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| 1 | Influence of mesoscale eddies on primary production in the South China Sea during spring inter-monsoon period显示文摘Mesoscale eddies have been suggested to have an impact on biological carbon fixation in the South China Sea(SCS). However, their overall contribution to primary production during the spring inter-monsoon period is still unknown. Based on large-scale biological and environmental in situ observations and synchronous remote sensing data, the distribution patterns of phytoplankton biomass and the primary production, and the role of mesoscale eddies in regulating primary production in different eddy-controlled waters were investigated. The results suggested that the surface chlorophyll a concentrations and water column integrated primary production(IPP) are significantly higher in cyclonic eddies and lower in the anticyclonic eddies as compared to that in non-eddy waters. Although eddies could affect various environmental factors, such as nutrients, temperature and light availability, nutrient supply is suggested to be the most important one through which mesoscale eddies regulated the distribution patterns of phytoplankton biomass and primary production. The estimated IPP in cyclonic and anticyclonic eddies are about 29.5% higher and 16.6% lower than the total average in the whole study area, respectively, indicating that the promotion effect of mesoscale cold eddies on the primary production was much stronger than the inhibition effect of the warm eddies per unit area. Overall, mesoscale eddies are crucial physical processes that affect the biological carbon fixation and the distribution pattern of primary production in the SCS open sea, especially during the spring inter-monsoon period. | HU Zifeng TAN Yehui SONG Xingyu ZHOU Linbin LIAN Xiping HUANG Liangmin HE Yinghui | 2014 | Acta Oceanologica Sinica2014，33，3： | 16 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 4 | Enhanced low-temperature performance of slight Mn-substituted LiFePO_4/C cathode for lithium ion batteries显示文摘Low temperature performance of LiFePO4/C cathode was remarkably improved by slight Mn-substitution. Electrochemical measurements showed that about 95% of the discharge capacity of LiFe0.98Mn0.02PO4/C cathode at 20°C was obtained at 0°C, compared to 85% of that of LiFePO4/C cathode. The LiFe0.98Mn0.02PO4/C sample also presented enhanced rate performance at –20°C with the discharge capacities of 124.4 mA h/g (0.1C), 99.8 mA h/g (1C), 80.7mAh/g (2C) and 70 mA h/g (5C), respectively, while pristine LiFePO4/C only delivered capacities of 120.5 mA h/g (0.1C), 90.7 mA h/g (1C), 70.4 mA h/g (2C) and 52.2 mA h/g (5C). Cyclic voltammetry measurements demonstrated an obvious improvement of the lithium insertion-extraction process of the LiFePO4/C cathode by slight Mn-substitution. The results of FSEM observation and electrical conductivity measurement indicated that slight Mn-substitution minimized the particle size of LiFe0.98Mn0.02PO4/C and also obviously improved the electrical conductivity of the compound, thus obviously enhances the interface reaction process on the cathode. | ZENG LingJie GONG Qiang LIAO XiaoZhen HE Li HE YuShi MA ZiFeng | 2011 | Chinese Science Bulletin2011，56，12： | 4 |
| 5 | A novel Co(phen)_2/C catalyst for the oxygen electrode in rechargeable lithium air batteries显示文摘A novel Co(phen)2/C catalyst was prepared by coating cobalt(II) phenanthroline (phen) chelate on BP2000 carbon black and then heat treating in an inert atmosphere. The obtained Co(phen)2/C product with 1.0 wt% cobalt loading exhibits similar morphology and porosity characteristics to those of the bare BP2000. X-ray diffraction measurements demonstrate a face-centered cubic (fcc) α-Co phase embedded in the carbon support after pyrolysis. Charge/discharge tests of the lithium-oxygen cells using the prepared Co(phen)2/C catalyst show high discharge capacities of 4870 mAh g-1 (0.05 mA cm-2 ), 3353 mAh g-1 (0.1 mA cm-2 ) and 3220 mAh g 1 (0.15 mA cm-2 ), respectively. The Co(phen) 2 /C cathode exhibits reasonable reversibility with capacity retention of 1401 mAh g-1 ( 0.1 mA cm-2 ) after 10 cycles. The superior electrochemical performance of the prepared Co(phen)2/C catalyst and low cost of the phenanthroline chelating agent indicate that Co(phen)2/C is a promising cheap catalyst for lithium-air batteries. | WANG Hong LIAO XiaoZhen JIANG QiZhong YANG XiaoWei HE YuShi Ma ZiFeng | 2012 | Chinese Science Bulletin2012，57，16： | 4 |
