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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with an Arg-Gly-Asp ligand显示文摘 | Xiong J P Stehle T Zhang R | 2002 | Science2002，296，5565： | 1 |
| 4 | Transient liquid - phase diffusion bonding of two- dimensional carbon- carbon composites to niobium alloy显示文摘 | J - L LI J - T XIONG F - S ZHANG | 2007 | Materials Science and Engineering A2007，，484： | 1 |
| 5 | Do-nor-acceptor pair luminescence of nitrogenimplanted ZnO single crystal显示文摘 | XIONG G UCER K B WILLIAMS R T | 2005 | J Appl Phys2005，97，4： | 1 |
| 6 | Ruttle stability and rutile/melt HFSE partitioinng during partial melting of hydrous basalt:implications for TTG genesis显示文摘 | Xiong X L Adam J Green T H | 2005 | Chemical Geology2005，218，： | 1 |
| 7 | Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol显示文摘 | Hsieh T C Xiong W Traganos F | 2002 | Anticancer Res2002，22，4： | 1 |
| 8 | A macroscopic approach to the lane for- mation phenomenon in pedestrian counterflow 显示文摘 | Xiong T Zhang P Wong S C Shu C W Zhang M | 2011 | Chinese Physical Letters2011，28，10： | 1 |
| 9 | Effect of a-A12O3 on the properties of cold sprayed A1/a-AI203 composite coatings on AZ91D magnesium alloy显示文摘 | TAO Y S XIONG T Y SUN C | 2009 | Appl Surf Sci2009，256，1： | 1 |
| 10 | New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancre- atic β-cells : the involvement of the Wnt signaling pathway effector β- catenin显示文摘 | Xiong X Shao W Jin T | 2012 | Islets2012，4，6： | 1 |
| 11 | Long-term in vivo Biodistribution Imaging and Toxicity of Polyacrylic Acid-coated Upconversion Nanophosphors 显示文摘 | Xiong L Q Yang T S Yang Y | 2010 | Biomaterials2010，31，27： | 1 |
| 12 | Study of W/HZSM-5-based catalysts for dehydro-aromatization of CH4 in absence of 02 (11):Action of promoters Zn and Li 显示文摘 | Xiong Z T Zhang H B Lin G D Zeng J L | 2001 | Catalysis Letters2001，74，34： | 1 |
| 13 | Neurotrophins induce BDNF expression through the glutamate receptor pathway in neocortical neurons显示文摘 | Futamura T Jourdi H | 2002 | Neuropharmacology2002，42，7： | 1 |
| 14 | Kinetics of carbon dioxide sorption on potassium-doped lithium zirconate 显示文摘 | Xiong R T Ida J I Lin Y S | 2003 | Chem Eng Sci2003，58，19： | 1 |
| 15 | Human tissue kallikrein induces hypotension in transgenic mice显示文摘 | Wang J Xiong W Yang Z Davis T Dewey MJ Chao J | 1994 | Hypertension1994，23，： | 1 |
| 16 | Erythropoietin for neonatal brain injury: opportunity and challenge显示文摘 | Xiong T Qu Y Mu D | 2011 | International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience2011，29，6： | 1 |
| 17 | The role of Nogo-A in neuroregeneration:a review显示文摘 | Wang T Xiong JQ Ren XB | 2012 | Brain Res Bull2012，87，6： | 1 |
| 18 | Sorption of phenanthrene by soils contaminated with heavy metals 显示文摘 | Gao Y Z Xiong W Ling W T | 2006 | Chemosphere2006，65，： | 1 |
| 19 | Biochemical susceptibility of myosin in chicken myofibrils subjected to hydroxyl radi- cal oxidizing systems 显示文摘 | Ooizumi T XIONG You-ling | 2004 | Journal of Agricultural and Food Chemistry2004，52，13： | 1 |
| 20 | Performance of three-phase three-dimensional electrode reactor for the reduction of COD in simulated wastewater-containing phenol显示文摘 | Ya Xiong Chun He Hans T K | | 0，，01： | 1 |
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