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| 1 | Grey Relation between Nonlinear Characteristic and Dynamic Uncertainty of Rolling Bearing Friction Torque显示文摘The rolling bearing friction torque which is characterized by its uncertainty and nonlinearity affects heavily the dynamic performance of a system such as missiles, spacecrafts and radars, etc. It is difficult to use the classical statistical theory to evaluate the dynamic evaluation of the rolling bearing friction torque for the lack of prior information about both probability distribution and trends. For this reason, based on the information poor system theory and combined with the correlation dimension in chaos theory, the concepts about the mean of the dynamic fluctuant range (MDFR) and the grey relation are proposed to resolve the problem about evaluating the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque. Friction torque experiments are done for three types of the rolling bearings marked with HKTA, HKTB and HKTC separately; meantime, the correlation dimension and MDFR are calculated to describe the nonlinear characteristic and the dynamic uncertainty of the friction torque, respectively. And the experiments reveal that there is a certain grey relation between the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque, viz. MDFR will become the nonlinear increasing trend with the correlation dimension increasing. Under the condition of fewer characteristic data and the lack of prior information about both probability distribution and trends, the unitive evaluation for the nonlinear characteristic and the dynamic uncertainty of the rolling bearing friction torque is realized with the grey confidence level of 87.7%-96.3%. | XIA Xintao WANG Zhongyu | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 13 |
| 2 | Multiple Measurement Models of Articulated Arm Coordinate Measuring Machines显示文摘The existing articulated arm coordinate measuring machines(AACMM) with one measurement model are easy to cause low measurement accuracy because the whole sampling space is much bigger than the result in the unstable calibration parameters. To compensate for the deficiency of one measurement model, the multiple measurement models are built by the Denavit-Hartenberg's notation, the homemade standard rod components are used as a calibration tool and the Levenberg-Marquardt calibration algorithm is applied to solve the structural parameters in the measurement models. During the tests of multiple measurement models, the sample areas are selected in two situations. It is found that the measurement errors' sigma value(0.083 4 mm) dealt with one measurement model is nearly two times larger than that of the multiple measurement models(0.043 1 mm) in the same sample area. While in the different sample area, the measurement errors' sigma value(0.054 0 mm) dealt with the multiple measurement models is about 40% of one measurement model(0.137 3 mm). The preliminary results suggest that the measurement accuracy of AACMM dealt with multiple measurement models is superior to the accuracy of the existing machine with one measurement model. This paper proposes the multiple measurement models to improve the measurement accuracy of AACMM without increasing any hardware cost. | ZHENG Dateng XIAO Zhongyue XIA Xiang | 2015 | Chinese Journal of Mechanical Engineering2015，28，5： | 6 |
| 3 | The tectonic differences between the east and the west in the deep-water area of the northern South China Sea显示文摘The deep-water area of the northern South China Sea, which has active and complicated tectonics, is rich in natural gas and gas hydrate. While the tectonic characteristics is different obviously between the east and the west because of the special tectonic position and tectonic evolution process. In terms of submarine geomorphology,the eastern shelf-slope structure in Pearl River Mouth Basin is characterized by having wide sub-basins and narrow intervening highs, whereas the western(Qiongdongnan Basin) structure is characterized by narrow subbasins and wide uplift. As to the structural features, the deep-water