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| 1 | Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos显示文摘有类型 II 的最近的进展定期聚类 interspaced 短 palindromic 重复(CRISPR ) 系统诺言染色体编辑的一条改进途径。然而,在模型有机体的这个系统的适用性和效率例如 zebrafish,几乎没被学习。这里,我们报导那指导 RNA 的 Cas9 核酸酶高效地便于染色体以一种简单、柔韧的方式在哺乳动物的房间和 zebrafish 胚胎编辑。当特定的 Cas/gRNA 被用来在 vivo 在 zebrafish 胚胎指向任何一个 etsrp, gata4 或 gata5 时,超过 35% 地点特定的体的变化被发现。Cas9/gRNA 高效地在结果导致了 etsrp 或 gata5 的 biallelic 变换体的房间,在 etsrp 在 fau 异种胚胎或贲门 bifida 显型 > tm236a 异种胚胎。最后,我们成功地完成了 Cas9/gRNA 系统在 zebrafish 胚胎导致的 mloxP 顺序的地点特定的插入。这些结果证明 Cas9/gRNA 系统有为 zebrafish 和另外的模型有机体成为一个简单、柔韧、有效的反向的基因工具的潜力。和另外的染色体工程技术, Cas9 系统为在生物学,农业,环境研究和药的应用是有希望的。 | Nannan Chang Changhong Sun Lu Gao Dan Zhu Xiufei Xu Xiaojun Zhu Jing-Wei Xiong Jianzhong Jeff Xi | 2013 | Cell Research2013，23，4： | 155 |
| 2 | Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients显示文摘Objective: The purposes of this study were to identify risk factors for cervical lymph node metastasis and to examine the association between BRAF^(V600E) status and clinical features in papillary thyroid microcarcinoma(PTMC).Methods: A total of 1,587 patients with PTMC, treated in Tianjin Medical University Cancer Institute and Hospital from January2011 to March 2013, underwent retrospective analysis. We reviewed and analyzed factors including clinical results, pathology records, ultrasound results, and BRAF^(V600E) status.Results: Multivariate logistic regression analyses demonstrated that gender(male) [odds ratio(OR) = 1.845, P = 0.000], age(< 45 years)(OR = 1.606, P = 0.000), tumor size(> 6 mm)(OR = 2.137, P = 0.000), bilateralism(OR = 2.011, P = 0.000) and extrathyroidal extension(OR = 1.555, P = 0.001) served as independent predictors of central lymph node metastasis(CLNM).Moreover, CLNM(OR = 29.354, P = 0.000) served as an independent predictor of lateral lymph node metastasis(LLNM). Among patients with a solitary primary tumor, those with tumor location in the lower third of the thyroid lobe or the isthmus were more likely to experience CLNM(P < 0.05). Univariate analyses indicated that CLNM, LLNM, extrathyroidal extension, and multifocality were not significantly associated with BRAF^(V600E) mutation.Conclusions: The present study suggested that prophylactic neck dissection of the central compartment should be considered in patients with PTMC, particularly in men with tumor size greater than 6 mm, age less than 45 years, extrathyroidal extension, and tumor bilaterality. Among patients with PTMC, BRAF^(V600E) mutation is not significantly associated with prognostic factors. For a better understanding of surgical management of PTMC and the risk factors, we recommend multicenter research and long-term follow-up. | Xiangqian Zheng Chen Peng Ming Gao Jingtai Zhi Xiukun Hou Jingzhu Zhao Xi Wei Jiadong Chi Dapeng Li Biyun Qian | 2019 | Cancer Biology & Medicine2019，16，1： | 54 |
| 3 | Inhibition of cerebral ischemia/reperfusion injuryinduced apoptosis:nicotiflorin and JAK2/STAT3 pathway显示文摘Nicotiflorin is a flavonoid extracted from Carthamus tinctorius.Previous studies have shown its cerebral protective effect,but the mechanism is undefined.In this study,we aimed to determine whether nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis through the JAK2/STAT3 pathway.The cerebral ischemia/reperfusion injury model was established by middle cerebral artery occlusion/reperfusion.Nicotiflorin(10 mg/kg) was administered by tail vein injection.Cell apoptosis in the ischemic cerebral cortex was examined by hematoxylin-eosin staining and terminal deoxynucleotidyl transferase d UTP nick end labeling assay.Bcl-2 and Bax expression levels in ischemic cerebral cortex were examined by immunohistochemial staining.Additionally,p-JAK2,p-STAT3,Bcl-2,Bax,and caspase-3 levels in ischemic cerebral cortex were examined by western blot assay.Nicotiflorin altered the shape and structure of injured neurons,decreased the number of apoptotic cells,down-regulates expression of p-JAK2,p-STAT3,caspase-3,and Bax,decreased Bax immunoredactivity,and increased Bcl-2 protein expression and immunoreactivity.These results suggest that nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis via the JAK2/STAT3 pathway. | Guang-qiang Hu Xi Du Yong-jie Li Xiao-qing Gao Bi-qiong Chen Lu Yu | 2017 | Neural Regeneration Research2017，12，1： | 40 |
