|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses显示文摘C 类型 lectin 受体(CLR ) 属于在他们的细胞外的域上包含糖类识别域(CRD ) 和钙绑定地点的蛋白质的一个大家庭。最近的研究显示许多 CLR 例如 Dectin-1, Dectin-2 和 Mincle,作为从感染的微生物认出糖类 ligands 的模式识别受体(PRR ) 工作。在 ligand 绑定之上,这些 CLR 通过他们的自己的 immunoreceptor 导致多重信号 transduction 串联基于酷氨酸的激活主题(ITAM ) 或与象 FcRγ 那样的包含 ITAM 适配器蛋白质交往;。新兴的证据显示导致 CLR 的发信号串联导致原子因素 kappaB 的激活(NF-κ B ) 通过一条 Syk 依赖、 CARD9 依赖的小径的 transcriptional 因素的家庭。NF-κ 的激活; B 在跟随微生物引起的感染和织物损坏的天生的有免疫力、煽动性的回答的正式就职起一个关键作用。在这评论,我们将在 CLR 导致的信号 transduction 小径上总结最近的进步,并且这些 CLR 怎么激活 NF-κ B 并且贡献天生的有免疫力、煽动性的回答。 | Lara M Kingeter Xin Lin | 2012 | Cellular & Molecular Immunology2012，9，2： | 14 |
| 4 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 5 | Spatial and Temporal Variability of Farm Size in China in Context of Rapid Urbanization显示文摘During the last 30 years,China has witnessed rapid economic growth and dramatic urbanization,with about 1.2 × 107rural people migrating annually into urban areas.Meanwhile,especially since 1995,the rural population has been declining,which is closely linked to land circulation and the increase in farm size in many villages.Increasing scale of farming operations is often regarded as a key to avoiding the abandonment of farmland and to increasing the income of rural farmers.However,until now,there has been little research on the spatial and temporal variability of farm size at the national level in China.Using data from the national agricultural census and rural household surveys,this study examines the characteristics of land use circulation and the consequent changes in the area of farmland per household.The results show that: 1) 12.2% of rural households were involved in land circulation at the national level.The highest amounts of land circulation have occurred in those provinces where the farmland per capita is more than 0.2 ha or less than 0.1 ha;2) over 80% of households operate less than 0.6 ha of farmland;3) the proportion of mid-sized farms(between 0.2 ha and 0.6 ha per household) has decreased while the smallest and the largest farms have increased.This bears some similarity with the phenomenon known as the ′disappearing middle′,referring to the changes in farm size.This study establishes a framework for interpreting the factors affecting the changes in farm size in China,which include two promoting factors(urbanization and agriculture) and four hindering factors(agricultual land system,household registration,stable clan system,and farmland loss). | TAN Minghong Guy M ROBINSON LI Xiubin XIN Liangjie | 2013 | Chinese Geographical Science2013，23，5： | 8 |
| 6 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 7 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 8 | Diaporthe species occurring on citrus in China显示文摘Diaporthe species are important pathogens of a wide range of hosts including many economically important crops.Diaporthe citri is generally accepted to cause melanose of Citrus fruits,leaves and shoots;stem-end rot of fruits and gummosis of perennial branches.In this study,147 strains of Diaporthe were isolated from diseased leaves,twigs,fruits and branches of Citrus from Shaanxi,Zhejiang,Guangxi,Fujian,Guangdong,Jiangxi,Hunan,Chongqing and Shanghai and identified by morphology and molecular analysis of nuclear ribosomal internal transcribed spacer(ITS),partial sequences of translation elongation factor 1-α(EF 1-α),tubulin(TUB)and calmodulin(CAL)genes.All strains from Citrus clustered in three clades.Diaporthe citri was the predominant species and is compared with strains from Florida,USA,where this species was first collected and described.Two new taxa differing from D.citri are described as D.citriasiana and D.citrichinensis in this paper.Inoculation tests indicate that all three species are able to cause stem-end rot of fruits,while only D.citri could cause melanose on leaves. | Feng Huang Xin Hou Megan M Dewdney Yushi Fu Guoqing Chen Kevin D Hyde Hongye Li | 2013 | Fungal Diversity2013，，4： | 4 |
