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| 1 | Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms显示文摘Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)remain unclear.The aim of this study was to investigate the possible mechanisms of PBD through brain imaging and explore the influence of psychotic symptoms on functional alterations in PBD patients.Twenty-nine psychotic and 26 non-psychotic PBD patients,as well as 19 age-and sex-matched healthy controls underwent a restingstate functional MRI scan and the data were analyzed by independent component analysis.The DMN component from the fMRI data was extracted for each participant.Spearman's rank correlation analysis was performed between aberrant connectivity and clinical measurements.The results demonstrated that psychotic PBD was characterized by aberrant DMN connectivity in the anterior cingulate cortex/medial prefrontal cortex,bilateral caudate nucleus,bilateral angular gyri,and left middle temporal gyrus,while non-psychotic PBD was not,suggesting further impairment with the development of psychosis.In summary,we demonstrated unique impairment in DMN functional connectivity in the psychotic PBD group.These specific neuroanatomical abnormalities may shed light on the underlying pathophysiology and presentation of PBD. | Yuan Zhong Chun Wang Weijia Gao Qian Xiao Dali Lu Qing Jiao Linyan Su Guangming Lu | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 2 | Optical Micro/Nano Fibers Enabled Smart Textiles for Human-Machine Interface显示文摘Wearable human-machine interface(HMI)is an advanced technology that has a wide range of applications from robotics to augmented/virtual reality(AR/VR).In this study,an optically driven wearable human-interactive smart textile is proposed by integrating a polydimethylsiloxane(PDMS)patch embedded with optical micro/nanofibers(MNF)array with a piece of textiles.Enabled by the highly sensitive pressure dependent bending loss of MNF,the smart textile shows high sensitivity(65.5 kPa^(−1))and fast response(25 ms)for touch sensing.Benefiting from the warp and weft structure of the textile,the optical smart textile can feel slight finger slip along the MNF.Furthermore,machine learning is utilized to classify the touch manners,achieving a recognition accuracy as high as 98.1%.As a proof-of-concept,a remote-control robotic hand and a smart interactive doll are demonstrated based on the optical smart textile.This optical smart textile represents an ideal HMI for AR/VR and robotics applications. | Shuqi Ma Xiaoyu Wang Pan Li Ni Yao Jianliang Xiao Haitao Liu Zhang Zhang Longteng Yu Guangming Tao Xiong Li Limin Tong Lei Zhang | 2022 | Advanced Fiber Materials2022，4，5： | 5 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Microstructure Control of Nanoporous Silica Thin Film Prepared by Sol-gel Process显示文摘Nanoporous 硅石电影被大音阶的第五音胶化过程与底准备,酸 andbase/acid 二拍子的圆舞催化作用。传播电子显微镜(TEM ) 和粒子尺寸分析器被用来描绘微观结构和粒子尺寸 sols.Scanningelectron 显微镜学(SEM ) 的分发,原子力量显微镜学(AFM ) 和分光镜的 ellipsometer 被用来描绘表面微观结构和硅石电影的光性质。大音阶的第五音的稳定性在长期的存储期间被调查。而且,硅石电影的光常数的分散关系,和微观结构的控制和由在大音阶的第五音胶化期间改变催化作用条件的电影的性质处理也被讨论。 | Yiqun XIAO Jun SHEN Zhiyong XIE Bin ZHOU Guangming WU | 2007 | Journal of Materials Science & Technology2007，23，4： | 4 |
| 5 | Mechanism studies on nitrogen removal when treating ammonium-rich leachate by sequencing batch biofilm reactor显示文摘The nitrogen removal mechanism was studied and analyzed when treating the ammonium-rich landfill leachate by a set of sequencing batch biofilm reactors(SBBRs),which was designed independently.At the liquid temperature of(32P0.4)°C,and after a 58-days domestica-tion period and a 33-days stabilization period,the efficiency of ammonium removal in the SBBR went up to 95%.Highly frequent intermittent aeration suppressed the activity of nitratebacteria,and also eliminated the influence on the activity of anaerobic ammonium oxidation(ANAMMOX)bacteria and nitritebacteria.This influence was caused by the accumulation of nitrous acid and the undulation of pH.During the aeration stage,the concentration of dissolved oxygen was controlled at 1.2-1.4 mg/L.The nitritebacteria became dominant and nitrite accumulated gradually.During the anoxic stage,along with the concentration debasement of the dissolved oxygen,ANAMMOX bacteria became domi-nant;then,the nitrite that was accumulated in the aeration stage was wiped off with ammonium simultaneously. | XU Zhengyong YANG Zhaohui ZENG Guangming XIAO Yong DENG Jiuhua | 2007 | Frontiers of Environmental Science & Engineering2007，1，1： | 3 |
