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| 1 | Simultaneous in-situ determination of U-Pb age and trace elements in zircon by LA-ICP-MS in 20 μm spot size显示文摘Simultaneous in-situ determination of U-Pb ages and 20 trace elements of three international zircon standards(91500,GJ1 and TEMORA 1) and one laboratory zircon standard(SK10-2) separated from Cenozoic fine-grained gabbro was carried out on quadrupole ICP-MS equipped with 193 nm excimer laser in 20 μm spot size. The weighted mean 206Pb/238U ages of 91500,GJ1 and TEMORA 1 are 1064.4±4.8 Ma(2σ ),603.2±2.4 Ma(2σ ) and 418.2±2.4 Ma(2σ ),respectively. The relative standard de-viations(RSDs) of 206Pb/238U ages(2σ ) are less than 2.2% for single measurements and 0.6% for weighted means. The obtained weighted mean 206Pb/238U ages of three standard zircons agree with the recommended values within 2σ error. The weighted mean 206Pb/238U age of SK10-2 is 31.42±0.25 Ma(2σ ) and the RSDs of 206Pb/238U ages(2σ ) are between 2.4% and 5.7% for single measurements and less than 0.8% for weighted mean. The obtained weighted mean 206Pb/238U age is in good agreement with the age obtained by Yuan(2004). Trace element concentrations of NIST612 and NIST614 obtained under the same LA-ICP-MS operating conditions agree with the recommended values within analytical error. The results indicate that it is possible to measure U-Pb age and trace elements simultaneously by LA-ICP-MS in a small spot size of 20 μm. | LIU XiaoMing GAO Shan DIWU ChunRong YUAN HongLin HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，9： | 107 |
| 2 | Nano-Graphene Oxide for Cellular Imaging and Drug Delivery显示文摘Two-dimensional graphene offers interesting electronic,thermal,and mechanical properties that are currently being explored for advanced electronics,membranes,and composites.Here we synthesize and explore the biological applications of nano-graphene oxide(NGO),i.e.,single-layer graphene oxide sheets down to a few nanometers in lateral width.We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments.We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration.The NGO sheets are found to be photoluminescent in the visible and infrared regions.The intrinsic photoluminescence(PL)of NGO is used for live cell imaging in the near-infrared(NIR)with little background.We found that simple physisorption viaπ-stacking can be used for loading doxorubicin,a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro.Owing to its small size,intrinsic optical properties,large specifi c surface area,low cost,and useful non-covalent interactions with aromatic drug molecules,NGO is a promising new material for biological and medical applications. | Xiaoming Sun Zhuang Liu Kevin Welsher Joshua Tucker Robinson Andrew Goodwin Sasa Zaric Hongjie Dai | 2008 | Nano Research2008，1，3： | 118 |
| 3 | Determination of U-Pb age and rare earth element concentrations of zircons from Cenozoic intrusions in northeastern China by laser ablation ICP-MS显示文摘Using the in situ zircon U-Pb dating method of LA-ICPMS, we analyzed the 31 Ma old SHRIMP U-Pb age of the Yongsheng nepheline syenite from southern Jilin Province under different spot sizes. The obtained ages are comparable with that of SHRIMP in both accuracy and precision. The age is also identical to that of the Yinmawanshan gabbro from the Liaodong Peninsula within error. Both the Yongsheng nepheline syenite and the Yinmawanshan gabbro represent the youngest known exposed intrusions in northeastern and even eastern China. The results indicate the Eocene mantle-derived magmatic underplating, and the rapid crustal uplifting of this region since 30 Ma. The analyses also document extremely high LREE concentrations and relatively flat REE patterns for the zircons from the Yongsheng nepheline syenite, which represent a new type of zircon REE pattern. | YUAN Honglin WU Fuyuan GAO Shan LIU Xiaoming XU Ping SUN Deyou | 2003 | Chinese Science Bulletin2003，48，22： | 252 |