| 9 | Microstructure and Wear Behaviour of Laser-Induced Thermite Reaction Al_2O_3 Ceramic Coatings on Pure Aluminum and AA7075 Aluminum Alloy显示文摘Wear-resistant laser-induced thermite reaction Al_2O_3 ceramic coatings can be fabricated on pure Al and AA7075 aluminum alloy by laser cladding(one-step method)and laser cladding followed by laser re-melting(two-step method)using mixed powders CuO-Al-SiO_2 in order to improve the wear properties of aluminum and aluminum alloy,respectively.The microstructure of the coatings was characterized by scanning electron microscopy(SEM)and X-ray diffraction(XRD).The wear resistance of the coatings was evaluated under dry sliding wear test condition at room temperature.Owing to the presence of hardα-Al_2O_3 andγ-Al_2O_3 phases,the coatings exhibited excellent wear resistance.In addition,the wear resistance of the coatings fabricated by two-step method is superior to that of the coatings fabricated by one-step method. | 黄开金 LIN Xin XIE Changsheng T M Yue | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，1： | 4 |
| 10 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 11 | Thermal internal boundary layer and its effects on air pollutants during summer in a coastal city in North China显示文摘The thermal internal boundary layer(TIBL) is associated with coastal pollution dispersion,which can result in high concentrations of air pollutants near the surface of the Earth. In this study, boundary layer height data which were obtained using a ceilometer were used to assess the effect of the TIBL on atmospheric pollutants in Qinhuangdao, a coastal city in North China.A TIBL formed on 33% of summer days. When a TIBL formed, the sunshine duration was 2.4 hr longer, the wind speed was higher, the wind direction reflected a typical sea breeze, and the boundary layer height was lower from 9:00 LT to 20:00 LT compared to days without a TIBL. If no TIBL formed, the average concentrations of PM_(2.5) and PM_(10) decreased with increasing boundary layer height. However, when a TIBL was observed, the average concentrations of PM_(2.5) and PM_(10) increased with increasing boundary layer height. Because the air from the sea is clean, PM_(2.5) and PM_(10) concentrations reached minimums in the daytime at 16:00 LT. After16:00 LT, the PM_(2.5) and PM_(10) concentrations increased rapidly on days when a TIBL formed,which indicated that the TIBL leads to the rapid accumulation of atmospheric pollutants in the evening. Therefore, the maximum concentrations of particulate matters were larger when a TIBL formed compared to when no TIBL was present during the night. These results indicate that it is suitable for outdoor activities in the daytime on days with a TIBL in coastal cities. | Jie Wei Guiqian Tang Xiaowan Zhu Lili Wang Zirui Liu Mengtian Cheng Christoph Münkel Xin Li Yuesi Wang | 2018 | Journal of Environmental Sciences2018，30，8： | 2 |
| 12 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 13 | Superhydrophobic silica nanocomposite coating by a low-temperature process显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of American Ceramic Society2004，87，9： | 1 |
| 14 | Superhydrophobie silica nanocom-poaite coating by a low-temperature proeess显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of the Ameri-Call Ceramic Socienty2004，87，9： | 1 |
| 15 | Photometric measurements of spring aerosol optical properties in dust and non-dust periods in China 显示文摘 | DU W P XIN J Y WANG M X | 2008 | Atmos Environ2008，42，34： | 1 |
| 16 | Exploring the Black Box: An Analysis of Work Group Diversity, Conflict, and Performance显示文摘 | PELLED L H EISENHARDT K M XIN K R | 1999 | Administrative Science Quarterly1999，44，1： | 1 |
| 17 | (A) 显示文摘 | Cao Huai xin Xu zong ben Zhang Jian hua Matrix-trace on C^*- algebra M | 2002 | Linear Algebra and its Applications2002，，345： | 1 |
| 18 | Fate of adipose-derived stronml vas- cular fraction cells after co-implantation with fat grafts: evidence of cell survival and differentiation in ischemic adipose tissue显示文摘 | Fu S Luan J Xin M | 2013 | Plast Reconstr Surg2013，132，2： | 1 |
| 19 | Dynamic spec- trum access: from cognitive radio to network radio 显示文摘 | SONG M XIN C ZHAO Y | 2012 | IEEE Wireless Communications2012，19，1： | 1 |
| 20 | Distributed memetic differential evolution with the synergy of lamarckian and baldwinian learning显示文摘 | Zhang C M Chen J Xin B | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员