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| 1 | Facile Synthesis of Porous Carbon Nitride Spheres with Hierarchical Three-Dimensional Mesostructures for CO_(2) Capture显示文摘Porous carbon nitride(CN)spheres with partially crystalline frameworks have been successfully synthesized via a nanocasting approach by using spherical mesoporous cellular silica foams(MCFs)as a hard template,and ethylenediamine and carbon tetrachloride as precursors.The resulting spherical CN materials have uniform diameters of ca.4μm,hierarchical three-dimensional(3-D)mesostructures with small and large mesopores with pore diameters centered at ca.4.0 and 43 nm,respectively,a relatively high BET surface area of~550 m^(2)/g,and a pore volume of 0.90 cm^(3)/g.High-resolution transmission electron microscope(HRTEM)images,wide-angle X-ray diffraction(XRD)patterns,and Raman spectra demonstrate that the porous CN material has a partly graphitized structure.In addition,elemental analyses,X-ray photoelectron spectra(XPS),Fourier transform infrared spectra(FT-IR),and CO_(2) temperature-programmed desorption(CO_(2)-TPD)show that the material has a high nitrogen content(17.8 wt%)with nitrogen-containing groups and abundant basic sites.The hierarchical porous CN spheres have excellent CO_(2) capture properties with a capacity of 2.90 mmol/g at 25℃and 0.97 mmol/g at 75℃,superior to those of the pure carbon materials with analogous mesostructures.This can be mainly attributed to the abundant nitrogen-containing basic groups,hierarchical mesostructure,relatively high BET surface area and stable framework.Furthermore,the presence of a large number of micropores and small mesopores also enhance the CO_(2) capture performance,owing to the capillary condensation effect. | Qiang Li Jianping Yang Dan Feng Zhangxiong Wu Qingling Wu Sung Soo Park Chang-Sik Ha Dongyuan Zhao | 2010 | Nano Research2010，3，9： | 24 |
| 2 | Dry/wet climate zoning and delimitation of arid areas of Northwest China based on a data-driven fashion显示文摘The division of arid areas is important in water and land resources management, planning and for a long-term agricultural, economic and social planning. Northwest China(NW) dominates the main arid areas in China. There is thus a need to adopt adequate concepts relative to the scope of arid areas of NW China and identify its climate types and characteristics. In this study, we analyzed climatic data over the last 30 years(1981–2010) from 191 stations in three provinces and three autonomous regions of NW China. The factor-cluster analysis tech- nique(FC), an objective and automated method was employed to classify the dry/wet climate zones. The traditional methods with predefined thresholds were adopted for providing a comparison with FC. The results showed that the wet/dry climate zones by FC were mainly distributed along mountains, rivers and desert borders. Climate-division boundaries relied heavily on the major terrain features surrounding the grouped stations. It also showed that the climate was dry in the plain sandy areas but relatively wet in the high mountain areas. FC method can reflect the climate characteristics more fully in NW China with varied and complicated topography, and outperform the tradi- tional climate classifications. Arid areas of NW China were defined as four climate types, including five resultant classes in FC classifications. The Qinling and Da Hinggan Mountains were two important boundaries, besides main administrative boundaries. The results also indicated that there are some differences between two traditional clas- sifications. The precipitation moved and fluctuated to an extent, which confirmed that climate change played an important role in the dry/wet climate zoning, and the boundaries of dry/wet climate zones might change and migrate with time. This paper is expected to provide a more in-depth understanding on the climate characteristics in arid areas of NW China, and then contribute to formulate reasonable water and land management planning and agri- cultural production programs. | QingLing GENG PuTe WU QingFeng ZHANG XiNing ZHAO YuBao WANG | 2014 | Journal of Arid Land2014，6，3： | 9 |
