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| 1 | Late Devonian red tide and mass extinction显示文摘Molecular stratigraphical, carbonate carbon isotopic, stratigraphical and paleontological data show that algal booming, eutrophication, anoxia, hypersalinity, positive δ13C excursion and biomass decreasing occurred in the offshore carbonate environments of the Frasnian-Famennian (F-F) transition, which hints that red tide might frequently take place in the F-F transition of Guangxi, South China. We suggest that the mass extinction of the reef ecosystems and the shallow-water marine organisms in the F-F transition of the lower-middle latitudes may be related to the frequent occurrence of red tide in that time. | GONG Yiming LI Baohua SI Yuanlan WU Yi | 2002 | Chinese Science Bulletin2002，47，13： | 14 |
| 2 | Genome Warehouse: A Public Repository Housing Genome-scale Data显示文摘The Genome Warehouse(GWH)is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission,storage,release,and sharing.As one of the core resources in the National Genomics Data Center(NGDC),part of the China National Center for Bioinformation(CNCB;http://gffzz77e3413bc06540edskxvwxnwfpp5x6qqx.ffgz.tsg.suse.edu.cn),GWH accepts both full and partial(chloroplast,mitochondrion,and plasmid)genome sequences with different assembly levels,as well as an update of existing genome assemblies.For each assembly,GWH collects detailed genome-related metadata of biological project,biological sample,and genome assembly,in addition to genome sequence and annotation.To archive high-quality genome sequences and annotations,GWH is equipped with a uniform and standardized procedure for quality control.Besides basic browse and search functionalities,all released genome sequences and annotations can be visualized with JBrowse.By May 21,2021,GWH has received 19,124 direct submissions covering a diversity of 1108 species and has released 8772 of them.Collectively,GWH serves as an important resource for genomescale data management and provides free and publicly accessible data to support research activities throughout the world.GWH is publicly accessible at http://gffzz77e3413bc06540edskxvwxnwfpp5x6qqx.ffgz.tsg.suse.edu.cn/gwh. | Meili Chen Yingke Ma Song Wu Xinchang Zheng Hongen Kang Jian Sang Xingjian Xu Lili Hao Zhaohua Li Zheng Gong Jingfa Xiao Zhang Zhang Wenming Zhao Yiming Bao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 3 | Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism显示文摘Autism spectrum disorder(ASD) is a spectral neurodevelopment disorder affecting approximately 1% of the population. ASD is characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Multiple factors, including genetic/genomic, epigenetic/epigenomic and environmental, are thought to be necessary for autism development. Recent reviews have provided further insight into the genetic/genomic basis of ASD. It has long been suspected that epigenetic mechanisms, including DNA methylation, chromatin structures and long non-coding RNAs may play important roles in the pathology of ASD. In addition to genetic/genomic alterations and epigenetic/epigenomic influences, environmental exposures have been widely accepted as an important role in autism etiology, among which immune dysregulation and gastrointestinal microbiota are two prominent ones. | YU Li WU YiMing WU Bai-Lin | 2015 | Science China(Life Sciences)2015，58，10： | 11 |
| 4 | Secure Consensus Control for Multi-Agent Systems With Attacks and Communication Delays显示文摘This paper addresses the consensus problem for nonlinear multi-agent systems suffering from attacks and communication delays. The network studied in this paper consists of two types of agents, namely, loyal agents and attack agents.The loyal agents update their states based on delayed state information exchanged with their neighbors. Meanwhile, the attack agents can strategically send messages with wrong values,or collude with other attack agents to disrupt the correct operation of the system. We design a novel delay robust secure consensus(DRSC) algorithm according to the neighboring nodes’ delayed information. Convergence analysis of the system under the protocol designed is provided by using Lyapunov-Krasovskii stability theory and Barbalat-like argument approach. Finally,an example and simulation results are presented to demonstrate the effectiveness of the algorithm. | Yiming Wu Xiongxiong He | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，1： | 11 |
