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| 1 | Analysis of status and countermeasures of cancer incidence and mortality in China显示文摘Cancer is the leading cause of human deaths in the world and produces serious economic burdens. On September 12, 2018, the academic journal A Cancer Journal for Clinicians published an article about the latest statistics of cancers worldwide, which provided a status report on the global burden of 36 cancers in 185 countries worldwide. Cancer has also become a serious public health problem in China and caused more and more attention of the government and people in recent years. This review analyzes the incidence, mortality and prevalent trend of cancers in China, discusses the reasons behind this status, and reviews the potential countermeasures for cancer prevention and control in China. | Chunchun Wu Mengna Li Hanbing Meng Yukun Liu Weihong Niu Yao Zhou Ran Zhao Yumei Duan Zhaoyang Zeng Xiaoling Li Guiyuan Li Wei Xiong Ming Zhou | 2019 | Science China(Life Sciences)2019，62，5： | 175 |
| 2 | Effects of process parameters on pore structure of semi-coke prepared by solid heat carrier with dry distillation显示文摘The semi-coke was prepared by solid heat carrier with dry distillation in single factor method. The pore structures of raw coal and semi-coke were characterized by Brunauer-Emmett-Teller (BET) and scanning electron microscope (SEM). The results show that the adsorption and desorption isotherm of semi-coke are not coincident. There was a wide pore distribution on the semi-coke, in which mesopores and micropores account for a considerable proportion. Also there are many more secondary pores. With the increase of the final temperature of heat carrier and constant temperature, as well as the decrease of volume ratio of coal and hot carrier reactor, specific surface area and pore volume of semi-coke increased rapidly first and then decreased and finally increased, along with the rapidly reduction of average pore size. SEM photos show that the surface of semi-coke becomes increasingly rough and glossy. | Zhou, Guoli Wu, Jianjun Miao, Zhenyong Hu, Xuelian Li, Xia Shi, Xin Cai, Zhidan Shang, Yukun | 2013 | International Journal of Mining Science and Technology2013，23，3： | 20 |
| 3 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 4 | Research on Kalman-filter based multisensor data fusion显示文摘Multisensor data fusion has played a significant role in diverse areas ranging from local robot guidance to global military theatre defense etc.Various multisensor data fusion methods have been extensively investigated by researchers,of which Klaman filtering is one of the most important.Kalman filtering is the best-known recursive least mean-square algorithm to optimally estimate the unknown states of a dynamic system,which has found widespread application in many areas.The scope of the work is restricted to investigate the various data fusion and track fusion techniques based on the Kalman Filter methods,then a new method of state fusion is proposed. Finally the simulation results demonstrate the effectiveness of the introduced method. | Chen Yukun Si Xicai Li Zhigang | 2007 | Journal of Systems Engineering and Electronics2007，18，3： | 11 |
| 5 | A new compensation current real-time computing method for power active filter based on double linear construction algorithm显示文摘Considering the detection principle that “when load current is periodic current, the integral in a cycle for absolute value of load current subtracting fundamental active current is the least”, harmonic current real-time detection methods for power active filter are proposed based on direct computation, simple iterative algorithm and optimal iterative algorithm. According to the direct computation method, the amplitude of the fundamental active current can be accurately calculated when load current is placed in stable state. The simple iterative algorithm and the optimal iterative algorithm provide an idea about judging the state of load current. On the basis of the direct computation method, the simple itera- tive algorithm, the optimal iterative algorithm and precise definition of the basic concepts such as the true amplitude of the fundamental active current when load current is placed in varying state, etc., the double linear construction idea is proposed in which the amplitude of the fundamental active current at the moment of the sample is accurately calculated by using the first linear construction and the condition which disposes the next sample is created by using the second linear construction. On the basis of the double linear con- struction idea, a harmonic current real-time detection method for power active filter is proposed based on the double linear construction algorithm. This method has the char- acteristics of small computing quantity, fine real-time performance, being capable of ac- curately calculating the amplitude of the fundamental active current and so on. | LI Zicheng SUN Yukun | 2006 | Science China(Technological Sciences)2006，49，4： | 8 |
