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| 1 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 2 | Importance of storage time in mesophilic anaerobic digestion of food waste显示文摘Storage was used as a pretreatment to enhance the methanization performance of mesophilic anaerobic digestion of food waste. Food wastes were separately stored for 0, 1,2, 3, 4, 5, 7, and 12 days, and then fed into a methanogenic reactor for a biochemical methane potential(BMP) test lasting up to 60 days. Relative to the methane production of food waste stored for 0–1 day(285–308 m L/g-added volatile solids(VSadded)), that after2–4 days and after 5–12 days of storage increased to 418–530 and 618–696 m L/g-VSadded,respectively. The efficiency of hydrolysis and acidification of pre-stored food waste in the methanization reactors increased with storage time. The characteristics of stored waste suggest that methane production was not correlated with the total hydrolysis efficiency of organics in pre-stored food waste but was positively correlated with the storage time and acidification level of the waste. From the results, we recommend 5–7 days of storage of food waste in anaerobic digestion treatment plants. | Fan Lü Xian Xu Liming Shao Pinjing He | 2016 | Journal of Environmental Sciences2016，28，7： | 6 |
| 3 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 4 | 缺血性脑卒中患者血压与住院临床结局的相关性显示文摘高血压是脑卒中的主要危险因素。研究表明,在缺血性脑卒中患者中,由于压力依赖性的脑血液流向缺血区域,脑卒中后高血压有益。然而,其他研究显示,脑卒中后的高血压与短期再发性脑卒中、脑出血性转化和脑水肿发生率升高有关。关于血压与脑卒中短期临床结局相关性的观察性研究结论相互矛盾。此外,关于血压的搏动组分(脉压)或稳定组分(平均动脉压)与临床结局相关性的数据有限。 | Bangalore S Schwamm L Smith EE Hellkamp AS Suter RE Xian Y Schulte PJ Fonarow GC Bhatt DL 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 5 |
| 5 | Shikonin attenuates hyperhomocysteinemia-induced CD4E^+T cell inflammatory activation and atherosclerosis in ApoE^−/− mice by metabolic suppression显示文摘T cell metabolic activation plays a crucial role in inflammation of atherosclerosis.Shikonin(SKN),a natural naphthoquinone with anti-inflammatory activity,has shown to exert cardioprotective effects,but the effect of SKN on atherosclerosis is unclear.In addition,SKN was found to inhibit glycolysis via targeting pyruvate kinase muscle isozyme 2(PKM2).In the present study,we investigated the effects of SKN on hyperhomocysteinemia(HHcy)-accelerated atherosclerosis and T cell inflammatory activation in ApoE^−/− mice and the metabolic mechanisms in this process.Drinking water supplemented with Hcy(1.8 g/L)was administered to ApoE^−/− mice for 2 weeks and the mice were injected with SKN(1.2 mg/kg,i.p.)or vehicle every 3 days.We showed that SKN treatment markedly attenuated HHcy-accelerated atherosclerosis in ApoE^−/− mice and significantly decreased inflammatory activated CD4^+T cells and proinflammatory macrophages in plaques.In splenic CD4^+T cells isolated from HHcy-ApoE^−/− mice,SKN treatment significantly inhibited HHcy-stimulated PKM2 activity,interferon-γsecretion and the capacity of these T cells to promote macrophage proinflammatory polarization.SKN treatment significantly inhibited HHcy-stimulated CD4^+T cell glycolysis and oxidative phosphorylation.Metabolic profiling analysis of CD4^+T cells revealed that Hcy administration significantly increased various glucose metabolites as well as lipids and acetyl-CoA carboxylase 1,which were reversed by SKN treatment.In conclusion,our results suggest that SKN is effective to ameliorate atherosclerosis in HHcy-ApoE^−/− mice and this is at least partly associated with the inhibition of SKN on CD4^+T cell inflammatory activation via PKM2-dependent metabolic suppression. | Si-lin Lü Guo-hui Dang Jia-cheng Deng Hui-ying Liu Bo Liu Juan Yang Xiao-long Ma Yu-tong Miao Chang-tao Jiang Qing-bo Xu Xian Wang Juan Feng | 2020 | Acta Pharmacologica Sinica2020，41，1： | 4 |
