 1 |
| 8 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 9 | Application- Level Traffic Monitoring and an Analysis on IP Networks 显示文摘 | Kim M S Won Y J Hong J W K | 2005 | ETRI Journal2005，27，11： | 1 |
| 10 | Evaluation of the diagnostic perfo- rmance of fibrin monomer in disseminated intravascular coagulation 显示文摘 | Park KJ K won EH Kim HJ | 2011 | Korean J Lab Med2011，31，3： | 1 |
| 11 | Powering fuel cells with CO via aqueous polyoxometalates and gold catalysts 显示文摘 | Won B K Voitl T Rodriguez-Rivera G J | 2004 | Science2004，305，： | 1 |
| 12 | Efficient siRNA delivery using water soluble lipopolymer for anti- angiogenic gene therapy 显示文摘 | WON J K CHIEN W C MINHYUNG L | 2007 | J Control Release2007，118，3： | 1 |
| 13 | Synthesis of acrylic acidbased superabsorbent interpenet rated with sodium sulfate using inverse-emulsionpolymerization显示文摘 | Won L D Geun S K Jong Y K | 2002 | European Polymer Journal2002，38，3： | 1 |
| 14 | Development of enhanced materials for direct-methanol fuel cell by combinatorial method and nanoscience显示文摘 | Won C C Min K J Yo J K | 2004 | Catalysis Today2004，9395，： | 1 |
| 15 | RT-PCR detection and identification of three species of Cucumoviruses with a genus-specific single pair of primers显示文摘 | Seung K C Jang K C Won M P | 1999 | Journal of Virological Methods1999，83，1： | 1 |
| 16 | Improved method for efficient production of biodiesel from palm oil显示文摘 | RAHMAN TALUKDER M M MIN BEATRICE K L PUAY SONG O PUAH S CHUAN WU J JAE WON C CHOW Y | 2008 | Energy Fuels2008，22，1： | 1 |
| 17 | 3-Oxoolean- 12-en-27-oie acid isolated from aeeriphyllum rossii induces caspase-8-dependent apoptosis in human promyeloeyfie leukemia HL-60 eells显示文摘 | Kim SS Won S J Kim N J Yoo JK Bae K Lee KT | 2009 | Biol Pharm Bull2009，32，1： | 1 |
| 18 | Effect of Cooling Rate on ZST,LIT and ZDT of Carbon Steels Near Melting Point显示文摘 | Won Y M Kim K H Yea T J | 1998 | ISIJ International1998，38，10： | 1 |
| 19 | A novel startup scheme of stator-flux-oriented vector-contr-olled induction motor drive without torque jerk显示文摘 | Chun Tae Won Choi Meong Kyu Bose B K | 2003 | Industry Applications IEEE Transactions2003，，： | 1 |
| 20 | A new process for the synthesis of diphenyl carbonate from dimethyl carbonate and phenol over heterogeneous catalysts显示文摘 | Won B K Jae S L | 1999 | Catalyst Letter1999，59，1： | 1 |
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