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| 1 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 2 | Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation,apoptosis,and oxidative stress显示文摘Cordycepin(3-deoxyadenosine)is a naturally occurring adenosine analog and one of the bioactive constituents isolated from Cordyceps sinensis,species of the fungal genus Cordyceps.It has traditionally been a prized Chinese folk medicine for the human well-being.However,the actions of cordycepin against renal ischemia/reperfusion injury(/R)are still unknown.In the present study,rats were subject to VR and cordycepin was intragastrically administered for seven consecutive days before surgery to investigate the effects and mechanisms of cordycepin against renal/R injury.The test results of kidney and peripheral blood samples of experimental animals showed that cordycepin significantly decreased serum blood urea nitrogen and creatinine levels and markedly attenuated cell injury.Mechanistic studies showed that cordycepin significantly regulated inflammation,apoptosis,and oxidative stress.These data provide new insights for investigating the natural product with the nephroprotective effect against I/R,which should be developed as a new therapeutic agent for the treatment of I/R in the future. | Feng Han Meng Dou Yuxiang Wang Cuixiang Xu Yang Li Xiaoming Ding Wujun Xue Jin Zheng Puxun Tian Chenguang Ding | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 9 |
| 3 | Comprehensive scan for nonmagnetic Weyl semimetals with nonlinear optical response显示文摘First-principles calculations have recently been used to develop comprehensive databases of nonmagnetic topological materials that are protected by time-reversal or crystalline symmetry.However,owing to the low symmetry requirement of Weyl points,a symmetry-based approach to identifying topological states cannot be applied to Weyl semimetals(WSMs).To date,WSMs with Weyl points in arbitrary positions are absent from the well-known databases. | Qiunan Xu Yang Zhang Klaus Koepernik Wujun Shi Jeroen van den Brink Claudia Felser Yan Sun | 2020 | npj Computational Materials2020，，1： | 3 |
| 4 | Ulinastatin reduces urinary sepsis?related inflammation by upregulatingIL?10 and downregulating TNF?α levels显示文摘 | Xian Chen Yi Wang Hongmei Luo Zhigang Luo Lisha Liu Wujun Xu Tao Zhang Ning Yang Xiangyang Long Neng Zhu Huang Xie Jun Liu | 2013 | Molecular Medicine Reports2013，，1： | 2 |
| 5 | Controllable release of ibuprofen from size-adjustable and surface hydrophobic mesoporous silica spheres显示文摘 | Wujun Xu Qiang Gao Yao Xu Dong Wu Yuhan Sun Wanling Shen Feng Deng | 2008 | Powder Technology2008，，1： | 1 |
| 6 | LincRNA-1614 coordinates Sox2/PRC2-mediated repression of developmental genes in pluripotency maintenance显示文摘 | Xudong Guo Zikang Wang Chenqi Lu Wujun Hong Guiying Wang Yanxin Xu Zhongmin Liu Jiuhong Kang | 2018 | Journal of Molecular Cell Biology2018，10，2： | 1 |
| 7 | Amino acid adsorptionon mesoporous materials: influence of types of amino acids, modification of mesoporous materials, and solution conditions 显示文摘 | Quang Gao Wujun Xu Yao Xu | 2008 | J PhysChem B2008，112，7： | 1 |
| 8 | Recombinase Polymerase Amplification(RPA)of Ca MV-35S Promoter and nos Terminator for Rapid Detection of Genetically Modified Crops显示文摘 | Chao Xu Liang Li Wujun Jin | 2014 | International Journal of Molecular Sciences2014，15，18： | 1 |
| 9 | Ulinastatin reduces urinary sepsis?related inflammation by upregulatingIL?10 and downregulating TNF?α levels显示文摘 | Xian Chen Yi Wang Hongmei Luo Zhigang Luo Lisha Liu Wujun Xu Tao Zhang Ning Yang Xiangyang Long Neng Zhu Huang Xie Jun Liu | 2013 | Molecular Medicine Reports2013，，1： | 1 |
| 10 | High-throughput first-principle prediction of collinear magnetic topological materials显示文摘The success of topological band theory and symmetry-based topological classification significantly advances our understanding of the Berry phase.Based on the critical concept of topological obstruction,efficient theoretical frameworks,including topological quantum chemistry and symmetry indicator theory,were developed,making a massive characterization of real materials possible.However,the classification of magnetic materials often involves the complexity of their unknown magnetic structures,which are often hard to know from experiments,thus,hindering the topological classification.In this paper,we design a high-throughput