| 6 | Upwelling Process of the Western Himalaya Mountains:Height and Velocity Estimation Evidenced by Formation and Evolution of the Zanda Basin,Tibet,China显示文摘把地质的调查, stratigraphic 节测量和室内的全面调查基于地, Zanda 盆在 Himalaya 板中的构造地点被查明,并且 Zanda 盆的形成和进化作为六个阶段在到早更新世的上新世期间被分类:(a) 主要指责裂缝的舞台,(b) 快指责裂缝的舞台,(c) 集中的指责裂缝的舞台,(d) 壅滞舞台,(e) 第二等的指责裂缝的舞台,和(f) 第二等的快指责裂缝的舞台。基于 Zanda 盆的这个六阶段的形成进化理论,当下列五上演,到早更新世的从上新世的西方的 Himalaya 山的 upwelling 过程被分类:(a) 慢 upwelling 舞台(5.44.4 妈) ,(b) 中间速度的 upwelling 舞台(4.43.5 妈) ,(c) 快 upwelling 舞台(3.53.2 妈) ,(d)停止 upwelling 阶段(3.22.7 妈) ,和(e) 快 upwelling 舞台(2.7 妈) 。研究从早上新世(4.7 妈) 在持续时间显示出那到上新世(2.67 妈) 的目的,它持续了 203 万年, Himalaya 山高举了在 0.74 mm/a 的速度的 1500 m;这属于中间速度的 upwelling。在在早更新世的早阶段的 131 万年期间, Himalaya 山在 1.15 mm/a 的速度在另一 1500 m 上面升起了;这是相当快的 upwelling。所有这些数据证明了西方的 Himalaya 山的 upwelling 沿着有 multi-stages,多速度,和非天律不变论的特征的一个复杂过程。 | ZHU Dagang MENG Xian' gang SHAO Zhaogang YANG Chaobin HAN Jian'en YU Jia MENG Qingwei Lü Rongping | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 7 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 8 | Composi tion and preservation of the Cheng jiang fauna-lower Cambrian soft-bodied biota显示文摘 | Hou Xian guang Ramskold L Bergstrom J | 1991 | Zoologica Scripta1991，20，： | 1 |
| 9 | New kinematic structures for2-, 3-, 4-, and 5-DOF parallel manipulator designs显示文摘 | FengG WeiM L Xian C Z | 2002 | Mecha- nism and Machine Theory2002，37，： | 1 |
| 10 | A research on the grain growth of WC-Co cemented carbide显示文摘 | Sun L Jia C C Xian M | 2007 | Internatinal Journal of Refractory Metals and Hard Materials2007，25，： | 1 |
| 11 | Some advanced plastic processing technologies and their numerical simulation显示文摘 | Yang H Zhan M Liu Y L Xian F J Sun Z C Lin Y Zhang X G | 2004 | J Mater Process Technol2004，151，13： | 1 |
| 12 | The prognostic role of the class Ⅲ beta-tubulin in non-small cell lung cancer (NSCLC) pa- tients receiving the taxane/vinorebine-based chemotherapy: a meta- analysis 显示文摘 | Yang YL Luo XP Xian L | 2014 | PLoS One2014，9，93： | 1 |
| 13 | Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism显示文摘 | Cong Luo Hai Jun Zhong Li Ming Zhu Xian Guo Wu Jie Er Ying Xiao Hong Wang Wang Xia Lü Qi Xu Yong Liang Zhu Jian Huang | 2012 | Molecular Biology Reports2012，，5： | 1 |
| 14 | The effect of matrix creep property on the consolidation process of SiC/Ti–6Al–4V composite显示文摘 | Ma Zhijun Yang Yanqing Lü Xianghong Luo Xian Chen Yan | 2006 | Materials Science & Engineering A2006，，： | 1 |
| 15 | A study on the receptive field of acupoints and the relationship between characteristics of needling sensation and groups of afferent fibres显示文摘 | Wang K M Yao S M Xian Y L | 1985 | Sci Sin B1985，28，9： | 1 |
| 16 | Combined analysis ofmRNA expression of ERCC1, BAG-l, BRCA1, RRM1 and TUBB3 to predict prognosis in patients with non-small cell lung cancer who received adjuvant chemotherapy显示文摘 | Leng XF1 Chen MW Xian L | 2012 | J Exp Clin Cancer Res2012，，31： | 1 |
| 17 | Research on evalu- ation model for secondary task driving safety based on driver eye movements显示文摘 | Jin L Xian H Jiang Y | 2014 | Advances in Mechan ical Engineering2014，，2014： | 1 |
| 18 | Removal of nutrients and veterinary antibiotics from swine wastewater by a constructed macrophyte floating bed system显示文摘 | Xian Q Hu L Chen H | 2010 | Journal of Environmental Management2010，91，12： | 1 |
| 19 | The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer s disease in the Han Chinese population显示文摘 | Jin C Zhang L Xian Y | 2014 | Neurosei Lett2014，563，： | 1 |
| 20 | Degradation of IGF-I in the aduh rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein显示文摘 | XIAN C J SHOUBRIDGE C A READ L C | 1996 | J Endocrinol1996，146，： | 1 |
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