| 6 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 7 | Machine learning method for tight-binding Hamiltonian parameterization from ab-initio band structure显示文摘The tight-binding(TB)method is an ideal candidate for determining electronic and transport properties for a large-scale system.It describes the system as real-space Hamiltonian matrices expressed on a manageable number of parameters,leading to substantially lower computational costs than the ab-initio methods.Since the whole system is defined by the parameterization scheme,the choice of the TB parameters decides the reliability of the TB calculations.The typical empirical TB method uses the TB parameters directly from the existing parameter sets,which hardly reproduces the desired electronic structures quantitatively without specific optimizations.It is thus not suitable for quantitative studies like the transport property calculations.The ab-initio TB method derives the TB parameters from the ab-initio results through the transformation of basis functions,which achieves much higher numerical accuracy.However,it assumes prior knowledge of the basis and may encompass truncation error.Here,a machine learning method for TB Hamiltonian parameterization is proposed,within which a neural network(NN)is introduced with its neurons acting as the TB matrix elements.This method can construct the empirical TB model that reproduces the given ab-initio energy bands with predefined accuracy,which provides a fast and convenient way for TB model construction and gives insights into machine learning applications in physical problems. | Zifeng Wang Shizhuo Ye Hao Wang Jin He Qijun Huang Sheng Chang | 2021 | npj Computational Materials2021，，1： | 2 |
| 8 | Multi-objective steady-state optimization of two-chamber microbial fuel cells显示文摘A microbial fuel cell(MFC)is a novel promising technology for simultaneous renewable electricity generation and wastewater treatment.Three non-comparable objectives,i.e.power density,attainable current density and waste removal ratio,are often conflicting.A thorough understanding of the relationship among these three conflicting objectives can be greatly helpful to assist in optimal operation of MFC system.In this study,a multiobjective genetic algorithm is used to simultaneously maximizing power density,attainable current density and waste removal ratio based on a mathematical model for an acetate two-chamber MFC.Moreover,the level diagrams method is utilized to aid in graphical visualization of Pareto front and decision making.Three biobjective optimization problems and one three-objective optimization problem are thoroughly investigated.The obtained Pareto fronts illustrate the complex relationships among these three objectives,which is helpful for final decision support.Therefore,the integrated methodology of a multi-objective genetic algorithm and a graphical visualization technique provides a promising tool for the optimal operation of MFCs by simultaneously considering multiple conflicting objectives. | Ke Yang Yijun He Zifeng Ma | 2017 | Chinese Journal of Chemical Engineering2017，25，8： | 1 |
| 9 | 显示文摘 | Liao Xiaozhen He Yushi Ma Zifeng | 2007 | J Power Sources2007，174，： | 1 |
| 10 | CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer显示文摘Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of patients.Thus,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic outcome.Methods:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with MLN8237.Then,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with MLN8237.For mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of MLN8237.Mechanistic studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic catastrophe.We further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor growth.Conclusions:These findings establish Haspin as a synthetic lethal target and demonstrate CHR-6494 as a potential combinational drug for promoting the therapeutic effects of MLN8237 on breast cancer. | Ailin Chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu | 2021 | Cancer Communications2021，41，2： | 1 |
| 11 | Transesterification of the crude oil of rapeseed with NaOH in supercrit- ieal and suberitical methanol显示文摘 | WANG LIANYUAN HE HUAYANG XIE ZIFENG | 2007 | Fuel Processing Technology2007，88，： | 1 |
| 12 | Electrochemical properties of P2-Na2/3O2 cathode material for sodium ion batteries when cycled in different voltage ranges显示文摘 | Wang Hong Yang Bingjian Liao Xiaozhen Xu Jing Yang Dezhi He Yushi Ma Zifeng | 2013 | Electrochimica Acta2013，113，： | 1 |
| 13 | Effects of fluorine-substitution on the electrochemical behavior of LiFe-PO4/C cathode materials 显示文摘 | Liao Xiaozhen He Yushi Ma Zifeng | 2007 | J Power Sources2007，174，2： | 1 |
| 14 | Rainfall forecast errors in different landfall stages of Super Typhoon Lekima (2019)显示文摘The rainfall forecast performance of the Tropical Cyclone(TC)version Model of Global and Regional Assimilation PrEdiction System(GRAPESTCM)of the China Meteorological Administration for landfalling Super Typhoon Lekima(2019)is studied by using the object-oriented verification method of contiguous rain area(CRA).The major error sources and possible reasons for the rainfall forecast uncertainties in different landfall stages(including near landfall and moving further inland)are compared.Results show that different performance and errors of rainfall forecast exist in the different TC stages.In the near landfall stage the asymmetric rainfall distribution is hard to be simulated,which might be related to the too strong forecasted TC intensity and too weak vertical wind shear accompanied.As Lekima moves further inland,the rain pattern and volume errors gradually increase.The Equitable Threat Score of the 24 h forecasted rainfall over 100 mm declines quickly with the time-length over land.The diagnostic analysis shows that there exists an interaction between the TC and the mid-latitude westerlies,but too weak frontogenesis is simulated.The results of this research indicate that for the current numerical model,the forecast ability of persistent heavy rainfall is very limited,especially when the weakened landing TC moves further inland. | Bin HE Zifeng YU Yan TAN Yan SHEN Yingjun CHEN | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 15 | Transesterification of the crude oil of rapeseed with NaOH in supercritical and subcritical methanol显示文摘 | Wang Lianyuan He Huayang Xie Zifeng | 2007 | Fuel Processing Technology2007，88，5： | 1 |