| 5 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 6 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 7 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 8 | Characteristics of deformation and stress distribution of small coa pillars under leading abutment pressure显示文摘Based on the engineering project on a small coal pillar of 12,521 working face roadway in Xieqiao Coalmine, data regarding surface displacements of the coal pillar, deep displacements and mining stress have been collected and analyzed. The results show that macroscopic transverse fractures of the inner coal pillar are developed within 2–4 m of the roadway surface, which is located outside the coal pillar anchorage zone. There is a displacement of 530 mm at the monitoring point in the 6 m deep zone of the pillar. Transfer of the fracture zone is found in a small coal pillar and the fractures within 3–4 m of the coal-rock zone from the roadway surface undergo propagation and closure of cracks which means this fracture zone is transferred from 3–4 m outside the roadway to only 2–3 m from the roadway surface. In the monitoring zone, vertical and horizontal stresses increase with a feature that shows that acceleration in the deep zone of the pillar is greater than that in the shallow zone. Furthermore, the acceleration of vertical stress is also greater than that of horizontal stress with a peak value in the 4 m zone.The research findings provide a reference for the regulation of a reasonable width of coal pillar in coalmines and optimal control design of surrounding rock. | Wu Hai Zhang Nong Wang Weijun Zhao Yiming Cao Peng | 2015 | International Journal of Mining Science and Technology2015，25，6： | 6 |
| 9 | Source apportionment of PM_(2.5)and visibility in Jinan,China显示文摘Atmospheric extinction is impacted by the chemical composition of particles.To better understand the chemical composition of PM_(2.5)(particles with diameters of less than 2.5μm)and its relationship with extinction,one-month sampling campaigns were carried out in four different seasons from 2013 to 2014 in Jinan,China.The seasonal average concentrations of PM_(2.5)were 120.9(autumn),156.6(winter),102.5(spring),and 111.8μg/m^(3)(summer).The reconstructed PM_(2.5)chemical composition showed that sulfate,nitrate,chlorine salt,organic matter(OM),mineral dust,elemental carbon(EC)and others accounted for 25%,14%,2%,24%,22%,3%and 10%,respectively.The relationship between the chemical composition of PM_(2.5)and visibility was reconstructed by the IMPROVE method,and ammonium sulfate,ammonium nitrate,OM and EC dominated the visibility.Seven main sources were resolved for PM_(2.5),including secondary particles,coal combustion,biomass burning,industry,motor vehicle exhaust,soil dust and cooking,which accounted for 37%,21%,13%,13%,12%,3%and 1%,respectively.The contributions of different sources to visibility were similar to those to PM_(2.5).With increasing severity of air pollution,the contributions of secondary particles and coal combustion increased,while the contribution of motor vehicle exhaust decreased.The results showed that coal combustion and biomass burning were still the main sources of air pollution in Jinan. | Mengtian Cheng Guiqian Tang Bo Lv Xingru Li Xinrui Wu Yiming Wang Yuesi Wang | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 10 | Intergranular corrosion behavior and mechanism of the stabilized ultra-pure 430LX ferritic stainless steel显示文摘Intergranular corrosion(IGC) behavior of the stabilized ultra-pure 430 LX ferritic stainless steel(FSS) was investigated by using double loop electrochemical potentiokinetic reactivation(DL-EPR) and oxalic acid etch tests to measure the susceptibility of specimens given a two-step heat treatment. The results reveal that IGC occurs in the specimens aged at the temperature range of 600–750℃ for a short time. The aging time that is required to cause IGC decreases with the increase of aging temperature. A longer aging treatment can reduce the susceptibility to IGC. The microstructural observation shows that M(23)C6 precipitates form along the grain boundaries, leading to the formation of Cr-depleted zones. The presence of Cr-depleted zones results in the susceptibility to IGC. However, the atoms of stabilizing elements replace chromium atoms to form MC precipitates after long-time aging treatment, resulting in the chromium replenishment of Cr-depleted zones and the reduction of the susceptibility to IGC. | Peize Cheng Ning Zhong Nianwei Dai Xuan Wu Jin Li Yiming Jiang | 2019 | Journal of Materials Science & Technology2019，35，8： | 5 |