sags in the east are all structurally halfgrabens, controlled by a series of south-dipping normal faults. While the west sags are mainly characterised by graben structures with faulting in both the south and north. With regards to the tectonic evolution, the east began neotectonic activity when the post-rifting stage had completed at the end of the Middle Miocene. In the Baiyun Sag, tectonic activity became strong and was characterised by rapid subsidence and obvious faulting. Whereas in the west, neotectonic activity began at the end of the Late Miocene with rapid deposition and weak fault activity. | XIA Zhongyu WAN Zhifeng WANG Xianqing SHI Qiuhua CAI Song XIA Bin | 2016 | Acta Oceanologica Sinica2016，35，1： | 4 |
| 4 | Mineral Chemistry and Geochemistry of Peridotites from the Zedang and Luobusa Ophiolites, Tibet: Implications for the Evolution of the Neo-Tethys显示文摘We present a new dataset on platinum group elements(PGEs), whole-rock major and trace elements, and mineral chemistry for the peridotites from the Zedang and Luobusa ophiolite suites, Tibet, in an attempt to better constrain the petrogenesis of the Zedang and Luobusa ophiolites and the tectonic evolution of the Neo-Tethys. Plots of chondrite-normalized PGE, PGE vs. Mg#, and PGE vs. Al_2O_3 suggest that the lherzolite and harzburgite from Zedang and Luobusa have similar PGE characteristics. The Zedang and Luobusa peridotites display U-shaped REE patterns and are enriched in some incompatible elements, indicative of melt-rock interaction. The PGE characteristics may be attributed to partial melting and heterogeneous melt-rock interaction. Mineral chemistry and whole rock major and trace elements data suggest that lherzolite and harzburgite from Zedang and Luobusa have similar geochemical properties. On the spinel Mg# vs. Cr# plot, the composition of the Zedang and Luobusa peridotites is consistent with both abyssal and subduction-zone peridotites. This study indicates that the Zedang and Luobusa peridotites have a similar origin and evolution path: they could have originated from a normal mid-ocean ridge environment and got refertilization in a supra-subduction zone setting. | Qiang Li Bin Xia Jianfeng Li Lianze Xia Qiangtai Huang Zhongyu Xia | 2015 | Journal of Earth Science2015，26，6： | 3 |
| 5 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 6 | Grey bootstrap method of evaluation of uncertainty in dynamic measurement显示文摘 | Xia Xintao Chen Xiaoyang Zhang Yongzhen Wang Zhongyu | 2007 | Science Direct Measurement2007，，41： | 1 |
| 7 | Diagnoses and Control of Roundness Error on Rolling Bearing Grinding Surface显示文摘 | Xintao Xia Zhongyu Wang Long Chen | 2005 | IDTP''20052005，2005，： | 1 |
| 8 | Zircon U-Pb Geochronology and Hf Isotopic Constraints on Petrogenesis of Plagiogranite from the Cuomuqu Ophiolite,Bangong Lake Area,North Tibet显示文摘Field observation,geochemical signatures and zircon Hf isotope data indicate that Cuomuqu ophiolite in the Bangonghu area was formed in a back-arc basin(BAB) above a suprasubduction zone(SSZ). Zircon U-Pb dating of the diabase from the Cuomuqu massif yielded an age of 164.3±1.9 Ma,thus indicating that the ophiolite complex was formed in the Middle Jurassic during back-arc extension of the mature Bangonghu-Nujiang Ocean. The zircon εHf(t) and TDMC values of the plagiogranite are similar to the εHf(t) and TDM of the diabase,respectively. The mode of occurrence of plagiogranites and their bulk-rock and Hf isotope characteristics indicate that they were derived from the mantle,associated with the surrounding gabbro and diabase,and were formed by partial melting of altered and hydrated mafic rocks under shear conditions during lateral drifting of the oceanic crust. The zircon U-Pb age of the plagiogranite is 156.4±1.4 Ma,and it is 7.9 Ma younger than the hosting diabase. In this study,zircon chronological and Hf isotopic data were tentatively analyzed to determine the genesis of plagiogranites in the Cuomuqu ophiolite complex. | YIN Zhengxin YUAN Yajuan Lü Baofeng CAI Zhourong ZHENG Hao HUANG Qiangtai XIA Bin ZHONG Yun XIA Zhongyu SHI Xiaolong GUAN Yao | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 1 |
