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| 1 | The influence of atmospheric Hg on Hg contaminations in rice and paddy soil in the Xunyang Hg mining district,China显示文摘To date, the Xunyang mercury(Hg) mining district is the only ongoing large-scale Hg mining district in China. To understand the influence of Hg contamination mode from the Hg mining and smelting activities, 27 sampling sites in the Xunyang Hg mining district were chosen in this study. Total gaseous mercury(TGM) in ambient air was measured using a Lumex-RA915 automatic Hg analyzer in2011. Rice samples and soil samples from rhizosphere were collected systematically and simultaneously. Total Hg(THg) and methylmercury(Me Hg) concentrations in rice grain and soil samples and Hg speciation with modified sequential selective extractions were measured. The local environment was seriously polluted with Hg. The TGM(302 ± 376 ng·m-3, ranging from 24 to 2220 ng·m^(-3)) in the local ambient air, THg(28 ± 30 mg·kg^(-1), ranging from 0.31 to 121 mg·kg^(-1)) and Me Hg(2.3 ± 1.9 lg·kg^(-1),ranging from 0.24 to 8.9 lg·kg^(-1)) in soil samples were at the sample level with Hg contaminated area. The THg concentration(26 ± 16 lg·kg^(-1)ranging from 4.5 to 71 lg·kg^(-1)) in most of the rice grain samples clearly exceeds the threshold level(20 lg·kg^(-1)) in the Chinese national guidelines for cereals(NY 861-2004). The inorganic mercury(IHg)(9.1 ± 5.6 lg·kg^(-1), ranging from 1.2 to 24 lg·kg^(-1)) and Me Hg(14 ± 9.8 lg·kg^(-1), ranging from 2.1 to 59 lg·kg^(-1))concentration in rice grain samples were at the same level with Hg contaminated area. The main species of Hg in paddy soils reveal strong complex Hg and residue Hg. According to the correlation analysis, a Hg pollution mode from local Hg mining and smelting was hypothesized, including Hg emission, transportation, methylation, and uptake process. | Ming Ao Bo Meng Atindra Sapkota Yonggui Wu Xiaoli Qian Guangle Qiu Shunqing Zhong Lihai Shang | 2017 | Acta Geochimica2017，36，2： | 5 |
| 2 | Enrichment of heavy metals in coal gangue by puff balls and mechanism research显示文摘Coal gangue with/without wild puff balls growing on or covering up were analyzed by means of inductively coupled plasma atomic emission spectrometry(ICP-AES) and atomic fluorescence spectrometry(AFS) to detect the contents of heavy metal elements in the plants. Seven heavy metals were chosen to do the experiments, which showed that the puff balls have strong enrichment capacity for heavy metals(As, Pb, Mn and Ni). The highest enrichment level was Mn, 220.3 mg/kg(dry weight) for puffball fruiting bodies, and the highest As, Cr and Pb enrichment levels for puffball mycelium were 111, 265.3 and 86 mg/kg, respectively. Cd, Mn and Ni could transfer from puffball mycelium to its fruiting bodies, while As, Cr, Pb and Co mainly accumulated in the mycelium. The contents of five organic acids(tartaric acid, glycolic acid, lactic acid, citric acid and malic acid) in puffballs were determined with high performance liquid chromatography. With water, ethanol and ethyl acetate as solvents, the puffball extracts performed dissolution reactions with coal gangue, in which the water extract(containing a large amount of organic acids) was most effective in releasing heavy metals, especially As, Pb, Cr, Mn, Co and Ni from coal gangue. As a pioneer species, puff balls absorbed the hazardous trace elements in coal gangue matrix to reduce its eco-toxicity, on the other hand, it raised the p H value of coal gangue, improving the vegetation growing conditions for coal gangue matrix to a certain extent and laying the foundation for ecological restoration of coal gangue dumps. | CHEN Miao ZHU Lijun WU Yonggui FU Tianling RAN Yan | 2014 | Chinese Journal Of Geochemistry2014，33，4： | 4 |
| 3 | Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer显示文摘Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line treatment agent in non-oncogene driven non-small cell lung cancer(NSCLC).This prospective study aimed to investigate the efficacy and safety of anlotinib plus S-1 for third-or later-line treatment in patients with advanced NSCLC.Methods Patients with histologically or cytologically confirmed NSCLC,and documented disease progression following second-line chemotherapy,and/or epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI)treatment were enrolled in this study.The patients were treated anlotinib(8 mg daily d 1–14)and S-1(60 mg/m^2 d 1–14)and the treatment was repeated every 3 weeks.Treatment was continued until