| 3 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 4 | Carbon nanotube glycol nanofluids: Photo-thermal properties, thermal conductivities and rheological behavior显示文摘The efficiency and effectiveness of solar energy capture and storage are to a large extent functions of the heat transfer and storage capacity of the medium used. This paper investigates the potential of using carbon nanotube (CNT)-glycol nanosuspension as such a medium, prepared by freeze drying-ultrasonic dispersing after oxidation treatment with HNO 3 . The influences of the mass fraction of CNTs glycol nanofluids and temperatures on photo-thermal properties, thermal conductivities and rheological behavior were investigated. The results show that CNTs with oxidation treatment exhibited good dis- persing performance. Strong optical absorption of the CNTs glycol nanofluids was detected in the range of 200-2500 nm. At room temperature, 18% enhancement was found in the photo-thermal conversion efficiency of the 0.5% mass fraction CNTs glycol nanofluids in comparison to the basic fluids, without significant increase in viscosity. At 55 C, CNTs glycol nanofluids with 4.0% mass fraction exhibited much lower viscosity and 25.4% higher thermal conductivity in comparison to that of pure glycol at room temperature. | Zhaoguo Meng Daxiong Wu Liangang Wang Haitao Zhu Qingling Li | 2012 | Particuology2012，10，5： | 5 |
| 5 | Construction of robust coupling interface between MoS2 and nitrogen doped graphene for high performance sodium ion batteries显示文摘As a layered inorganic material,MoS2 has recently attracted intensive attention as anode for sodium ion batteries(SIBs).However,this anode is plagued with low electronic conductivity,serious volume expansion and sluggish kinetics,resulting in capacity fading and poor rate performance.Herein,we develop an interface engineering strategy to substantially enhance the sodium storage performance of MoS2 by incorporating layered MoS2 into three dimensional N-doped graphene scaffold.The strong coupling-interface between MoS2 and N-doped graphene scaffold can not only stabilize the MoS2 structure during sodium insertion/extraction processes,but also provide plenty of anchor sites for additional surface sodium storage.The 3D MoS2@N-doped graphene composite as anode for SIBs performs an outstanding specific capacity of 667.3 mA h g^-1 at 0.2 A g^-1,a prolonged stability with a capacity retention of 94.4%after 140cycles and excellent rate capability of 445 mA h g^-1 even at a high rate of 10 A g^-1.We combined experiment and theoretical simulation to further disclose the interaction between MoS2 and N-doped graphene,adsorption and diffusion of sodium on the composite and the corresponding sodium storage mechanism.This study opens a new door to develop high performance SIBs by introducing the interface engineering technique. | Yun Qiao Jiawei Wu Xiaoguang Cheng Yudong Pang Zhansheng Lu Xiangdong Lou Qingling Li Jin Zhao Shuting Yang Yang Liu | 2020 | Journal of Energy Chemistry2020，29，9： | 3 |
| 6 | Soil temperature estimation at different depths,using remotely-sensed data显示文摘Soil temperatures at different depths down the soil profile are important agro-meteorological indicators which are necessary for ecological modeling and precision agricultural activities. In this paper, using time series of soil temperature(ST) measured at different depths(0, 5, 10, 20, and 40 cm) at agro-meteorological stations in northern China as reference data, ST was estimated from land surface temperature(LST) and normalized difference vegetation index(NDVI) derived from AQUA/TERRA MODIS data, and solar declination(Ds) in univariate and multivariate linear regression models. Results showed that when daytime LST is used as predictor, the coefficient of determination(R^2) values decrease from the 0 cm layer to the 40 cm layer. Additionally, with the use of nighttime LST as predictor, the R^2 values were relatively higher at 5, 10 and 15 cm depths than those at 0, 20 and 40 cm depths. It is further observed that the