| 6 | Recent Progress of MXene-Based Nanomaterials in Flexible Energy Storage and Electronic Devices显示文摘The increasing demands for wearable electronics have stimulated the rapid development of flexible energy storage devices.MXenes are considered as promising flexible electrodes due to the ultrahigh volumetric specific capacitance,metallic conductivity,superior hydrophily,and rich surface chemistry. | Qi Yang Yukun Wang Xinliang Li Hongfei Li Zifeng Wang Zijie Tang Longtao Ma Funian Mo Chunyi Zhi | 2018 | Energy & Environmental Materials2018，1，4： | 8 |
| 7 | Fluxes of methane,carbon dioxide and nitrous oxide in an alpine wetland and an alpine grassland of the Tianshan Mountains,China显示文摘Methane(CH4), carbon dioxide(CO2) and nitrous oxide(N2O) are known to be major greenhouse gases that contribute to global warming. To identify the flux dynamics of these greenhouse gases is, therefore, of great significance. In this paper, we conducted a comparative study on an alpine grassland and alpine wetland at the Bayinbuluk Grassland Eco-system Research Station, Chinese Academy of Sciences. By using opaque, static, manual stainless steel chambers and gas chromatography, we measured the fluxes of CH4, N2O and CO2 from the grassland and wetland through an in situ monitoring study from May 2010 to October 2012. The mean flux rates of CH4, N2O and CO2 for the experimental alpine wetland in the growing season(from May to October) were estimated at 322.4 μg/(m2?h), 16.7 μg/(m2?h) and 76.7 mg/(m2?h), respectively; and the values for the alpine grassland were –88.2 μg/(m2?h), 12.7 μg/(m2?h), 57.3 mg/(m2?h), respectively. The gas fluxes showed large seasonal and annual variations, suggesting weak fluxes in the non-growing season. The relationships between these gas fluxes and environmental factors were analyzed for the two alpine ecosystems. The results showed that air temperature, precipitation, soil temperature and soil moisture can greatly influence the fluxes of CH4, N2O and CO2, but the alpine grassland and alpine wetland showed different feedback mechanisms under the same climate and environmental conditions. | GuiXiang HE KaiHui LI XueJun LIU YanMing GONG YuKun HU | 2014 | Journal of Arid Land2014，6，6： | 7 |
| 8 | Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress显示文摘Background: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress(HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation(PA).Results: Supplementation with resveratrol(2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione(GSH)level, reducing reactive oxygen species(ROS) and up-regulating the expression of Sirtuin 1(SIRT1). It was also found that melatonin(10^(-7)mol/L) and the combination of resveratrol(2.0 μmol/L) plus melatonin(10^(-7)mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under HS.Conclusions: This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. | Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang Yukun Song Pingli He Guoshi Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 7 |
| 9 | Carbon Storage and Vertical Distribution in Three Shrubland Communities in Gurbantünggüt Desert,Uygur AutonomousRegion of Xinjiang,Northwest China显示文摘This study was carried out in the Gurbantünggüt Desert,Uygur Autonomous Region of Xinjiang,Northwest China in August,2009.To quantify the storage,contribution and vertical distribution patterns of plant biomass carbon (PBC)and soil organic carbon(SOC)in the study area,we investigated the carbon concentrations and its vertical distribution in three different desert shrubland communities dominated by Reaumuria soongorica,Haloxylon ammodendron+R.soongorica and Tamarix ramosissima+R.soongorica,respectively.We analyzed vertical distribution of root biomass carbon and soil carbon contents by excavating soil profiles for each dominated community.The results show that SOC is considerably the larger carbon pool in the soil layers of 1.0-3.0 m(the mean value of three shrubland communities is 38.46%)and 3.0-5.0 m(the mean value is 40.24%).In contrast,70.74%of belowground biomass carbon storage in 0-1.0 m layer,and its content decrease with increasing soil depth.The Haloxylon ammodendron+R. soongorica shrubland community has the highest belowground biomass carbon among three selected communities. This study highlights the importance of SOC stored in deep soil layers(lower than 3.0 m from the surface)in arid shrubland communities in the global carbon balance.In addition,it provides the data support for revealing deep soil solid carbon potential,and offers scientific basis for the further research in the carbon cycle of terrestrial ecosystem. | GONG Yanming HU Yukun FANG Fei LIU Yanyan LI Kaihui ZHANG Guangming | 2012 | Chinese Geographical Science2012，22，5： | 6 |
