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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Topic enhanced deep structured semantic models for knowledge base question answering显示文摘Knowledge Base Question Answering(KBQA) is a hot research topic in natural language processing(NLP). The most challenging problem in KBQA is how to understand the semantic information of natural language questions and how to bridge the semantic gap between the natural language questions and the structured fact triples in knowledge base. This paper focuses on simple questions which can be answered by a single fact triple in knowledge base. We propose a topic enhanced deep structured semantic model for KBQA. The proposed method considers the task of KBQA as a matching problem between questions and the subjects and predicates in knowledge base. And the proposed model consists of two stages to match the subjects and predicates, respectively. In the first stage, we propose a Convolutional based Topic Entity Extraction Model(CTEEM) to extract topic entities mentioned in questions. With the extracted entities, we can retrieve the relevant candidate fact triples from knowledge base and obviously decrease the amount of noising candidates. In the second stage, we employ Deep Structured Semantic Models(DSSMs) to compute the semantic relevant score between questions and predicates in the candidates. And we combine the semantic level and the lexical level scores to rank the candidates. We evaluate the proposed method on KBQA dataset released by NLPCC-ICCPOL 2016. The experimental results show that our proposed method achieves the third place among the 21 submitted systems.Furthermore, we also extend the DSSM by using Bi LSTM and integrate a convolutional structure on the top of Bi LSTM layers. Our experimental results show that the extension models can further improve the performance. | Zhiwen XIE Zhao ZENG Guangyou ZHOU Weijun WANG | 2017 | Science China(Information Sciences)2017，60，11： | 10 |
| 3 | Polymeric biomaterials for biophotonic applications显示文摘With the growing importance of optical techniques in medical diagnosis and treatment,there exists a pressing need to develop and optimize materials platform for biophotonic applications.Particularly,the design of biocompatible and biodegradable materials with desired optical,mechanical,chemical,and biological properties is required to enable clinically relevant biophotonic devices for translating in vitro optical techniques into in situ and in vivo use.This technological trend propels the development of natural and synthetic polymeric biomaterials to replace traditional brittle,nondegradable silica glass based optical materials.In this review,we present an overview of the advances in polymeric optical material development,optical device design and fabrication techniques,and the accompanying applications to imaging,sensing and phototherapy. | Dingying Shan Ethan Gerhard Chenji Zhang John William Tierney Daniel Xie Zhiwen Liu Jian Yang | 2018 | Bioactive Materials2018，3，4： | 6 |
| 4 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 5 | mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris显示文摘Pemphigus vulgaris(PV)is a chronic and potentially life-threatening autoimmune blistering disease.Aberrant mTOR pathway activity is involved in many autoimmune diseases.This study investigated the correlation of mTOR pathway(PI3K/AKT/mTOR/p70S6K)activity with the loss of balance in T helper 2/regulatory T(Th2/Treg)cells in the peripheral blood of PV patients.CD4^(+)T cells were isolated from 15 PV patients and 15 healthy controls(HCs),the ratios of Th2/CD4^(+)T cells and Treg/CD4^(+)T cells,the activity of the mTOR pathway(PI3K/AKT/mTOR/p70S6K),the transcription factors and cytokines of Th2 and Treg cells were detected.Primary CD4^(+)T cells from PV patients were cultured under Th2-or Treg-polarizing conditions with or without rapamycin in vitro.We found that PV patients showed significantly elevated serum IL-4 when compared with HCs,and serum IL-4 level was positively correlated with the titer of anti-Dsg1/3 antibody and disease severity,while the serum TGF-βlevel was negatively correlated with the titer of anti-Dsg3 antibody and disease severity.Meanwhile,PV