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| 1 | Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell显示文摘Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration(IVDD).However,the increased levels of reactive oxygen species(ROS)in the degenerated region will impede the efficiency of human adipose-derived stem cells(human ADSCs)transplantation therapy.It inhibits human ADSCs proliferation,and increases human ADSCs apoptosis.Herein,we firstly devised a novel amphiphilic copolymer PEG-PAPO,which could self-assemble into a nanosized micelle and load lipophilic kartogenin(KGN),as a single complex(PAKM).It was an injectable esterase-responsive micelle,and showed controlled release ability of KGN and apocynin(APO).Oxidative stimulation promoted the esterase activity in human ADSCs,which accelerate degradation of esterase-responsive micelle.Compared its monomer,the PAKM micelle possessed better bioactivities,which were attributed to their synergistic effect.It enhanced the viability,autophagic activation(P62,LC3 II),ECM-related transcription factor(SOX9),and ECM(Collagen II,Aggrecan)maintenance in human ADSCs.Furthermore,it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in rats.Therefore,PAKM micelles perform promoting cell survival and differentiation effects,and may be a potential therapeutic agent for IVDD. | Chao Yu Dongdong Li Chenggui Wang Kaishun Xia Jingkai Wang Xiaopeng Zhou Liwei Ying Jiawei Shu Xianpeng Huang Haibin Xu Bin Han Qixin Chen Fangcai Li Jianbin Tang Chengzhen Liang Nigel Slater | 2021 | Bioactive Materials2021，6，10： | 3 |
| 2 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 3 | High entropy ultra-high temperature ceramic thermal insulator(Zr_(1/5)Hf_(1/5)Nb_(1/5)Ta_(1/5)Ti_(1/5))C with controlled microstructure and outstanding properties显示文摘Due to advancements of hypersonic vehicles,ultra-high temperature thermal insulation materials are urgently requested to shield harsh environment with superhigh heat flux.Toward this target,ultra-high temperature ceramics(UHTCs)are the only choice due to their excellent capability at ultra-high temperatures.We herein report a novel highly porous high entropy(Zr_(1/5)Hf_(1/5)Nb_(1/5)Ta_(1/5)Ti_(1/5))C fabricated by foam-gelcasting-freeze drying technology combined with in-situ pressureless reaction sintering.The porous(Zr_(1/5)Hf_(1/5)Nb_(1/5)Ta_(1/5)Ti_(1/5))C exhibited ultra-high porosity of 86.4%-95.9%,as well as high strength and low thermal conductivity of 0.70–11.77 MPa and 0.164–0.239 W/(m·K),respectively.Specifically,Si C sintering additive only locates at the pit of the surface of sintering neck between UHTC grains,and there is no secondary phase or intergranular film at the grain boundary.Besides,the oxidation resistance of high entropy carbide powders is greatly improved compared with that of the mixed five carbide powders.This work clearly highlights the merits of highly porous high entropy(Zr_(1/5)Hf_(1/5)Nb_(1/5)Ta_(1/5)Ti_(1/5))C as an ultra-high temperature thermal insulation material. | Zhuojie Shao Zhen Wu Luchao Sun Xianpeng Liang Zhaoping Luo Haikun Chen Junning Li Jingyang Wang | 2022 | Journal of Materials Science & Technology2022，，24： | 1 |
| 4 | A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair显示文摘The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair SCI.However,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue interface.In the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and PPy.The gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels injectable.In vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of astrocytes.The in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity areas.In vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional recovery.RNA sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling cascades.Overall,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord. | Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke Wang Jiawei Shu Xianpeng Huang Jingkai Wang Kaishun Xia Liwei Ying Kesi Shi Chenggui Wang Xuhua Wang Fangcai Li Qian Zhao Qixin Chen | 2022 | Bioactive Materials2022，7，9： | 0 |
| 5 | A multiple coupling approach to produce high-performance SERS substrates显示文摘Creating hotspots with significantly enhanced electromagnetic(EF) field, efficiently placing target molecules in hotspot region, and achieving uniform and reproducible Raman signals are three critical issues for developing high-performance SERS substrates. In this work, large area gold nanoparticle cluster pillar array with a gold mirror at bottom was facilely fabricated by combined use of nanosphere lithography and self-assembly approach. It is both theoretically and experimentally found that through multiple coupling interactions, the electromagnetic fields at interparticle gaps within the gold clusters were significantly enhanced in our three-dimentional(3D) pillar array substrates, which can result in one order of magnitude stronger as compared with random gold clusters on a two-dimentional planar case.Due to the periodic stucture, our substrates also possess the capbility of producing highly uniform and reproducible SERS signals. Attractively, in our case, a photoresponsive polymer was used for the formation of