| 10 | Effects of Yishengukang decoction on expression of bone-specific alkaline phosphatase,carboxyterminal propeptide of typeⅠprocollagen,and carboxyterminal cross-linked telepeptide of typeⅠcollagen in malignant tumor patients with bone metastasis显示文摘OBJECTIVE: To investigate the effect of Yishengukang decoction on the expression of the metabolic bone markers, bone-specific alkaline phosphatase(BAP), carboxyterminal propeptide of type Ⅰ procollagen(PICP), and carboxyterminal cross-linked telepeptide of type Ⅰ collagen(ICTP), in cancer patients with bone metastasis.METHODS: Patients(n = 180) were divided into three groups:(a) bone metastasis patients treated with Yishengukang and pamidronate disodium injection(treatment group, n = 60);(b) bone metastasis patients treated with pamidronate disodium injection alone(control group, n = 60);(c) cancer patients without metastatic bone lesion(non-bone metastasis group, n = 60). Serum levels of the metabolic markers BAP, PICP, and ICTP were detected by enzyme-linked immunosorbent assay pre- and post-therapy.RESULTS: A significant decrease in serum BAP level was observed in the treatment group compared with the control group. However there were no significant differences in serum levels of PICP and ICTP before or after treatment compared with the control group.CONCLUSION: Yishengukang decoction combined with pamidronate disodium injection reduced serum BAP level to a greater extent that pamidronate disodium injection alone. Furthermore, the combined therapy was more beneficial in regulating imbalanced bone metabolism after bone metastasis,and may represent the molecular mechanism underpinning the effects of Yishengukang decoction. | Yin Yukun Feng Li Zhou Lei Li Jie Gao Yin Wang Ningjun Yu Jianhua Jiang Zhenglong He Shengqi Lu Dianrong Wang Fang Du Yanlin | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 6 |
| 11 | Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk/Rb/E2F pathway in nasopharyngeal carcinoma cells显示文摘proto-oncogene c-Myc 编码涉及细胞的增长,区别,和 apoptosis 的规定的一个抄写因素。几研究显示 c-Myc 的在表示上是在鼻咽的癌(NPC ) 的经常的基因畸形。因此,明确地在确定的 NPC 房间线由基因工具减少它的水平帮助更好在 NPC 的致病理解它的角色。在这研究,第一次,我们成功地由采用一条基于 DNA 的 RNA 干扰途径与稳定地压制的 c-Myc 表示建立了并且描绘 NPC 5-8F 房间线。c-Myc 的抑制在 5-8F 房间导致了减少的房间生长,殖民地形成,和房间周期前进。在 vivo 肿瘤,形成试金表明减少的 c-Myc 击倒在裸体老鼠的 5-8F 房间的 tumorigenic 潜力。在分子的水平,我们发现 c-Myc 击倒能减少涉及 Cdk/Rb/E2F 小径,包括的 CDK4, cyclin D1, CDK2, pRb, E2F3,和 DP2,并且显著地减少了 cyclin D1 的倡导者活动的几个批评分子的表示。一起拿,这些调查结果在鼻咽的 carcinogenesis 提供珍贵机械学的卓见进 c-Myc 的角色并且建议 c-Myc 击倒可以是为 NPC 的处理的一条潜在的治疗学的途径。 | Zhaoxia Niu Huaying Liu Ming Zhou Heran Wang Yukun Liu Xiayu Li Wei Xiong Jian Ma Xiaoling Li Guiyuan Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 5 |
| 12 | Inadvertent insertion of nephrostomy tube into the renal vein following percutaneous nephrolithotomy: A case report and literature review显示文摘Percutaneous nephrolithotomy(PCNL)is an effective and well accepted procedure for the treatment of large and complex renal calculi.We encountered a patient with a mis-placed percutaneous nephrostomy drainage tube(PNDT)into the contralateral renal vein re-sulting thrombus formation after undergoing right side PCNL.We placed a temporary filter to prevent embolism and started anti-coagulation therapy immediately and finally the PNDT was removed without bleeding. | Guangju Ge Zhenghui Wang Mingchao Wang Gonghui Li Zuhao Xu Yukun Wang Shawpong Wan | 2020 | Asian Journal of Urology2020，7，1： | 3 |
| 13 | Carbazole-endcapped Spiro[fluorene-9,9'-xanthene] with Large Steric Hindrance as Hole-transporting Host for Heavily-doped and High Performance OLEDs显示文摘 | Xianghua Zhao Yukun Wu Nannan Shi Xiaoyu Li Yi Zhao Mingli Sun Dongxue Ding Hui Xu Linghai Xie | 2015 | Chinese Journal of Chemistry2015，33，8： | 3 |
