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| 1 | Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS显示文摘Osteoporosis is caused by an osteoclast activation mechanism.People suffering from osteoporosis are prone to bone defects.Increasing evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis.It is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone defects.Previous studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat osteoporosis.However,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain unclear.In present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-TCP.The introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant properties.The in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in vivo.Mechanistically,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation.These results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect. | Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong | 2021 | Bioactive Materials2021，6，11： | 7 |
| 2 | Rapid detection of pesticide residues in Chinese herbal medicines by molecularly imprinted membrane electrospray ionization mass spectrometry显示文摘Chinese herbal medicines(CHMs)play an increasingly important role in the field of medicine and affects public health in the world.Although more and more strict has been employed to ensure the quality and safety of CHMs,pesticide residues in CHMs remain a serious issue and are the bottleneck for the global development of CHMs.In this work,we applied molecularly imprinted membrane electrospray mass spectrometry(MIM-ESI MS)for rapid detecting 4 classes of pesticide residues in CHMs,including organophosphorus(OPP),carbamates,pyrethroids and neonicotinoids in CHMs.Compared with our previous ambient ionization method MESI,MIM-ESI is capable of achieving a~50-fold increase in the detection limit of conventional analytical methods owing to the specificity recognition and unique enrichment of MIM.The optimal experimental conditions were determined,and the method was further validated for its sensitivity and specificity.Our data showed that MIM-ESI MS is applicable for the direct quantitation of pesticide residues in CHMs.This detection technology may help to ensure the quality of CHMs in the future. | Chunmei Wu Tianyi Li Dongju Li Shanshan Jia Jianmei Huang Haimin Lei Mei Zhang | 2021 | Chinese Chemical Letters2021，32，7： | 6 |
| 3 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 4 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 5 | A mini-review on ZnIn_(2)S_(4)-Based photocatalysts for energy and environmental application显示文摘As one of the most attractive and eco-friendly technologies,semiconductor photocatalysis is demonstrated as a potential strategy to solve global energy shortage environmental pollution problems.Regarding semiconductor-based photocatalysts,Zinc indium sulfide(ZnIn_(2)S_(4)) with various morphological structures has become research hotspots owing to its superior visible light absorption,high chemical durability and low cost.Nevertheless,the photocatalytic activity of pristine ZnIn_(2)S_(4) is unsatisfactory due to limited range of visible light absorption and fast recombination rate of light-induced electrons and holes.Different modification strategies,such as metal deposition,element doping,vacancy engineering and semiconductor combination,have been systematically developed for enhancing the photocatalytic performance of ZnIn_(2)S_(4) materials.In order to promote further developments of ZnIn_(2)S_(4) in photocatalytic applications,this mini-review summarizes the progress of recent research works for the construction of highly activity ZnIn_(2)S_(4)-based photocatalysts for the first time.In addition,the typical applications of ZnIn_(2)S_(4)-based photocatalytic materials have been critically reviewed and described such as in hydrogen evolution from photocatalytic water splitting,carbon dioxide photoreduction,and treatment of water pollution.The current challenges and further prospects for the development of ZnIn_(2)S_(4) semiconductor photocatalysts are finally pointed out. | Guping Zhang Hao Wu Dongyun Chen Najun Li Qingfeng Xu Hua Li Jinghui He Jianmei Lu | 2022 | Green Energy & Environment2022，7，2： | 2 |
| 6 | Synthesis of MCM-22 zeolite by an ultrasonic-assisted aging procedure显示文摘 | Wang Baoyu Wu Jianmei Yuan Zhongyong | 2008 | Ultrasonics Sonochemistry2008，15，： | 1 |
| 7 | Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model显示文摘 | Jianmei Cai Zhimin Kang Wen Wu Liu Xu Luo Sun Qiang John H. Zhang Shigeo Ohta Xuejun Sun Weigang Xu Hengyi Tao Runping Li | 2008 | Neuroscience Letters2008，，2： | 1 |
| 8 | Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication显示文摘 | Sahibzada T. Rasool Heng Tang Jianmei Wu Wei Li Muhammad Mahmood Mukhtar Jingwen Zhang Yongxin Mu Huang Xioa Xing Jianguo Wu Ying Zhu | 2008 | Immunology Letters2008，，2： | 1 |
