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| 1 | Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo显示文摘 | Wonhwa Lee Hayoung Yoo Jeong Ah Kim Sangkyu Lee Jun-Goo Jee Min Young Lee You-Mie Lee Jong-Sup Bae | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 2 | Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs显示文摘 | Eun-Ju Yang Wonhwa Lee Sae-Kwang Ku Kyung-Sik Song Jong-Sup Bae | 2012 | Food and Chemical Toxicology2012，，5： | 1 |
| 3 | Potent HIV protease inhibitors incorporate- ing high-affinityp2-1igands and sulfonamide isostere显示文摘 | Arun KG John FK Wonhwa C | 1998 | Bioorganic & Medicinal Chemistry Letters1998，8，： | 1 |
| 4 | Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo 显示文摘 | Wonhwa Lee Sae-Kwang Ku Byung-Woon Min | 2014 | Fitoterapia2014，92，： | 1 |
| 5 | Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models显示文摘 | Wonhwa Lee Tae Hoon Kim Sae-Kwang Ku Kyoung-jin Min Hyun-Shik Lee Taeg Kyu Kwon Jong-Sup Bae | 2012 | Toxicology and Applied Pharmacology2012，，1： | 1 |
| 6 | A study on the energy consumption unit of subway stations in Korea显示文摘 | Wonhwa Hong Samuel Kim | 2004 | Building and Environment2004，39，12： | 1 |
| 7 | Anti-inflammatory Effects of Oleanolic Acid on LPS-Induced Inflammation In Vitro and In Vivo显示文摘 | Wonhwa Lee Eun-Ju Yang Sae-Kwang Ku Kyung-Sik Song Jong-Sup Bae | 2013 | Inflammation2013，，： | 1 |
| 8 | GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro显示文摘Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health Organization.This is the first time that the WHO has declared a pandemic since H1N1 in 2009.As of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(http://gffzze7c39cdc9e894ca6sx05nxk9k5pv565bx.ffgz.tsg.suse.edu.cn/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics. | Kyung Soo Hong June Hong Ahn Jong Geol Jang Jong Ho Lee Hong Nam Kim Dongha Kim Wonhwa Lee | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 9 | COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm显示文摘Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is unknown.Here,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19.Intriguingly,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining severity.We confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU patients.Using an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary damages.These results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients. | Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang Chun Gwon Park Eun Young Choi Jong-Sup Bae Young-Kyo Seo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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