| 4 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 5 | Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes:A Randomized, Double-blind, Multicenter Clinical Trial显示文摘 | Xi Wang Dan HU Song Dang He Huang Cong-Xin Huang Ming-Jie Yuan Yan-Hong Tang Qing-Shan Zheng Fang Yin Shu Zhang Bo-Li Zhang Run-Lin Gao | 2017 | Chinese Medical Journal2017，，14： | 33 |
| 6 | Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products显示文摘最近的婴儿的公式奶粉污染事件证明了在牛奶质量控制的经典标记或标准在识别鈥渕a nipulated 鈥 ? 是不够的差质量的牛奶。在现在的学习,我们第一次证明奶牛牛奶包含大量 microRNAs ( miRNAs )并且牛奶特定的 miRNAs 的唯一的表示侧面能为未加工的牛奶和牛奶相关的商业产品的质量控制用作新奇指示物和可能的新标准,例如液体牛奶和粉状的公式牛奶。用定序的 Solexa,首先,我们系统地在未加工的牛奶屏蔽了 miRNA 表示并且在未加工的牛奶识别了 245 miRNAs 的一个总数。不同于层次在哺乳的不同时期是其表达式将近相同的另外的经典 biomarkers,单个 miRNAs 能显著地在哺乳过程期间被改变,含有那 miRNAs 可以是更精确的指示物反映牛奶的优秀改变。第二,使用 TaqMan 基于探查的 miRNA 量的 RT-PCR ,我们进一步识别了七 miRNAs 重要地在整个哺乳过程,和更多有相对一致的表情,这七牛奶特定的 miRNAs 的表示侧面能为区别用作理想的 biomarker 差质量或从纯未加工的牛奶的 鈥渕a nipulated 鈥?牛奶,象为商业乳制品的质量控制一样,例如液体,牛奶和粉状的公式挤。一起,我们的调查结果为为决定未加工的牛奶或牛奶相关的商业产品的质量理解牛奶 miRNAs 和一个新潜在的标准的生理的角色提供一个基础。 | Xi Chen Chao Gao Haijin Li Lei Huang Qi Sun Yanye Dong Chunliang Tian Shengpu Gao Hailin Dong Danping Guan Xiaoyun Hu Shujian Zhao Liang Li Lin Zhu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Cell Research2010，20，10： | 29 |
| 7 | Advances in theory and applications of fuzzy clustering显示文摘The summarization and evaluation of the advances in fuzzy clustering theory are made in the aspects including the criterion functions, algorithm implementations, validity measurements and applications. Several important directions for a further study and the application prospects are also pointed out. | GAO Xinbo & XIE Weixin1. Institute of Electronic Engineering, Xidian University, Xi’an 710071, China 2. President office, Shenzhen University, Shenzhen 518060, China. | 2000 | Chinese Science Bulletin2000，45，11： | 25 |
| 8 | Northernmost paleo-tethyan oceanic basin in Tibet:Geo-chronological evidence from ^(40)Ar/^(39)Ar age dating of Dur'ngoi ophiolite显示文摘Whole rock 40Ar/39Ar age dating has been conducted on a basalt sample from Dur’ngoi ophiolite, Qinghai Province, which was reported to be the northernmost pa-leo-tethyan oceanic basin in Tibet. A high temperature pla-teau age (345.3±7.9 Ma) with an isochorn age (336.6±7.1 Ma) has been obtained, representing the eruption time of oceanic crust Considering related geological settings, the new age provides constraints on the northernmost pa-leo-tethyan suture zone in Tibet and the tectonic evolution of Paleo-tethys in Northeast Tibet and adjacent areas. | CHEN Liang, SUN Yong, PEI Xianzhi, GAO Ming, FENG Tao, ZHANG Zhongqing & CHEN Wen1. Laboratory of Continental Dynamics, Northwest University, Xi’an 710069, China 2. Department of Geology, Northwest University, Xi’an, 710069, China 3. Institute of Geology, Chinese Academy of Geological Sciences, Beijing, 100037, China | 2001 | Chinese Science Bulletin2001，46，14： | 24 |
| 9 | Geochemistry and U-Pb zircon geochronology of Late-Mesozoic lavas from Xishan,Beijing显示文摘Zircon U-Pb dating by both SHRIMP and LA-ICP-MS and geochemical study of the Tiaojishan Formation and the Donglintai Formation from Xishan, Beijing, reveal that ages of upper lavas of Tiaojishan Formation and Middle of Donglintai Formation are 137.1±4.5 Ma(2σ ) and 130-134 Ma, respectively. The fomer is slightly older than the latter and the age difference between these two formations is less than 5 Ma. These lines of evidence prove that the two volcanoes erupted within a short time. The age of the Tiaojishan Formation from Xishan, Beijing is distinctively different from that of the