multiple linear regression models for soil temperature estimation outperform the univariate linear regression models based on the root mean squared errors(RMSEs) and R^2. These results have demonstrated the potential of MODIS data in tandem with the Ds parameter for soil temperature estimation at the upper layers of the soil profile where plant roots grow in. To the best of our knowledge, this is the first attempt at the synergistic use of LST, NDVI and Ds for soil temperature estimation at different depths of the upper layers of the soil profile, representing a significant contribution to soil remote sensing. | HUANG Ran HUANG Jian-xi ZHANG Chao MA Hong-yuan ZHUO Wen CHEN Ying-yi ZHU De-hai Qingling WU Lamin R.MANSARAY | 2020 | Journal of Integrative Agriculture2020，19，1： | 2 |
| 7 | Comparison of classification methods for the divisionsof wet/dry climate regions in Northwest China显示文摘 | Geng qingling Wu Pute Zhao Xining | 2014 | International Journal of Climatology2014，34，7： | 1 |
| 8 | Effects of promoters and preparation procedures on reforming of methane with carbon dioxide over Ni/Al2O3 catalyst 显示文摘 | Cheng Zhenxing Wu Qingle Lu Jin | 1996 | Catal Today1996，30，： | 1 |
| 9 | In vitro and in vivo evaluation of improved EGFR targeting peptide-conjugated phthalocyanine photosensitizers for tumor photodynamic therapy显示文摘Phthalocyanine(Pc) is one of the most promising photosensitizer candidates because of its strong absorption(extinction coefficient ε > 10~5 LmoI ~1 cm^1) at long wavelengths and strong singlet oxygen generation abilities(a singlet oxygen quantum yield of approximately 50%). However, low tumor targeting, low water solubility and a high tendency to aggregate appear to significantly restrict the compound's application in tumor treatment. Conjugating Pc with peptide ligands could be a useful strategy for alleviating these problems. Here, to further optimize the structures of peptide-conjugated zinc Pcs for PDT therapy, we finely tuned the hydrophilicity of the modified Pc aromatic macrocycle with varied length of polyethylene glycol(PEG) and added an extra PEG linker and an extra glutamic acid between the Pc ring and the peptide ligand to reduce the influence of the ligand on the Pc aromatic ring.Among the synthesized conjugates, Pc-3 showed greatly improved targeting towards tumors and abolished inoculated tumors with only a single PDT treatment in a subcutaneous xenograft tumor model,making this approach a promising therapeutic agent for the treatment of cancer. | Qingle Chen Yanhong Ma Jisi Zhao Mei Zhao Wenjing Li Qian Liu Li Xiong Wenjie Wu Zhangyong Hong | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
| 10 | Syn-thesis of ordered mesoporous alumina with large poresizes and hierarchical structure显示文摘 | Wu Qingling Zhang Fan Yang Jianping | 2011 | Microporous andMesoporous Materials2011，143，23： | 1 |
| 11 | Synthesis of ordered mesoporous alumina with large pore sizes and hierarchical structure 显示文摘 | Wu Qingling Zhang Fan Yang Jianping | 2011 | Micropor Mesopor Mater2011，143，： | 1 |
| 12 | Vojta and Bobath combined treatment for high risk infants with brain damage at early period显示文摘BACKGROUND: In the process of early screening and interventions to high risk infants with brain damage, the occasion and choosing methods of interventions and the combined application of different interventions are still at the exploratory phase. OBJECTIVE: To observe the efficacy of early intervention using Vojta and Bobath combined treatment in high risk infants with brain damage, and investigate the effect of early rehabilitation on the prognosis. DESIGN: A randomized controlled comparative observation. SETTING: Daqing Oil Field General Hospital of Heilongjiang Province. PARTICIPANTS: Eighty-four high risk infants younger than 1 year were selected from the Department of Pediatrics, Daqing Oil Field General Hospital of Heilongjiang Province from October 2005 to October 2006, including 52 boys (62%) and 32 girls (38%). The treatment started at the age of 0–3 months in 11 cases (13%), 4–6 months in 28 cases (33%), 7–9 months in 35 cases (42%), and 10–12 months in 10 cases (12%). Infants with at least two of the followings were enrolled, including 7 Vojta abnormal postural reflexes, slow or disorder of motor development, increase of muscular tension, postural abnormality, primary reflection residual and CT/MRI abnormalities. Informed consents were obtained from their guardians. The 84 infants were randomly divided into treatment group (n =42) and control group (n =42). METHODS: All the children were intravenously injected with cerebroprotein hydrolysate injection or cattle encephalon glycoside and ignotin injection, 10 times as a course for 2–5 courses; Besides, the infants in the treatment group also received early rehabilitative training of Vojta and Bobath combined treatment, once a day, 40 minutes per time, 5 times a week followed by a 2-day rest, 1 month as a course, and totally 2–5 courses. The Vojta method was to facilitate the automatic regulation by reflexlocomotion. Bobath method was to inhibit abnormal posture but facilitate the normal one, thus it is also called neurodevelopmental therapy realized by reflex inhibition and facilitation. The rehabilitation was evaluated clinically using Gesell Development Schedules (GDS) after the courses when the infants were 1 year old. GDS included five aspects of adaptive behavior, gross motor, refine motor, speech, individual-social behavior. The developmental quotient (DQ) could be calculated according to their development. DQ=developmental age/actual age×100, < 85 points was taken as abnormal; The higher the DQ value, the better the development. ② Evaluation of efficacy: Cured: Developmental order reached normal or generally normal, abnormal posture disappeared, muscular tension ameliorated, symmetric limbs' motor function, free movement, normal intelligence, powerful reaction, and clear speech. Significant effect: Developmental order tended to normal, abnormal posture disappeared incompletely, muscular tension ameliorated incompletely, transient pause in the flexion and extension of limbs, good reaction, and improved intelligence. Effective: Developmental order improved to a certain degree, muscular tension ameliorated, limbs' motor function and posture improved as compared with before treatment, but still under control, intelligence improved a little. Invalid: No obvious changes before and after treatment. Total significant effective rate=(cured cases+cases of significant effect)/total cases ×100%. ③ The enumeration data and measurement data were compared with chi-square test and t test respectively. MAIN OUTCOME MEASURES: Clinical efficacy and GDS results at 1 year old in both groups. RESUTLS: All the 84 infants were involved in the analysis of results. ① Efficacy: The total significant effective rate in the treatment group was higher than that in the control group (93%, 74%, χ2=4.2, P < 0.05). ② Results of GDS evaluation: The DQ values of individual intercourse and social adaptation in the treatment group (93.57±11.23, 95.13±9.32) were higher than those in the control group (88.27±10.18, 90.10±10.67, t =2.267, 2.301, P < 0.05); The DQ values of gross motor, fine motor and speech in the treatment group (90.78±10.20, 98.63±9.23, 93.69±11.31) were higher than those in the control group(84.32±11.33, 87.80±8.61, 85.52±10.61, t =2.746, 5.560, 2.746, P < 0.01). The interventional effects on each functional area were significant, especially the gross motor, fine motor and speech. CONCLUSION: The Vojta and Bobath combined treatment on the basis of drug therapy can improve the general developments of abilities in motor, intelligence, social intercourse, social adaptation and speech of high risk infants with brain damage, also can improve the curative efficacy. | Chunyan Wu Xiaohui Peng Xuesong Li Qingling Niu Hong Guo Huitao Huang | 2007 | Neural Regeneration Research2007，2，2： | 1 |
| 13 | Proteomic-based Analysis for Identification of Proteins Involved in 5-fluorouracil Resistance in Hepatocellular Carcinoma显示文摘 | Yi Tan Shukui Qin Xin Hou Xiujuan Qian Jun Xia Yumei Li Rui Wang Changjie Chen Qingling Yang Lucio Miele Qiong Wu Zhiwei Wang | 2014 | Current Pharmaceutical Design2014，，1： | 1 |