patients showed increased Th2/CD4^(+)T cell ratio;decreased Treg/CD4^(+)T cell ratio;elevated mRNA of PI3K,AKT,mTOR and protein of PI3K(P85),AKT,p-AKT(Ser473),mTOR,p-mTOR(Ser2448),p-p70S6K(Thr389),GATA3;reduced protein of forkhead box protein 3.Rapamycin inhibited Th2 cell differentiation and promoted Treg cell differentiation in vitro.These data suggest a close association between mTOR pathway activation and the loss of balance in Th2/Treg cells in peripheral blood of PV patients.Inhibiting mTORC1 can help restore the Th2/Treg balance. | Kuan Lai Wenjing Zhang Songshan Li Zhiwen Zhang Shuangde Xie Meinian Xu Changxing Li Kang Zeng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 4 |
| 6 | Development and Evaluation of a Loop-mediated Isothermal Amplification Assay for the Rapid Detection and Identification of Pectobacterium carotovorum on Celery in the Field显示文摘Pectobacterium carotovorum is the causal agent of bacterial soft rot in a wide range of vegetable host species.Once P.carotovorum infects the plant,the spread of the disease is difficult to control.In this study,a rapid and sensitive method based on loop-mediated isothermal amplification(LAMP)was developed for detecting P.carotovorum in celery with soft rot using a primer set designed from the pmrA conserved sequence of P.carotovorum.The specificity of the LAMP primer set for P.carotovorum was extensively validated on both P.carotovorum strains and nontarget strains.The sensitivity was 1 pg of P.carotovorum genomic DNA,which demonstrated 10 times more sensitive than the conventional PCR assay.LAMP was also used to detect P.carotovorum in bacterial suspension.The lowest detection concentration was 104 CFU·mL^−1.In addition,a LAMP assay,in conjunction with a crude DNA extraction method,was successfully performed on P.carotovorum-infected samples derived from both artificially and naturally infected plants.In summary,the LAMP assay established in this study constitutes a simple,sensitive,and rapid method for the detection of P.carotovorum,and has potential application in the control of celery soft rot disease through early detection. | Yanxia Shi Zhiwen Jin Xianglong Meng Lixue Wang Xuewen Xie Ali Chai Baoju Li | 2020 | Horticultural Plant Journal2020，6，5： | 3 |
| 7 | Different Ablation Models for the Wall-plasma Interaction Process in Pulsed Plasma Thruster显示文摘Ablation excited by current pulses is a very critical physical process in pulse plasma thrusters(PPT).Its effects on wall-plasma interaction directly determine the PPT performances.In order to reveal the process of the ablated wall interaction with the discharge plasma in PPT,ablation models formulated by three different boundary conditions at the wall-plasma interface are studied.These are the two widely used high-speed evaporation models(Model-L and Model-M),and the recently developed Keida-Zaghloul model(Model-K)of the Knudsen layer that takes into account the internal degrees of freedom on the energy flux conservation.First,fundamental mechanisms of the three ablation models are clarified by comparative analysis in order to gain a comprehensive understanding of the wall-plasma interaction.Then,the applicability of different ablation models with the numerical solutions of LES-6 PPT is investigated in detail using magnetohydrodynamic(MHD)modeling.Results show that Model-L and Model-M are actually special cases of Model-K when a simplified jump conditions limited by high velocity at the vapor/plasma interface is used;A ratio of ablation rate in Model-L to that in Model-M is about 0.8at the same wall surface temperature,while it rises to 1 at different surface temperature determined by Model-L and Model-M in PPT.Even though Model-K solution requires significant computational time,it shows more accurate ablation feature for the wall-plasma interaction and possesses better computing precision of impulse bit during post-pulse which is useful for future studies of the late time ablation. | YANG Lei LIU Xiangyang WANG Siyu XIE Kan WU Zhiwen WANG Ningfei | 2013 | 高电压技术2013，39，9： | 3 |