| 14 | Calibration procedures for the CHASE/HIS science data显示文摘The Hα line is an important optical line in solar observations containing the information from the photosphere to the chromosphere. To study the mechanisms of solar eruptions and the plasma dynamics in the lower atmosphere, the Chinese Hα Solar Explorer(CHASE) was launched into a Sun-synchronous orbit on October 14, 2021. The scientific payload of the CHASE satellite is the Hα Imaging Spectrograph(HIS). The CHASE/HIS acquires, for the first time, seeing-free Hα spectroscopic observations with high spectral and temporal resolutions. It consists of two observational modes. The raster scanning mode provides full-Sun or region-of-interest spectra at Hα(6559.7-6565.9 ?) and Fe I(6567.8-6570.6 ?) wavebands. The continuum imaging mode obtains full-Sun photospheric images at around 6689 ?. In this paper, we present detailed calibration procedures for the CHASE/HIS science data, including the dark-field and flat-field correction, slit image curvature correction, wavelength and intensity calibration, and coordinate transformation. The higher-level data products can be directly used for scientific research. | Ye Qiu ShiHao Rao Chuan Li Cheng Fang MingDe Ding Zhen Li YiWei Ni WenBo Wang Jie Hong Qi Hao Yu Dai PengFei Chen XiaoSheng Wan Zhi Xu Wei You Yuan Yuan HongJiang Tao XianSheng Li YuKun He Qiang Liu | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 3 |
| 15 | Development of microstructural inhomogeneity in multi-pass flow forming of TA15 alloy cylindrical parts显示文摘Revealing the development of microstructural inhomogeneity in the multi-pass flow forming of titanium alloy components is of great significance to the microstructure control and property tailoring.To this end,the microstructural inhomogeneity of TA15 alloy spun cylindrical parts was analyzed based on the deformation history.The results indicate that the material underwent significant compressive strain in the normal direction(ND),tension strain in the rolling and circumferential directions(RD and CD),while tension strain in the CD is slightly small due to the limited material flow in this direction.These strain characteristics make the microstructure,especially the primary a(ap),present different morphologies in the different planes of the part.Meanwhile,the combined effects of inhomogeneous deformation and temperature distribution in the ND also cause the inhomogeneity of microstructure morphology and parameters in this direction.Quantitative analyses show that with the forming pass increasing,the aspect ratio of apincreases most in the normal-rolling plane,then in the normal-circumferential plane and least in the circumferential-rolling plane,whereas apcontent decreases in an opposite trend.Along the ND,the aspect ratio and content of apis relatively high in the outer and inner surface areas but lowest in the central area,and these inhomogeneous characteristics can be gradually diminished with the forming pass increasing.Furthermore,the variation of hardness inhomogeneity factor indicates that a four-pass forming with the total reduction ratio of 63%could obtain a homogenous microstructure along the ND of the TA15 alloy spun cylindrical part. | Xianxian WANG Pengfei GAO Mei ZHAN Ke YANG Yunda DONG Yukun LI | 2020 | Chinese Journal of Aeronautics2020，33，7： | 3 |
| 16 | Recent advances in electrospun electrode materials for sodium-ion batteries显示文摘Sodium-ion batteries(SIBs)have been considered as an ideal choice for the next generation large-scale energy storage applications owing to the rich sodium resources and the analogous working principle to that of lithium-ion batteries(LIBs).Nevertheless,the larger size and heavier mass of Na^(+)ion than those of Li^(+)ion often lead to sluggish reaction kinetics and inferior cycling life in SIBs compared to the LIB counterparts.The pursuit of promising electrode materials that can accommodate the rapid and stable Na-ion insertion/extraction is the key to promoting the development of SIBs toward a commercial prosperity.One-dimensional(1 D)nanomaterials demonstrate great prospects in boosting the rate and cycling performances because of their large active surface areas,high endurance for deformation stress,short ions diffusion channels,and oriented electrons transfer paths.Electrospinning,as a versatile synthetic technology,features the advantages of controllable preparation,easy operation,and mass production,has been widely applied to fabricate the 1 D nanostructured electrode materials for SIBs.In this review,we comprehensively summarize the recent advances in the sodium-storage cathode and anode materials prepared by electrospinning,discuss the effects of modulating the spinning parameters on the materials’micro/nano-structures,and elucidate the structure-performance correlations of the tailored electrodes.Finally,the future directions to harvest more breakthroughs in electrospun Na-storage materials are pointed out. | Yao Wang Yukun Liu Yongchang Liu Qiuyu Shen Chengcheng Chen Fangyuan Qiu Ping Li Lifang Jiao Xuanhui Qu | 2021 | Journal of Energy Chemistry2021，30，3： | 3 |
| 17 | Controlled synthesis of T-shaped BiVO 4 and enhanced visible light responsive photocatalytic activity显示文摘 | Shuying Dong Chongfei Yu Yukun Li Yihui Li Jianhui Sun Xiaofei Geng | 2014 | Journal of Solid State Chemistry2014，，： | 3 |
