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| 1 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 2 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 3 | A high precision time-to-digital converter based on multi-phase clock implemented within Field-Programmable-Gate-Array显示文摘In this paper, the design of a coarse-fine interpolation Time-to-Digital Converter (TDC) is implemented in an ALTERA’s Cyclone FPGA. The carry-select chain performs as the tapped delay line. The Logic Array Block (LAB) having a propagation delay of 165 ps in the chain is synthesized as delay cell. Coarse counters triggered by the global clock count the more significant bits of the time data. This clock is also fed through the delay line, and LABs create the copies. The replicas are latched by the tested event signal, and the less significant bits are encoded from the latched binary bits. Single-shot resolution of the TDC can be 60 ps. The worst Differential Nonlinearity (DNL) is about 0.2 Least Significant Bit (LSB, 165 ps in this TDC module), and the Integral Nonlinearity (INL) is 0.6 LSB. In comparison with other architectures using the synchronous global clock to sample the taps, this architecture consumed less electric power and logic cells, and is more stable. | CHEN Kai LIU Shubin AN Qi | 2010 | Nuclear Science and Techniques2010，21，2： | 7 |
| 4 | Nanotechnology-based strategies for treatment of ocular disease显示文摘Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional noninvasive and invasive treatments, such as eye drops,injections and implants, the current treatments either suffer from low bioavailability or severe adverse ocular effects. Alternatively, the emerging nanoscience and nanotechnology are playing an important role in the development of novel strategies for ocular disease therapy. Various active molecules have been designed to associate with nanocarriers to overcome ocular barriers and intimately interact with specific ocular tissues. In this review, we highlight the recent attempts of nanotechnology-based systems for imaging and treating ocular diseases, such as corneal d iseases, glaucoma, retina diseases, and choroid diseases. Although additional work remains, the progress described herein may pave the way to new,highly effective and important ocular nanomedicines. | Yuhua Weng Juan Liu Shubin Jin Weisheng Guo Xingjie Liang Zhongbo Hu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 6 |
| 5 | A low dead time vernier delay line TDC implemented in an actel flash-based FPGA显示文摘In this paper,a high precision vernier delay line(VDL) TDC(Time-to-Digital Convertor) in an actel flash-based Field-Programmable-Gate-Arrays A3PE1500 is implemented,achieving a resolution of 16.4-ps root mean square value or 42-ps averaged bin size.The TDC has a dead time of about 200 ns while the dynamic range is 655.36 μs.The double delay lines method is employed to cut the dead time in half to improve its performance.As the bin size of the TDC is dependent on temperature,a compensation algorithm is adopted as temperature drift correction,and the TDC shows satisfying performance in a temperature range from –5℃ to +55℃. | QIN Xi FENG Changqing ZHANG Deliang ZHAO Lei LIU Shubin AN Qi | 2013 | Nuclear Science and Techniques2013，24，4： | 4 |
| 6 | Review of local mean decomposition and its application in fault diagnosis of rotating machinery显示文摘Rotating machinery is widely used in the industry.They are vulnerable to many kinds of damages especially for those working under tough and time-varying operation conditions.Early detection of these damages is important,otherwise,they may lead to large economic loss even a catastrophe.Many signal processing methods have been developed for fault diagnosis of the rotating machinery.Local mean decomposition(LMD)is an adaptive mode decomposition method that can decompose a complicated signal into a series of mono-components,namely product functions(PFs).In recent years,many researchers have adopted LMD in fault detection and diagnosis of rotating machines.We give a comprehensive review of LMD in fault detection and diagnosis of rotating machines.First,the LMD is described.The advantages,disadvantages and some improved LMD methods are presented.Then,a comprehensive review on applications of LMD in fault diagnosis of the rotating machinery is given.The review is divided into four parts:fault diagnosis of gears,fault diagnosis of rotors,fault diagnosis of bearings,and other LMD applications.In each of these four parts,a review is given to applications applying the LMD,improved LMD,and LMD-based combination methods,respectively.We give a summary of this review and some future potential topics at the end. | LI Yongbo SI Shubin LIU Zhiliang LIANG Xihui | 2019 | Journal of Systems Engineering and Electronics2019，30，4： | 4 |