| 4 | Hf isotopes of the 3.8 Ga zircons in eastern Hebei Province, China: Implications for early crustal evolution of the North China Craton显示文摘Zircon U-Pb dating indicates that the fuchsite quartzite in eastern Hebei Province was derived from weathering and erosion of the 3.6-3.8 Ga granitic rocks. In-situ zircon Hf analyses show that the Lu-Hf isotopic system remained closed during later thermal disturbances. Zircons with concordant ages have Hf isotopic model ages of about 3.8 Ga, suggesting a recycling of this ancient crust. The ~3.8 Ga zircons have similar Hf isotopic compositions to those of chondrite, indicating that their source rocks (granitic rocks) were derived from partial melting of the juvenile crust which originated from a mantle without significant crust-mantle differentiation. Therefore, it is proposed that there was no large-scale crustal growth before ~3.8 Ga in eastern Hebei Province. Considering zircon Hf isotopic data from other areas, it is concluded that the most ancient crust in the North China Craton probably formed at about 4.0 Ga, and the possibility to find crust older than 4.0 Ga is very limited. | WU Fuyuan YANG Jinhui LIU Xiaoming LI Tiesheng XIE Liewen YANG Yueheng | 2005 | Chinese Science Bulletin2005，50，21： | 51 |
| 5 | Mesozoic Bimodal Volcanic Suite in Zhalantun of the Da Hinggan Range and Its Geological Significance: Zircon U-Pb Age and Hf Isotopic Constraints显示文摘Mesozoic bimodal volcanic rocks of basaltic andesite and rhyolite are widely distributed in the Da Hinggan Range, but their petrogenetic relationships and geodynamic implications are rarely constrained. Detailed studies on doleritic and porphyry dikes in the Zhalantun area indicate that they display features of magma mixing, suggesting their coeval formation. In situ zircon U-Pb dating shows that the porphyry was emplaced in the Early Cretaceous with a 206Pb/238U age of 130±1 Ma. Zircons from the dolerite also yield an Early Cretaceous emplacement age of 124±2 Ma although some inherited zircons have been identified. These age results indicate that the Early Cretaceous was an important period of magmatism in the Da Hinggan Range. Zircons from porphyry are characterized by positive value of εHf(t) as high as 10.3±0.5 with Hf depleted mantle model age of 349–568 Ma, whereas magmatic zircons from the dolerite have εHf(t) value of 11.0±1.4 with Hf depleted mantel model age of 342–657 Ma, consistent with those from the porphyry. Considering other data on the geological evolution of this area, it is concluded that the mafic magma originated from the partial melting of Paleozoic enriched lithospheric mantle, whereas the felsic magma came from recycling of juvenile crust formed during the Paleozoic. Both of the protoliths are closely related to the subduction of the Paleo-Asian Ocean during the Paleozoic, indicating that the Paleozoic is an important period of large-scale crustal growth in the area. | ZHANG Jiheng GE Wenchun WU Fuyuan LIU Xiaoming | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 52 |
| 6 | Zircon U-Pb geochronology of basement metamorphic rocks in the Songliao Basin显示文摘Zircon LA-ICP MS U-Pb dating of six metamorphic rocks and a metagranite (breccia) from southern basement of the Songliao Basin are reported in order to constrain the formation ages of basement. The basement metamorphic rocks in the Songliao Basin mainly consist of metagabbro (L45-1), amphibolite (SN117), metarhyolitical tuff (G190), sericite (Ser) schist (N103), chlorite (Chl) schist (T5-1), biotite (Bi)-actinolite (Act)-quartz (Q) schist (Y205), and metagranite (L44-1). The cathodoluminesence (CL) images of the zircons from metagabbro (L45-1) and metagranite (L44-1) indicate that they have cores of magmatic origin and rims of metamorphic overgrowths. Their U-Pb isotopic ages are 1808±21 Ma and 1873±13 Ma, respectively. The zircons with oscillatory zoning from amphibolite (SN117) and Chl schist (T5-1), being similar to those of mafic igneous