| 9 | Design of high-efficient and universally applicable blades of tidal stream turbine显示文摘 | Wu Baigong Zhang Xueming Chen Jianmei | 2013 | Energy2013，60，10： | 1 |
| 10 | Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication显示文摘 | Sahibzada T Rasool Heng Tang Jianmei Wu | 2008 | Immunology Letters2008，117，2： | 1 |
| 11 | Study on the bioavailability of baicalin-phospholipid complex by using HPLC显示文摘 | WU Jianmei CHEN Dawei ZHANG Ruhua | 1999 | Biomedical Chromatography1999，13，7： | 1 |
| 12 | The development of ph- armaceutics and clinical research norcantharidin显示文摘 | Wu Jianmei Ren Tianchi Yu Mei | 2002 | Chin Pharm2002，37，8： | 1 |
| 13 | All‑Fiber Integrated Thermoelectrically Powered Physiological Monitoring Biosensor显示文摘Advanced fabric electronics for long-term personal physiological monitoring,with a self-sufficient energy source,high integrity,sensitivity,wearing comfort,and homogeneous components are urgently desired.Instead of assembling a self-powered biosensor,comprising a variety of materials with different levels of hardness,and supplementing with a booster or energy storage device,herein,an all-fiber integrated thermoelectrically powered physiological monitoring device(FPMD),is proposed and evaluated for production at an industrial scale.For the first time,an organic electrochemical transistor(OECT)biosensor is enabled by thermoelectric fabrics(TEFs)adaptively,sustainably and steadily without any additional accessories.Moreover,both the OECT and TEFs are constructed using a cotton/poly(3,4-ethylenedioxythiophene):poly(styrenesulfon ate)/dimethylsulfoxide/(3-glycidyloxypropyl)trimethoxysilane(PDG)yarn,which is lightweight,robust(90°bending for 1000 cycles)and sweat-resistant(ΔR/R0=1.9%).A small temperature gradient(ΔT=2.2 K)between the environment and the human body can drive the high-gain OECT(71.08 mS)with high fidelity,and a good signal to noise ratio.For practical applications,the on-body FPMD produced an enduring and steady output signal and demonstrated a linear monitoring region(sensitivity of 30.4 NCR(normalized current response)/dec,10 nM~50µM)for glucose in artificial sweat with reliable performance regarding anti-interference and reproducibility.This device can be expanded to the monitoring of various bio-markers and provides a new strategy for constructing wearable,comfortable,highly integrated and self-powered biosensors. | Xing Qing Huijun Chen Fanjia Zeng Kangyu Jia Qing Shu Jianmei Wu Huimin Xu Weiwei Lei Dan Liu Xungai Wang Mufang Li Dong Wang | 2023 | Advanced Fiber Materials2023，5，3： | 1 |
| 14 | Synthesis of poly(pyridine-imide)s and their electronic memory performances显示文摘In this paper,poly(pyridine-imide)s,PI-Ph and PI-Naphth,were successfully synthesised and fabricated for use as memory devices.The Al/PI-Ph/indium tin oxide(ITO)device showed dynamic random access memory characteristics,whereas Al/PI-Naphth/ITO showed rewritable(FLASH)memory characteristics.Characterisation of their UV,cyclic voltammograms,and density functional theory,were used to illustrate the different memory behaviours.The results show that the stability of electric-field-induced-charge-transfer complexes can affect memory performance. | Haifeng Chen Linxin Wu Xiong Xiao Hongliang Wang Jun Jiang Lihua Wang Qingfeng Xu Jianmei Lu | 2017 | Science China Chemistry2017，60，2： | 1 |
| 15 | Free-standingβ-Ta_(2)O_(5)/SWCNTs composite film for high-rate Li-ion storage显示文摘The rapid development of portable and wearable electronic devices is responding to the urgent demand for high-efficiency flexible energy storage devices.Flexible supercapacitors,showing long cycle life,high power density,and good safety,are considered ideal candidates.Nevertheless,the relatively low energy density restricts their practical applications.With a large dielectric constant of 18-46,Ta_(2)O_(5)-based materials typically exhibit excellent electron-binding ability,which is critical for enhancing the energy density of supercapacitors.In this work,the free-standingβ-Ta_(2)O_(5)/single-walled carbon nanotubes(SWCNTs)composite film was prepared,with a highβ-Ta_(2)O_(5)loading of over 70%.By anchoringβ-Ta_(2)O_(5)nanoparticles onto the surface of SWCNTs,the system’s flexibility and conductivity were significantly enhanced,which also facilitated the intercalation electrodynamics of metal cations.As a result,the flexibleβ-Ta_(2)O_(5)/SWCNTs film exhibits excellent Li-ion storage performance,with a high volumetric specific capacitance of 392.3 F cm^(-3)at the scan rate of 10 mV s^(-1)and 198.9 F cm^(-3)at 500 mV s^(-1).In addition,the asymmetric device,assembled by theβ-Ta_(2)O_(5)/SWCNTs and activated carbon films,shows a high energy density of 45.5 Wh kg^(-1)at the power density of 10.8 kW kg^(-1).This technique opens up a new avenue for improving the energy density and rate performance of flexible supercapacitors. | WU ZhiMin LIU JiaJia HE XingYu BIAN Jing ZHU XianJun CHEN JianMei LI JianMin | 2024 | Science China(Technological Sciences)2024，67，2： | 0 |