| 9 | Relationship Between Vibration and Noise d Rolling Bearing via GRA显示文摘 | Xia Xintao Wang Zhongyu Sun Liming | 2004 | The Journal of Grey System2004，16，3： | 1 |
| 10 | Estimation of non-statistical uncertainty using fuzzy-set theory显示文摘 | Xia Xintao Wang Zhongyu Gao Yongsheng | 2000 | Measurement Science and Technology2000，11，4： | 1 |
| 11 | 中国男性乳腺癌患者临床特征:公开发表文章的总结(英文)显示文摘Objective:The extremely low incidence of male breast cancer (MBC) leads to lack of prospective randomized phase III studies worldwide. Especially in China,all studies on Chinese patients with MBC were based on small sample size and single institute experience. The aim of this study was to provide overall view of characteristics of Chinese patients with MBC by means of summarizing all related papers published in Chinese journals. Methods: An online search was made in CBM,VIP,CNKI,and CBA databases to find all published articles of interest on Chinese patients with MBC. And eight subjects including the proportion of MBC in all breast cancer,age,tumor location,clinical stages,pathological subtypes,treatment modalities,ER/PR expression,and 5-year survival rate were selected to calculate the proportion and their 95% interval confidence. Results: There were 122 papers with 2584 patients enrolled. The basic features of Chinese patients with MBC included:(1) MBC only with a proportion of 1.06% of all the breast cancer; (2) The mean age at diagnosis was 57.6 years old; (3) Tumor mainly located in the areolar region (74.83%) with obvious nipple and/or skin involvement; (4) Nearly 62.62% patients were in early stage before accepting treatment; (5) Infiltrating ductal carcinoma accounted for 79.05% of all pathological subtypes; (6) ER/PR expression rate was 65.86%; (7) Radical resection was up to 86.06% in all surgical modalities; (8) The 5-year survival rate was 57.33%. Conclusion: The results showed in this study were an overall view of Chinese patients with MBC whose characteristics were similar to that reported in the West. Though this study provided a little bit stronger confidence than a single study collected in this paper,studies with more powerful evidence are urgently demanding in China. | Liangping Xia Zhongyu Yuan Xi Wang Jiehua He Bei Zhang Guifang Guo Feifei Zhou Fang Wang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 1 |
| 12 | Grey relational analysis for optimized solution显示文摘 | XIA Xintao WANG Zhongyu | 2004 | The Journal of Grey System2004，16，2： | 1 |
| 13 | Estimation of non-statistical uncertainty using fuzzy-set theory 显示文摘 | XIA Xintao WANG Zhongyu GAO Yongsheng | 2000 | Measurement Science and Technology2000，11，4： | 1 |
| 14 | Estimation of non-statistical uncertainty using fuzzy-set theory显示文摘 | XIA Xintao WANG Zhongyu Gao Yongsheng | | 0，，： | 1 |
| 15 | Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division显示文摘细菌的房间分割严格地在相等的女儿房间的形成被调整。这个过程被一系列空间、时间的管理者管理,并且这块地感兴趣的几个新因素最近被识别了。这里,我们在 zoonotic 病原体链球菌 suis 的房间分割报导 gluconate 5 脱氢酶(Ga5DH ) 的要求。Ga5DH 催化 5-ketogluconate 的可逆减小到 D-gluconate 并且对房间分割的地点局部性。在 S 的 Ga5DH 的删除。suis 与加入子孙的异常 septa 导致了丰满的形态学。重要增加也在房间长度被观察。这些缺点决心是在 S 的 Ga5DH 剥夺的后果。引起 FtsZ delocalization 的 suis。另外,有在 vitro 的 Ga5DH 的 FtsZ 的相互作用被蛋白质相互作用试金证实。这些结果显示 Ga5DH 可以工作在 S 期间阻止宫外的 Z 戒指的形成。suis 房间分割。 | Zhongyu Shi Chunling Xuan Huiming Han Xia Cheng Jundong Wang Youjun Feng Swaminath Srinivass Guangwen Lu George F. Gao | 2014 | Protein & Cell2014，5，10： | 0 |
| 16 | Nail pigmentation induced by chemotherapy:an observational study of patients with early-stage breast cancer显示文摘Purpose:Chemotherapy-induced nail pigmentation is a common adverse efect,but prospective studies focussing on its onset,recovery,and severity are few.We aim to evaluate the pattern of chemotherapy-induced nail pigmentation in early-stage breast cancer patients by calculating the comprehensive score based on hyperpigmentation area and color depth of the nail plate.Methods:This prospective,observational study was conducted between February 2019 and December 2019.Early-stage breast cancer patients scheduled to receive