| 16 | Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma显示文摘Application of differentiation therapy targeting cellular plasticity for the treatment of solid malignancies has been lagging.Nasopharyngeal carci noma(NPC)is a distinctive cancer with poor differe ntiatio n and high prevalenee of Epstein-Barr virus(EBV)infection.Here,we show that the expressi on of EBV latent protein LMP1 in duces dediffere ntiated and stem-like status with high plasticity through the transcriptional inhibition of CEBPA.Mechanistically,LMP1 upregulates STAT5A and recruits HDAC 1/2 to the CEBPA locus to reduce its histone acetylation.HDAC inhibition restored CEBPA expression,reversing cellular dedifferentiation and stem-like status in mouse xeno graft models.These fin dings provide a novel mecha nistic epigenetic-based in sight into virus-induced cellular plasticity and propose a promising concept of differentiation therapy in solid tumor by using HDAC inhibitors to target cellular plasticity. | Jiajun Xie Zifeng Wang Wenjun Fan Youping Liu Fang Liu Xiangbo Wan Meiling Liu Xuan Wang Deshun Zeng Van Wang Bin He Min Yan Zijian Zhang Mengjuan Zhang Zhijie Hou Chunli Wang Zhijie Kang Wenfeng Fang Li Zhang Eric W-F Lam Xiang Guo Jinsong Yan Yixin Zeng Mingyuan Chen Quentin Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 17 | Efficacy and safety of the combination of Liushen capsules and Arbidol in the treatment of COVID-19:protocol for a randomized,multi-center pilot study显示文摘Background:From early experience,some Traditional Chinese Medicine and Arbidol had effects of against COVID-19,infer that the combination of Liushen capsules and Arbidol may further increase the therapeutic.Methods/Design:We conducted a randomized,blank parallel-controlled,open-label,multi-center,basal therapy-loaded design clinical trial.A total of 40 patients are going to be recruited after satisfying the criteria.Participants will be allocated randomly into the treatment group with the combination of Arbidol and Liushen capsules and the control group with the basic therapy.Each group will receive treatment at least 7-days or until the virus becomes negative,and visits after drug administration at day 3(visit 1),the day when the virus becomes negative(visit 2),day 7(visit 3),the day before discharge(visit 4)and day 28(visit 5),to collect their survival status and disease prognosis so that the efficacy and safety of a combination of Arbidol and Liushen capsule will be evaluated.Discussion:We described the protocol of the first clinical trial for treatment COVID-19 by using a combination of Arbidol and Liushen capsules.The results of this study will provide a basis for the design and sample size estimate of subsequent large-scale clinical trials.Trial registration:This study has been registered at Chinese clinical trial Registry(chictr.org.cn):ChiCTR2000029993. | Yangqing Zhan Zhengtu Li Jiayang He Shaoqiang Li Ye Lin Jingyi Liang Jie Zhou Yanmei Wu Xuandan Su Feng Ye Zifeng Yang | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 18 | Ecological Investigation and Ecological Security Assessment of Xizhijiang River Basin in Huizhou City of Guangdong Province显示文摘In addition to such ecological problems as the pollution of the water system,the unreasonable structure of the upstream Basin and the insufficient water conservation forests,the Xizhi River Basin also faces human decision-making problems such as imperfect ecological compensation mechanism.In view of the above problems,using the DPSIR model(Drivers,Pressures,States,Impacts,Responses),this paper analyzed eucalyptus forest in Xizhi River Basin to assess the security of the Xizhi River ecological Basin,and finally concluded that the ecological status of Xizhi River Basin remains safe. | Jianqiao QIN Zifeng HE Jianmei CHEN Xiaoping HUANG Dongni YU Shaoli WU | 2021 | Asian Agricultural Research2021，13，2： | 0 |
| 19 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
| 20 | Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness显示文摘Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.Here,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer stemness.Deconvolution of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE activity.Specifically,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved hub.Upon activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial rejuvenating.Accordingly,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like cells.These findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals. | Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu Feng Jiesi Feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
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