disease progression or unacceptable toxicity occurred.The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),and adverse events(AEs)were reviewed and evaluated.Results Forty-one patients were enrolled in the study between June 2018 and December 2018.The total ORR and DCR were 26.8%and 80.5%,respectively.The median PFS was 5.2 months[95%confidence interval(CI),3.9 to 6.6 months].In the univariate analysis,there was a significant difference in the median PFS between patients with brain metastases and those without brain metastases(4.8 months vs 5.9 months,respectively;P=0.039).The Eastern Cooperative Oncology Group(ECOG)performance status(P=0.002),lines of therapy(P=0.015),and therapeutic evaluation(P=0.014)were independent factors that influenced PFS.The most common AEs were hypertension,proteinuria,myelosuppression,gastrointestinal reactions,fatigue,and mucositis.Conclusion Anlotinib plus S-1 is an effective and safe regimen for advanced NSCLC as third-or later-line therapy. | Heng Cao Kai Liang Peng Liu Jing Wang Yuanyuan Ji Lujuan Xu Weilong Wu Shengnan Guo Xuekun Song Yonggui Hong | 2020 | Oncology and Translational Medicine2020，6，1： | 4 |
| 4 | Simultaneous evaluation of two branches of a multifunctional integrated optic chip with an ultra-simple dual-channel configuration显示文摘We propose an ultra-simple dual-channel configuration for simultaneously evaluating two branches of a multifunctional integrated optic chip(MFIOC). In the configuration, the MFIOC is employed as a beam splitter to construct the demodulation interferometer together with a 2 × 2 fiber coupler. Interference happens between polarization modes traveling through different channels of the MFIOC. The cross-couplings of each channel are respectively characterized by the interference peaks which distribute on opposite sides of the central interference peak. Temperature responses of the MFIOC are experimentally measured from-40°C to 80°C. Results show that the proposed configuration can achieve simultaneous dual-channel transient measurements with resolution of-90 d B and dynamic range of 90 d B. In addition, the two channels of the configuration have consistent measuring performance, and the two branches of the MFIOC have different responses to temperature variation. | Yonggui Yuan Chuang Li Jun Yang Ai Zhou Shuai Liang Zhangjun Yu Bing Wu Feng Peng Yu Zhang Zhihai Liu Libo Yuan | 2015 | Photonics Research2015，3，4： | 2 |
| 5 | Construction of Multi-Substituted Benzenes via NHC-Catalyzed Reactions of Carboxylic Esters显示文摘 | Jichang Wu Chengli Mou Yonggui Robin Chi | 2018 | Chinese Journal of Chemistry2018，36，4： | 2 |
| 6 | QTL mapping for flour and noodle colour components and yellow pigment content in common wheat显示文摘 | Yelun Zhang Yunpeng Wu Yonggui Xiao Zhonghu He Yong Zhang Jun Yan Yan Zhang Xianchun Xia Chuanxi Ma | 2009 | Euphytica2009，，3： | 1 |
| 7 | Characterization of red mud derived from a combined Bayer process and bauxite calcinations method显示文摘 | LIU Yong LIN Chuxia WU Yonggui | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 8 | Influence of litter decomposition on iron and manganese in the sediments of wetlands for acid mine drainage treatments显示文摘Plant litter will influence the bioavailability of heavy metals in sediments of wetlands used to treat acid mine drainage. To investigate the effect of plant litter on sediments in wetlands and define the comprehensive and continuous role of plant litter, different mass ratios(0%,5%, 20%) of litter were added into the sediments to study the influence of litter decomposition on the overlying water and sediments. The changes in pH, EC, Eh, Fe, and Mn of the overlying water and the organic matter in the sediments and the forms of Fe and Mn after 1, 7, 14, 21, and 28 days of litter decomposition were studied. The results indicated that litter decomposition increased the pH, EC, and reduced Eh of the overlying water. Litter decomposition promoted the release of Fe and Mn from the sediments into the overlying water and with the continuous decomposition of litter, the concentration of Fe and Mn in the overlying water declined. Litter decomposition increased the content of the organic matter in the sediment, and the forms of Fe and Mn indicated that litter decomposition could significantly affect the transformation of the forms of Fe and Mn.Reducible Fe was the main form in the sediments. Litter decomposition promoted the transformation of reducible Fe, the main form found in the sediments, intoexchangeable and oxidizable Fe, but had no effect on residual form. Exchangeable Mn was the main form in the sediments, and litter decomposition accelerated the transformation of reducible Mn, most commonly found in the sediments, into oxidizable Mn and had little influence on the exchangeable and residual forms. | Xiuyue Xu Yonggui Wu Yiling Rao Tianling Fu Xingyu Wu | 2019 | Acta Geochimica2019，38，1： | 1 |