| 7 | A digitalizing board for the prototype array of LHAASO WCDA显示文摘In this paper,a digitalizing board for readout of PMT signals in the prototype array of WCDA(water Cerenkov detector array)for LHAASO(Large high altitude air shower observatory)is designed.The prototype array is composed of 9 PMTs,including the pulse time and charge measurement from the PMTs,and clock generation and trigger decision.In the digitalizing board,FPGA reconfiguration and data readout via VME bus are implemented.Test results show that the performances meet well with the requirements of readout electronics.It has been installed in Yangbajing and tests with the prototype array and DAQ is ongoing. | HAO Xinjun LIU Shubin ZHAO Lei AN Qi | 2011 | Nuclear Science and Techniques2011，22，3： | 4 |
| 8 | A time-over-threshold technique for PMT signals processing显示文摘A novel front-end circuit designed for PMT signals processing considering the solution of 'Time Walk' correction is discussed in this paper. We are trying to apply the TOT (Time over Threshold) technique to our research. Different from traditional ways, where amplitude is measured, time width is measured for slew correction here, which takes the advantage of TDC. Expensive fast ADCs are abandoned and the whole time measurement electronics design becomes more effective and economical. Test boards have been developed and a convenient method is introduced to evaluate our TOT technique. Results have shown that a 10ps slew correction resolution is achieved throughout the amplitude range from -108mV to -2000mV for negative signals of both 5 ns leading and trailing edge with 10 ns 50%-50% pulse width. | LIU Xuzong LIU Shubin AN Qi | 2007 | Nuclear Science and Techniques2007，18，3： | 4 |
| 9 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 10 | Characterizing optical dipole trap via fluorescence of trapped cesium atoms显示文摘Optical dipole trap (ODT) is becoming an important tool of manipulating neu- tral atoms. In this paper ODT is realized with a far-off resonant laser beam strongly fo- cused in the magneto-optical trap (MOT) of cesium atoms. The light shift is measured by simply monitoring the fluorescence of the atoms in the magneto-optical trap and the opti- cal dipole trap simultaneously. The advantages of our experimental scheme are discussed, and the effect of the beam waist and power on the potential of dipole trap as well as heating rate is analyzed. | LIU Tao GENG Tao YAN Shubin LI Gang ZHANG Jing WANG Junmin PENG Kunchi ZHANG Tiancai | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，3： | 4 |
| 11 | A beam position measurement system of fully digital signal processing at SSRF显示文摘This fully digital beam position measurement instrument is designed for beam position monitoring and machine research in Shanghai Synchrotron Radiation Facility. The signals received from four position-sensitive detectors are narrow pulses with a repetition rate up to 499.654 MHz and a pulse width of around 100 ps, and their dynamic range could vary over more than 40 dB in machine research. By the employment of the under-sampling technique based on high-speed high-resolution A/D conversion, all the processing procedure is performed fully by the digital signal processing algorithms integrated in one single Field Programmable Gate Array. This system functions well in the laboratory and commissioning tests, demonstrating a position resolution (at the turn by turn rate of 694 kHz) better than 7 μm over the input amplitude range of -40 dBm to 10 dBm which is well beyond the requirement. | YAN Han ZHAO Lei LIU Shubin CHEN Kat WU Weihao AN Qi LENG Yongbin YI Xing YAN Yingbing LAI Longwei | 2012 | Nuclear Science and Techniques2012，23，2： | 3 |
