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| 1 | In-situ trace element analyses of zircons from Dabieshan Huangzhen eclogite:Trace element characteristics of eclogite-facies metamorphic zircon显示文摘The internal structures of zircons in eclogite from Huangzhen have been studied by cathodoluminescence (CL) microscopy. Two growth stages were distinguished: protolith magmatic cores and metamorphic overgrowth rims. These different domains were analyzed for trace elements using LAM-ICP-MS. The protolith and the overgrowth zircons have different trace elements characteristics. The trace element contents of protolith zircons are high and very variable. The overgrowth zircons show a typical trace element feature of equilibrium with garnet, e.g. low contents of HREE (132.2-197.6μg/g) and small differential degree of HREE ((Yb/Gd)cN=8.6-11.9). The contents of Nb, Ta and the ratio of Nb/Ta are lower in the metamorphic domains (0.5-1.4μg/g, 0.7-1.5μg/g, 0.3-1.3, respectively) than in the protolith domains (3.8-19.7μg/g, 2.7-12.1μg/g, 1.0-4.6, respectively). This is the first time to give the evidence that the metamorphic zircon equilibrates with the rutile, which formed during the peak metamorphic stage. | WU Yuanbao CHEN Daogong XIA Qunke TU Xianglin CHENG Hao | 2002 | Chinese Science Bulletin2002，47，16： | 26 |
| 2 | Projected Shifts in Kppen Climate Zones over China and Their Temporal Evolution in CMIP5 Multi-Model Simulations显示文摘Previous studies have examined the projected climate types in China by 2100. This study identified the emergence time of climate shifts at a 1?scale over China from 1990 to 2100 and investigated the temporal evolution of K o¨ppen–Geiger climate classifications computed from CMIP5 multi-model outputs. Climate shifts were detected in transition regions(7%–8% of China's land area) by 2010, including rapid replacement of mixed forest(Dwb) by deciduous forest(Dwa) over Northeast China, strong shrinkage of alpine climate type(ET) on the Tibetan Plateau, weak northward expansion of subtropical winterdry climate(Cwa) over Southeast China, and contraction of oceanic climate(Cwb) in Southwest China. Under all future RCP(Representative Concentration Pathway) scenarios, the reduction of Dwb in Northeast China and ET on the Tibetan Plateau was projected to accelerate substantially during 2010–30, and half of the total area occupied by ET in 1990 was projected to be redistributed by 2040. Under the most severe scenario(RCP8.5), sub-polar continental winter dry climate over Northeast China would disappear by 2040–50, ET on the Tibetan Plateau would disappear by 2070, and the climate types in 35.9%and 50.8% of China's land area would change by 2050 and 2100, respectively. The results presented in this paper indicate imperative impacts of anthropogenic climate change on China's ecoregions in future decades. | Duo CHAN Qigang WU Guixiang JIANG Xianglin DAI | 2016 | Advances in Atmospheric Sciences2016，33，3： | 10 |
| 3 | A comparative study on the levels of serum cytokines and cortisol among post-traumatic stress disorder patients of Li and Han ethnicities in Hainan显示文摘 | Chen Tao Guo Min Gao Yunsuo Chen Feng Guo Juncheng Liu Tao Wu Duoyu Jiang Xianglin | 2014 | Chinese Medical Journal2014，，15： | 8 |
| 4 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 5 | Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal,intragastric and intravenous administration显示文摘The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate(TMPP)in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes:intranasal(i.n.),intragastric(i.g.)and intravenous(i.v.)administration.After i.n.,i.g.and i.v.administration of a single-dose at 10 mg/kg,cerebral cortex dialysates and plasma samples drawn from the carotid artery were collected at timed intervals.The concentration of TMPP in the samples was analyzed by HPLC.The area under the concentration-time curve(AUC)and the ratio of the AUCbrain to the AUCplasma(drug targeting efficiency,DTE)was calculated to evaluate the brain targeting efficiency of the drug via these different routes of administration.After i.n.administration,TMPP was rapidly absorbed to reach its peak plasma concentration within 5 min and showed a delayed uptake into cerebral cortex(t_(max)=15 min).The ratio of the AUCbrain dialysates value between i.n.route and i.v.injection was 0.68,which was greater than that obtained after i.g.administration(0.43).The systemic bioavailability obtained with i.n.administration was greater than that obtained by the i.g.route(86.33%vs.50.39%),whereas the DTE of the nasal route was 78.89%,close to that of oral administration(85.69%).These results indicate that TMPP is rapidly absorbed from the nasal mucosa into the systemic circulation,and then crosses the blood-brain barrier(BBB)to reach the cerebral cortex.Intranasal administration of TMPP could be a promising alternative to intravenous and oral approaches. | Dongmei Meng Haoyang Lu Shanshan Huang Minyan Wei Pingtian Ding Xianglin Xiao Yuehong Xu Chuanbin Wu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 5 |
| 6 | Advanced cold spray technology:Deposition characteristics and potential applications显示文摘Cold spray technology,originated from the Institute of Theoretical and Applied Mechanics Siberian branch of the Russian Academy of Sciences,is a rapidly emerging industrial coating technology.Cold sprayed particles with high-velocity impact onto a substrate so as to induce severe plastic deformation and then create a deposit.For its low temperature and high velocity compared with thermal spraying,the cold spraying process is increasingly used in the industries for protective coating.The deposition characteristics of the particles,coating formation and bonding mechanism of the cold spraying process are different from thermal spraying.Many theory investigations of the cold spraying process contribute to the development of the high performance coatings,which makes the cold spraying process as a popular research field.Presently,the deposition characteristics,bonding mechanism,process optimization as well as classical applications of the cold spraying technology in the past are reviewed,and the interesting points for the further development,optimization and applications of this technology are also recommended. | WU XiangKun ZHANG JiShan ZHOU XiangLin CUI Hua LIU JingChun | 2012 | Science China(Technological Sciences)2012，55，2： | 5 |