rocks, yield ages of 274 ± 3.4 Ma and 264 ± 3.2 Ma, re-spectively. The zircons from metarhyolitical tuff (G190) and Ser schist (N103) display typical magmatic growth zoning and yield ages of 424 ± 4.5 Ma and 287 ± 5.1Ma, respectively. Most of zircons from Bi-Act-Q schist (Y205) are round in shape and different in absorption degree in the CL images, implying their sedimentary detritals. U-Pb dating yield concordant ages of 427 ± 3.1Ma, 455 ± 12 Ma, 696 ± 13 Ma, 1384±62 Ma, 1649±36 Ma, 1778±18 Ma, 2450±9 Ma, 2579±10 Ma, 2793±4 Ma and 2953±14 Ma. The above-mentioned results indicate that the Precambrian crystalline basement (1808―1873 Ma) exists in the southern Songliao Basin and could be related to tectonic thrust, and that the Early Paleozoic (424―490 Ma) and Late Paleozoic magmatisms (264―292 Ma) also occur in the basin basement, which are consistent with the ages of the detrital zircons from Bi-Act-Q schist in the basement. | PEI FuPing XU WenLiang YANG DeBin ZHAO QuanGuo LIU XiaoMing HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，7： | 57 |
| 7 | U–Pb ages and Hf isotopes for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southwestern margin of the North China Craton显示文摘In situ U-Pb dating and Lu-Hf isotopic analysis were carried out for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southern margin of the North China Craton (NCC). The re- sults provide further constraints on the crustal formation and evolution history of NCC. Four 207Pb/206Pb age populations were obtained from 99 analyses, with clusters at ~3.40 Ga, 2.77―2.80 Ga, ~2.50 Ga and 2.34 Ga, respectively. The 3.40 Ga old zircons have similar Hf isotopic compositions to those from Ar- chean rocks in the Jidong and Anshan areas of NCC. However, crustal remnants older than 3.6 Ga have been identified in the southern margin of NCC, the South China Craton, the northwestern part of the Qinling Orogen and its adjacent area. Thus, it is not easy to trace the source rock from which the 3.40 Ga detrital zircons were derived. It can be inferred that the crustal remnants older than 3.40 Ga might have been widely distributed in the North China Craton. The 2.77―2.80 Ga zircons make up a relatively small proportion and have the highest εHf (t) values (up to 6.1±1.6), consistent with the Hf isotopic composition of the depleted mantle at 2.83 Ga. Their single-stage Hf model age of 2.83 Ga is close to their crystallized age, suggesting that their source rocks were extracted from the contemporaneous depleted mantle. The ~2.50 Ga zircon grains constitute about 85% of the total grain population and their Hf isotopic compositions indicate major growth of juvenile crust at ~2.50 Ga but minor reworking of ancient crust. The youngest zircon dated in this study gave an U-Pb age of 2337±23 Ma, which can be considered the maximum depositional age of the formation of the Songshan Group. | DIWU ChunRong SUN Yong YUAN HongLin WANG HongLiang ZHONG XingPing LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，18： | 54 |
| 8 | Timing of the Wudangshan, Yaolinghe volcanic sequences and mafic sills in South Qinling: U-Pb zircon geochronology and tectonic implication显示文摘The Wudangshan, Yaolinghe volcanic-sedimentary sequences and doleritic-gabbroic sills comprise the largest exposed Precambrian basement in South Qinling. Zircons separated from 5 volcanic-pyroclas- tic samples of the Wudangshan Group, 2 volcanic samples of the Yaolinghe Group and one sample for the mafic sills were used for U-Pb dating by laser ablation-inductively coupled plasma mass spec- trometry (LA-ICPMS). The results reveal that the Wudangshan volcanic sequence was formed at (755±3) Ma (a weighted mean from the 5 samples, MSWD=0.47), whereas the Yaolinghe volcanic suite and the mafic sill were crystallized at (685±5) (2 samples, MSWD=0.36) and (679±3) Ma (MSWD=1.6), respectively, which are equal to each other within analysis errors. These ages are markedly younger than those previously