| 6 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 2 |
| 7 | Influence of Environmental Conditions on the Sound Velocity Ratio of Seafloor Surficial Sediment显示文摘In this work,we investigated the influences of salinity,temperature,and hydrostatic pressure on the acoustics of seafloor surficial sediment by theoretically and experimentally analyzing the sound velocity ratio of the seafloor sediment to the bottom sea-water in typical environmental conditions.Temperature-and pressure-controlled experiments were conducted to examine the charac-teristics of the sound velocity ratio,the results of which agree with the theoretical analysis using the effective density fluid model.Of the three environmental factors considered,the sound velocity ratio was found to be sensitive to temperature and pressure but not to salinity,with the sound velocity ratio decreasing with temperature and hydrostatic pressure.With respect to surficial sediments,pore water plays a key role in the sound velocity ratio of sediment influenced by different environmental factors.The sound velocities of different types of sediments(sandy,silty,and clayey)change similarly with temperature,but change slightly differently with hydro-static pressure.The influence of environmental factors on the sound velocity ratio of seafloor sediment is independent of the detec-tion frequency.The results show that the sound velocity ratio can change up to 0.0008 per℃ when the temperature ranges from 2℃ to 25℃ and up to 0.00064MPa−1 when the seawater depth pressure ranges from 0MPa to 40MPa. | ZOU Dapeng ZENG Ziwen KAN Guangming LIU Wei XIAO Tibing | 2021 | Journal of Ocean University of China2021，20，3： | 2 |
| 8 | Biotinylated dextran amine anterograde tracing of the canine corticospinal tract显示文摘In this study, biotinylated dextran amine (BDA) was microinjected into the left cortical motor area of the canine brain. Fluorescence microscopy results showed that a large amount of BDA-labeled pyramidal cells were visible in the left cortical motor area after injection. In the left medulla oblongata, the BDA-labeled corticospinal tract was evenly distributed, with green fluorescence that had a clear boundary with the surrounding tissue. The BDA-positive corticospinal tract entered into the right lateral funiculus of the spinal cord and descended into the posterior part of the right lateral funiculus, close to the posterior horn, from cervical to sacral segments. There was a small amount of green fluorescence in the sacral segment. The distribution of BDA labeling in the canine central nervous system was consistent with the course of the corticospinal tract. Fluorescence labeling for BDA gradually diminished with time after injection. Our findings indicate that the BDA anterograde tracing technique can be used to visualize the localization and trajectory of the corticospinal tract in the canine central nervous system. | Xiao Han Guangming Lv Huiqun Wu Dafeng Ji Zhou Sun Yaofu Li Lemin Tang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 9 | Estrogen inhibits lipid peroxidation after hypoxic-ischemic brain damage in neonatal rats显示文摘Sprague-Dawley neonatal rats within 7 days after birth were used in this study. The left common carotid artery was occluded and rats were housed in an 8% O2 environment for 2 hours to establish a hypoxic-ischemic brain damage model. 17β-estradiol (1 × 10-5 M) was injected into the rat abdominal cavity after the model was successfully established. The left hemisphere was obtained at 12, 24, 48, 72 hours after operation. Results showed that malondialdehyde content in the left brain of neonatal rats gradually increased as modeling time prolonged, while malondialdehyde content of 17β-estrodial-treated rats significantly declined by 24 hours, reached lowest levels at 48 hours, and then peaked at 72 hours after injury. Nicotinamide-adenine dinucleotide phosphate histochemical staining showed the nitric oxide synthase-positive cells and fibers dyed blue/violet and were mainly distributed in the cortex, hippocampus and medial septal nuclei. The number of nitric oxide synthase-positive cells peaked at 48 hours and significantly decreased after 17β-estrodial treatment. Our experimental findings indicate that estrogen plays a protective role following hypoxic-ischemic brain damage by alleviating lipid peroxidation through reducing the expression of nitric oxide synthase and the content of malondialdehyde. | Hui Zhu Xiao Han Dafeng Ji Guangming Lv Meiyu Xu | 2012 | Neural Regeneration Research2012，7，31： | 1 |