Chende Basin. This indicated that the ages of Tiaojishan lavas varied in different regions. The Tiaojishan Formation consists of typical adakite (SiO2=56%, Na2O = 3.99-6.17, Na2O/K2O = 2.2-3.1, Sr = 680-1074×10?6, Y = 13.2-16.3×10?6, Yb = 1.13-1.52×10?6, Sr/Y = 43-66), high-Mg adakite and high-Mg andesite (Mg# = 54-55). Features of continental crust of adakite from the Tiao-jishan Formation and its syngeneric middle silicic vocanic rocks, such as typical Nd-Ta negative ab-normality and Pb possive abnormality, indicate that these lavas are originated from partial melts of continental crust. These results suggest that the adakite from the Tiaojishan Formation of Xishan, Beijing derived from thickened eclogitic lower crust and lithosphere beneath the North China craton at mesozoic that was foundered into the aesthenosphere, and subsequenctly partially melted and in-teracted with mantle olivine during melts upward migration. The age of lavas from the Tiaojishan Formation restrained the foundation which should last at least until 137 Ma. Lavas of the Donglintai Formation are rhyolith and andesite with normal Mg# and thus they did not interact with the mantle. These lavas represent remobilized melts of lower crust material caused by mantle aesthenosphere upwelling migration induced by foundation. | YUAN Honglin1, LIU Xiaoming1, LIU Yongsheng2, GAO Shan1,2 & LING Wenli2 1. Key Laboratory of Continental Dynamics, Northwest University, Xi’an 710069, China 2. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China | 2006 | Science China Earth Sciences2006，49，1： | 22 |
| 10 | The distribution rule and seepage effect of the fractures in the ultra-low permeability sandstone reservoir in east Gansu Province,Ordos Basin显示文摘To study the impact of the fractures on development in the ultra-low permeability sandstone reservoir of the Yangchang Formation of the Upper Triassic in the Ordos Basin,data on outcrops,cores,slices,well logging and experiments are utilized to analyze the cause of the formation of the fractures,their distribution rules and the control factors and discuss the seepage flow effect of the fractures. In the studied area developed chiefly high-angle tectonic fractures and horizontal bedding fractures,inter-granular fractures and grain boundary fractures as well. Grain boundary fractures and intragranular fractures serve as vital channels linking intragranular pores and intergranular solution pores in the reservoir matrix,thus providing a good connectivity between the pores in the ultra-low perme-ability sandstone reservoir. The formation of fractures and their distribution are influenced by such external and internal factors as the palaeo-tectonic stress field,the reservoir lithological character,the thickness of the rock layer and the anisotropy of a layer. The present-day stress field influences the preservative state of fractures and their seepage flow effect. Under the tec-tonic effect of both the Yanshan and Himalayan periods,in this region four sets of fractures are distributed,respectively assuming the NE-SW,NW-SE,nearly E-W and nearly S-N orientations,but,due to the effect of the rock anisotropy of the rock formation,in some part of it two groups of nearly orthogonal fractures are chiefly distributed. Under the effect of the present-day stress field,the fractures that assume the NE-SW direction have a good connectivity,big apertures,a high permeability and a minimum starting pressure,all of which are main advantages of the seepage fractures in this region. With the development of oilfields,the permeability of the fractures of dif-ferent directions will have a dynamic change. | ZENG LianBo1,GAO ChunYu2,QI JiaFu1,WANG YongKang2,LI Liang2 & QU XueFeng2 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Changqing Oilfield Branch,PetroChina,Xi’an 163517,China | 2008 | Science China Earth Sciences2008，51，S2： | 22 |