| 7 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 8 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 9 | Clinical outcomes of coronavirus disease 2019 (COVID-19) in cancer patients with prior exposure to immune checkpoint inhibitors显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has affected over 6,000,000 people globally[1].Patients with COVID-19 manifest with symptoms of fever,dry cough,dyspnea,and present with radiological changes that are consistent with atypical pneumonia[2].Pathogenetic mechanisms for these abnormalities involve the systemic immune response that is associated with the hyperactivation of peripheral CD8+and CD4+T cells,and a cytokine storm[3].Globally,the reported prevalence of patients with COVID-19 and cancer ranges from 0.5%to 6.0%in the different case series[4]. | Qiuji Wu Qian Chu Hongyan Zhang Bin Yang Xudong He Yahua Zhong Xianglin Yuan Melvin L.K.Chua Conghua Xie | 2020 | Cancer Communications2020，40，8： | 3 |
| 10 | Numerical investigation of the rebounding and the deposition behavior of particles during cold spraying显示文摘Particles may rebound from a substrate surface during cold spraying,which affects the quality of the coating.In this paper,the rebound phenomenon and its consequences on deposition behavior have been analyzed using the finite element analysis software ANSYS/LS-DYNA version 970.In a range of particle velocities of 50-1000 m/s,increases of the impact velocity caused a rapid decline of the rebound coefficient R to a low point Rmin.After that,R began to rise slowly.Then the effect of the impact velocities and material properties on the rebound phenomenon were analyzed.Both the material strength and density influenced this rebound phenomenon.Four stages of the impact process and a model of strain distribution were proposed in detail to explain the rebound phenomenon. | Xianglin ZHOU Xiangkun WU Jianguo WANG Jishan ZHANG | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，1： | 2 |
| 11 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 12 | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5显示文摘Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. | WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 13 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 14 | Highly stableβ‑ketoenamine‑based covalent organic frameworks(COFs):synthesis and optoelectrical applications显示文摘Covalent organic frameworks(COFs)are one class of porous materials with permanent porosity and regular channels,and have a covalent bond structure.Due to their interesting characteristics,COFs have exhibited diverse potential applications in many felds.However,some applications require the frameworks to possess high structural stability,excellent crystallinity,and suitable pore size.COFs based onβ-ketoenamine and imines are prepared through the irreversible enol-to-keto tautomerization.These materials have high crystallinity and exhibit high stability in boiling water,with strong resistance to acids and bases,resulting in various possible applications.In this review,we frst summarize the preparation methods for COFs based onβ-ketoenamine,in the form of powders,flms and foams.Then,the efects of diferent synthetic methods on the crystallinity and pore structure of COFs based onβ-ketoenamine are analyzed and compared.The relationship between structures and diferent applications including fuorescence sensors,energy storage,photocatalysis,electrocatalysis,batteries and proton conduction are carefully summarized.Finally,the potential applications,large-scale industrial preparation and challenges in the future are presented. | Yaqin Li Maosong Liu Jinjun Wu Junbo Li Xianglin Yu Qichun Zhang | 2022 | Frontiers of Optoelectronics2022，15，3： | 2 |
| 15 | Using Mind Map as Learning Tool in 'Data Structure' Teaching显示文摘 | Feijuan He Xianglin Miao Bei Wu Siyu Yao | 2014 | IEEE2014，，： | 1 |
| 16 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 17 | Fast Image Segmentation Based on Multilevel Banded Closed-Form Method显示文摘 | Han Shoudong Tao Wenbing Wu Xianglin | 2010 | Pattern Recognition Letters2010，31，3： | 1 |
| 18 | Development, characterization and appli- cations of a novel estrogen receptor beta monoclonal antibody 显示文摘 | Xianglin Wu Malayannan Subramaniam Vivian Ne- gron | 2012 | Journal of Cellular Biochemistry2012，113，2： | 1 |
| 19 | COVID-19-associated gastrointestinal and liver injury:clinical features and potential mechanisms显示文摘Coronavirus disease-2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The infection is spreading globally and poses a huge threat to human health.Besides common respiratory symptoms,some patients with COVID-19 experience gastrointestinal symptoms,such as diarrhea,nausea,vomiting,and loss of appetite.SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2(ACE2)and there is increasing evidence of a possible fecal–oral transmission route.In addition,there exist multiple abnormalities in liver enzymes.COVID-19-related liver injury may be due to drug-induced liver injury,systemic inflammatory reaction,and hypoxia–ischemia reperfusion injury.The direct toxic attack of SARS-CoV-2 on the liver is still questionable.This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19. | Peijie Zhong Jing Xu Dong Yang Yue Shen Lu Wang Yun Feng Chunling Du Yuanlin Song Chaomin Wu Xianglin Hu Yangbai Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 20 | Building global imagefeatures for scene recognition 显示文摘 | MENG Xianglin WANG Zhengzhi WU Lizhen | 2012 | Patter Recognition2012，，45： | 1 |
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