documented for the rocks. The newly obtained ages for the Wudangshan and Yaolinghe Groups are identical to those of the bottom Liantuo and slightly older than those of the Nantuo Forma- tions, respectively, lower strata of the Nanhua (middle to late Neoproterozoic) stratotype section in eastern Three Gorges, Yangtze craton. A range of inherited magmatic zircons was recognized with ages of 830 to 780 Ma, which are typical of Neoprotzrozoic magmatisms recorded along the margins and interior of the Yangtze craton. Thus, there is Neoproterozoic basement comprising 830―780 Ma igne- ous suites in South Qinling; the inherited zircons were detrital sediments derived from the northern margin of the Yangtze craton. Accordingly, it is suggested that the South Qinling is a segment of the Yangtze craton before the Qinling Orogeny. | LING WenLi REN BangFang DUAN RuiChun LIU XiaoMing MAO XinWu PENG LianHong LIU ZaoXue CHENG JianPing YANG HongMei | 2008 | Chinese Science Bulletin2008，53，14： | 44 |
| 9 | U-Pb zircon dating constraints on formation time of Qilian high-grade metamorphic rock and its tectonic implications显示文摘In order to constrain the formation time of high-grade metamorphic rocks in the Qilian Mountains, U-Pb zircon dating was carried out by using LA-ICPMS technique for a paragneiss of the Hualong Group in the Qilian Mountains basement series and a weakly foliated granite that intruds into the Hualong Group. Zircons from the paragneiss consist dominantly of detrital magma zircons with round or sub-round shape. They have 207Pb/206Pb ages mostly ranging from 880 to 900 Ma, with a weighted mean age of 891 ±9 Ma, which is interpreted as the magma crystallization age of its igneous provenance and can be taken as a lower age limit for the Hualong Group. Magma crystallization age for the weak-foliated granite is 875±8 Ma, which can be taken as an upper age limit for the Hualong Group. Accordingly, the formation time of the Hualong Group is constrained at sometime between 875 and 891 Ma. A few zir- cons from both paragneiss and weak-foliated granite display old inherited ages of 1000 to 1700 Ma and young metamorphic ages of Early Paleozoic. The zircon age distribution pattern confirms that the Qilian Mountains and the northern margin of Qaidam Basin had a united basement, with geotectonic affinity to the Yangtze Block. The results also reveal that sediments of the Hualong Group formed by rapid accumulation due to rapid crustal uplift-erosion. This process may result from intensive Neoproterozoic orogenesis due to assembly of the suppercontinent Rodinia. | XU WangChun ZHANG HongFei LIU XiaoMing | 2007 | Chinese Science Bulletin2007，52，4： | 32 |
| 10 | LA-ICP-MS zircon U-Pb dating from granitoids in southern basement of Songliao basin:Constraints on ages of the basin basement显示文摘Seven LA-ICP-MS zircon U-Pb datings from granitoids in the southern basement of the Songliao basin were done in order to constrain the ages of the basin basement. The cathodoluminescence (CL) images of the zircons from seven granitoids indicate that they are euhedral-subhedral ones with striped ab-sorption and obvious oscillatory zoning rims. The dating results show that a weighted mean 206Pb/238U age is 236±3 Ma for quartz diorite (sample No.T6-1) located in the western slope of the basin,that weighted mean 206Pb/238U ages are 319±1 Ma (2126 m) and 361±2 Ma (1994 m) for diorite (sample No.YC1-1) and granite (sample No.YC1-2) located in northern part of southeastern uplift of the basin,respectively,and that weighted mean 206Pb/238U ages are 161±5 Ma,165±2 Ma,165±1 Ma and 161±4 Ma for samples Q2-1,SN121,SN122,and SN72 granitoids located in southern part of southeastern uplift of the basin,respectively. The statistical results of ages suggest that the middle Jurassic granitoids con-stitute the main part of basement granitoids,and that the Hercynian and Indo-Sino magmatisms also occur in the basin basement. It is implied that the Songliao basin should be a rift one formed in the intracontinent or active continental margin settings in the late Mesozoic after the Middle Jurassic orogeny took place. | GAO FuHong XU WenLiang YANG DeBin PEI FuPing LIU XiaoMing HU ZhaoChu | 2007 | Science China Earth Sciences2007，50，7： | 31 |