| 8 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 9 | The experiment study of spatial mask effect显示文摘masker 与 maskee 的理论分析和实验是空间的在方位角的分离证明当 masker 和 maskee 空间地被分开时,阀值趋于到落下和空间揭露的 producethe 现象。结果也证明空间揭露与频率有关。频率越高,空间揭露是越多 stronger。最大的揭露是 15 dB。主要暗示是 masker 和 maskee 什么时候采购原料,空间地在方位角被分开,因为头的影响,单耳的 Signal-to-Mask 比率(SMR ) 将增加相关转移功能(HRTF ) 。同时,由更高听觉的系统的听觉的信息的有两耳的处理是空间揭露的另一个原因。 | XIE Zhiwen YIN Junxun RAO Dan | 2006 | Chinese Journal of Acoustics2006，25，1： | 2 |
| 10 | Corrigendum to“First demonstration of improving laser propagation inside the spherical hohlraums by using the cylindrical laser entrance hole”[Matter Radiation Extremes 1(1)(2016)2-7]显示文摘Corrigendum Text:On page 2 of this letter,there is a misprint in the unit.The unit of the geometrical dimension of the spherical hohlraums on this page should always be“mm”rather than“mm”,i.e.in the second paragraph,“…with 800 J per beam at 0.35 mm…”should be“…with 800 J per beam at 0.35 mm…”,“The slit of 400 mm width is parallel…”should be“The slit of 400 mm width is parallel…”,“The laser focal diameter is about 500 mm…”should be“The laser focal diameter is about 500 mm…”;in the third paragraph,“…we take 850 mm as the radius…”should be“…we take 850 mm as the radius…”,“The LEH radius R_(L) is 400 mm…”should be“The LEH radius R_(L) is 400 mm…”,“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”should be“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”.This mistake does not affect any of the main results of the original letter. | Wenyi Huo Zhichao Li Dong Yang Ke Lan Jie Liu Guoli Ren Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Xuefei Xie Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Guanghui Yuan Haijun Zhang Baibin Jiang Lizhen Huang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Yongkun Ding Xiantu He Weiyan Zhang | 2016 | Matter and Radiation at Extremes2016，1，2： | 1 |
| 11 | Fourth - generation plasma immersion ion implantation and deposition facility for hybrid surface modification layer fabrication显示文摘 | Langping Wang Lei Huang Zhiwen Xie | 2008 | Rev Sci Instrum2008，79，： | 1 |
| 12 | Organising a juvenile ratio monitoring programme for 10 key waterbird species in the Yangtze River floodplain:analysis and proposals显示文摘Background:In the face of continued degradation and loss of wetlands in the Yangtze River floodplain(YRF),there is an urgent need to monitor the abundance and distribution of wintering waterbirds.To understand fully observed annual changes,we need to monitor demographic rates to understand factors affecting global population size.Annual reproduction success contributes to dynamic changes in population size and age structure,so an assessment of the juvenile ratio(i.e.first winter birds as a proportion of total number aged)of overwintering waterbirds can be an important indicator of the reproductive success in the preceding breeding season.Methods:During 2016-2019,we sampled juvenile ratios among 10 key waterbird species from the wetlands in the YRF.Based on these data,we here attempt to establish a simple,efficient,focused and reliable juvenile ratio monitoring scheme,to assess consistently and accurately relative annual breeding success and its contribution to the age structure among these waterbird species.Results:We compared juvenile ratio data collected throughout the winter and found that the optimal time for undertaking these samples was in the early stages of arrival for migratory waterbirds reaching their wintering area(early to mid-December).We recommend counting consistently at key points(i.e.those where>1%biogeographical flyway population were counted)at sites of major flyway importance(Poyang Lake,East Dongting Lake,Shengjin Lake,Caizi Lake,Longgan Lake and Chen Lake).Based on this,the error rate of the programme(155 planned points,the count of 10 waterbird species is 826-8955)is less than 5%.Conclusions:We established a juvenile ratio monitoring programme for 10 key waterbird species in the wetlands of the YRF,and discuss the feasibility and necessity of implementing such a future programme,and how to use these data in our monitoring and understanding of the population dynamics of these waterbird populations. | Yuxi Wang Iderbat Damba Qingshan Zhao Yanbo Xie Xueqing Deng Rdi Ga Guanhua Liu Zhiwen Xu Yue Li Dali Gao Wenbin Xu Guoxun Chen Lei Cao | 2021 | Avian Research2021，12，4： | 1 |