workflow to classify magnetic topological materials by automating the search for collinear magnetic structures and the characterization of their topological natures.We computed 1049 chosen transition-metal compounds(TMCs)without oxygen and identified 64 topological insulators and 53 semimetals,which become 73 and 26 when U correction is further considered.Due to the lack of magnetic structure information from experiments,our high-throughput predictions provide insightful reference results and make the step toward a complete diagnosis of magnetic topological materials. | Yunlong Su Jiayu Hu Xiaochan Cai Wujun Shi Yunyouyou Xia Yuanfeng Xu Xuguang Xu Yulin Chen Gang Li | 2022 | npj Computational Materials2022，，1： | 0 |
| 11 | Comparison of Five Endogenous Reference Genes for Specific PCR Detection and Quantification of Rice显示文摘Endogenous reference genes (ERGs) provide vital information regarding genetically modified organisms (GMOs). The successful detection of ERGs can identity GMOs and the source of genes, verify stability and reliability of the detection system, and calculate the level of genetically modified (GM) ingredients in mixtures. The reported ERGs in rice include sucrose-phosphate synthase (SPS), phospholipase D (PLD), RBE4 and rice root-specific GOS9 genes. Based on the characteristics of ERGs, a new ERG gene, phosphoenolpyruvate carboxylase (PEPC), was selected, and further compared with the four existing genes. A total of 18 rice varieties and 29 non-rice crops were used to verify the interspecies specificity, intraspecies consistency, sensitivity, stability and reliability of these five ERGs using qualitative and quantitative PCR. Qualitative detection indicated that SPS and PEPC displayed sufficient specificity, and the detection sensitivity was 0.05% and 0.005%, respectively. Although the specificity of both RBE4 and GOS9 were adequate, the amplicons were small and easily confused with primer dimers. Non-specific amplification of the PLD gene was present in maize and potato. Real-time quantitative PCR detection indicated that PLD, SPS and PEPC displayed good specificity, with R2 of the standard curve greater than 0.98, while the amplification efficiency ranged between 90% and 110%. Both the detection sensitivities of PLD and PEPC were five copies and that of SPS was ten copies. RBE4 showed typical amplification in maize, beet and Arabidopsis, while GOS9 was found in maize, tobacco and oats. PEPC exhibited excellent detection sensitivity and species specificity, which made it a potentially useful application in GM-rice supervision and administration. Additionally, SPS and PLD are also suitable for GM-rice detection. This study effectively established a foundation for GMO detection, which not only provides vital technical support for GMO identification, but also is of great significance for enhancing the comparability of detection results, and the standardization of ERG testing in GM-rice. | ZHANG Xiujie JIN Wujun XU Wentao LI Xiaying SHANG Ying LI Sha OUYANG Hongsheng | 2019 | Rice science2019，26，4： | 0 |
| 12 | In silico curation of QTL-rich clusters and candidate gene identification for plant height of bread wheat显示文摘Many genetic loci for wheat plant height(PH) have been reported, and 26 dwarfing genes have been catalogued. To identify major and stable genetic loci for PH, here we thoroughly summarized these functionally or genetic verified dwarfing loci from QTL linkage analysis and genome-wide association study published from 2003 to 2022. A total of 332 QTL, 270 GWAS loci and 83 genes for PH were integrated onto chromosomes according to their locations in the IWGSC RefSeq v2.1 and 65 QTL-rich clusters(QRC) were defined. Candidate genes in each QRC were predicted based on IWGSC Annotation v2.1 and the information on functional validation of homologous genes in other species. A total of 38 candidate genes were predicted for 65 QRC including three GA2ox genes in QRC-4B-IV, QRC-5A-VIII and QRC-6A-II(Rht24) as well as GA 20-oxidase 2(TaSD1-3A) in QRC-3A-IV. These outcomes lay concrete foundations for mapbased cloning of wheat dwarfing genes and application in breeding. | Dengan Xu Chenfei Jia Xinru Lyu Tingzhi Yang Huimin Qin Yalin Wang Qianlin Hao Wenxing Liu Xuehuan Dai Jianbin Zeng Hongsheng Zhang Xianchun Xia Zhonghu He Shuanghe Cao Wujun Ma | 2023 | The Crop Journal2023，11，5： | 0 |
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