| 14 | A migration imaging method using CGP stacked cylindrical waves显示文摘鉴于在 Songliao 盆的薄沙水库的地震探索问题,这篇论文用叠的 CGP (普通地震检波器点) 提出一个迁居成像方法圆柱的波浪。由这个工具,地震数据应该从与小射击点间距和小地震检波器间隔射击布局系统的一个中点被获得。用如此的地震数据, CGP 集合首先被叠填写圆柱的波浪节。圆柱的波浪节向下借助于光线路径被移植并且想象下面去的波浪和波浪方程的继续向下继续起来去的波浪。从在建议移植成像方法举办的 Songliao 盆表演 TK8157 地震的线处理的当模特儿的分析和数据的结果更高地震的分辨率和忠实。而且,建议方法被证明为发现小沙身体更有效,小差错, stratigraphic 拧外面等等。 | Li Zishun Long Jiangnan Wu Qingling | 2006 | Applied Geophysics2006，3，2： | 1 |
| 15 | Rapid magnetic-mediated solid-phase extraction and pre-concentration of selected endocrine dis- mpting chemicals in natural waters by poly ( acrylic acid) coated Fe304 core-shell magnetite microspheres for their liquid chromatography-tandem mass spectromeWy determination显示文摘 | LI Qingling LAM M H W WU R S S | 2010 | Jour- nal of Chromatography A2010，1217，8： | 1 |
| 16 | Physical Activity,Sedentary Behavior,and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients:The MIDiab Study显示文摘The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity(MVPA)time and sedentary(SED)time with a history of cardiovascular disease(CVD)and multifactorial(i.e.,blood pressure(BP),body mass index(BMI),low-density lipoprotein cholesterol(LDL-C),and glycated hemoglobin A1c(HbA1c))control status among type 2 diabetes mellitus(T2DM)patients in China.A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes(MIDiab)study was performed.Patients were grouped according to their self-reported MVPA time(low,<150 min·week−1;moderate,150 to<450 min·week−1;high,≥450 min·week−1)and SED time(low,<4 h·d–1;moderate,4 to<8 h·d–1;high,≥8 h·d–1).Participants who self-reported a history of CVD were identified as having a CVD risk.Odds ratios(ORs)and 95%confidence intervals(CIs)of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models,adjusting for China’s geographical region characteristics.The participants had a mean±standard deviation(SD)age of(60.87±8.44)years,44.5%were women,and 25.1%had CVD.After adjustment for potential confounding factors,an inverse association between high MVPA time and CVD risk that was independent of SED time was found,whereas this association was not observed in the moderate-MVPA group.A higher MVPA time was more likely to have a positive effect on the control of BMI.Compared with the reference group(i.e.,those with MVPA time≥450 min·week−1 and SED time<4 h·d–1),CVD risk was higher in the low-MVPA group:The OR associated with an SED time<4 h·d–1 was 1.270(95%CI,1.040–1.553)and that associated with an SED time≥8 h·d–1 was 1.499(95%CI,1.149–1.955).We found that a high MVPA time(i.e.,≥450 min·week−1)was associated with lower odds of CVD risk regardless of SED time among patients with T2DM. | Yafei Wu Guijun Qin Guixia Wang Libin Liu Bing Chen Qingbo Guan Zhongshang Yuan Xu Hou Ling Gao Chao Xu Haiqing Zhang Xu Zhang Qiu Li Yongfeng Song Fei Jing Shizhan Ma Shanshan Shao Meng Zhao Qingling Guo Nanwei Tong Hongyan Zhao Xiaomin Xie Chao Liu Zhongyan Shan Zhifeng Cheng Xuefeng Yu Shulin Chen Tao Yang Yangang Wang Dongmei Li Zhaoli Yan Lixin Guo Qiuhe Ji Wenjuan Wang Jiajun Zhao | 2023 | Engineering2023，，1： | 1 |
| 17 | Effects of promoters and preparation procedures on reforming of methane with carbon dioxide over Ni/Al2O3 catalyst显示文摘 | Cheng Zhenxing Wu Qingle Li Jinlu | 1996 | Catalysis Today1996，30，123： | 1 |
| 18 | Chemical composition and pharmacological properties of Flos sophorae immaturus, Flos sophorae and Fructus sophorae: a review显示文摘The flower buds and fruits of Sophora japonica are known as Flos sophorae immaturus(Chinese Huaimi,FSI),Flos sophorae(Chinese Huaihua,FLS)and Fructus sophorae(Chinese Huaijiao,FRS)due to their different physiological forms.FSI and FLS are precious resources of homology of medicine and food,while FRS is a valuable Chinese herb,and all of which have been used for thousands of years.There are great differences in the active ingredients,functions and toxicological properties of FSI,FLS and FRS.However,they are often confused and assumed to have fairly similar validity,which is detrimental to their precision