| 11 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 12 | Petrogenesis of Mesozoic High-Mg Diorites in Western Shandong: Evidence from Chronology and Petro-geochemistry显示文摘The high-Mg diorites, widely occurring in western Shandong, have important implications in the study of the relationship between the Mesozoic magmatism and the nature of the lithosphere and its thinning period in the eastern North China craton (NCC). The Tietonggou and Jinling intrusions are typically representatives. LA-ICP-MS zircon U-Pb dating, major and trace element and Sr-Nd isotopic compositions of the Mesozoic intrusive rocks from western Shandong, eastern China, were analyzed. The weighted mean 206Pb/ 238U ages from LA-ICP-MS zircon U-Pb dating results for early norite-diorite, late pyroxene-diorite from the Tietonggou intrusion and biotite-diorite from the Jinling intrusion are (131.4±4.9) Ma(n=15), (134.5±2.3) Ma(n=13), and (132.8±4.2) Ma(n=12), respectively, implying that they were formed in the Early Cretaceous. The weighted mean 207Pb/ 206Pb ages for round zircons from late pyroxene-diorite in the Tietonggou intrusion is (2 513±54) Ma(n=8), suggesting that the basement of the North China craton should exist in the research area. The high-Mg diorites are characterized by enrichment in MgO, Na2O, and light rare earth elements (LREE), and they are poor in heavy rare earth elements (HREE) and high field strength elements (HFSE), being similar to adakite. The existence of the mantle peridotite xenoliths with a high-Mg feature for these intrusive rocks implies that their primary magma should be derived from the upper mantle. However, Sr-Nd isotopic compositions (I sr: 0.704 75-0.707 15; ε Nd(130 Ma) values: -3.95 to -13.30), depletion in HFSE, and the occurrence of Archean inherited zircons suggest that crustal materials could be involved in the derivation of the primary magma. The compositional difference between the diorites from the Tietonggou and Jinling intrusions could be attributed to those of magma sources and degrees of partial melting. The Early Cretaceous high-Mg diorites are considered to have been formed by the mixed melting of the delaminated lithosphere (lithospheric mantle + crust) and asthenosphere, based on their geochemistry, the mantle-derived xenoliths, and the Early Mesozoic lithospheric evolutionary history of the eastern North China craton. | Yang Chenghai Xu Wenliang Yang Debin Liu Changchun Liu Xiaoming Hu Zhaochu | 2005 | Journal of China University of Geosciences2005，16，4： | 24 |
| 13 | U-Pb dating of detrital zircons from the Wudangshan Group in the South Qinling and its geological significance显示文摘U-Pb dating was made by the LA-ICP-MS method for detrital zircons from the Wudangshan volcanic-sedimentary succession in the South Qinling. Samples comprise quartz sandstones of the Wudangshan Group collected from the base of the Yangping For-mation and an upper layer of the Shuangtai Formation overlain its volcanic sequence, and two river-sand collections from the drainage systems cutting across the two formations, respectively. The results show that the Yangping detrital zircons are domi-nated by 830–780 Ma grains with a minor population of ~1.0–0.84 Ga and sporadic grains of ~2.6, ~2.4 and 2.0 Ga, whereas the Shuangtai zircons yield an upper intercept age of 763±33 Ma, identical to the timing of the Wudangshan volcanism within error, with few concordant grains of 1.9 and 0.86 Ga. Age spectra for the two river-sand samples are similar to those of the Yangping and Shuangtai Formations, respectively. It thus suggests that the Wudangshan strata are less than 780 Ma, whereas their major detrital zircon populations of 1.0–0.85 Ga and 830–780 