| 10 | Pedological characteristics of Mn mine tailings and metal accumulation by native plants显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xin Xiao Xiaochen Song Zongyi Min | 2008 | Chemosphere2008，，9： | 1 |
| 11 | Highly oxidized magma and fluid evolution of Miocene Qulong giant porphyry Cu-Mo deposit, Southern Tibet, China显示文摘 | Xiao Bo Qin Kezhang Li Guangming | 2012 | Resource Geology2012，62，1： | 1 |
| 12 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 1 |
| 13 | D-band frontier: A new hydrogen evolution reaction activity descriptor of Pt single-atom catalysts显示文摘Hydrogen evolution reaction(HER) is crucial for achieving sustainable development and carbon neutrality, and thus demands efficient catalysts, which necessitates fundamental theory to relieve trial-and-error experiment. To fast screen HER candidates, most studies focus on d-band center(ε)associated with the Gibbs energy of H* adsorption(ΔG). Unfortunately, εrule is not applicable to Pt single atoms on transition metal disulfides(Pt_(1)/TMDs) because of the additional contributions from p states of S atom. Here, we propose a new HER descriptor — d-band frontier(d) by defining the weight of d-band in the energy range of [-1.0 eV, 1.0 eV] of Pt single atoms. This dis exactly correlated with the ΔGof Pt_(1)/TMDs, and thus perfectly describes the structure–activity relationship, as validated by systematical experimental evidences. Moreover, this ddescriptor can be extended to Pt single atoms anchored on other supports(e.g., CN, C, MoO, and CoO), indicating its promising generality. | Guangming Zhan Yancai Yao Fengjiao Quan Huayu Gu Xiao Liu Lizhi Zhang | 2022 | Journal of Energy Chemistry2022，31，9： | 1 |
| 14 | Rhamnolipid based glycerol-in-diesel microemulsion fuel: Formation and characterization显示文摘 | Lijian Leng Xingzhong Yuan Guangming Zeng Xiaohong Chen Hou Wang Hui Li Lihuan Fu Zhihua Xiao Longbo Jiang Cui Lai | 2015 | Fuel2015，，： | 1 |
| 15 | Three-dimensional reconstruction of human spinal cord based on histological serial sections显示文摘BACKGROUND: It is not possible to reconstruct the inner structure of the spinal cord, such as gray matter and spinal tracts, from the Visual Human Project database or CT and MRI databases, due to low image resolution and contrast in macrosection images. OBJECTIVE: To explore a semi-automatic computerized three-dimensional (3D) reconstruction of human spinal cord based on histological serial sections, in order to solve issues such as low contrast. DESIGN, TIME AND SETTING: An experimental study combining serial section techniques and 3D reconstruction, performed in the laboratory of Human Anatomy and Histoembryology at the Medical School of Nantong University during January to April 2008. SETTING: Department of Anatomy, Institute of Neurobiology, Jiangsu Province Key Laboratory of Neural Regeneration, Laboratory of Image Engineering. MATERIALS: A human lumbar spinal cord segment from fresh autopsy material of an adult male. METHODS: After 4% paraformaldehyde fixation for three days, serial sections of the lumbar spinal cord were cut on a Leica cryostat and mounted on slides in sequence, with eight sections aligned separately on each slide. All sections were stained with Luxol Fast Blue to reveal myelin sheaths. After gradient dehydration and clearing, the stained slides were coverslipped. Sections were observed and images recorded under a light microscope using a digital camera. Six images were acquired at ×25 magnification and automatically stitched into a complete section image. After all serial images were obtained, 96 complete serial images of the human lumbar cord segment were automatically processed with 'Curves', 'Autocontrast', ' Gray scale 8 bit', 'Invert', 'Image resize to 50%' steps using Photoshop 7.0 software. All images were added in order into 3D-DOCTOR 4.0 software as a stack, where serial images were automatically realigned with neighboring images and semi-automatically segmented for