| 9 | Preparation,characterization and adsorptive study of rare earth ions using magnetic GMZ bentonite显示文摘 | WU Dongbei ZHU Chunming CHEN Yonggui | | 0，，： | 1 |
| 10 | MicroRNAs与癌症显示文摘MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process. | Libo Xiao Zhiping Wu Rui Feng Qishun Zhu Chenwei Gao Yan Chen Chun Hou Yonggui Wu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，9： | 1 |
| 11 | Preparation, characterization and adsorptive study of rare earth ions using magnetic GMZ bentonite 显示文摘 | Wu Dongbei Zhu Chunming Chen Yonggui | 2012 | Applied Clay Science2012，6263，： | 1 |
| 12 | Effects of thin covers on the release of coal gangue contaminants显示文摘 | FU Tianling WU Yonggui OU Lisha | 2012 | Energy Procedia2012，16，： | 1 |
| 13 | Common susceptibility variants of KDR and IGF-1R are associated with poststroke depression in the Chinese population显示文摘Background Depression,one of the most frequent complications after stroke,increases the disease’s burden and physical disability.Poststroke depression(PSD)is a multifactorial disease with genetic,environmental and biological factors involved in its occurrence.Genetic studies on PSD to date have mainly focused on the monoamine system and brain-derived neurotrophic factors.However,understanding is still limited about the influence of the single nucleotide polymorphism(SNP)of other neurotrophic factors on PSD.Aims The present study aimed to investigate the relationship between seven vascular endothelial growth factor(VEGF)family gene variants that occur with PSD.Methods A multicentre candidate gene study from five hospitals in Jiangsu Province from June 2013 to December 2014 involved 121 patients with PSD and 131 patients with non-PSD.Demographic characteristics and neuropsychological assessments were collected.Theχ^(2)test was used to evaluate categorical variables,while the independent t-test was applied to continuous variables.SNPs in seven genes(VEGFA,VEGFB,KDR,FLT-1,IGF-1,IGF-1R and PlGF)were genotyped.Single-marker association for PSD was analysed byχ^(2)tests and logistic regression using SPSS and PLINK software.Results Patients with PSD included more women and those with lower education levels,lower body mass indexes,lower Mini-Mental State Examination scores,and higher scores on the 17-item Hamilton Depression Rating Scale than non-PSD patients.Ninety-two SNPs with seven genes were genotyped and passed quality control.The rs7692791 CC genotypes,the C allele of KDR and the rs9282715 T allele of IGF-1R increased the risk for PSD(χ^(2)=7.881,p=0.019;χ^(2)=4.259,p=0.039;χ^(2)=4.222,p=0.040,respectively).In addition,the SNP rs7692791 of KDR was significantly associated with PSD by the logistic regression of an additive model(p=0.015,OR=9.584,95%CI:1.549 to 59.31).Conclusions Patients with rs7692791 C allele carriers or the CC genotype of KDR and the rs9282715 T allele of IGF-1R may have PSD susceptibility.Findings such as these may help clinicians to identify the high-risk population for PSD earlier and,thus,enable them to provide more timely interventions. | Yingying Yue Linlin You Fuying Zhao Kezhong Zhang Yanyan Shi Hua Tang Jianxin Lu Shenghua Li Jinxia Cao Deqin Geng Aiqin Wu Yonggui Yuan | 2023 | General Psychiatry2023，36，1： | 1 |
| 14 | Management of post-stroke neuropsychiatric disorders显示文摘Post-stroke neuropsychiatric(NP) disorders are common and have complex etiologies.Multiple factors such as lesion location, personality characteristics, socioeconomic status, pre-stroke psychiatric history, and family support are the determining factors in most cases. Although depression and anxiety are more common, emotional incontinence and catastrophic reactions are also frequently observed. Post-stroke depression(PSD)has been associated with an increased risk of stroke recurrence. Despite its serious consequences and high prevalence, PSD remains undetected and untreated. Treatment options of NP disorders depend on severity, presentation at the time of diagnosis, and patient cooperation, and include antidepressants, mood stabilizers, exercise therapy, psychotherapy, and even revascularization. The efficient management of NP disorders improves outcomes, quality of life, and survival rates in post-stroke patients. However,very few studies have identified definitive treatment for these patients; therefore, further research is required. | Ahsan Ali Khan Lukui Chen Guilong Zhang Xiaoyuan Guo Guojian Wu Hong Wang Yang You Yuchun Gu Yonggui Yuan | 2016 | Translational Neuroscience and Clinics2016，2，4： | 1 |