| 11 | Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site显示文摘Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients. | Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 22 |
| 12 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 13 | Geochemistry of the high-Mg andesites at Zhangwu, western Liaoning: Implication for delamination of newly formed lower crust显示文摘Ten volcanic samples at Zhangwu,western Liaoning Province,North China were selected for a sys-tematic geochemical,mineralogical and geochronological study,which provides an opportunity to ex-plore the interaction between the continental crust and mantle beneath the north margin of the North China craton.Except one basalt sample(SiO2= 50.23%),the other nine samples are andesitic with SiO2 contents ranging from 53% to 59%.They have relatively high MgO(3.4%―6.1%,Mg#=50―64) and Ni and Cr contents(Ni 27×10?6―197×10?6,Cr 51×10?6―478×10?6).Other geochemical characteristics of Zhangwu high-Mg andesites(HMAs) include strong fractionation of light rare earth elements(LREE) from heavy rare earth elements(HREE),and Sr from Y,with La/Yb greater than 15,and high Sr/Y(34― 115).Zircons of andesite YX270 yield three age groups with no Precambrian age,which precludes ori-gin of the Zhangwu HMAs from the partial melting of the Precambrian crust.The oldest age group peaking at 253 Ma is interpreted to represent the collision of the Siberia block and the North China block,resulting in formation of the Central Asian orogenic belt by closure of the Mongol-Okhotsk Ocean.The intermediate age group corresponds to the basalt underplating which caused the wide-spread coeval granitoids in the North China craton with a peak 206Pb/238U age of 172 Ma.The youngest age group gives a 206Pb/238U age of 126±2 Ma,which is interpreted as the eruption age of the Zhangwu HMAs.The high 87Sr/86Sri(126 Ma)>0.706 and low εNd(t)= ?6.36―?13.99 of the Zhangwu HMAs are distinct from slab melts.The common presence of reversely zoned clinopyroxene phenocrysts in the Zhangwu HMAs argues against the origin of the Zhangwu HMAs either from melting of the water saturated mantle or melting of the lower crust.In light of the evidence mentioned above,the envisaged scenario for the formation of the Zhangwu HMAs is related to the basaltic underplating at the base of the crust,which led to the thickening of the lower crust and formation of lower crustal eclogite,followed by foundering of the eclogitic lower crust into the asthenosphere.The foundered eclogite then melted and the resul-tant melts interacted with surrounding peridotite during their upward transport,which finally produced the high-Mg andesites.This well explains the high-Mg adakitic characters and absence of ancient in-herited zircon in the Zhangwu lavas. | HUANG Hua1,GAO Shan1,2,HU ZhaoChu1,LIU XiaoMing2 & YUAN HongLing2 1 State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences,Wuhan 430074,China 2 State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi’an 710069,China | 2007 | Science China Earth Sciences2007，50，12： | 20 |
| 14 | Porous Graphene Microflowers for High-Performance Microwave Absorption显示文摘Graphene has shown great potential in microwave absorption(MA) owing to its high surface area, low density,tunable electrical conductivity and good chemical stability.To fully realize graphenes& MA ability, the microstructure of graphene should be carefully addressed. Here we prepared graphene microflowers(Gmfs) with highly porous structure for high-performance MA filler material. The efficient absorption bandwidth(reflection loss B-10 dB) reaches 5.59 GHz and the minimum reflection loss is up to -42.9 dB, showing significant increment compared with stacked graphene. Such performance is higher than most graphene-based materials in the literature. Besides, the low filling content(10 wt%) and low density(40–50 mg cm^(-3))are beneficial for the practical applications. Without compounding with magnetic materials or conductive polymers,Gmfs show outstanding MA performance with the aid of rational microstructure design. Furthermore, Gmfs exhibit advantages in facile processibility and large-scale production compared with other porous graphene materials including aerogels and foams. | Chen Chen Jiabin Xi Erzhen Zhou Li Peng Zichen Chen Chao Gao | 2018 | Nano-Micro Letters2018，10，2： | 20 |