white matter and gray matter. Finally, simple surface and volume reconstruction were completed on a personal computer. The reconstructed human lumbar spinal cord segment was interactively observed, cut, and measured. MAIN OUTCOME MEASURES: The reconstructed human lumbar spinal cord segment. RESULTS: Compared with serial images obtained from other image modalities, such as CT, MRI, and mac- rosections from The Visual Human Project database, the Luxol Fast Blue stained histological serial section images exhibited higher resolution and contrast between gray and white matter. Image processing and 3D reconstruction steps were semi-automatically performed with related software. The 3D reconstructed human lumbar cord segment were observed, cut, and measured on a PC. CONCLUSION: A semi-automatically computerized method, based on histological serial sections, is an effective way to 3D-reconstruct the human spinal cord. | Guangming Lü Huiqun Wu Lemin Tang Xiao Han Dafeng Ji Xiaosong Gu | 2008 | Neural Regeneration Research2008，3，7： | 1 |
| 16 | Preparation of high nitrogen and nickel-free austenitic stainless steel by powder injection molding显示文摘High nitrogen and nickel-free austenitic stainless steel has received much recognition worldwide because it can solve the problem of 'nickel-allergy' and has outstanding mechanical and physical properties. In this article, 0Cr17Mn11Mo3N was prepared by powder injection molding (PIM) technique accompanied with solid-nitriding. The results show that the critical solid loading can achieve up to 64vol% by use of gas-atomized powders with the average size of 17.4 μm. The optimized sintering conditions are de-termined to be 1300°C, 2 h in flowing nitrogen atmosphere, at which the relative density reaches to 99% and the N content is as high as 0.78wt%. After solution annealing at 1150°C for 90 min and water quench, the 0.2% yield strength, ultimate tensile strength (UTS), elongation, reduction in area, and hardness can reach as high as 580 MPa, 885 MPa, 26.0%, 29.1%, and Hv 222, respectively. | Dawei Cui Junsheng Jiang Guangming Cao Enzhong Xiao Xuanhui Qu | 2008 | Journal of University of Science and Technology Beijing2008，15，2： | 1 |
| 17 | A social epidemiological study on HIV/AIDS in a village of Henan Province, China显示文摘 | Jin Yan Shuiyuan Xiao Liang Zhou Yong Tang Guangming Xu Dan Luo Qifeng Yi | 2013 | AIDS Care2013，，3： | 1 |
| 18 | Numerical simulation and experimental research on heat transfer and flow resistance characteristics of asymmetric plate heat exchangers显示文摘The asymmetric plate heat exchanger(APHE)has the possibility of achieving balanced pressure drops on both hot and cold sides for situations with unbalanced flow,which may in turn enhance the heat transfer.In this paper,the single-phase water flow and heat transfer of an APHE consisted of two types of plates are numerically(400≤Re≤12000)and experimentally(400≤Re≤3400)investigated.The numerical model is verified by the experimental results.Simulations are conducted to study the effects of,an asymmetric index proposed to describe the geometry of APHEs.The correlations of the Nusselt number and friction factor in the APHEs are determined by taking and working fluids into account.It is found that an optimal exists where the pressure drops are balanced and the heat transfer area reaches the minimum.The comparison between heat transfer and flow characteristics of the APHEs and the conventional plate heat exchanger(CPHE)is made under various flow rate ratios of the hot side and the cold side and different allowable pressure drops.The situations under which APHE may perform better are identified based on a comprehensive index. | Shaozhi ZHANG Xiao NIU Yang LI Guangming CHEN Xiangguo XU | 2020 | Frontiers in Energy2020，14，2： | 1 |
| 19 | Pedological characteristics of Mn mine tailings and metal accumulation by native plants显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xin Xiao Xiaochen Song Zongyi Min | 2008 | Chemosphere2008，，9： | 1 |
| 20 | Secreted IL‐1α promotes T‐cell activation and expansion of CD11b+Gr1+ cells in carbon tetrachloride‐induced liver injury in mice显示文摘 | Dandan Lin Lei Lei Yinsheng Zhang Bo Hu Guangming Bao Yonghao Liu Yuan Song Chunliang Liu Yan Wu Lixiang Zhao Xiao Yu Haiyan Liu | 2015 | Eur. J. Immunol2015，，： | 1 |
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