| 11 | Geology and Geochemistry of the Yangtizishan-Moshishan Metamorphosed Sedimentary Anatase Deposit in Zhenglan Qi,Inner Mongolia:Discovery of a New Genetic Type of Titanium Deposit显示文摘锐钛矿和它的 allomorphic 矿物质金红石在钛矿物质资源之中有最突出的经济意义并且在中国当前组成非常需要的矿物质资源之一。Yantizishan-Moshishan 锐钛矿沉积物先前被叫作基于作者相信的最近的调查和探索的铁沉积物属于一种新基因类型是大变形沉积锐钛矿主导的沉积物的。矿石身体在 Mesoproterozoic (1751 妈) 发生在 stratoid 和透镜的形式片岩, metasandstone (metasiltstone ) ,和角闪岩。富有的矿石让 perthitic 组织主要包括 interbedded 石英 perthite (与传播锐钛矿和金红石) 并且锐钛矿 perthite。矿石矿物质主要是锐钛矿并且辅助地金红石和钛铁矿(?????????? ￡吗? | ZHAO Yiming LI Daxin WU Liangshi CHEN Wenming FENG Chengyou WANG Peihua GAO Xuedong | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 4 |
| 12 | Photoinduced large polaron transport and dynamics in organic-inorganic hybrid lead halide perovskite with terahertz probes显示文摘Organic-inorganic hybrid metal halide perovskites(MHPs)have attracted tremendous attention for optoelectronic applications.The long photocarrier lifetime and moderate carrier mobility have been proposed as results of the large polaron formation in MHPs.However,it is challenging to measure the effective mass and carrier scattering parameters of the photogenerated large polarons in the ultrafast carrier recombination dynamics.Here,we show,in a one-step spectroscopic method,that the optical-pump and terahertz-electromagnetic probe(OPTP)technique allows us to access the nature of interplay of photoexcited unbound charge carriers and optical phonons in polycrystalline CH_(3)NH_(3)PbI_(3)(MAPbI_(3))of about 10μm grain size.Firstly,we demonstrate a direct spectral evidence of the large polarons in polycrystalline MAPbI_(3).Using the Drude-Smith-Lorentz model along with the Frӧhlich-type electron-phonon(e-ph)coupling,we determine the effective mass and scattering parameters of photogenerated polaronic carriers.We discover that the resulting moderate polaronic carrier mobility is mainly influenced by the enhanced carrier scattering,rather than the polaron mass enhancement.While,the formation of large polarons in MAPbI_(3)polycrystalline grains results in a long charge carrier lifetime at room temperature.Our results provide crucial information about the photo-physics of MAPbI3 and are indispensable for optoelectronic device development with better performance. | Zuanming Jin Yan Peng Yuqing Fang Zhijiang Ye Zhiyuan Fan Zhilin Liu Xichang Bao Heng Gao Wei Ren Jing Wu Guohong Ma Qianli Chen Chao Zhang Alexey VBalakin Alexander PShkurinov Yiming Zhu Songlin Zhuang | 2022 | Light(Science & Applications)2022，11，8： | 4 |
| 13 | A Multi-semantics Classification Method Based on Deep Learning for Incredible Messages on Social Media显示文摘How to classify incredible messages has attracted great attention from academic and industry nowadays.The recent work mainly focuses on one type of incredible messages(a.k.a rumors or fake news)and achieves some success to detect them.The existing problem is that incredible messages have different types on social media,and rumors or fake news cannot represent all incredible messages.Based on this,in the paper,we divide messages on social media into five types based on three dimensions of information evaluation metrics.And a novel method is proposed based on deep learning for classifying the five types of incredible messages on social media.More specifically,we use attention mechanism to obtain deep text semantic features and strengthen emotional semantics features,meanwhile,construct universal metadata as auxiliary features,concatenating them for incredible messages classification.A series of experiments on two representative real-world datasets demonstrate that the proposed method outperforms the state-of-the-art methods. | WU Lianwei RAO Yuan YU Hualei WANG Yiming AMBREEN Nazir | 2019 | Chinese Journal of Electronics2019，28，4： | 4 |