| 15 | Characterization of red mud derived from a combined bayer process and bauxite calcination method显示文摘 | Liu Yong Lin Chuxia Wu Yonggui | 2007 | J Hazard Mater2007，146，12： | 1 |
| 16 | Effects of a proline solution cover on the geochemical and mineralogical characteristics of high-sulfur coal gangue显示文摘Batch experiments were conducted to comparatively evaluate the inhibition effects and mechanisms of a low-concentration(1%) proline solution cover on the release of pollutants from high-sulfur coal gangue. Highsulfur coal gangue was continuously immersed in a proline solution and in deionized water(as a control treatment) for540 days. The results showed that the coal gangue in the control treatment was oxidized and generated leachate with poor water qualities, i.e., the leachate exhibited lower p H values, higher redox potential values, higher pollutant concentrations(SO_4^(2-), Fe, Mn, Cu, and Zn), and high levels of acidophilic sulfur-oxidizing bacteria. However,compared to the control treatment, the addition of the proline solution(1%) significantly improved the water quality of the leachate by significantly reducing the Eh values, the pollutant concentrations(SO_4^(2-), Fe^(2+), Fe, Mn,Cu, and Zn), and the activity of acidophilic sulfur-oxidizing bacteria and by significantly increasing the pH value to neutral. The proline treatment significantly inhibited the oxidation of coal gangue and the release of pollutants,mainly by inhibiting the activity of acidophilic sulfur-oxidizing bacteria and by altering the heavy metal fractions and the mineralogical characteristics. Therefore, in engineering practice, workers should consider using an environmental friendly aqueous proline solution cover toachieve the in-situ control of pollutant releases from coal gangue dumps. | Youfa Luo Yonggui Wu Tianling Fu Hu Wang Rongrong Xing Zhilin Zheng | 2018 | Acta Geochimica2018，37，5： | 1 |
| 17 | Failure mechanism analysis andConservation Research of an Ancient Seawall along the Qiantang River, China 显示文摘 | Wang Lizhong Xie Yonggui Wu Youxia | 2012 | Journal of Coastal Research2012，28，6： | 1 |
| 18 | Characterization of red mud derived rom a combined Bayer Process and bauxite calcination method 显示文摘 | Liu Yong Lin Chuxia Wu Yonggui | 2007 | J Hazard Mater2007，146，12： | 1 |
| 19 | Piperazine:Its role in the discovery of pesticides显示文摘Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of agrochemicals.From 2000 to 2022,many piperazine-containing compounds were found to exhibit excellent activities against fungi,bacteria,insects,plant viruses,and weeds and have also been used as plant growth regulators.Currently,the development of novel pesticides to prevent the invasion of crop pathogens and ensure the quality and yields of crops is still needed.We herein investigated and summarized the role that piperazine plays in the discovery of pesticides to provide a comprehensive summary of the broad activities of piperazine derivatives in agricultural applications and offer a potential reference for novel pesticide design using piperazine-containing compounds.Moreover,structure–activity relationships(SARs)analyses of bioactive piperazine-containing compounds are also discussed for a deeper understanding. | Wei Zhang Shengxin Guo Lijiao Yu Ya Wang Yonggui Robin Chi Jian Wu | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 20 | Hydrazone derivatives in agrochemical discovery and development显示文摘As a common active substructure,hydrazone has attracted increasing attention and is considered essential for pesticide discovery.It has been widely regarded as a potential insecticidal,antibacterial,antifungal,antiviral,and herbicidal agent.In this review,we highlight the pesticide versatility of hydrazone fragments and provide a comprehensive summary of the biological activity,structure-activity relationship analysis(SARs),and primary mechanism of their analogs.This profile is expected to give valuable information for discovering new pesticides. | Ya Wang Shengxin Guo Lijiao Yu Wei Zhang Zhenchao Wang Yonggui Robin Chi Jian Wu | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
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