| 13 | Fourth-generation plasma immersion ion implantation and deposition facility for hybrid surface modification layer fabrication显示文摘 | Wang Langping Huang Lei Xie Zhiwen | 2008 | Rev Sci Ins2008，79，2： | 1 |
| 14 | Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition显示文摘 | Chengwu Song Chao Xie Zhiwen Zhou Shanggong Yu Nianbai Fang Ching Liang Hsieh | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 15 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 16 | Correlation between microstructure evolution and high temperature properties of TiA1SiN hard coatings with different Si and A1 content显示文摘 | Tian Chen Zhiwen Xie Feng Gong | 2014 | Applied Surface Science2014，314，： | 1 |
| 17 | The developments and challenges of cerium half-cell in zinc–cerium redox flow battery for energy storage显示文摘 | Zhipeng Xie Qingchao Liu Zhiwen Chang Xinbo Zhang | 2012 | Electrochimica Acta2012，，： | 1 |
| 18 | A preliminary study on spatial unmasking of virtual separated sources显示文摘An experimental method with headphone virtual reproduction is proposed and a series of experiments to study forward masking effect when the masker and the masked signal are spatially separated in azimuth are conducted. Then, the masking thresholds are compared with those when the masker and the masked signal source are at the same place. The results show that, although both the thresholds of 0° and ±30° sound images increase with the sound pressure level (SPL) of the masker, spatial unmasking may be really observed. The maximum unmasking is as large as 15 dB. This spatial unmasking effect is mainly attributed to better-ear contribution. | XIE ZhiWen JIN Jing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 0 |
| 19 | First experimental comparisons of laser-plasma interactions between spherical and cylindrical hohlraums at SGⅢ laser facility显示文摘We present our recent laser-plasmas instability(LPI)comparison experiment at the SGIII laser facility between the spherical and cylindrical hohlraums.Three kinds of filling are considered:vacuum,gas-filling with or without a capsule inside.A spherical hohlraum of 3.6 mm in diameter,and a cylindrical hohlraum of 2.4 mm?4.3 mm are used.The capsule diameter is 0.96 mm.A flat-top laser pulse with 3 ns duration and up to 92.73 kJ energy is used.The experiment has shown that the LPI level in the spherical hohlraum is close to that of the outer beam in the cylindrical hohlraum,while much lower than that of the inner beam.The experiment is further simulated by using our 2-dimensional radiation hydrodynamic code LARED-Integration,and the laser back-scattering fraction and the stimulated Raman scatter(SRS)spectrum are post-processed by the high efficiency code of laser interaction with plasmas HLIP.According to the simulation,the plasma waves are strongly damped and the SRS is mainly developed at the plasma conditions of electron density from 0.08 n_(c) to 0.1 n_(c) and electron temperature from 1.5 keV to 2.0 keV inside the hohlraums.However,obvious differences between the simulation and experiment are found,such as that the SRS back-scattering is underestimated,and the numerical SRS spectrum peaks at a larger wavelength and at a later time than the data.These dif-ferences indicate that the development of a 3D radiation hydrodynamic code,with more accurate physics models,is mandatory for spherical hohlraum study. | Yaohua Chen Zhichao Li Xufei Xie Chunyang Zheng Chuanlei Zhai Liang Hao Dong Yang Wenyi Huo Guoli Ren Jie Liu Xiaoshi Peng Tao Xu Yulong Li Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Yonggang Liu Huiyue Wei Xiangming Liu Weiyi Cha Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Haijun Zhang Baibin Jiang Wei Zhang Kai Du Xuewei Deng Yongkun Ding Xiaofeng Wei Wanguo Zheng Xiaodong Chen Xiantu He Ke Lan | 2017 | Matter and Radiation at Extremes2017，2，2： | 0 |
| 20 | The influence of time delay on forward masking when spatially separated sound image reproduced with headphone显示文摘与耳机的虚拟繁殖,健全图象是几乎空间的在向前掩盖上的 masker 和掩盖的信号之间的延期时间的影响在方位角分开了是阀值趋于随延期 time.Furthermore 的增加戏剧性地减少的 studied.The 结果表演,在空间分离的情况下,有与 maximmn 掩盖阀值的 difierences 大约 15 dB.However , masker 水平什么时候是阀值的 70 dB.the 差别,作为 dela | XIE Zhiwen JIN Jing | 2008 | Chinese Journal of Acoustics2008，27，4： | 0 |
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