| 15 | Geochemistry of high-Mg andesites from the early Cretaceous Yixian Formation, western Liaoning: Implications for lower crustal delamination and Sr/Y variations显示文摘85 volcanic rocks of the Yixian Formation from the Sihetun type section were collected and analyzed for geochemical and isotopic compositions. Major element compositions indicate that the Sihetun volcanic rocks are high magnesium andesites with some basalts occurring at the bottom of section. The Sihetun high magnesium andesites (SiO2 = 52.82―59.31wt%, Al2O3 = 14.15―16.35wt%) show many characteristics of adakites such as depletion in heavy rare-earth elements (HREE; Yb = 1.03―1.88 μg/g) and Y(12―20 μg/g) and high Sr (620―1323 μg/g) and Sr/Y(32―88), with high LaN/YbN ratio (10―25). They share similar major and trace element characteristics to volcanic rocks from the Xinglonggou Formation except their lower Nd isotope ratios (143Nd/144Nd (130Ma) = 0.5118―0.5119, ε Nd (130Ma) = ?11.6―?13.8, 87Sr/86Sr (130 Ma) = 0.7058―0.7064. They were in- terpreted in a way that eclogite that formed at the base of thickened Archean lower crust of the North China craton foundered into the convecting mantle and subsequently melted and interacted with peridotite. However, compared to the Xinglonggou volcanic rocks, the source of the Sihetun magma contained more ancient continental crustal material in order to explain its evolved Nd isotopes. The age of the Sihetun Formation was 120 to 130 Ma, and this indicates that delamination lasted to the early Cretaceous period. The Sr contents and Sr/Y ratios of the Sihetun high-Mg andesites show sig- nificant negative correlations with SiO2 for samples with SiO2 > 56%. These suggest that the Sr and Sr/Y values were reduced due to fractional crystallization of plagioclase. Accordingly, the effect of crystallization on volcanic Sr and Sr/Y ratio has to be taken into account. | WANG Xiaorui1, GAO Shan1,2, LIU Xiaoming1, YUAN Honglin1, HU Zhaochu1, ZHANG Hong1,3 & WANG Xuance4 1. State Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi`an 710069, China 2. State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China 3. Shenyang Institute of Geology and Mineral Resources, Shenyang 110032, China 4. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 2006 | Science China Earth Sciences2006，49，9： | 19 |
| 16 | Opening of an early Paleozoic limited oceanic basin in the northern Altyn area: Constraints from plagiogranites in the Hongliugou-Lapeiquan ophiolitic mélange显示文摘This paper reports petrological and geochemical features and zircon U-Pb age of plagiogranite from the Hongliugou-Lapeiquan ophiolitic mélange belt in the northern Altyn Tagh. The zircon U-Pb dating results yield a mean 238U/206Pb age of 512.1 - 1.5 Ma, representing an emplacement time of the plagiogranites in the Middle Cambrian. The plagiogranites are interpreted to have derived from anatexis of hydrated amphibolites by ductile shearing during transports of the oceanic crust. Thus it is believed that the formation age of such type of plagiogranite was coeval to or slightly younger than the spreading of the Hongliugou-Lapeiquan limited oceanic basin. The new results from the plagiogranites suggest that an oceanic basin existed in the northern Altyn area during the Middle Cambrian. | GAO XiaoFeng XIAO PeiXi GUO Lei DONG ZengChan XI RenGang | 2011 | Science China Earth Sciences2011，54，12： | 18 |