Ma are consistent with timing of the Hannan magmatic activities along the northwestern margin of the South China Block. This suggests a Hannan or adjacent area provenance for the Wudangshan strata. The Wudang area is characterized by rift-related igneous events at ~755 and ~680 Ma, respectively, pointing to a tectono-magmatic history different from the Hannan area. It is inferred that the ~755 Ma magmatism is likely to indicate a separation of the South China Block from the supercontinent Rodinia, while the ~680 Ma event suggests a further split between the South Qinling and some unknown continent. | LING WenLi DUAN RuiChun LIU XiaoMing CHENG JianPing MAO XinWu PENG LianHong LIU ZaoXue YANG HongMei REN BangFang | 2010 | Chinese Science Bulletin2010，55，22： | 24 |
| 14 | ~4.1 Ga xenocrystal zircon from Ordovician volcanic rocks in western part of North Qinling Orogenic Belt显示文摘High-precision U-Pb dating by in situ LA-ICP-MS yields an age of 4079±5 Ma for a xenocrystal zircon from Ordovician volcanics of the Caotangou Group in western part of the North Qinling Orogenic Belt. As a result, the North Qinling Orogenic Belt becomes one of a few localities in the world that contain Hadean age records (4276±6 Ma and 4404±8 Ma detrital zircons from Jack Hill of the Yilgarn craton, 4016 Ma Acasta gneisses of the Wopmay Orogeny and Burang quartzite with detrital zircon of 4103 Ma in Tibet). It is also the first report of the Hadean age in Phanerozoic volcanics. The finding of the 4.1 Ga xenocrystal zircon provides not only the geochronological record of the oldest crustal materials in China, but also the condition for further search for rocks forming in the region during the early time of the Earth’s evolution. Thirty-six zircon U-Pb dates from the Ordovician volcanic rocks are subgrouped into seven generations that represent different tectono-magmatic events in the North Qinling Orogenic Belt. Among them, two periods of 0.9-1.5 Ga and 0.4-0.5 Ga are consistent with Mesoproterozoic and Early Paleozoic orogenies, respectively. | WANG HongLiang CHEN Liang SUN Yong LIU XiaoMing xu XueYi CHEN JuanLu ZHANG Hong DIWU ChunRong | 2007 | Chinese Science Bulletin2007，52，21： | 23 |
| 15 | Geochronology and geochemistry of the Fangcheng Neoproterozoic alkali-syenites in East Qinling orogen and its geodynamic implications显示文摘Finding of Neoproterozoic syenites at Fangcheng in the northern Qinling region of the East Qinling orogen provides an important constraint on timing of tectonic transformation to extensional regime. The alkaline pluton consists mainly of nepheline syenite,aegirine syenite,and alkali-feldspar syenite. The syenites are of intermediate (SiO2=54%―62%),rich in alkali (K2O+Na2O=12%―15%),aluminum (Al2O3=16.81%―23.26%) and large ion lithophile elements (LILE),without any obvious Nb,Ta,Zr,and Hf anoma-lies. The Fangcheng syenites are geochemically characterized by relative enrichment of LREE,minor differentiation of HREE,significant negative Eu anomalies (Eu=0.13―0.23),less negative εNd(t) values of -1.37 to -3.90,young Nd model ages of 1364 to 1569 Ma,and high zircon saturation temperatures of 915 to 1044℃. The syenitic magmas probably originated from small proportion melting of upper mantle in an extensional regime of intraplate-anorogenic tectonic setting,and have been slightly contaminated by crustal materials during ascending and/or emplacement. LA-ICP-MS zircon U-Pb dating yields ages of 844.3±1.6 Ma (MSWD=0.86),suggesting that the Fangcheng alkaline syenites formed in the early Neo-proterozoic. They are the oldest Neoproterozoic alkaline rocks ever recognized in the Qinling orogen as well as in South China. This implies that the tectonic regime of the Qinling region would have transformed from post-collisional stretch to intraplate-anorogenic extension no later than 844 Ma. | BAO ZhiWei WANG Qiang BAI GuoDian ZHAO ZhenHua SONG YaoWu LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，13： | 22 |