development of resources of homology of medicine and food.This review summarized the active constituents,analytical techniques and pharmacological properties of FSI,FLS and FRS,then systematically compared their differences.The article will help people better understand and distinguish the differences and characteristics of FSI,FLS and FRS in bioactive constituents,content of functional components and pharmacological properties,which can contribute to their highly efficient targeted applications in the future food and medical fields. | Ping Shi Jiajun Liao Ting Duan Qingling Wu Xiaoni Huang Xiaodong Pei Chenghua Wang | 2023 | Journal of Future Foods2023，3，4： | 0 |
| 19 | Effects of a polyamine inhibitor on the microstructure and macromechanical properties of hydrated shale显示文摘China is rich in shale gas resources,however,wellbores in shale gas reservoirs are frequently unstable.This has a serious impact on the shale gas drilling cycle.Polyamine,a common additive in water-based shale drilling fluids,can effectively inhibit shale hydration.However,there is a lack of quantitative research on the effect of polyamine inhibitors on the microstructure and macromechanical properties of shale.Therefore,this study investigated those issues via a systematic hydration experiment carried out on shale from the Longmaxi Formation.The results show that microfractures are created and expand during shale hydration,that they also connect to form a complex microfracture network,and that 3%polyamine inhibitors(polyamine solution with volume fraction of 3%)can effectively inhibit their evolution.The ultrasonic velocities and UCS of the Longmaxi shale are significantly anisotropic;the former first increases and then decreases with the laminae angle,reaching its maximum when the laminae angle is 30°.The UCS of the shale is highest and lowest,respectively,when the laminae angles are 0°or 90°and 30°.In general,these UCS appear as a'U'pattern,high on two sides with a dip in the center.Polyamines can effectively inhibit both the expansion of shale and the reduction of P-wave and S-wave velocities,the UCS,and elastic modulus.The UCS of a shale sample was reduced by 28%e40%after immersion for 96 h in water,compared to 2%e20%after immersion in a 3%polyamine inhibitor for the same amount of time.The inhibiting effect of the polyamine was remarkable. | Yunlei Hu Xiangchao Shi Qingling Li Leiyu Gao Feng Wu Gang Xie | 2022 | Petroleum2022，8，4： | 0 |
| 20 | Complete genome sequence of Lactobacillus fermentum 9-4,a purine-degrading Lactobacillus probiotic isolated from Chinese fermented rice-flour noodles显示文摘Lactobacillus fermentum 9-4 is a purine-degrading probiotic firstly isolated from traditional fermented rice-flour noodles with special characteristics of southern China's Guangxi Zhuang Autonomous Region.L.fermentum 9-4 could efficiently reduce the purine contents in foods with excellent purine-nucleoside assimilation and purine-metabolizing enzymatic activities.Crude cell lysate of L.fermentum 9-4 showed strong purine degradation abilities on nucleosides including inosine,guanosine,and purines including xanthine and uric acid,indicating a complete purine metabolic pathway to degrade purine substances to allantoin.In this study,the whole genome of L.fermentum 9-4 was sequenced.Its genome consisted of a 2085632 bp circular chromosome without plasmid.The GC content of circular chromosome was 51.25%,including 2089 coding sequences(CDs),15 rRNA operons and 59 tRNA coding genes.Genetic analysis showed that at least 5 protein coding genes were related to purine lowering ability.In addition,neither toxic virulence factor nor drug resistance gene was identified by searching the virulence factor database and drug resistance gene database,suggesting good safety of L.fermentum 9-4.The results showed that L.fermentum 9-4 has a good potential for the development and utilization as a purine-degrading probiotic for low-purine foods. | Tiantian Gao Lianghua Lu Qingling Wu Chenghua Wang | 2023 | Journal of Future Foods2023，3，2： | 0 |
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