| 17 | THE INFLUENCE OF CAVITY DAMAGE ON MECHANICAL PROPERTIES OF SUPERPLASTICALLY-DEFORMED MATERIALS AND ITS PREDICTION显示文摘Aluminium alloy LY12CZ sheet without any pre-treatment has been used to study the influence of cavity damage on the mechanical properties of the superplastically-deformed materials room temper- ature. The experimental results show that: (1) the lower the rate of cavitation as the superplastic strain increases, the higher the superplasticity is; (2) the mechanical properties of superplastically- deformed materials at room temperature decrease as the superplastically-deformed strain increases, especially, a noteworthy decrease in elasticity modulus, yield strenth and ultimate strength at room temperature begins to appear as the level of cavitation by area comes up to about 4%, while at the same level the reduction in area drops down a very large quantity. Then, a three-layer back- propagation neural network has been developed to predict the machanichl properties of the superplasti- cally-deformed material.The results acquired from the neural network are very | M. B. Liu, Z. C. Zhao,H. Gao,M. Q. Li and S. C. Wu College of Materials Science and Engineering, Northwestern Polytechnical University, Xi’an 710072, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 18 |
| 18 | Pharmacokinetics of traditional Chinese syndrome and recipe:a hypothesis and its verification(Ⅰ)显示文摘AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe(TCR)-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics(PK)of samedose of drug was studied in the animal model oftraditional Chinese syndrome(S)and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK(S-PK)and traditionalChinese recipe PK(R-PK).Firstly,the observedtetramethylpyrazine(TMP)PK in healthy,chronically reserpinized rats(rat model ofspleen deficiency syndrome,RMSDS)andRMSDS treated with Sijunzi decoction(SJZD)forconfirmation were used to verify S-PK; secondly,the ferulic acid(FA)PK in healthy andhigh molecular weight dextran(HMWD)-inducedrabbit model with blood stasis syndrome(RDBSS)was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii(LW),LW and Salvia miltiorrhiza(LW&SM)decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,(13.61±2.56)h-1,area under the blooddrug concentration-time curve[AUC,(24.88±9.76)μg.h-1mL-1],maximum drug concentration[Cmax,(4.82±1.23)μg·mL-1]of serum TMP inRMSDS were increased markedly(P<0.05)compared with those[Ka=(5.41±1.91)h-1,AUC=(5.20±2.57)μg·h-1·mL-1,Cmax=(2.33±1.77)μg·mL-1]of healthy rats(HR).Theapparent first-order rate constant for α and βdistribution phase[α=(0.38±0.09)h-1,β=(0.06±0.03)h-1,the apparent first-orderintercompartmental transfer rate constants[K10=(0.24±0.07)h-1,K12=(0.11±0.02)h-1,K21=(0.11±0.02)h-1]of serum TMP in RMSDS weredecreased significantly(P<0.01)comparedwith those[K10=(0.88±0.20)h-1,K12=(1.45±0.47)h-1,K21=(0.72±0.22)h-1]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[(5.6690±2.3541)μg·h-1·mL-1] in RMBSS were also higherthan those[AUC=(2.7566±0.8232)μg·h-1·mL-1]of healthy rabbits(P<0.05).The Ka(11.51±2.82)h-1,AUC(0.84±0.17)μg·h-1·mL-1of LW & SM-derived TMP in serum weremuch lower(P<0.05)than those[Ka=(19.58±4.14)h-1,AUC=(1.27±0.26)μg·h-1·mL-1]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis. | Xi Huang Ping Ren Ai Dong Wen Li Li Wang Li Zhang Feng Gao Laboratory of Clinical Pharmacology of Chinese Medicine,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Pharmacy,Xijing Hospital,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China Department of Physiology,The Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 16 |
| 19 | Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume显示文摘AIM: Our research attempted to evaluate the overall functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and ChildPugh′s classification, and to discuss its value of clinical application.METHODS: Ninety two patients with portal hypertension due to hepatic cirrhosis were investigated. All had a historyof haematemesis and hematochezia, esophageal and gastric fundus varices, splenomegaly and hypersplenia.A 2-year follow-up was routinely performed and no one was lost. Twenty two healthy volunteers were used as control group. Blood and