| 14 | Chemically Binding Scaffolded Anodes with 3D Graphene Architectures Realizing Fast and Stable Lithium Storage显示文摘Tree-dimensional(3D)graphene has emerged as an ideal platform to hybridize with electrochemically active materials for improved performances.However,for lithium storage,current anodic guests ofen exist in the form of nanoparticles,physically attached to graphene hosts,and therefore tend to detach from graphene matrices and aggregate into large congeries,causing considerable capacity fading upon repeated cycling.Herein,we develop a facile double-network hydrogel-enabled methodology for chemically binding anodic scafolds with 3D graphene architectures.Taking tin-based alloy anodes as an example,the doublenetwork hydrogel,containing interpenetrated cyano-bridged coordination polymer hydrogel and graphene oxide hydrogel,is directly converted to a physical-intertwined and chemical-bonded Sn−Ni alloy scafold and graphene architecture(Sn−Ni/G)dual framework.Te unique dual framework structure,with remarkable structural stability and charge-transport capability,enables the Sn−Ni/G anode to exhibit long-term cyclic life(701 mA h g^(−1) afer 200 cycles at 0.1 A g^(−1))and high rate performance(497 and 390 mA h g^(−1) at 1 and 2 A g^(−1),respectively).Tis work provides a new perspective towards chemically binding scafolded low-cost electrode and electrocatalyst materials with 3D graphene architectures for boosting energy storage and conversion. | Ping Wu Zhiwei Fang Anping Zhang Xiao Zhang Yawen Tang Yiming Zhou Guihua Yu | 2019 | Research2019，，1： | 4 |
| 15 | Highly Efficient Synthesis of Environmentally Friendly Ag-modified TiO2 Nanoflowers to Enhance Photocatalytic Performance显示文摘Ag-modified TiO2 nanoflowers were prepared using a two-step process. The experimental process is green and free from contamination and can be synthesized directly at room temperature. Compared with pure TiO2, Ag-modified TiO2 enhances the absorption of visible light and effectively promotes the detachment of photoelectron pairs, Ag-TiO2 has a significantly enhanced visible light response activity to photodecomposition of methyl orange(MO). It is shown that the strong interaction between Ag nanoparticles and TiO2 enhances the photocatalytic activity of TiO2 nanoflowers. The self-made open-air reactor was used to test the photocatalytic performance of different samples. The results showed that Ag-modified TiO2 nanoflowers had excellent photodegradation ability. After repeated photodegradation of MO, Ag-modified TiO2 nanoflowers showed good stability. | 李洋 CAI Lun WU Hongbiao HUANG Qilin DU Yiming LIU Shiqiu SHENG Zongqiang CHEN Changzhao | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，6： | 3 |
| 16 | Devonian Frasnian-Famennian Transitional Milankovitch Cycles and High-Resolution Stratigraphic Correlation显示文摘Four hierarchical cyclothems, superbundlesets, bundlesets,bundles and laminae, have been identified from the Devonian Frasnian-Famennian carbonate strata in Guangxi, South China. Their hierarchical structures, ratio relation ships and sequence in conodont zones are continuous and stable and can be traced across different facies zones and sedi mentary basins. Our data show that hierarchically organized superbundlesets, bundlesets, bundles and laminae correspond to the long eccentricity, eccentricity, obliquity or precession and sub-Milankovitch cycles respectively. Their periods were 400,000, 100,000, 33,333, 16,667 and 8,000-17,000 a, respectively. The ratios of long eccentricity to eccentricity, ec centricity to obliquity, and eccentricity to precession in the Devonian are 1:4, 1:3 and 1:6 respectively. Using these hier archical Milankovitch cyclothems, chronostratigraphical division and correlation can be realized at a resolution of 100 ka or 10 ka at the Frasnian-Famennian transition. The time intervals of the Upper rhenana Zone, linguiformis Zone, and the Lower, Middle and Upper triangularis Zone are 0.6, 0.8, 0.3, 0.3 and 0.3 Ma, respectively. Sea-level changes of the Frasnian-Famennian transition were not coherent and synchronous at the resolution of 100 ka or 10 ka in the basin-slope carbonate sequences of Guangxi, South China. | GONG Yiming Faculty of Earth Science, China University of Geosciences, Wuhan, 430074LI Baohua Laboratory of Marine Geology, Tongji University, Shanghai 200092and WU Yi Guangxi Institute of Geology, Nanning 530023 | 2001 | Acta Geologica Sinica(English Edition)2001，75，4： | 3 |