| 12 | The clock system for LHAASO WCDA based on reduced White Rabbit显示文摘Due to the large scale of Water Cherenkov Detector Array in Large High Altitude Air Shower Observatory, the frontend digitization is imperative.Thus a clock distribution system is desired,which broadcasts the synchronous clock signals with low jitter to the frontend electronics distributed in the field of 90 000 m^2.The White Rabbit protocol provides an option,which has been approved to achieve sub-ns accuracy and ps jitter in the synchronization of around 1 000 nodes in the order of 10 km.But the hierarchy of the original is too complex for Large High Altitude Air Shower Observatory application.Thus we proposed a reduced scheme based on the White Rabbit protocol.The validation circuit shows that the clock skew due to the fiber length difference can be adjusted to less than 25 ps and the clock jitter is less than 62 ps. | LI Cheng LIU Shubin SHANG Linfeng CAO Ping AN Qi | 2012 | Nuclear Science and Techniques2012，23，4： | 3 |
| 13 | Identification of micro RNAs in six solanaceous plants and their potential link with phosphate and mycorrhizal signalings显示文摘To date, only a limited number of solanaceous miRNAs have been deposited in the miRNA database. Here,Rgenome-wide bioinformatic identification of miRNAs was performed in six solanaceous plants(potato, tomato, tobacco,eggplant, pepper, and petunia). A total of 2,239 miRNAs were identified following a range of criteria, of which 982 were from potato, 496 from tomato, 655 from tobacco, 46 from eggplant,45 were from pepper, and 15 from petunia. The sizes of miRNA families and miRNA precursor length differ in all the species.Accordingly, 620 targets were predicted, which could be functionally classified as transcription factors, metabolic enzymes, RNA and protein processing proteins, and other proteins for plant growth and development. We also showed evidence for miRNA clusters and sense and antisense miR NAs.Additionally, five Pi starvation- and one arbuscular mycorrhiza(AM)-related cis-elements were found widely distributed in the putative promoter regions of the miRNA genes. Selected miRNAs were classified into three groups based on the presence or absence of P1BS and MYCScis-elements, and their expression in response to Pi starvation and AM symbiosis was validated by quantitative reverse transcription-polymerase chain reaction(qRT-PCR). These results show that conserved miRNAs exist in solanaceous species and they might play pivotal roles in plant growth, development, and stress responses. | Mian Gu Wei Liu Qi Meng Wenqi Zhang Aiqun Chen Shubin Sun Guohua Xu | 2014 | Journal of Integrative Plant Biology2014，56，12： | 3 |
| 14 | Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis显示文摘天门冬素(Asn/N ) 连接了 glycans 为蛋白质合拢, trafficking,和 endoplasmic 是重要的在优核质的联系蜂窝胃的降级。glycoproteins 的成熟包含在 Golgi 由另外的糖分子的 mannosidases 和三分支的 N-glycans 的增加整修 mannosyl 残余。然而,调停 Golgi 的甘露糖整修的生物重要性充分没被理解。这里,我们显示出二机能上地冗余的 mannosidases, MNS1 和 MNS2 的那废除,为在 A 和工厂 N-glycans 的 C 分支上整修的 -1,2-mannose 负责在 Arabidopsis 在盐压力条件下面导致严重的根生长抑制。相反,有在 oligosaccharide 先锋的生合成的缺点的异种当甘露糖整修不在时显示了提高的盐忍耐。然而,在 EBS3 的变化,为分叉的 N-glycan 先锋的形成被要求,压制了 mns1 mns2 的盐敏感的显型两倍异种。有趣地,我们观察了那 ? 纤维素生合成在高咸度下面在 mns1 mns2 根被损害。一致地, ? 许多膜抛锚了 endo -- 在纤维素生合成起一个关键作用的 1,4-endoglucanase (RSW2/KOR ) 和它的变异的变体 rsw2-1 ? 被调制由 ? 在盐应力下面整修的 -1,2-mannose。RSW2 的 Overexpression 能部分救 mns1 mns2 的盐敏感的显型。一起拿,这些结果建议 N-glycans 整修的那 MNS1/2-mediated 甘露糖在 modulating glycoprotein 丰富是关键的在植物承受盐应力。 | Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu Yonghua Yang Jianming Li Zhi Hong | 2018 | Molecular Plant2018，11，5： | 3 |
| 15 | Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response显示文摘The breakthrough development of induced pluripotent stem cells(iPSCs)raises the prospect of patient-specific treatment for many diseases through the replacement of affected cells.However,whether iPSC-derived functional cell lineages generate a deleterious immune response upon auto-transplantation remains unclear.In this study,we differentiated five human iPSC lines from skin fibroblasts and urine cells into neural progenitor cells(NPCs)and analyzed their immunogenicity.Through co-culture with autogenous peripheral blood mononuclear cells(PBMCs),we showed that both somatic cells and iPSC-derived NPCs do not stimulate significant autogenous PBMC proliferation.However,a significant immune reaction was detected when these cells were co-cultured with allogenous PBMCs.Furthermore,no significant expression of perforin or granzyme B was detected following stimulation of autogenous immune effector cells(CD3+CD8 T cells,CD3+CD8+T cells or CD3 CD56+NK cells)by NPCs in both PBMC and T cell co-culture systems.These results suggest that human iPSC-derived NPCs may not initiate an immune response