pillar array structure. Its unique photoinduced deformation makes it possible to reversibly open and close the gaps of the closely packed Au NP array, thus enabling efficient placement or entrapment of probe molecules into hotspot sites between adjacent nanoparticles. | Xianpeng Yin Hao Dong Shiqiang Wang Yun Liang Ning Gao Wanlin Zhang Li Tian Fuwei Sun Guangtao Li | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 6 | New organic scintillation fiber detector for the measurement of intense pulsed fission neutron显示文摘To measure the pulsed neutron of a pulsed fission source,an organic scintillation fiber(OSF) detector with separation structure has been designed.The proposed detector employs UV optical fibers as the light guide,and the sensitive region of the detector is composed of a linear array of OSFs,which are individually connected to the optical fibers.The other end of the light guide is coupled to a photomultiplier tube.The key properties of the device including the energy response,time response,neutron sen-sitivity,and radiation effect of the optical fiber were studied.The detector has a relatively high n/? sensitivity ratio,which in-creases as the diameter of the OSF decreases,and ratios greater than 10 could be achieved when the diameter of the OSF is less than 0.3 mm.The sensitivity of the detector to neutrons ranges from 10?14 to 10?20 C cm2/n,and has a response time of 3 ns(FWHM).The proposed detector is also highly flexible.For instance,the probe can be set close to the source,while the PMT can be placed far away from radiation,allowing easy shielding.Due to these characteristics,pulsed fission neutrons in the vi-cinity of the source can be accurately measured. | CHEN Liang OUYANG XiaoPing ZHANG ZhongBing LIU JinLiang ZHANG XianPeng | 2012 | Science China(Technological Sciences)2012，55，1： | 0 |
| 7 | Image reconstruction of a neutron scatter camera显示文摘Recently, Sandia Laboratories developed a neutron scatter camera to detect special nuclear materials. This camera exhibits the following advantages: high efficiency, direction discrimination, neutron-gamma discrimination ability, and wide field of view. However, using the direct projection method, the angular resolution of this camera is limited by uncertainties in the energies estimated from pulse height and time of flight measurements. In this study, we established an eight-element neutron scatter camera and conducted the experiment with a ^(252)Cf neutron source. The results show that it has an angular resolution better than 8°(1s) and a detection efficiency of approximately 2.6′10-4. Using maximum likelihood expectation maximization method, the image artifact was eliminated, and the angular resolution was improved. We proposed an average scattering angle method to estimate the scattering energy of neutrons and Compton gamma rays. As such, we can obtain a recognizable image and energy spectrum of the source with some degradation of energy and image resolutions. Finally, a newly measured light response function based on the MPD^(-4) device was used for image reconstruction. Although we did not obtain a better result than that of the standard light response function, we have observed the effects of light response function on image reconstruction. | ZHANG XianPeng ZHANG Mei SHENG Lang ZHANG ZhongBing LI Kui Nian PENG BoDong ZHANG XiaoDong OUYANG XiaoPing LIU Jun LIU JinLiang CHEN Liang ZHU Jie HE ChaHui | 2016 | Science China(Technological Sciences)2016，59，1： | 0 |
| 8 | Bone analysis using an aggregation-induced emission-active iridium complex显示文摘Fluorescent analysis of bone provides valuable insights into bone structures.However,conventional dyes suffer from low specificity on bone tissue,small stokes shift,short fluorescent lifetime,and aggregation-caused quenching effect,which result in low efficacy and artifacts.In this work,we design an aggregation-induced emission(AIE)-active iridium(III)complex(Ir-BP2)as a highly selective,convenient,nondestructiveness,and dual-mode staining agent for bone analysis.Ir-BP2 containing phosphonate groups selectively binds to hydroxyapatites,the main component of bone matrix,and exhibits turn-on AIE phosphorescence with prolonged lifetime.Ir-BP2 exhibits promising biosafety and offers higher accuracy in staining calcium deposits than conventional Alizarin Red S staining assay when it is employed in real-time monitoring of osteogenesis differentiation process.A ready-to-use staining spray of Ir-BP2 is fabricated.By using fluorescent imaging and lifetime imaging,Ir-BP2 staining provides valuable insights into bone microstructure analysis,microdamage diagnosis,and bone growth state identification.Further,Ir-BP2 is successfully applied on a human spine vertebra for diagnosing bone invasiveness of eosinophilic granuloma,validating its clinical practice.This work presents a powerful tool in bone analysis and will lead to new approaches for the diagnosis and treatment of bone-related diseases. | Xianpeng Zhang Xinling Liu Hongwen Yu Shuang Shen Junchao Zhi Zhen GaoJingqi Xin Jiaqi Song Liang Shao Caiting Meng Feifei An Taotao Huo Shichang Liu Ye Zhang Li Xu Guanying Li | 2023 | Aggregate2023，4，6： | 0 |
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