anthracyclines combined with cyclophosphamide or taxanecontaining regimens were enrolled.The clinicopathologic characteristics and treatment protocols were collected.The onset,patterns,and duration of nail changes were photographed and recorded regularly.Results:A total of 90 patients were enrolled.The most common nail change was nail pigmentation(n=81,90.0%),followed by onycholysis(n=39,43.3%),Beau’s lines(n=19,21.1%),Mees’lines(n=16,17.8%),Muehrcke’s lines(n=7,7.8%),and hemorrhage(n=1,1.1%).Forty-four(48.9%)patients developed severe nail pigmentation.The median onset time of nail pigmentation was 37 days after the initiation of chemotherapy.At the latest follow-up,55(67.9%)patients achieved remission of melanonychia with the median recovery time of 118 days.The median duration of nail pigmentation was 214 days.Conclusion:Our study revealed the specifc pattern of chemotherapy-induced nail pigmentation,which onsets early and recovers slowly with a high incidence of severe nail pigmentation,in early-stage breast cancer patients.The results provide reference for further intervention studies.Trial Registration:ClinicalTrials.gov Identifer:NCT04215744.Registered 30 December 2019—Retrospectively registered. | Kuikui Jiang Simei Shi Qiulian Lin Peng Sun Luan Zhang Zhongyu Yuan Ruoxi Hong Yanxia Shi Xia Liu Jingmin Zhang Jiajia Huang Xiwen Bi Wen Xia Qianyi Lu Qiufan Zheng Shusen Wang Fei Xu | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 17 | Metronomic chemotherapy of cyclophosphamide plus methotrexate for advanced breast cancer:Real-world data analyses and experience of one center显示文摘Background:Real-world data of the CM regimen[cyclophosphamide(CTX)plus methotrexate(MTX)]in metronomic pattern for advanced breast cancer is limited to small-sample or retrospective studies.This study was aimed to determine the effectiveness and safety of CM regimen in treating advanced breast cancer and to identify which patients are most likely to benefit from metronomic CM regimen.Methods:Patients with advanced breast cancer who received the metronomic CM regimen at least once between January 2009 and February 2019 in Sun Yat-sen University Cancer Center were included.Clinicopathological characteristics were collected.Overall survival(OS)and progression-free survival(PFS)were assessed using Kaplan-Meier estimates.Characteristics between patients with PFS<6 months and≥6 months were compared using the Chi-square test.Univariate and multivariate Cox regression model was used to estimate the prognostic factors for PFS and OS.Results:A total of 186 patients were included.The median age and follow-up were 49 years and 13.3 months,respectively.Over 50%of the patients were estrogen receptor/progesterone receptor-positive,and 60.8%had been heavily treated(≥3 lines).The objective response rate was 3.8%,the disease control rate at 12 weeks was 41.4%,and the clinical benefit rate at 24 weeks was 31.2%(58/186).The median PFS was 4.0 months[95%confidence interval(CI):3.6-4.7 months],the median duration of clinical benefit was 9.5 months(95%CI:8.2-10.8 months),and the median OS was 26.8 months(95%CI:20.9-37.7 months).Multivariate analysis for PFS revealed the CM regimen as maintenance therapy and no liver metastasis as favorable prognostic factors.Furthermore,patients without liver metastasis were more likely to have a PFS over 6 months than those with liver involvement(P=0.022).Liver,lymph node,and brain metastases were unfavorable prognostic factors for OS.The CM regimen was well-tolerated without newly reported adverse events.Conclusions:The CM regimen was effective in selected patients.In clinical practice,it would be better used as maintenance therapy and in patients without liver metastasis.Further follow-up investigation should be performed to examine its effect when used in combination with other treatments and determine predictive biomarkers. | Qianyi Lu Kaping Lee Fei Xu Wen Xia Qiufan Zheng Ruoxi Hong Kuikui Jiang Qinglian Zhai Yuan Li Yanxia Shi Zhongyu Yuan Shusen Wang | 2020 | Cancer Communications2020，40，5： | 0 |
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