| 16 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 17 | One-step scalable preparation of N-doped nanoporous carbon as a high-performance electrocatalyst for the oxygen reduction reaction显示文摘做 N 的多孔的碳材料被 ethylenediaminetetraacetic 酸(EDTA ) 和三聚氰胺的简单一步舞热分解面对 KOH 和公司(NO3 ) 准备了 2 敨匠戭獡摥瀠潨潴慣慴祬瑳 ? 景敦楲杮洠牯 ? 晥敦瑣癩? 湥楶潲浮湥慴? 灡汰捩瑡潩獮慭吗?? | Zhenyu Liu Guoxin Zhang Zhiyi Lu Xiuyan Jin Zheng Chang Xiaoming Sun | 2013 | Nano Research2013，6，4： | 21 |
| 18 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 19 | Constraints on the age of the Tuchengzi Formation by LA-ICP-MS dating in northern Hebei-western Liaoning, China显示文摘Accurately determining the age of the Tuchengzi Formation has direct influence on confirming the boundary between the Jurassic and the Cretaceous systems in northern Hebei-western Liaoning, and on related geological problems in China. However, the Tuchengzi Formation mainly consists of sedi-mentary rocks, with a poor fossil record and especially lack of index fossils. The Tuchengzi Formation is also lack of the type of volcanic rocks that can provide an isotopic age. Therefore, the age of the Tuchengzi Formation has been uncertain. Based on our systematic dating of the tuff interbedded in the Tuchengzi Formation of Chengde and Jinlingsi-Yangshan basins in northern Hebei-western Liaoning, combined with the dating results of previous researchers, here we suggest that the age range of the Tuchengzi Formation in northern Hebei-western Liaoning is from 147 Ma to 136 Ma. It implied that the Tuchengzi Formation was mainly formed in the Early Cretaceous. | ZHANG Hong WEI ZhongLiang LIU XiaoMing LI Dong | 2009 | Science China Earth Sciences2009，52，4： | 18 |
| 20 | Zircon U-Pb dating on the Mesozoic volcanic suite from the Qingshan Group stratotype section in eastern Shandong Province and its tectonic significance显示文摘A geochronological study of zircon U-Pb on the volcanic rocks from the stratotype section of the Qingshan Group within the Jiaozhou Basin, eastern Shandong Province, is presented. The zircons were analyzed using the method of in situ ablation of a 193 nm excimer laser system coupled with an up to date ICP-MS system. Among the three formations of the Qingshan Group, zircons recovered from the lowest part of the Houkuang Fm. were dated at 106±2 Ma (95% confidence, the same below), whereas those from the lower and upper parts of the Shiqianzhuang Fm. were given ages of 105±4 Ma and 98±1 Ma, respectively. A spatially decreasing trend for the Mesozoic magmatic timing from west to east in the province is observed through comparing the data of this study with those by previous works on the Qingshan volcanic lavas occurring at western Shandong and within the Yishu fault zone. The Qingshan volcanic rocks are constituent of the 'Shoshonite Province' in East China. Exposed at most provinces of central East China along the Tan-Lu fault and the Yangtze fault zones, these volcanic suites are characterized by shoshonite and high-K calcalkalic rocks in lithology and thought to be correlated with the partial melting of continental mantle in genesis. It is also shown that the Qingshan potassic volcanic suite from eastern Shandong basins is distinctly younger than those from other ar-eas of the shoshonite province. By contrary, ages of the Mesozoic to Cenozoic alkaline basalts, sourced by asthenospheric mantle, from both northern Huaiyan basin and northern Dabie belt along the Tan-Lu fault zone and from the Ningwu, Lishui and Luzong basins along the Yangtze fault zone are observably older than those occurring within eastern Shandong. The revealed temporal and spatial patterns in magmatism for the two types of volcanic suites make an important geochronological con-straint on the Mesozoic to Cenozoic dynamic evolution model of the subcontinental lithosphere in East China. | LING WenLi XIE XianJun LIU XiaoMing CHENG JianPing | 2007 | Science China Earth Sciences2007，50，6： | 18 |
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