| 18 | Plant diversity-productivity patterns in the alpine steppe environment of the Central Tianshan Mountains显示文摘The biodiversity-productivity relationship is an important topic in the research of bio- diversity and ecosystem function. The plant diversity-productivity pattern is commonly unimodal and positively correlated. This paper researches the characteristics of plant diversity-productivity patterns in the Bayanbuluk alpine steppe in the central Tianshan Mountains, Xinjiang, China, and analyzes the effects of environmental factors on the distribution of plant communities, species composition, plant diversity and productivity in the steppe. The results show a positive correlation between plant diversity and productivity. DCCA (detrended canonical correspondence analysis) ordination reveals a significant relationship between the effects of air temperature, soil moisture content, available soil nitrogen, relative humidity and pH value on the distribution and composition of plant communities. There are significant correlations between the soil moisture content, relative humidity, pH value, air temperature and species richness and the aboveground biomass of Gramineae and Cyperaceae, and also significant correlations between the relative humidity, pH values and the total aboveground biomass of plant communities. | Hu, YuKun Li, KaiHui Gong, YanMing Yin, Wei | 2009 | Journal of Arid Land2009，1，1： | 3 |
| 19 | Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy显示文摘The RAS-RAF-MEK-ERK signaling pathway(MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antitumor strategy.Dozens of potent non-ATP-competitive allosteric MEK1/2 inhibitors have been developed that have produced substantial improvement in clinical outcomes over the past decade.However, the efficacy of these agents is limited, and response rates are variable in a wide range of tumors that harbor RAS and RAF mutations due to the development of resistance, which is derived mainly from the persistence of MAPK signaling and increased activation of the mutual feedback networks.Both intrinsic and acquired resistance to MEK inhibitors necessitates the synergistic targeting of both pathways to restore the therapeutic effects of a single agent.In this review, the significant role of the MAPK pathway in carcinogenesis and its therapeutic potential are comprehensively examined with a focus on MEK inhibitors.Then, the activation of feedback networks accompanying MEK inhibition is briefly reviewed.Combination strategies that involve the simultaneous inhibition of the original and resistance pathways are highlighted and elaborately described on the basis of the latest research progress.Finally, the obstacles to the development of MEK-related combination systems are discussed in order to lay the groundwork for their clinical application as frontline treatments for individual patients with MAPK-hyperactivated malignancies. | Yanan Li Qingrong Dong Yukun Cui | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 20 | Estimating leaf mercury content in Phragmites australis based on leaf hyperspectral reflectance显示文摘Introduction:Highmercury(Hg)concentrations affect the chlorophyll in leaves,therebymodifying leaf spectra.Hyperspectra is a promising technique for the rapid,nondestructive evaluation of leaf Hg content.In this study,we investigated Hg contents and reflective hyperspectra of reed leaves(Phragmites communis)in a gold mining(Jilin province,China).Spectral parameters sensitive to Hg content were identified through basic spectral transformations,continuous wavelet transformation(CWT),and spectral indices techniques.Leaf Hg inversion models were developed using stepwise multiple linear regression,partial least squares regression,and random forest algorithms.Outcomes:The results indicated that:1)leaf Hg content decreased with increasing distance from the mine:Jiapigou(JPG)>Erdaocha(EDC)>Laojingchang(LJC)>Erdaogou(EDG)>Lingqian(LQ)>Weishahe(WSH).2)Hg–sensitive wavelengths were primarily in the visible region;CWT increased the correlation between hyperspectral data and leaf Hg content,and improved the regression and accuracy of inversion;3)the continuumremoval–CWT–stepwise multiple linear regression was better for estimating low leaf Hg content;while the differential spectral index–partial least squares regression was better for estimating high leaf Hg content.Conclusion:These hyperspectral inversion methods could be used for rapid,nondestructive monitoring of wetland plants. | Weiwei Liu Mengjie Li Manyin Zhang DaanWang Ziliang Guo Songyuan Long Si Yang Henian Wang Wei Li Yukun Hu Yuanyun Wei Hongye Xiao | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
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