| 17 | Insight into the structural evolution of porous and fractured media by forced aeration during heap leaching显示文摘Despite lots of techniques in improving the heap leaching performance,many constraints on the industrial applications remain.We proposed a correspondingly effective and new idea of introducing forced aeration to improve the bad permeability and leaching effect of Yangla Copper Mine(YCM)during heap leaching.The dual-media theory was employed to study the impact mechanism of forced aeration on the variations of porous and fractured media during the column leaching experiments.An X-Ray Computed Tomography(CT)set was utilized to perform the pore imaging of the specimens and the fracture morphology of the particles within the columns was analyzed by Scanning Electron Microscope(SEM)as aeration rate(AR)changed.The results show that there exists copious fine particles within the heap of YCM,the particle size distribution of which is not reasonable.The forced aeration can not only promote the development of the porous and fractured structures but effectively break the blocked seepage paths.Then the leaching degree is improved and the seepage performance of the solute within the solution is enhanced.Therefore,the forced aeration is probable of making the leaching performance greatly improved. | Yu Shaofeng Wu Aixiang Wang Yiming | 2019 | International Journal of Mining Science and Technology2019，29，5： | 3 |
| 18 | Controlled patterning of upconversion nanocrystals through capillary force显示文摘Lanthanide-doped upconversion nanoparticles(UCNPs)can absorb near-infrared photons and convert them into visible and ultraviolet emissions.These nanomaterials possess extraordinary optical performance and hold potential as active platforms for a variety of technological applications.The ability to fabricate highly ordered nanoparticle-based photonic elements over a large area is of fundamental significance for luminescence tuning.Despite all the efforts made,however,large-area spatial patterning of UCNPs into ordered arrays with high controllability remains a challenge.In this study,we report a highthroughput strategy to pattern optical nanomaterials through the use of polymer microspheres and templated assembly of UCNPs.This technique utilizes capillary force to drive hybrid clusters into the physical template,resulting in large-area,spatially ordered arrays of particles.The findings reported in this work may promote the development of novel nonlinear optical devices,such as solid-state laser arrays,high-density optical storage,and anti-counterfeiting labels. | Yiming Wu Jiahui Xu Xiaogang Liu | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 19 | Devonian Sequence Stratigraphy and Sea Level Change Cycles in South China显示文摘The Devonian is well developed in South China and has drawn a great attention from the geologists both at domestic and abroad. On the basis of study on the sequence stratigraphy in more than 10 sections in Guizhou, Guangxi, Longmenshan and Southern Qinling within South China we have identified 21 sequences and T-R cycles that correspond to third-order sea level changes. These sea level change cycles were controlled by autorhythm(Pragian,Eifelian), allorhythm(Lochkovian,Emsian,Givetian) and coupling rhythm mechanisms (frasian, Famennian and F-F boundary). | Du Yuansheng Gong Yiming (Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074) Wu Yi (Guangxi Institute of Geology, Nanning 530023) Liu Benpei Feng Qinglai (Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074) | 1996 | Journal of Earth Science1996，15，1： | 3 |
| 20 | GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine显示文摘Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent. | Lei Luo Yiming Qi Hong Zhong Shinan Jiang Hu Zhang Hao Cai Yahui Wu Zhongwei Gu Qiyong Gong Kui Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
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