urine samples were collected 4times before and after intravenous D-sorbitol infusion.The hepatic clearance (CLH) of D-sorbitol was then calculated according to enzymatic spectrophotometric method while the total blood flow (QToTAL) and intrahepatic shunt (RINs) were detected by multicolor Doppler ultrasound, and the liver volume was measured by spiral CT. Data were estimated by t-test, variance calculation and chi-squared test. The relationships between all these parameters and different groups were investigated according to Child-Pugh classification and postoperative complications respectively.RESULTS: Steady blood concentration was achieved 120 mins after D-sorbitol intravenous infusion, which was (0.358±0.064) mmoⅠ@L-1 in cirrhotic group and (0.189±0.05)mmol@L-1 in control group (P<0.01). CLH=(812.7±112.4) ml@min-1,QTOTAL=(1280.6±131.4) ml@min-1, and RINS=(36.54±10.65)%in cirrhotic group and CLH=(1248.3±210.5) ml.min-1, QTOTAL=(1362.4-±126.9) ml@min-1, and RINS=(8.37±3.32) % in control group (P<0.01). The liver volume of cirrhotic group was 1057±249 cm3, 851±148 cm3 and 663±77 cm3 in Child A, B and C group respectively with significant difference (P<0.001).The average volume of cirrhotic liver in Child B, C group was significantly reduced in comparison with that in control group (P<0.001). The patient, whose liver volume decreased by 40 % with the CLH below 600 ml@min-1, would have a higher incidence of postoperative complications. There was no strict correspondent relationship between CLH, liver volume and Child-Pugh′s classification.CONCLUSION: The hepatic clearance of D-sorbitol, CT measured liver volume can be reliably used for the evaluation of hepatic functional blood flow and liver metabolic volume. Combined with the Child-Pugh′s classification, it could be very useful for further understanding the liver functional reserve, therefore help determine reasonable therapeutic plan, choose surgical procedures and operating time. | Yi-Ming Li Fan Lv Xin Xu Hong Ji Wen-Tao Gao Tuan-Jie Lei Gui-Bing Ren Zhi-Lan Bai Qiang Li General Surgery Department,the 2~(nd)Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,ShaanXi Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 16 |
| 20 | Supramolecular complex formation of β-cyclodextrin polymer with substituted salicylic acid or 3-hydroxy-2-naphthoic acid and their electrorheological behaviors显示文摘According to the chemical design, electrorheological properties of supramolecular complex from b-cyclodextrin polymer (b -CDP) were discussed. Six supramolecular complexes of -cyclodextrin polymer with substituted salicylic acid and 3-hydroxy-2-naphthoic acid were syn-thesized by the solid-phase self-assembly method, and their component and structure were characterized by NMR, FT-IR, UV-vis and the fluorescence analysis. Then the electrorheological properties of their suspensions in silicone oil were investigated under DC electric fields. It was found that the yield stresses of these supramolecular complex ER fluids were 7.3—9.8 kPa at 4 kV/mm in DC electric field, which were enhanced by 34%—72% compared with that of pure b-CDP. Among them, that of b-CDP/3-hydroxy-2-naphthoic acid ER fluid was the highest. It was also found that the ER effect of supramolecular complexes can be controlled by changing dif-ferent guests. When the substituted group is at phenyl ring, ER behavior can be slightly adjusted by the different substituted groups, their number as well as their position at phenyl ring. This can be proved by the measurement of dielectric properties. | GAO Ziwei1,2, ZHAO Xiaopeng1, SUN Ping2 & SI Gang2 1. Institute of Electrorheological Technology141#, Department of Applied Physics, Northwestern Polytechnical University, Xian 710072, China 2. Department of Chemistry, School of Chemistry and Material Science, Shaanxi Normal University, Xi’an 710062, China | 2004 | Science China Chemistry2004，47，4： | 15 |
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