| 16 | Comments on‘MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche’显示文摘For a long period of time,intestinal mesenchymal stromal cells(IMSC)have been considered as a relatively simple and homogeneous group of cells.These cells could effectively regulate intestinal homeostasis and epithelium integrity via producing growth factors and cytokines(Powell et al.,2011).With the help of single-cell transcriptomics studies,it has now been clear that IMSC are quite complex and heterogeneous(Kinchen et al.,2018). | Ningbo Wu Hongxiang Sun Jianmei Tan Yao Zhang Bing Su | 2021 | Journal of Molecular Cell Biology2021，13，6： | 0 |
| 17 | Ecological Investigation and Ecological Security Assessment of Xizhijiang River Basin in Huizhou City of Guangdong Province显示文摘In addition to such ecological problems as the pollution of the water system,the unreasonable structure of the upstream Basin and the insufficient water conservation forests,the Xizhi River Basin also faces human decision-making problems such as imperfect ecological compensation mechanism.In view of the above problems,using the DPSIR model(Drivers,Pressures,States,Impacts,Responses),this paper analyzed eucalyptus forest in Xizhi River Basin to assess the security of the Xizhi River ecological Basin,and finally concluded that the ecological status of Xizhi River Basin remains safe. | Jianqiao QIN Zifeng HE Jianmei CHEN Xiaoping HUANG Dongni YU Shaoli WU | 2021 | Asian Agricultural Research2021，13，2： | 0 |
| 18 | A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor显示文摘A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a secondgeneration ALK inhibitor, in patient plasma and brain tumor tissue samples. Sample preparation involved simple protein precipitation with acetonitrile. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C_(18) column using a 4-min gradient elution consisting of mobile phase A(0.1% formic acid in water) and mobile phase B(0.1% formic acid in acetonitrile), at a flow rate of 0.4 m L/min. Ceritinib and the internal standard([^(13)C_6]ceritinib) were monitored using multiple reaction monitoring mode under positive electrospray ionization. The lower limit of quantitation(LLOQ) was 1 n M of ceritinib in plasma. The calibration curve was linear over ceritinib concentration range of 1–2000 n M in plasma. The intra-and interday precision and accuracy were within the generally accepted criteria for bioanalytical method( o15%).The method was successfully applied to assess ceritinib brain tumor penetration, as assessed by the unbound drug brain concentration to unbound drug plasma concentration ratio, in patients with brain tumors. | Xun Bao Jianmei Wu Nader Sanai Jing Li | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 0 |
| 19 | Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis显示文摘Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor(GLP-1 R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver fibrosis in various rodent models, with remarkable potency, selectivity, extended half-life and low toxicity. Four types of liver fibrosis animal models which were induced by CCl_(4), a-naphthyl-isothiocyanate(ANIT), bile duct ligation(BDL) and Schistosoma japonicum were used in our study. We found that TB001 treatment dose-dependently significantly attenuated liver injury and collagen accumulation in these animal models. In addition to decreased levels of extracellular matrix(ECM) accumulation during hepatic injury, activation of hepatic stellate cells was also inhibited via suppression of TGF-β expression as well as downstream Smad signaling pathways particularly in CCl_(4)-and S. japonicum-induced liver fibrosis. Moreover, TB001 attenuated liver fibrosis through blocking downstream activation of proinflammatory nuclear factor kappa B/NF-kappa-B inhibitor alpha(NFκB/IKBa) pathways as well as cJun N-terminal kinase(JNK)-dependent induction of hepatocyte apoptosis. Furthermore, GLP-1 R and/or GCGR knock-down results represented GCGR played an important role in ameliorating CCl_(4)-induced hepatic fibrosis. Therefore, TB001 can be used as a promising therapeutic candidate for the treatment of multiple causes of hepatic fibrosis demonstrated by our extensive pre-clinical evaluation of TB001. | Nazi Song Hongjiao Xu Jiahua Liu Qian Zhao Hui Chen Zhibin Yan Runling Yang Zhiteng Luo Qi Liu Jianmei Ouyang Shuohan Wu Suijia Luo Shuyin Ye Runfeng Lin Xi Sun Junqiu Xie Tian Lan Zhongdao Wu Rui Wang Xianxing Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
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