in autogenous transplants,and thus set a base for further preclinical evaluation of human iPSCs. | HUANG Ke LIU PengFei LI Xiang CHEN ShuBin WANG LiHui QIN Li SU ZhengHui HUANG WenHao LIU JuLi JIA Bei LIU Jie CAI JingLei PEI DuanQing PAN GuangJin | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 16 | A new TOF system for target recoil-ion momentum spectroscopy at IMP显示文摘A high resolution time measurement system with high data transfer rate was designed for the COLTRIMS (Cold Target Recoil-Ion Momentum Spectroscopy) system in Institute of Modern Physics,Chinese Academy of Sciences.It is used to measure the Time of Flight(TOF) with a high resolution for all 20 channels.Based on the PCI Extensions for Instrumentation(PXI) standard,the readout electronics system consists of one Clock-Trigger fan-out module and four TOF modules.Test results show that the system meets the demands of COLTRIMS,with a time resolution of better than 25 ps and a data transfer rate over 20 MB/s. | ZHOU Jiawen LIU Shubin YIN Chunyan AN Qi ZHAO Lei | 2011 | Nuclear Science and Techniques2011，22，6： | 2 |
| 17 | Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing mortality.Currently,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed. | Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang | 2017 | Science China(Life Sciences)2017，60，9： | 2 |
| 18 | Boron-doping induced lithophilic transition of graphene for dendrite-free lithium growth显示文摘Li metal,possessing advantages of high theoretical specific capacity and low electrochemical potential,is regarded as the most promising anode material for next-generation batteries.However,despite decades of intensive research,its practical application is still hindered by safety hazard and low Coulombic efficiency,which is primarily caused by dendritic Li deposition.To address this issue,restraining dendrite growth at the nucleation stage is deemed as the most effective method.By utilizing the difference of electronegativity between boron atoms and carbon atoms,carbon atoms around boron atoms in boron-doped graphene(BG)turn into lithiophilic sites,which can enhance the adsorption capacity to Li^(+)at the nucleation stage.Consequently,an ultralow overpotential of 10 mV at a current density of 0.5 mA/cm^(2) and a high average Coulombic efficiency of 98.54%over more than 140 cycles with an areal capacity of 2 mAh/cm^(2) at a current density of 1 m A/cm^(2) were achieved.BG-Li|LiFePO_(4) full cells delivered a long lifespan of480 cycles at 0.5 C and excellent rate capability.This work provides a novel method for rational design of dendrite-free Li metal batteries by regulating nucleation process. | Wei Liu Pengbo Zhai Shengjian Qin Jing Xiao Yi Wei Weiwei Yang Shiqiang Cui Qian Chen Chunqiao Jin Shubin Yang Yongji Gong | 2021 | Journal of Energy Chemistry2021，30，5： | 2 |
| 19 | Clinical characteristics and prognosis of triple-negative breast cancer显示文摘客观我们调查了临床的特征,和三元组否定的乳癌的预示的因素。130 个三元组否定的乳癌病人在临床的特征和预后上被考察的方法。所有情况是免疫组织化学决定的雌激素受体,孕酮受体,和 HER2/neu 的表示的缺乏。结果 17.1% 所有乳癌病人(774 个案例) 是三元组否定的乳癌,并且 68.9% 三元组否定的乳癌病人(91 个案例) 是绝经前的。53.8% 病人(71 个案例) 与 T2 尺寸有肿瘤,并且(52 个病人) 他们中的 39.4% 个有淋巴节点转移。没有淋巴节点转移,在有淋巴节点转移的病人的恶化的率在病人显然比那高(P = 0.001 ) 。后续的中部的时间是 63 个月。33 案例 relapsed 和 20 个病人死了。23 个病人有至少二机关转移。5 年的没有疾病、全面的幸存率是 73.8% 和 85.7% 。结论三元组否定的乳癌病人通常在治疗以后在 2 3 年里有多重远转移的高率。淋巴节点的地位是最重要的预示的因素。有淋巴节点转移的三元组否定的胸 caner 病人有差的预后。 | Hua Cao Maosheng Yan Shubin Wang Tao Zheng Ruilian Xu Yixin Chen Yajie Liu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 2 |
| 20 | Chemical Concepts from Density Functional Theory显示文摘Chemical concepts such as structure,bonding,reactivity,etc.have been widely used in the literature and text books to appreciate molecular properties and chemical transformations.Even though modern theoretical and computational chemistry is well established from the perspective of accuracy and complexity,how to quantify these concepts is a still unresolved task.Conceptual density functional theory and its related recent developments provide unique opportunities to tackle this problem.In this Special Issue,27 contributions from top investigators over the world are collected to highlight the state-of-art research on this topic,which not only showcases the status of where we are now but also unveils a number to possible future directions to be pursued. | LIU Shubin ZHANG Xiaojuan | 2018 | 物理化学学报2018，34，6： | 2 |
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